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All Journal Indonesian Journal of Pharmaceutical Science and Technology Mutiara Medika: Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran dan Kesehatan JURNAL IBNU SINA BIOMEDIKA Buletin Farmatera Hasil Pengabdian Kepada Masyarakat Jurnal Aisyah : Jurnal Ilmu Kesehatan JURNAL ILMIAH MAKSITEK JURNAL ILMIAH SIMANTEK JURNAL ILMIAH KOHESI Budapest International Research in Exact Sciences (BirEx Journal) Jurnal Implementa Husada ABDI SABHA (Jurnal Pengabdian kepada Masyarakat) DedikasiMU: Journal of Community Service Empowerment: Jurnal Pengabdian Masyarakat Indonesian Journal of Cancer Jurnal Salingka Abdimas Eduvest - Journal of Universal Studies PROSIDING SEMINAR NASIONAL PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT (SNPPM) UNIVERSITAS MUHAMMADIYAH METRO Jurnal Pandu Husada
Humairah Medina Liza Lubis
Universitas Muhammadiyah Sumatera Utara
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High-Grade Endometrial Stromal Sarcoma Humairah Medina Liza Lubis
Buletin Farmatera Vol 2, No 2 (2017)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (134.115 KB) | DOI: 10.30596/bf.v2i2.937

Abstract

High-Grade Endometrial Stromal SarcomaAbstrak: High-grade endometrial stromal sarcoma merupakan tumor yang agresif dan pada kebanyakan kasus, kematian sering terjadi tiga tahun setelah histerektomi.Ditandai dengan ketiadaan diferensiasi spesifik dan gambaran histologis yang tidak menyerupai stroma endometrium. Insidensinya diperkirakan sekitar 10% dari keseluruhan tumor mesenkim uterus dan hanya 0,2% dari seluruh keganasan uterus. Sering ditemukan pada korpus uterustetapi dapat meluas ke ekstrauterus.Umumnya keluhan berupa perdarahan pervaginam, nyeri panggul dan pada pemeriksaan fisik terkadang menunjukkan pembesaran uterus atau penonjolan tumor melewati cervical os. Kami melaporkan satu kasus yang ditemukan di praktek swasta dokter spesialis Patologi Anatomi dan RSUP H. Adam Malik Medan pada seorang wanita berumur 27 tahun dengan keluhan perdarahan pervaginam sejak 6 tahun yang lalu. Dilakukan STAH dan BSO di rumah sakit daerah dan beberapa bulan kemudian dilakukan biopsi serviks. Pemeriksaan histopatologi pada endometrium dan serviks didapatkan gambaran yang sama berupa komponen sarcomatous yang diduga berasal dari stroma endometrium. Imunohistokimia menggunakan marker S-100 protein, Vimentin, Desmin, SMA dan CD10, dengan komponen mesenkim yang positif pada Vimentin, Desmin dan SMA, sedangkan komponen epitelial negatif dengan S-100 protein. Kemudian untuk membedakannya dengan limfoma Non Hodgkin dipakai marker CD10 dengan hasil negatif.Sehingga dapat disimpulkan sebagai kasus High-Grade Endometrial Stromal Sarcoma pada endometrium dan serviks.Kata kunci: high-grade endometrial stromal sarcoma, low-grade endometrial stromal sarcoma, stroma endometrium, imunohistokimia. High-Grade Endometrial Stromal Sarcoma Abstract: High-grade endometrial stromal sarcoma is an aggressive tumor, and death occurs from tumor dissemination within three years after hysterectomy in most cases. A high grade endometrial sarcoma that lacks specific differentiation and bears no histological resemblance to endometrial sarcoma. Represent approximately10% of all uterine mesenchymal tumors. Most occurs in corpus uterine and adjacent to extra uterine. The patient had vaginal bleeding, pelvic pain and on physical examination findings uterine enlargement throughout cervical os. We report an unusual case of ESS arising in a-27-year-old woman had vaginal bleeding since 6 years previously. She had undergone subtotal hysterectomy and bisalphyngoovorectomy previously and a few months ago had cervical biopsy. On histological findings, sarcomatous component was suspectly endometrial stromal origin. Immunostaining showed that mesenchymal component were vimentin, desmin, and SMA-positive, whereas epithelial component were S-100 protein-negative. Distinction ESS from Non Hodgkin lymphoma was usedCD10 antigen, and the result was stained negative for CD10. The conclusion for this case was High-Grade endometrial stromal sarcoma on endometrial and cervical uterine.Keywords: High-Grade Endometrial Stromal Sarcoma, Low-Grade Endometrial Stromal Sarcoma, endometrial stromal, imunohistochemistry
IbM PENERAPAN IPTEK DALAM MENDIAGNOSIS KANKER PAYUDARA SEBAGAI UPAYA DETEKSI DINI DAN SKRINING UNTUK MEMBANTU PROGRAM NASIONAL DALAM HAL PENGENDALIAN KANKER DI INDONESIA Humairah Medina Liza Lubis
JURNAL PRODIKMAS Hasil Pengabdian Kepada Masyarakat Vol 1, No 01 (2016)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (339.925 KB) | DOI: 10.30596/jp.v1i01.921

