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All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology JMM (Jurnal Masyarakat Mandiri) Jurnal Kreativitas PKM Abdimas Umtas : Jurnal Pengabdian kepada Masyarakat JURNAL FARMASI GALENIKA JURNAL FARMASIMED (JFM) Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Jurnal Media Informatika Jurnal Pengabdian Masyarakat : Pemberdayaan, Inovasi dan Perubahan Jurnal Ilmu Medis Indonesia Journal Of Human And Education (JAHE) Jurnal Farmasi Klinik dan Sains Indonesian Research Journal on Education Madani: Multidisciplinary Scientific Journal Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Journal of Information System, Technology and Engineering Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Borneo Journal of Pharmacy Journal of Public Health Science (JoPHS) Jurnal Kefarmasian Indonesia Science: Indonesian Journal of Science Journal of Pharmacopoeia Jurnal Ilmiah Ilmu Kesehatan World Health Digital Journal (wolgitj)
Saeful Amin, Saeful
Prodi Farmasi, STIKes Bakti Tunas Husada Tasikmalaya
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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ANALISIS ZAT WARNA EKSTRAK ETIL ASETAT BUAH TOMAT APEL (Lycopersicon esculentum Miller) MENGGUNAKAN SPEKTROFOTOMETER ULTRAVIOLET-VISIBLE Amin, Saeful; Nurcahya, Eulis
JURNAL FARMASI GALENIKA Vol 5 No 2 (2018): Jurnal Farmasi Galenika Volume 5 No. 2, 2018
Publisher : Sekolah Tinggi Farmasi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (587.856 KB)

Abstract

Tumbuhan Lycopersicon esculentum Miller dikenal juga dengan buah tomat apel yang mengandung zat warna alami yaitu likopen. Penelitian ini dilakukan terhadap zat warna hasil ekstraksi dari buah tomat apel (Lycopersicon esculentum Miller). Tahapan pengujian dilakukan dengan menentukan panjang gelombang maksimum yang bertujuan untuk mengetahui nilai absorbansi tertinggi dari optimasi pelarut dan perbedaan waktu ekstraksi dengan mengukur serapan pada panjang gelombang 400-800 nm menggunakan spektrofotometer UV-Vis. Dilakukan optimasi pelarut dan perbedaan waktu ekstraksi dengan penentuan absorbansi pada pencarian panjang gelombang maksimum. Uji stabilitas terhadap pH dilakukan pada pH 4 pH 7 pH 10 yang dilihat berdasarkan nilai absorbansi tertinggi dan uji stabilitas terhadap suhu pemanasan dilakukan pada suhu 30oC, 40oC, 50oC, 60oC, 70oC. Hasil penelitian bahwa kondisi optimum ekstraksi zat warna dari buah tomat apel (Lycopersicon esculentum Miller) yaitu menggunakan pelarut etil asetat dengan waktu ekstraksi 10 menit pada pH 7 dan suhu 60oC.
Synthesis and Characterization Molecularly Imprinted Polymers for Analysis of Dimethylamylamine Using Acrylamide as Monomer Functional Amin, Saeful; Damayanti, Sophi; Ibrahim, Slamet
Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 2, AGUSTUS 2018
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v8i2.330

Abstract

A selective separation techniques with Molecularly Imprinted Polymer (MIP) for High-Performance Liquid Chromatography (HPLC) has been developed for the assay of Dimethylamylamine (DMAA) doping compounds. Molecular imprinted polymer (MIP) is a technique to produce a polymer having the cavity due to the disposal of the templates, in which the cavity serves to recognize the molecules of the same size, structure, chemical and physical properties. The selectivity and affinity of the templates itself will increase, while the concentration value is increasing. MIP is made by DMAA as template, acrylamide as functional monomer, ethylene glycol dimethacrylate (EGDMA) as cross linking, azobisisobutyronitrile (AIBN) as the initiator and chloroform as a porogen solvent; using bulk method. The aim of research are conduct the MIP for the DMAA compound analysis, then the formed MIP is characterized by using Fourier Transform Infra Red (FTIR) and Scanning Electron Microscopy (SEM) to find out the polymer complexes formed and the morphological form of the MIP. The MIP formed then was analyzed by using High-Performance Liquid Chromatography (HPLC) to know the amount of the DMAA, the adsorption capacity, and the adsorption condition found in the MIP. The result of analysis on the content of DMAA in the MIP by using UV-Vis Spectrophotometer is 1.957 mg. Scanning Electron Microscopy (SEM) shows that the MIP has irregular and rough morphological structure; while the NIP has irregular morphology structures and smooth surfaces shape
Ethanol solvent and pH effect on antioxidant activity of purple sweet potato (Ipomoea batatas L.) Nurzaman, Mochamad Herdi; Adlina, Salsabila; Herdianti, Nita; Amin, Saeful
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.30406

