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All Journal Jurnal Ilmu Pertanian Indonesia Jurnal Pendidikan Biologi Undiksha Biotropika Jurnal Sumberdaya Hayati Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Pembelajaran dan Biologi Nukleus Jurnal Ilmiah Kesehatan Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Jurnal Abdimas Berdaya : Jurnal Pembelajaran, Pemberdayaan dan Pengabdian Masyarakat Jurnal Biosense Quagga: Jurnal Pendidikan dan Biologi Bagimu Negeri : Jurnal Pengabdian Kepada Masyarakat Maximus: Journal of Biological and Life Sciences Indonesian Journal of Jamu
Iffa Afiqa Khairani
Institut Teknologi Sumatera
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Molecular Insights into the Therapeutic Potential of Curcuma amada Rhizome: A Network Pharmacology and Docking Approach Fatriani, Rizka; Istiadi, Khaerunissa Anbar; Khairani, Iffa Afiqa
Jurnal Jamu Indonesia Vol. 10 No. 2 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i2.397

Abstract

The rhizome of Curcuma amada (ginger mango) has traditionally been used for various medicinal purposes. However, its molecular targets and mechanisms of action are still poorly understood. This study aimed to predict the potential bioactive compounds and target proteins of C. amada using network pharmacology and molecular docking approaches. A total of 110 compounds were identified, and their predicted targets were analyzed through a protein-protein interaction (PPI) network, enrichment, and disease analysis. Key targets include phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA) and tyrosine-protein kinase JAK2 (JAK2), both of which are closely related to cancer-related pathways. Four compounds, β-eudesmol, (E,Z)-farnesol, spathulenol, and τ-muurolol, were selected for molecular docking studies. Validation of the docking protocol through re-docking showed low RMSD values ​​(0.667 Å for PIK3CA and 0.474 Å for JAK2), confirming the reliability of the method. The docking results demonstrated that the native ligands and selected compounds formed multiple hydrogen bonds and extensive hydrophobic interactions with key residues in the active site. Notably, most of the interactions were hydrophobic, which is consistent with the volatile nature of the ligands. The binding affinity was below –5 kcal/mol for all tested compounds. These findings suggest that C. amada rhizomes contain bioactive compounds capable of modulating cancer-related targets, thus providing a molecular basis for their potential therapeutic effects. 
IMMUNOSTIMULATORY EFFECT OF VITAMIN C ON MICE INDUCED BY STAPHYLOCOCCUS AUREUS Khairani, Iffa Afiqa; Riana, Elisa Nurma; Maretta, Gres; Azizah, Najla Nur; Putri, Isnaini Anggraini; Maruli, Berkat Afni; Mulyadi, Salsa Pratiwi; Antonius, Antonius
MAXIMUS: Journal of Biological and Life Sciences Vol. 1 No. 2 (2023)
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat (LPPM), Institut Teknologi Sumatera, Lampung Selatan, Lampung, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/maximus.v1i2.1636

Abstract

Several compounds that can boost immune activity (immunostimulatory) include vitamin E, curcumin, flavonoids, and vitamin C. In this study, ascorbic acid or vitamin C, was used as one method to enhance the immune system. This study aims to determine the immunostimulatory effect of vitamin C on the phagocytosis activity of macrophages in mice induced by Staphylococcus aureus. The mice were divided into two groups: the control group, which received 0.3 ml of distilled water orally, and the treatment group, which received 0.036 mg/g BW of vitamin C orally for 14 days. On the 15th day, each mouse was intraperitoneally induced with 0.5 mL of Staphylococcus aureus bacterial suspension and left for two hours. The phagocytic activity value represents the percentage of active macrophage cells among all macrophages observed. The result showed that the value of % phagocytic activity in the control group was 21.43% ± 7.92, whereas the % phagocytic activity in the treatment group was 48.31% ± 22.27. The group of mice given vitamin C 0.036 mg/g BW orally showed increased phagocytic activity compared to the control group mice. This shows that vitamin C has potential as an immunostimulator.
Quantitative Analysis of Phytochemical Compounds and Antihyperglycemic Potential of Robusta Coffee from West Lampung Khairani, Iffa Afiqa; Mulyana, Jeane Siswitasari; Olivia, Rahel Noviantika; Riana, Elisa Nurma; Anisa, Hida Arliani Nur
Jurnal Sumberdaya Hayati Vol. 10 No. 1 (2024): 2024
Publisher : Departemen Biologi, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jsdh.10.1.1-6