Abstract

Program ini bertujuan untuk melatih mobilisasi, advokasi dan sosial agar mampu memberdayakan dosen dan mahasiswa FK UMSU guna mencegah, mendeteksi, dan mendiagnosis kanker payudara. Selain itu masyarakat yang hidup di sekitar pasien akan diberi pembelajaran agar dapat memberikan motivasi dan semangat hidup serta mendukung pasien karena bagi sebagian besar orang, kanker adalah momok yang sangat menakutkan dan pasien akan selalu hidup di bawah bayang-bayang kematian. Selain itu juga bertujuan untuk meningkatkan kompetensi dokter Patologi Anatomi, dosen bidang ilmu lain, mahasiswa, pemberdayaan tenaga laboran dan menggalakkan pemakaian laboratorium terpadu FK UMSU untuk pusat penelitian dosen dan mahasiswa, meningkatkan kualitas pendidikan dan pembelajaran di FK UMSU, meningkatkan layanan kanker payudara serta mendukung program pengendalian kanker payudara nasional.Keyword : Diagnosa Dini, Kanker Payudara, Skrining
Program Bersih-Bersih Telinga (BBT) Siswa Sekolah Dasar Negeri Kecamatan Tanjung Pura Guna Meningkatkan Kualitas Pendengaran dan Pembelajaran Humairah Medina Liza Lubis; Siti Masliana Siregar
JURNAL PRODIKMAS Hasil Pengabdian Kepada Masyarakat Vol 2, No 2 (2018)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (59.538 KB) | DOI: 10.30596/jp.v2i2.2463

Abstract

Gangguan pendengaran pada anak semakin banyak ditemukan di masyarakat terutama pada masyarakat kalangan menengah kebawah tetapi belum begitu mendapat perhatian serius dari masyarakat karena gejalanya tidak tampak dari luar. Pada anak-anak, dampaknya lebih berat lagi karena memengaruhi perkembangannya hingga dewasa. Gangguan pendengaran mengakibatkan anak sekolah sulit menerima pelajaran dan produktifitas menurun. Ini dikarenakan, telinga mempunyai peranan yang besar dalam kehidupan sehari-hari. Tingkat  keberhasilan  proses  belajar  murid  di  pedesaan jauh menurun dibandingkan dengan anak-anak seusia mereka yang mengenyam pendidikan di kota besar sehingga  timbul  pemikiran kemungkinan terjadinya gangguan  pendengaran akibat kelainan liang dan gendang telinga merupakan salah satu penyebab berkurangnya minat dan konsentrasi siswa terhadap proses penerimaan pembelajaran di sekolah. Masyarakat juga kurang memperdulikan masalah kesehatan dan kebersihan telinga. Akibat keterbatasan pengetahuan dan ekonomi, masyarakat tidak memahami cara melakukan pembersihan telinga dengan baik. Pada beberapa kasus bahkan anak-anak dan warga membersihkan telinga dengan bulu ayam dan batang padi yang tentu saja tingkat sterilitasnya sangat rendah. Akibatnya akan terjadi infeksi pada liang telinga yang berimbas pada penurunan pendengaran dan angka kesakitan yang meningkat.
Perbandingan Efektivitas Pemberian Silver Sulfadiazine dengan Gel Lidah Buaya (Aloe Vera) 99% pada Tikus Putih ( Rattus Norvegicus L.) Jantan Galur Wistar Sebagai Pengobatan Luka Bakar Atika Rahmi; Ratih Yulistika Utami; Hervina Hervina; Humairah Medina Liza Lubis
JURNAL IMPLEMENTA HUSADA Vol 1, No 1 (2020)
Publisher : UMSU