Abstract

Air pollution induces the production of reactive oxygen species (ROS), which can cause tissue damage when excessive. Antioxidants help counteract this damage, and purple sweet potatoes, rich in anthocyanins, are a promising natural antioxidant source. This study aimed to determine the effect of solvent acidity variations on the antioxidant activity of purple sweet potato (PSP) tuber extract and identify the optimal pH condition. Using the DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging assay, ethanol solvents at different pH levels (non-acidified ethanol, pH 2.5, pH 2, and pH 1.5) were tested. The results showed that higher acidity enhanced antioxidant activity, with the strongest activity observed at pH 1.5, yielding an IC50 value of 9.74±0.23 ppm. Although less potent than Vitamin C (IC50 1.22±0.04 ppm), the extract demonstrated significant potential as a natural antioxidant source. Further studies on anthocyanin content are recommended to better understand its contribution to antioxidant activity.
Pharmacy Education: Preparing Pharmacists for Global Challenges in the Digital Age Amin, Saeful; Fadli, Fadli; Justicia, Adhisty Kharisma
Journal of Pharmacopoeia Vol. 2 No. 1 (2025): MARCH-JP
Publisher : Pt. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/r72dcy77

Abstract

This study aims to examine the development of pharmacy education in the digital era, as well as to prepare pharmacists to face global challenges. The method used is the Systematic Literature Review (SLR), which is carried out by collecting, evaluating, and synthesizing previous research results comprehensively. The research process includes identifying literature through academic databases such as Scopus, PubMed, Google Scholar, and ScienceDirect, selecting studies based on inclusion and exclusion criteria, extracting data related to objectives, methods, results, and conclusions, synthesizing findings, and reporting research results. The results of the study indicate that pharmacy education needs to transform to prepare competent pharmacists in the digital era. Integration of technology into the curriculum such as e-learning, blended learning, augmented reality (AR), and virtual reality (VR) provides a more flexible learning experience. In addition, mastery of technology such as big data, artificial intelligence (AI), and pharmacy information systems is essential to support evidence-based decision making and efficiency of health services. The challenges faced include limited infrastructure, resistance to change, and the gap between the competencies taught and the digital skills needed in the world of work. Therefore, curriculum updates and training for pharmacists who are already working are very necessary to ensure pharmacists are prepared to face an increasingly digitalized profession
Kimia Medisinal dan Perannya Dalam Pengembangan Terapi Personalisasi M, Maesaroh; Amin, Saeful
Madani: Jurnal Ilmiah Multidisiplin Vol 3, No 3 (2025): April 2025
Publisher : Penerbit Yayasan Daarul Huda Kruengmane

