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All Journal Medula Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Wiyata : Penelitian Sains dan Kesehatan Diklabio: Jurnal Pendidikan dan Pembelajaran Biologi Jurnal Teknologi Sistem Informasi dan Aplikasi PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Dunia Farmasi J-HESTECH (Journal Of Health Educational Science And Technology) PREPOTIF : Jurnal Kesehatan Masyarakat Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Insan Farmasi Indonesia JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Jurnal Farmasi Indonesia Jurnal Bisnis dan Ekonomi Media Farmasi Conference Proceedings International Conference on Education Innovation and Social Science International Journal of Contemporary Sciences (IJCS)
Evi Kurniawati, Evi
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Medula

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Skrining Fitokimia Kualitatif Ekstrak Etanol 96% dan H-Heksana Kulit Batang Bakau Lindur (Bruguiera gymnorrhiza) Ismunanto, Aziza Regina Kinasih; Kurniawati, Evi; Putri, Giska Tri; Susianti, Susianti
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1253

Abstract

Lindur mangrove plants (Bruguiera gymnorrhiza) are known to contain secondary metabolite compounds which function as antibacterials. These secondary metabolite compounds include alkaloids, flavonoids, tannins, phenols, saponins, terpenoids and steroids. The design of this research was experimental, carried out to determine and compare the phytochemical components contained in 96% ethanol extract and n-hexane of Bruguiera gymnorrhiza mangrove bark. Bruguiera gymnorrhiza mangrove bark was taken at KPH Gunung Balak, East Lampung, then 4.5 kg of wet mangrove bark was obtained and dried for 7 days, then the extract was made using the maceration method for 3x24 hours using 2 types of solvents, namely 96% ethanol and n-hexane with a ratio of 1:10 between simplicia and solvent. Thick extracts were obtained from the two types of solvents which were then carried out qualitative phytochemical tests.  The results of this study showed that 96% ethanol extract and n-hexane of Bruguiera gymnorrhiza mangrove bark positively contained secondary metabolite compounds. The 96% ethanol extract of Bruguiera gymnorrhiza mangrove bark contains all types of secondary metabolite compounds, namely alkaloids, flavonoids, tannins, phenols, saponins, terpenoids and steroids, while the n-hexane extract contains secondary metabolite compounds, namely alkaloids, flavonoids, tannins, phenols, terpenoids, steroid but does not contain saponins. The conclusion of this research is that the 96% ethanol extract of Bruguiera gymnorrhiza mangrove bark contains more secondary metabolite compounds than the n-hexane extract of Bruguiera gymnorrhiza mangrove bark.
Tinjauan Pustaka: Pengaruh Hipertensi Kronis pada Ibu Hamil terhadap Kejadian Preeklampsia Putri, Morica Angellia Shyama; Kurniati, Intanri; Putri, Giska Tri; Kurniawati, Evi
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1458

Abstract

Chronic hypertension in pregnant women is a medical condition that can significantly affect maternal and fetal health. Chronic hypertension is defined as high blood pressure that has been present before pregnancy or diagnosed before 20 weeks of gestation. Risk factors that affect this condition include older maternal age, obesity, family history of hypertension, and an unhealthy lifestyle. The pathophysiology of chronic hypertension that progresses to preeclampsia involves endothelial dysfunction, which causes vasoconstriction and decreased placental perfusion, leading to placental hypoxia and increased oxidative stress, which further triggers activation of systemic inflammatory pathways causing damage to target organs such as the kidneys (proteinuria) and liver (elevated liver enzymes). The prevalence of chronic hypertension in pregnant women in Indonesia is quite high. According to data from the Lampung Provincial Health Office in 2018, hypertension in pregnancy caused 15.16% of maternal deaths. In addition, data from Riskesdas 2018 shows that the prevalence of hypertension in pregnant women in Indonesia is 6.18%, with the highest prevalence in West Java Province at 10.57%. The purpose of this article is to provide a better understanding of the effect of chronic hypertension in pregnant women on the incidence of preeclampsia. This article will discuss the association of chronic hypertension with the risk and underlying mechanisms of preeclampsia.
PENGARUH EKSTRAK DAUN RANDU (Ceiba pentandra) TERHADAP PROSES PENYEMBUHAN LUKA SAYAT PADA MENCIT (Mus musculus L) Jezmy, Beby Kelidia; Oktarlina, Rasmi Zakiah; Sari, Ratna Dewi Puspita; Kurniawati, Evi
Medula Vol 15 No 2 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i2.1607

Abstract

Wound causes mechanical bleeding, inducing a response of the body to fix itself which undergoes a wound healing process through a few phases; hemostasis, inflammation, proliferation, and maturation or remodelling. Wound healing is a complex process due to biocellular and biochemistry activities occuring continously. One of the natural treatments is the administration of randu (Ceiba pentandra) leaf, a Spermatophyte which has been identified and used for its healing properties. This study was an experimental study with a post-test-only control group design, and datas were analyzed using a non-parametric Kruskal Wallis test. Treatments were given randu (Ceiba pentandra) leaf extract, grouped into 4: (K1): a negative control group, (P1): 40 ml of randu (Ceiba pentandra) leaf extract, (P2): 60 ml of randu (Ceiba pentandra) leaf extract, and (P3): 80 ml of randu (Ceiba pentandra) leaf extract. Through this study, randu (Ceiba pentandra) leaf extracts were rated based on the its wound healing rate and showed results of 80 ml, 60 ml, and 40 ml respectively. There is an effect of administration of randu (Ceiba pentandra) leaf extract on cut wound healing in mice (Mus musculus L) (p=0,037)  
Co-Authors Afandi Ali Ikhwan Anis Akhwan Dhafin Ardianto, Dimas Arief, Muhtosim Asih Imulda Hari Purwani Dewy Resty Basuki, Dewy Resty Eko Sri Wahyuni Esti Ambar Widyaningrum Esti Ambar Widyaningrum Faisal Akhmal Muslikh Fendy Prasetyawan Fita Sari, Fita Fitriani, Marina Giska Tri Putri Herlinda Mawardika Ida Kristianingsih Intanri Kurniati Irawati, Renny Nur Satya Irawati, Reny Nur Satya Ismunanto, Aziza Regina Kinasih Jezmy, Beby Kelidia Kharisma, Krisna KRISNA KHARISMA PERTIWI Lestari, Tri Puji Ma'arif, Burhan Mawarni, Agrintya Indah Mita Riandini, Hanifa Ninis Yuliati, Ninis Putri, Morica Angellia Shyama Rachma Nurhayati Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Riadi, Refren Rilawati, Fentyana Dwi Rizky, Fara Nikhmatul Salmasfattah, Novyananda Shofiatul Fajriyah Shoviantari, M.Farm., Apt., Fenita Sony Andika Saputra Sugiyartono, Sugiyartono Susianti, Susianti Tri Puji Lestari Zenmas, Syendriva Zeptyan