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jih.v1i1.4541

Abstract

Introduction: Burn injury is a common cause of morbidity and mortality. Outcomes of morbidity and disability for deep burns patients still not improved. Many modalities for wound bed preparation was not satisfied. Aloe vera gel have been used as an anti-inflammatory natural agent, for treatment many deseases. It has also been used in the traditional medicine of many cultures and said to be beneficial in the treatment of disorders such as burns Objective: To find out the comparison of the effectiveness of administration of silver sulfadiazine and aloe vera gel 99% as a treatment of burns in white rat (Rattus norvegicus L.) male Wistar strain. Methodology: The research used True Experiment method with "pretest-posttest with control group design" design Result: The results show that the P value for aloe vera  number is  <0.05, and the P value for Silver sulfadiazinee levels also showing <0.05.  Conclusion: There is a difference in  effectiveness of giving 99% aloe vera gel as a treatment for burns in white rats (Rattus norvegicus L.) male Wistar strain.Keywords: Burn Injury,Aloe Vera, Silver sulfadiazinee
Pembekalan Pasien Tuberkulosis Tentang Bahaya Resistensi Multipel Obat Antituberkulosis di Kota Medan Humairah Medina Liza Lubis; Emni Purwoningsih; Ratih Yulistika Utami
ABDI SABHA (Jurnal Pengabdian kepada Masyarakat) Vol. 1 No. 1 (2020): Oktober
Publisher : CERED Indonesia Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53695/jas.v1i1.67

Abstract

Tuberculosis (TB) is an infectious disease caused by bacterial infection Mycobacterium tuberculosis (MTB). TB infection is still a health problem in the world and Indonesia since 1989-1992 there has been an increase in this disease, which is associated with an increase in the HIV / AIDS epidemic, urbanization and migration due to the recession that hit the world. Along with the increase in this disease a new problem arises, namely TB with multiple anti-tuberculosis drug resistance (Multidrug Resistant Tuberculosis / MDR-TB). The community service objectives are (1) finding new TB patients, MDR-TB and drug cessation cases, (2) providing health debriefing about the dangers of Multiple Anti-Tuberculosis Drug Resistance to partners, (3) providing counseling about healthy food and balanced nutrition to partners , (4) empower TB health cadres and Drug Drugs Supervisors in each neighborhood in Pahlawan Village as a system of coordination in handling TB in their respective work areas. There were 30 new cases of TB and 5 cases with MDR TB that needed serious treatment from the medical staff and related health services.
Pemberdayaan Ibu Pengajian Sebagai Upaya Pencegahan Kanker Serviks di Kota Medan Siti Mirhalina; Humairah Medina Liza Lubis; Emni Purwoningsih
ABDI SABHA (Jurnal Pengabdian kepada Masyarakat) Vol. 1 No. 1 (2020): Oktober
Publisher : CERED Indonesia Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53695/jas.v1i1.68