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.15187886

Abstract

Personalized therapy is a treatment approach that considers genetic, environmental, and lifestyle variations of each individual to optimize the effectiveness and safety of therapy. This study aims to analyze the role of medicinal chemistry in the development of personalized therapy through the perspective of rational design of drug molecules, structural modification, and optimization of pharmacokinetic-pharmacodynamic properties. The method used is a systematic literature review with the PRISMA approach to scientific publications in 2013-2023 that focus on the integration of medicinal chemistry with pharmacogenomics and personalized therapy. The results of the study showed that medicinal chemistry plays an important role in four main areas: (1) drug design based on specific genetic targets with high selectivity (76% of publications); (2) development of prodrugs and drug delivery systems that are responsive to individual biomarkers (63% of publications); (3) optimization of pharmacokinetics based on genetic variations of drug metabolizing enzymes (58% of publications); and (4) development of molecular probes for companion diagnostics (52% of publications). Further analysis identified the development trends of personalized therapy including multi-target drug design based on patient molecular profiles and big data-based medicinal chemistry strategies. The main challenges identified include the complexity of molecular modification to achieve pharmacokinetic profiles that match specific genetic subtypes and the limitations of experimental models that represent individual heterogeneity. In conclusion, medicinal chemistry plays a fundamental role in realizing the concept of personalized therapy through the design and optimization of drug molecules that match individual patient characteristics. Further research is needed for the development of medicinal chemistry methodologies integrated with omics technology and artificial intelligence to accelerate the translation of the concept of personalized therapy into real clinical applications in Indonesia.
Obat-Obatan Laboratorium: Peran Kimia Medisinal Dalam Kesehatan Husen, Desinta Nurohman; Amin, Saeful
Madani: Jurnal Ilmiah Multidisiplin Vol 3, No 3 (2025): April 2025
Publisher : Penerbit Yayasan Daarul Huda Kruengmane

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.15186482

Abstract

Medicinal chemistry is a branch of science that combines the principles of chemistry and pharmacology to identify, evaluate, and assess drugs that have the potential to become new therapeutic agents. This article discusses the current state of medicinal chemistry and its applications in contemporary health, such as advances in treatment technology, computerization in medicinal chemistry, and innovations in contemporary medicinal chemistry. The methodology used is a systematic literature review related to scientific publications from 2018 to 2024. The research findings show that advances in computer technology, high- throughput screening, and structure-based drug design have accelerated the process of developing new drugs. In addition, there are other types of identification, such as peptide-based medicine, nanomedicine, and the use of intelligence in medicine. The main factors in the development of modern medicine include antimicrobial resistance, the ability to treat long- term diseases, and its bioavailability. The conclusion shows that medicinal chemistry remains an important foundation in the development of new therapies, with suggestions for improving multidisciplinary approaches, investing in computational technology, and focusing on personalized medicine approaches for more effective and safe drug development. 
Peran Kimia Medisinal Dalam Pengembangan Obat Baru Khaerina, Yunisa; Amin, Saeful
Madani: Jurnal Ilmiah Multidisiplin Vol 3, No 3 (2025): April 2025
Publisher : Penerbit Yayasan Daarul Huda Kruengmane

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5281/zenodo.15187685

Abstract

Medicinal chemistry plays a crucial role in the discovery and development of new, effective and safe drugs. This study aims to analyze the contribution of medicinal chemistry in the stages of drug development, from identification of target compounds to optimization of pharmacokinetic characteristics. The method used is a systematic literature review of the latest research and developments in the field of medicinal chemistry over the past ten years. The results of the study indicate that structure-based and computer-aided (in silico) approaches have significantly increased the efficiency of drug discovery, while molecular modification techniques contribute to the development of drugs with higher efficacy and minimal side effects. The analysis also identifies trends in nanotechnology-based drug development, the use of artificial intelligence, and green chemistry approaches in the synthesis of medicinal compounds. In conclusion, medicinal chemistry continues to develop as a vital discipline in facing the complex challenges of developing new drugs to overcome diseases that do not yet have adequate treatment. Further research is recommended to optimize the integration of various medicinal chemistry approaches with other interdisciplinary fields to accelerate the discovery of innovative new drugs.
Peran Pendidikan Tinggi dalam Kesehatan Masyarakat: Studi Kasus tentang Kesadaran dan Pencegahan COVID-19 Amin, Saeful; Nurhadiska, Muchamad Nizam
Science: Indonesian Journal of Science Vol. 2 No. 1 (2025)
Publisher : LPPI Yayasan Almahmudi bin Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/science.v2i1.247