Abstract

West Lampung Regency in Lampung Province produces high quality robusta coffee with a distinct, strong bitter flavour. Bitter flavour indicates the amount of bioactive substances produced by plants called phytochemicals. The aim of this study is to analyse the phytochemical compounds and antihyperglycemic potential of robusta coffee beans from West Lampung, Indonesia. Quantitative phytochemical analysis was carried out using the thin layer chromatography method and spectrophotometry. Animal experimental design using robusta coffee on hyperglycemia conditions in mice which was induced by alloxan 170 mg/kgBW subcutaneously and given by 1 ml of brewed robusta coffee for 10 days. The robusta coffee from West Lampung contained total caffeine 4,014.87 µg/g, total flavonoid content (TFC) 93.6 mg quercetin equivalent per gram of sample, with total alkaloid content (TAC) 0.848 mg of quinine equivalent per gram of sample, total tannin content (TTC) 182.3 mg of tannic acid equivalent per gram of sample, and total saponin content (TSC) 24.2 mg of quillaja bark equivalent per gram of sample. The administration of 1 ml/mice/day of robusta coffee brewed for 10 days did not show a decrease in blood sugar level in hyperglycemic mice, due to the short duration of the study, so the role of coffee in decreasing hyperglycemia conditions has not been optimally observed.
Antioxidant Activity and Immunomodulatory Effect of Stachytarpheta sp. Leaf Extract on Phagocytic Activity of Mice Peritoneal Macrophages in Alloxan Induction Iffa Afiqa Khairani; Wahyuni Dian Lestari; Elisa Nurma Riana; Jeane Siswitasari Mulyana; Hida Arliani Nur Anisa; Rizka Fatriani; Silvia Andriani
Quagga: Jurnal Pendidikan dan Biologi Vol 17 No 2 (2025): QUAGGA : Jurnal Pendidikan dan Biologi
Publisher : Program Studi Pendidikan Biologi, Fakultas Keguruan dan Ilmu Pendidikan, Universitas Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25134/quagga.v17i2.404

Abstract

Hyperglycemia is a condition characterized by elevated blood glucose levels, which is a hallmark of diabetes mellitus. Prolonged hyperglycemia not only disrupts glucose homeostasis but also impairs the immune response. The condition of hyperglycemia in the body can increase free radicals and oxidative stress, thus can impair various macrophage functions, including their ability to engulf and eliminate pathogens. The bioactive constituents in Stachytarpheta sp. may contribute to reducing oxidative damage and enhancing immune system function. This study aims to evaluate both the antioxidant capacity and the immunomodulatory effects of Stachytarpheta sp. leaf extract on the phagocytic activity of peritoneal macrophages in alloxan-induced diabetic mice. Alloxan is widely used in research to induce hyperglycemia (diabetic conditions) in experimental animals. The antioxidant activity of the extract was evaluated using the DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging assay, while phagocytic activity of peritoneal macrophages was performed in vivo using male mice. Stachytarpheta sp. leaf extract from Beteng Sari Village, East Lampung has very strong antioxidant activity against DPPH with IC50 value 14,85 ± 0,30 μg/mL. This extract at doses of 200, 300, and 400 mg/kgBW can be an immunomodulator that maintains the phagocytic activity of macrophage cells in alloxan-induced mice.
Dampak Kualitas Tidur terhadap Sindrom Pramenstruasi pada Perempuan di Tiga Kecamatan Kabupaten Agam, Sumatera Barat Rara Mulia Sari; Winati Nurhayu; Iffa Afiqa Khairani; Andy Darmawan
Jurnal Penelitian Pendidikan IPA Vol 11 No 12 (2025): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i12.13021

Abstract

Premenstrual Syndrome (PMS) significantly impacts reproductive-age females, yet the interplay of lifestyle factors in rural contexts remains under-researched. This study aimed to analyze the relationship between sleep quality and PMS severity among females in Agam Regency, West Sumatra. A quantitative survey was conducted with 124 participants selected via purposive sampling. Data were collected using the Pittsburgh Sleep Quality Index (PSQI) and the Premenstrual Symptoms Screening Tool (PSST), then analyzed using Linear Models (LM) in R. Results showed that 84.67% of respondents reported poor sleep quality. LM analysis revealed that poor sleep quality significantly predicted severity across all PMS categories: PMDD (p = 0.0054), psychological/somatic symptoms (p = 0.0013), and daily dysfunction (p = 0.0007). Additionally, higher BMI was linked to increased PMDD symptoms (p = 0.0290), while stress significantly influenced daily functional impairment (p = 0.0234). In conclusion, poor sleep quality is a primary predictor of severe PMS, exacerbated by high BMI and stress. These findings suggest that sleep hygiene and stress management are critical non-pharmacological interventions for improving menstrual health in rural populations.
EFEK EKSTRAK KULIT BUAH KABAU (Archidendron bubalinum (Jack) I.C Nielsen) TERHADAP AKTIVITAS MAKROFAG MENCIT JANTAN SETELAH DIPAPARKAN CdCl2 Riana, Elisa Nurma; Khairani, Iffa Afiqa; Anisa, Hida Arliani Nur; Fatriani, Rizka; Andriani, Silvia
JURNAL BIOSENSE Vol 9 No 2 (2026): Edisi April 2026
Publisher : Universitas PGRI Banyuwangi, Jalan Ikan Tongkol No 01, Telp (0333) 421593, 428592 Banyuwangi 68416