Abstract

According to Riskesdas data in 2013 in Indonesia, it is estimated that 40,000 new cases of cervical cancer are found each year. The incidence of cancer sufferers continues to increase and requires immediate treatment to prevent the continued increase in cancer death rates. This can be achieved, one of which is the right detection of cancer, both diagnosis and prognosis. The objectives of this community service are: (1) Finding cervical cancer cases that become an iceberg phenomenon and undetectable at an early stage, (2) Providing debriefing about Pap smear screening programs in Medan that do not run routinely or are not even carried out (3 ) Providing information on the importance of Pap smears in women of reproductive age,  (4) Empowering cadres in this case the members of the Istiqomah Mosque study in each neighborhood in Pahlawan Village as a system of coordination in treating cervical cancer in their respective work areas. Of the 30 people who had Pap smear tests, none of them found suspicious results, only in the form of inflammation of the cervix which could be treated with antibiotics. Keywords: members of Istiqomah mosque, prevention, cervical cancer  
Anti-Cervical Cancer Study of a Labdane-type Diterpene Obtained from Legundi Fruit (Vitex triolia L.) Targeting the Bcl-2 Gene Humairah Medina Liza Lubis; Emni Purwoningsih; Nurfadly Nurfadly
Buletin Farmatera Vol 7, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v7i3.11728

Abstract

Abstract: The development and induction of cervical cancer carcinogenesis are linked to sexually transmitted Human Papillomavirus (HPV) infection, and can affect human genes, particularly those involved in the apoptotic process, one of which is the Bcl-2 gene. Several synthetic compounds, including pyrimidineylpiperazine, phenylpyrazole, kendomycin, and navitoclax, have been shown to be effective in inhibiting the antiapoptotic activity of Bcl-2, but it is the labdane-type diterpene content of the natural legundi fruit plant (Vitex trifolia L.) that has anticancer bioactivity, particularly in the process of genetic mutations, Apoptotic inhibition and therapeutic failure have yet to be discovered, particularly in cervical cancer. The study's goal was to investigate the mechanism of interaction (molecular docking) of labdane type-diterpene compounds with the antiapoptotic protein Bcl-2. In silico (docking molecular) research was used to determine the interaction between legundi fruit ligands and the Bcl-2 target protein in cervical cancer. The docking analysis results will then be visualized with the Discovery Studio 4.1, LigPlot+, and Ligand Scout 3.1 software. The interaction of proteins and ligands was studied to determine the number and type of bonds formed, such as hydrogen and hydrophobic bonds. The results were as follows: Gibbs energy -7.8, pKi 1.91 m, 10 hydrophobic bonds, and hydrophobic residues Leu80, Leu82, Thr83, Thr86, Ala87, Cys90, Met118, Glu121, Ser122, and Leu130. The findings presented here suggest that labdane-type diterpenes are powerful anticancer agents capable of inducing apoptosis and inhibiting the antiapoptotic action of the Bcl-2 gene, which should be investigated further in (pre)clinical studies.
In Silico Study of Cembranoid-Type Diterpene Targeting Kirsten Rat Sarcoma Virus (KRAS) Gene in Lung Cancer Teuku Baihaqi Septiady; Muhammad Rafli Hidayatullah; Ainur Rofiq; Afifah Endah Dwi Purianti; Indyra Mahrani Lubis; Nesya Alya Fayyaza; Humairah Medina Liza Lubis
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 4, No. 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.42821