Abstract

Pandemi COVID-19 telah menyoroti peran penting institusi pendidikan tinggi dalam kesadaran dan strategi pencegahan kesehatan masyarakat. Penelitian ini bertujuan untuk mengeksplorasi kontribusi universitas dalam meningkatkan pemahaman masyarakat tentang COVID-19 dan mempromosikan langkah-langkah pencegahan. Menggunakan pendekatan metode campuran, data dikumpulkan melalui survei dan wawancara dengan mahasiswa, fakultas, dan anggota komunitas. Temuan menunjukkan bahwa inisiatif pendidikan secara signifikan meningkatkan kesadaran tentang penularan dan metode pencegahan COVID-19, yang mengarah pada kepatuhan yang lebih tinggi terhadap protokol kesehatan di kalangan masyarakat. Selain itu, penelitian ini menekankan pentingnya kolaborasi antara institusi pendidikan dan organisasi kesehatan masyarakat dalam menghadapi krisis kesehatan. Sebagai kesimpulan, pendidikan tinggi memainkan peran vital dalam membentuk respons kesehatan masyarakat dan membangun masyarakat yang terinformasi dengan baik.
STUDI LITERATUR : TINJAUAN KIMIA MEDISINAL TERHADAP PERAN SENYAWA BIOAKTIF DAUN SIRIH MERAH (Piper crocatum) SEBAGAI AGEN ANTIDIABETES MELITUS Amin, Saeful; Rangga Pratama, Andi
Jurnal Ilmiah Ilmu Kesehatan Vol. 3 No. 2 (2025): Volume 3, Nomor 2, Tahun 2025
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jiik.v3i2.44385

Abstract

Daun sirih merah merupakan tanaman liar yang menyebar ke seluruh Indonesia, daun sirih merah merupakan jenis tanaman herbal tradisional. Biasanya dimanfaatkan sebagai obat herbal, ramuan, tanaman upacara adat dan konsumsi sehari hari. Telah banyak didapatkan berbagai macam obat tradisional yang terbukti mampu mengobati berbagai penyakit. Secara tradisional daun sirih merah memiliki senyawa antidiabetes yaitu mengandung senyawa flavonoid, saponi, tannin dan alkaloid. Sehingga tujuan dalam kajian Pustaka untuk mengetahui kandungan daun sirih merah terhadap penurunan kadar gula darah. Metodologi penelitian ini yakni menulis artikel berdasarkan tinjauan studi literature. Kriterianya adalah jurnal yang diterbitkan 5 tahun terakhir dan terindeks di Google Scholar. Berdasarkan studi literature dari berbagai jurnal diperoleh bahwa daun sirih merah memiliki senyawa bioaktif antidiabetagonik.
Peran Senyawa Polifenol dalam Mekanisme Antioksidan: Tinjauan dari Aspek Kimia Medisinal Amin, Saeful; Assafa, Zifa
Jurnal Ilmiah Ilmu Kesehatan Vol. 3 No. 2 (2025): Volume 3, Nomor 2, Tahun 2025
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jiik.v3i2.44456