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/biosense.v9i2.7817

Abstract

Logam kadmium (Cd) yang berasal dari kegiatan industri seperti produksi baterai, pelapisan logam, penggunaan pupuk fosfat, pembakaran bahan bakar fosil, dan pembuatan plastik dapat meningkatkan produksi reactive oxygen species (ROS). Produksi ROS berlebih dalam tubuh akan menyebabkan penyakit dan mempengaruhi sistem imun tubuh akibat stres oksidatif. Stres oksidatif merupakan suatu kondisi ketidakseimbangan antara radikal bebas dan antioksidan. Untuk melindungi tubuh dari stres oksidatif diperlukan suatu senyawa antioksidan, seperti yang terkandung dalam kulit buah kabau (Archidendron bubalinum). Penelitian ini bertujuan mengetahui mengetahui adanya peningkatan aktivitas fagositosis makrofag pada mencit Jantan yang dipaparkan CdCl2. Penelitian ini bersifat eksperimental menggunakan rancangan acak lengkap (RAL). Mencit yang digunakan 24 ekor dengan 6 kelompok yang terdiri dari 3 kelompok kontrol dan 3 kelompok perlakuan. Hasil pengujian menunjukkan bahwa pemberian ekstrak kulit buah kabau dosis 95 mg/kgBB, 190 mg/kgBB dan 380 mg/kgBB pada uji aktivitas fagositosis makrofag menunjukkan hasil yang signifikan sebesar p = 0,005. Hal ini berarti bahwa ekstrak kulit buah kabau dapat meningkatkan sistem imun mencit dengan perlakuan P2 memiliki aktivitas fagositosis tertinggi yaitu 55,91%.
Integrated Metabolite Profiling and Network Pharmacology Reveal the Multitarget Therapeutic Potential of Curcuma amada Rhizome Fatriani, Rizka; Istiadi, Khaerunissa Anbar; Khairani, Iffa Afiqa; Anisa, Hida Arliani Nur
Biotropika: Journal of Tropical Biology Vol. 14 No. 1 (2026)
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Curcuma amada Roxb. (mango ginger) is a medicinal plant traditionally known for its antioxidant, anti-inflammatory, and anticancer effects, however, the underlying molecular mechanisms are not fully understood. In this study, we combined metabolite profiling with in silico analysis (network pharmacology and molecular docking) to understand the bioactivity of C. amada. Gas chromatography-mass spectrometry (GC-MS) revealed a diverse metabolite composition with fifty-two compounds detected in the ethanol extract. Target prediction of the compounds was performed using SwissTargetPrediction, BindingDB, and ChEMBL. Hub genes were identified using Maximum Clique Centrality (MCC), which identified ESR1, PPARG, and NR3C1 as the main hub genes. Enrichment analysis showed a strong association with cancer-related pathways, particularly the PI3K–Akt signalling, endocrine resistance, and cell senescence pathways, as well as the biological processes regulating apoptosis, stress response, and intracellular signalling. Molecular docking studies of PPARG and ESR1 showed that the metabolites retinal, coronarin E, and 1H-cycloprop[e]azulene derivatives had stable binding affinities and interacted with residues in the ligand-binding domain (LBD) of the target proteins. Our findings suggest that C. amada exerts therapeutic effects through multiple mechanisms. Not a single molecule or pathway, but a coordinated network of metabolites acting on multiple targets. This integrative approach provides a scientific basis for the traditional use of C. amada and highlights its potential as a promising resource for drug discovery, particularly in the field of cancer therapy.
Co-Authors Anbar Istiadi, Khaerunissa Andri Jaya Kesuma Andriani, Silvia Andriyana, Ahmad Dodi ANDY DARMAWAN Andy Darmawan Anisa, Hida Arliani Nur Anshori, Andi Antonius Antonius Arliani Nur Anisa, Hida Azizah, Najla Nur Dewi Chusniasih Evi Kurniawaty Fatriani, Rizka Gres Maretta, Gres Haryandi, Yopi Hendri Busman Hida Arliani Nur Anisa Imaniar, Lisana Husna Jeane Siswitasari Mulyana Khaerunissa Anbar Istiadi Kurnia Wahyuni Kurniawaty, Evi Leksikowati, Sovia Santi Maruli, Berkat Afni Mulyadi, Salsa Pratiwi Mulyana, Jeane Siswitasari Nanda, M. Zulhiyadi Natalia Pardede, Desta Novriadi, Novriadi Nuning Nurcahyani Nurhayu, Winati Olivia, Rahel Noviantika Prastya, Muhammad Eka Primahana, Gian Puspa, Egita Windrianatama Putri, Isnaini Anggraini Rara Mulia Sari Restiawati, Nawang Riana, Elisa Nurma Rizka Fatriani Sahroni, Mizan Sandro, Mario Silvia Andriani Silvia Andriani Siswahyudianto Suryanti, Erma Wahyuni Dian Lestari Wandasari, Septi Putri Winati Nurhayu Yanti Ariyanti, Yanti Ariyanti Yogi Catur Putra