Abstract

Lung cancer is genetic changes in the V-Ki-ras2 gene Kirsten rat sarcoma viral oncogene homolog(KRAS), which is involved in signaling pathways related to proliferation, cell differentiation, andapoptosis. Point mutations in the KRAS gene were detected in 15% to 20% of all Non-Small Cell LungCarcinoma (NSCLCs) and about 30% of lung adenocarcinomas, with the most common mutation beingat codon 12. This study aimed to determine the binding reaction between diterpene-type cembranoidcompounds from tobacco leaves (Nicotiana tabacum L.) and KRAS in human lung cancer. We foundthe presence of a cembranoid-type diterpene active compound in the form of thunbergol (C20H34O)with Gas Chromatography and Mass Spectroscopy (GC-MS) examination. Based on the resultsof molecular docking, it was found that the diterpene-type cembranoid ligand binds to the KRASreceptor with a yield of G -7.0 kcal/mol, pKi 7.35 M, one hydrogen bond with type ILE36 (1,937 Å).In conclusion, diterpene-type cembranoid can be considered an anticancer compound because of themolecular interaction with cembranoid-type diterpene through cell proliferation and differentiationpathways, as well as apoptosis.
Sosialisasi Dan Edukasi Pencegahan Covid-19 Dalam Memasuki Pembelajaran Tatap Muka Di Desa Percut Sei Tuan Ceri Permata Ayuni; Nurfadly Nurfadly; Humairah Medina Liza Lubis
JURNAL PRODIKMAS Hasil Pengabdian Kepada Masyarakat Vol 7, No 2 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/jp.v7i2.12833

Abstract

Coronavirus Disease (COVID-19) masihmenjadi ancaman di berbagai Negara seluruh dunia, khususnya di Indonesia dan Sumatera Utara. Penyakit ini menyerang semua golongan, anak-anak, dewasa dan lansia. Pembukaaan sekolah yang dilakukan pemerintah, anak-anak serta remaja perlu mendapatkan edukasi yang mudah dipahami mengenai COVID-19 dan cara pencegahannya saat proses pembelajaran dilakukan secara tatap muka. Hal ini yang menjadi dasar penulis dalam melakukan kegiatan Kuliah Kerja Nyata (KKN) dengan memberikan penyuluhan atau sosialisasi tentang COVID-19 dan upaya pencegahannya kepada siswa SD, SMP, dan SMA di Desa Percut dalam melakukan pembelajaran tatap muka.Tujuan kegiatan ini yaitu agar mampu menekan angka positif COVID-19 di Indonesia, khususnya Sumatera Utara. Kegiatan sosialisasi ini dilaksanakan dengan cara memberikan pengetahuan tentang pentingnya memahami dan mengaplikasikan protokol kesehatan pencegahan COVID-19 terutama cuci tangan dan memakai masker pelindung muka dengan baik dan benar, port de entry dari virus tersebut serta memberikan gambaran tentang bahaya jika tidak mematuhi protokol kesehatan pencegahan COVID-19 seperti gejala dan tanda yang akan ditimbulkan dan dilanjutkan dengan praktek secara langsung mengenai cara memakai dan melepaskan masker serta mencuci tangan dengan baik dan benar. Penyampaian materi dilakukan dengan menggunakan media slide power point dan video animasi, tidak lupa pula di sela-sela penyampaian materi diadakannya kegiatan ice breaking, dan diakhir penyampaian materi dilakukan quiz terkait materi yang disampaikan sebelumnya.
CD4+ and CD8+ Tumor-Infiltrating Lymphocytes (TILs) Biomarkers: Role in Predicting the Stadium and Prognosis of Cervical Cancer Humairah Medina Liza Lubis; Rafa Nabila Haifa; Rizky Yusfasari; Muhammad Zikri Agung Ramadhan
Indonesian Journal of Cancer Vol 16, No 4 (2022): December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v16i4.906