Abstract

Senyawa polifenol merupakan kelompok senyawa bioaktif yang tersebar luas dalam tanaman dan dikenal memiliki potensi sebagai antioksidan alami. Peranannya dalam menetralisir radikal bebas serta mencegah kerusakan oksidatif pada biomolekul menjadikannya subjek penting dalam penelitian farmasi dan kimia medisinal. Aktivitas antioksidan polifenol berkaitan erat dengan struktur kimianya, terutama keberadaan gugus hidroksil dan sistem konjugasi yang memungkinkan donasi elektron atau atom hidrogen. Selain itu, kemampuan polifenol untuk mengkhelasi ion logam transisi serta memodulasi jalur pensinyalan seluler menambah kompleksitas mekanisme kerjanya. Namun, keterbatasan dalam bioavailabilitas dan stabilitas biologis menjadi tantangan utama dalam aplikasinya secara klinis. Tinjauan ini membahas secara komprehensif struktur, mekanisme aksi, serta pendekatan kimia medisinal untuk mengoptimalkan aktivitas antioksidan polifenol. Pendekatan ini meliputi modifikasi struktur, penggunaan sistem penghantaran cerdas, dan analisis hubungan struktur-aktivitas guna meningkatkan efektivitas serta ketersediaan biologis senyawa polifenol sebagai agen terapeutik.
Co-Authors Abdurrahman, Muhammad Iqmal Afifah, Fitri Nur Aisyah, Rohmah Ala Anistia Widya Allita, Nur Alya, Elsa Amelya, Isti Nisa Amelya, Risna Anggi Setiawan, Rio Anisa, Anis Anna Yuliana, Anna Annisa, Hilma Tri Ansyirohanisa Apriliani, Cici Aprillia, Ade Yeni Ardian, Mohamad Idwar Arman, Siti Alisa Assafa, Zifa Athaya, Rahil Auliya, Shafa Awalia, Najla Nisa Az Zahra, Siti Zulfa Azijah, Rachma Nur Azzahra, Shafa Meyliana Beni Maulana Habib Cahya, Nabilla Amelia Claudya, Stefanie Darmawan, Muhammad Rahmat De Hiban Fauzan Mabruro Destian, Lufi Fadli Fadli Fajarini, Syifa Rizkia Fajrin, Ari Muhammad Fatihatul Makia, Fina Fauzi, Rifqi Ahmad Febriana Nur Anggraeni Fernanda, Refa Fitri, Nabila Ainul Fitria, Annisya Ahya Friana, Derina Agus Fuadah, Iga Syamratul GUNAWAN, ADRI Gunawan, Febrianti Rizki Guspiana, Rudi Hasanah, Muna Shintya Heppi Syofya, Heppi Herawati, Tantri Herdianti, Nita Heryanto, Popih Huda, Dian Fitri Kulyatul Huda, Muhammad Ismail Sabilul Hurry, Zulfan Alfairuz Zabbady Husen, Desinta Nurohman Ibadurrahman, Rifki Ilham Alifiar, Ilham Imani, Anneu Deanti Ira Rahmiyani Jannah, Isma Aenul Judijanto, Loso Justicia, Adhisty Kharisma Jutti Levita Khaerina, Yunisa Kurniawan, Yoga Sugama Kushariyadi Kusumadewi, Fitria Balqis Lansini, Sinka M, Maesaroh Maharani, Cici Maharani, Komang Dewi Maria, Hana Diana Meilani, Yeni Muhammad Rahmat Darmawan Muhtar, Nenden Laila Nurafifah Mulhimah, Ai Mustafidah, Syifa Nabila, Nazelia Saila Nabila, Tiana Zulfa Nabila, Yesita Yumna Nadhira Alika Putri Neng Widy Widiyawati Nurahman, Rima Putri Nurassyifa, Reva Puspa Rizkia Nurcahya, Eulis Nurhadiska, Muchamad Nizam Nurliawati, Fadhillathul Paridah, Dea Nur Pebiansyah, Anisa Pitara, Devi Pujiyani, Delya Putri, Listya Nurina Rachmat, Shinta Widia Rahmawati, Desti Rais, Rinovian Ramadani, Adinda Laisya Ramdhiani, Nova Dwi Rangga Pratama, Andi Riedho Prima Cahya Riesna Apramilda Riska Prasetiawati, Riska Rizky Pratama Putra Rusdaita, Febia Citraeni Rusiyana, Nisrina Putri Salimah, Suci Intan Salsabila Adlina Saputra, Erwin Yuliana Satria, Deagi Taufik Shaleha, Resha Resmawati Sheryl, Vanessa Angelica Slamet Ibrahim - Soegeng Wahyoedi Sophi Damayanti Sri Adi Sumiwi Sudrajat, Nisya Aulia Rahmatillah Sumantri, Tri Adi Sumardiawan, Dhiyaa Kaamilah Supriatna, Galuh Taruna Syamsudin, Atasya Taufik Hidayat Tia Setiawati Wardiah, Shelya Nurul Weguna, Asti Awaliyah Wibisono, Mohammad Alfin Wihdatunnisa, Imelda Yuliani, Renny Yulianingsih, Tipani Sri Yulianingsih Yustianti, Fitria Zahra, Hanum Nurannisa Zahra, Naila Maulida Zain, Dichy Nuryadin Ziani, Ziani