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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Kedokteran (Journal of Medical Science) Medical Journal of Indonesia Majalah Kedokteran Molecular and Cellular Biomedical Sciences (MCBS) Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Eksakta : Berkala Ilmiah Bidang MIPA Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia JURNAL ETIKA KEDOKTERAN INDONESIA Respiratory Science Pharmaceutical Sciences and Research (PSR) MEDICINUS Eduvest - Journal of Universal Studies Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Anna Rozaliyani
Department Of Parasitology, Faculty Of Medicine, Universitas Indonesia The Indonesian Society Of Respirology Indonesia Pulmonary Mycoses Centre
Aerospace Engineering Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Journal : Respiratory Science

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Immunopathogenesis of Pneumocystis Pneumonia (PCP) and Its Clinical Implications Malik, Andi Sri Suryani; Agustin, Heidy; Nurwidya, Fariz; Rozaliyani, Anna
Respiratory Science Vol. 5 No. 3 (2025): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i3.172

Abstract

Pneumocystis pneumonia (PCP) is a serious lung infection caused by Pneumocystis jirovecii, primarily affecting immunocompromised individuals. It remains a major health concern, especially in HIV/AIDS patients and those undergoing immunosuppressive therapy. This review discusses how the immune system responds to P. jirovecii and why immunocompromised individuals are more vulnerable. In healthy individuals, CD4+ T cells, B cells, and macrophages help control the infection. However, in immunocompromised individuals, a weakened immune response allows fungal overgrowth, leading to severe lung damage. The review also covers symptoms, diagnosis, and treatment options. TMP-SMX is the preferred treatment, while alternative drugs are available for those who cannot tolerate it. Understanding the immune response to PCP can help improve treatment and patient care.
Co-Authors Abul A'la Al Maududi Adrir, Mutia Syarifah Agus Dwi Susanto Agus Purwadianto Agustin, Heidy Ali Sulaiman Alvin Kosasih Ammar Abdurrahman Hasyim Anna Ujainah Anna Ujainah, Anna Annisa Mulia Anasis Anwar Jusuf Arief Riadi Arifin Arifin Nawas Arifin Nawas Arifin, Arief Riadi Ary Indriana Savitri Asiyah Taqiyya Fakhrur Razi Azharul Yusri Aziziah, Aziziah Bahtiar Husain Bambang Dwi Hasto Baskoro, Hario Boedi Swidharmoko Broto Wasisto Budi Prasetyo Budi Prasetyo C. Martin Rumende, C. Martin Christy Efiyanti Damayanti, Triya Denny Grecius Siregar Dewi Rizki Agustina Dewi Rizki Agustina, Dewi Rizki Diah Handayani Djatikusumo, Ari Dodi Sudiana Elisna Syahruddin Elqowiyya, Aqidatul Islamiyyati Erlang Samudro Erlina Burhan Evy Yunihastuti Fadlika Harinda Faisal, Hana Khairina Putri Fariz, Nurwidya Febriani Endiyarti Findra Setianingrum Findra Setianingrum Findra Setianingrum Frans Santosa Ghina Faradisa Hatta Hansel Tengara Widjaja Hario Baskoro Hasto, Bambang Dwi Hasyim, Ammar Abdurrahman Henie Widowati Heri Wibowo Heri Wibowo Husain, Bahtiar Ikhwan Rinaldi Indah Kusumawati Susanti Julian Julitasari Sundoro Kartika, Emiliana Kusumowidagdo, Gladys Librianty, Nurfanida Lisnawati Rachmadi Lukman Edwar Malik, Andi Sri Suryani Mardianto, Umar Marissa, Melani Mohammad Baharuddin Muh Ronike Yunus Muhammad Alkaff Muhammad Baharudin Muhammad Yadi Permana Mulyati Mulyati Mulyati Tugiran Oktarina, Caroline Pane, Irene Audrey Davalynn Prijo Sidipratomo Priyanti ZS Pukovisa Prawiroharjo Putri Dianita Ika Meilia Putri Dianita Ika Meilia R Sjamsuhidajat Rani Sauriasari Rani Sauriasari Ratika Rahmasari Retno Wahyuningsih Rianto Setiabudi Rianto Setiabudy Rianto Setiabudy Ridhawati Sjam Ridhawati, Ridhawati Rizki Oktarini Robiatul Adawiyah Robiatul Adawiyah Robiatul Adawiyah Rulliana Agustin Rulliana Agustin Samoedro, Erlang Sandra Widaty Sarah Almira Satria Pratama Satria Pratama Satria Pratama Savitri, Ary Indriana Setianingrum, Findra Sita Andarini Sresta Azahra Theola, Jason Tugas Ratmono Tugas Ratmono, Tugas Tugiran, Mulyati Vincent Pratama Wawang Sukarya Wawang Sukarya Yudantha, Anggun R. Yuli Budiningsih Yunita, Fenny Yuwono, Edho Zahrah Annisa Zaini, Jamal Zubairi Djoerban