Abstract

Background: Tumor-infiltrating lymphocytes (TILs), mainly CD4+ and CD8 + T cells, have been extensively described in anti-tumor immunity, and knowledge of CD4+ and CD8+ T lymphocytes’ interplay in mediating the control of tumor growth exists. We use the role of TILs in predicting the prognosis of cervical cancer patients and develop the discovery of new immunotherapy strategies that specifically target TILs.Methods: A systematic review of studies carried out a histopathological and immunohistochemical examination of TILs and an immunotherapy treatment.Results: 10 articles were selected for a systematic review. Expression of TILs was associated with the progression of NIS to cervical cancer. CD4+ and CD8+ TILs can determine the stage and prognosis of cervical cancer. TILs immunotherapy is effective for all cervical cancer patients. Combination chemotherapy with anti-TILs immunotherapy and combination therapy for PD-1 and TILs was found to have a better potential for cervical cancer therapy.Conclusions: TILs can be a prognostic biomarker and a marker to predict cervical cancer.
Co-Authors Afelita, Tia Afif Fadhilah Irsyad Afifah Endah Dwi Purianti Ainur Rofiq Ainur Rofiq Aisyah Salsabila Alamsyah, Tegar Alfarisi, Bunail Isna Amanda Farra Assyfah Aminuyati Amira Fazhira Ance Roslina ANNISA . ANNISA FITRI HENDEWI Annisa Rifqa Hestiana Annissa Ambaravista Nasution Atika Dwiyanti Atika Rahmi Atmaja, Pramudia Barasa, Neza Farach Addiba Berkah Tania Sawitri Bunail Isna Alfarisi Ceri Permata Ayuni Charisma Yani Roza Cindy, Tiara Safira Cindykia, Assyifa DEA YULIA LUBIS Delyuzar, Delyuzar Des Suryani Des Suryani DEWI AGUSTIN HAKIM HARAHAP Dilma Ayu Khairani DIWA AULIA AHMAD Dwiyanti, Atika Fadillah, Akram Fadlina, Shofiah Dina Fayyaza, Nesya Alya Filzah, Rahmah Fitri Nur Malini Frina Aeni Putri Galang Ramadhan Hasanah, Nurul HENDRA SUTYSNA Herian, M. Fauzan Alfatin Hervina, Hervina Hestiana, Annisa Rifqa Hidayatullah, Muhammad Rafli HSB, Fatur M Ahmad IBNU AFIF ARMADI Ilham Hariaji Indyra Mahrani Lubis Irsyad, Afif Fadhilah Islami, M. Dian Isnaini Ulfa Jamilah, Qurratu Kasturi KARTIKA HANDAYANI Kesuma, Ilham Jaya KHAIRATUL FITHRIYAH Kirana Arum Indra Laden Laden, Laden LITA SEPTINA Lubita, Mardiyah M. Dian Islami Malini, Fitri Nur MEIZLY ANDINA Muhammad Al Anas Muhammad Farouq Hilmi Harahap Muhammad Fathurridha Arabia Salim Muhammad Rafli Hidayatullah Muhammad Zikri Agung Ramadhan Muhammad Zulfikar Karim Chan Nasution, Annissa Ambaravista Nasution, Reyhan Khaira Helmita Nesya Alya Fayyaza Noviardy, Arya Nurcahaya Sinaga Nurfadly, Nurfadly Oche Axena Yulhan Purwoningsih, Emni Qatrunnada Medina Salim Qatrunnada Medina Salim Rafa Nabila Haifa Rafa Nabila Haifa Rahma Rifda F.S. Lubis Rahmah Filzah Raihana Zavira Ramadhan, Galang Ramadhan, Reza Mukti Ratih Yulistika Utami RIFQY IMSYA AL AYYUBI LUBIS Rizkitha Martono Putri Rizky Yusfasari Robitah Asfur Salsabila, Aisyah Salsabila, Salsabila Sari, Indah Permata Sembiring, Khairul Rasyid Septiady, Teuku Baihaqi Shaik Hussain, Basrah Bee Binte SITI MIRHALINA Siti Mulyani Sitompul, Asma Dwi Nantika Sri Rezeki Arbaningsih Tania Mulia Utami Tegar Alamsyah Teuku Baihaqi Septiady USWATUL KHOIROT Utami, Tania Mulia Widya Yustika Yulhan, Oche Axena Yusmawati Yusran Yustika, Widya Zavira, Raihana Zulkarnain, Rizki Chairani