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All Journal ODONTO Dental Journal Majalah Obat Tradisional Dentino: Jurnal Kedokteran Gigi Dental Journal (Majalah Kedokteran Gigi) Dentin Jurnal Radiologi Dentomaksilofasial Indonesia (JRDI) Odonto dental journal Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
Aspriyanto, Didit
Department Of Dentomaxillofacial Radiology, Faculty Of Dentistry, Universitas Lambung Mangkurat, Banjarmasin, Indonesia, 70236
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Energy Environmental Science Health Professions Medicine & Pharmacology Physics Public Health

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ANTIBACTERIAL EFFECTIVENESS OF RAMBAI (Sonneratia Caseolaris) LEAVES EXTRACT AGAINST STREPTOCOCCUS MUTANS Aniqah Nor Rahmatika; Didit Aspriyanto; Muhammad Yanuar Ichrom Nahzi
Dentino: Jurnal Kedokteran Gigi Vol 9, No 1 (2024)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v9i1.18859

Abstract

Background: The 2018 Riskesdas data stated that dental caries prevalence in Indonesia was 88.8%. Dental caries is a multifactorial disease characterized by hard tissue damage to the enamel, dentin, and cementum of the teeth. One of the causes of caries is the presence of a microorganism called Streptococcus mutans. Rambai leaf extract (Sonneratia caseolaris) is a typical plant of South Kalimantan with content flavonoids, tripernoids, tannins, phenols, steroids that have antibacterial properties against the growth of Streptococcus mutans which can prevent caries. Purpose: To determine the difference in the effectiveness of the antibacterial extract of rambai leaves (Sonneratia caseolaris) against bacteria Streptococcus mutans in vitro. Methods: This research was a true experimental with a post-test-only design and a control group, using six treatment groups, namely 20%, 40%, 60%, 80%, positive control (povidone iodine 1%), and negative control (aquadest) respectively. Each treatment got 3 repetitions. The antibacterial test method used in this study was the liquid dilution method to determine the Minimun Inhibitory Concentration (MIC) by using Spectrophotometer and solid dilution to determine the Minimum Bactericidal Concentration (MBC) by using tools Colony Counter. Results: Based on the results and data analysis, it can be seen that the rambai leaf extract has a MIC of 20% and a MBC of 60%. Conclusion: Rambai leaf extract (Sonneratia caseolaris) can inhibit and have antibacterial activity against the growth of Streptococcus mutans. Keywords: Antibacterial, Rambai leaf extract, Streptococcus mutans
TOXICITY TEST OF KELAKAI LEAF EXTRACT (Stenochlaena palustris) TOWARD WISTAR RATS LIVER (Rattus norvegicus) Krisna Erlangga Putra Ramadhani; I Wayan Arya Krishnawan Firdaus; Yusrinie Wasiaturrahmah; Didit Aspriyanto; Erida Wydiamala
Dentino: Jurnal Kedokteran Gigi Vol 10, No 1 (2025)
Publisher : FKG ULM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/dentino.v10i1.22200

Abstract

Background: Kelakai leaf extract can be used as an alternative wound healing medicine because it contains flavonoid and phenolic compounds that act as antioxidants. Before use, herbal plants must ensure the level of safety that can be obtained from toxicity tests, one of which is in vivo which can be seen from their effect on the liver of Wistar rats based on SGOT and SGPT levels. Purpose: Proving there is no toxic effect from the administration of kelakai leaf extract doses of 2,000, 2,500, and 3,000 mg/kgBW on the liver of Wistar rats based on SGOT and SGPT levels. Method: Pure laboratory experimental research with posttest-only design with control group design, consisting of 16 wistar rats divided into 4 groups with 1 negative control group given distilled water and 3 treatment groups given doses of kelakai leaf extract 2,000, 2,500 and 3,000 mg/kgBW twice a day every morning and evening for 28 days. Results: SGOT and SGPT levels after 28 days were still in the normal range. SGOT levels in treatment groups 1, 2, and 3 were 61.244 U/L, 58.953 U/L, and 53.536 U/L. SGPT levels in treatment groups 1, 2 and 3 were 25.137 U/L, 23.331 U/L, and 21.179 U/L. Based on statistical tests, there were significant differences in all treatment groups. Conclusion: There is no toxic effect from the administration of kelakai leaf extract doses of 2,000, 2,500, 3,000 mg/kgBW orally for 28 days on the liver of Wistar rats based on SGOT and SGPT levels.
Co-Authors Adhimas Rilo Pambudi Agung Satria Wardhana Ahda Ahda Annisa Aila At-Thoyyar Aliffia Azizah Kawiadji Alya Royyana Amy Nindia Carabelly Aniqah Nor Rahmatika Arifin, Rahmad Audina, Nina Aulia Azizah Baehaqi Bayu Indra Sukmana Bayu Yordha Senggara Beta Widya Oktiani Brachmedio Barito Syech Erlangga Debby Saputera, Debby Desty Ayu Dwiyanti Dewi Nurdiana Dewi Puspitasari Dian Dwiyanti Diana Wibowo Dita Puspita Sari Diza Afira Hutasuhut Dwi Kurniawan, Fajar Kusuma Dwiyanti, Dian Eka Dwita Natasya Fitri Siregar Eny Febriyanti Erida Wydiamala Erika Norfitriyah Firda Damayanti Helda Helda Hendrik Setia Budi I Wayan Arya Krishnawan Firdaus Ichrom Nahzi, Muhammad Yanuar Ihsan, Muhammad Fauzan Ika Kusuma Wardani Intan Nirwana, Intan Jatmiko, Habibi Naufal Khairunnisa Puspita Sari Krisna Erlangga Putra Ramadhani Lisa Shofa’ Nur Aini Maydina Izzatul Yazidah Milka Widya Sari Muhammad Hasanu Reksi Muhammad Yunanda Anhar Nadhira Agnia Rosdayatri Nadia Chairina Nahzi, Yanuar Ichrom Naila Khairiyah Nina Audina Nisa Azaria Nor Helma Warni Norfitriyah, Erika Noval Ihza Maulana Nurlailatul Rahmah Nurrahman, Tri Nurul A'idah Nurul Fathanah Putri Oktiani, Beta Widya Pambudi, Adhimas Rilo Prilly Sonya Puteri Priyawan Rachmadi Raket Rizki Rahmaningtyas Ramadhaniyah, Nur Ramadhanty, Aina Renie Kumala Dewi Rima Permata Sari Rini Rahmiyati Rosihan Adhani, Rosihan Rudie Syahrizal Akhmad Sari, Galuh Dwinta Sari, Milka Widya Sarifah, Norlaila Senggara, Bayu Yordha Setyawardhana, Raden Harry Dharmawan Sherli Diana Syifa Ennisa Timothy Jogy Sotarduga Parhusip Tri Putri, Deby Kania US Ramadilla Ramadilla Utami, Juliyatin Putri Widodo Widodo Yusrinie Wasiaturrahmah