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All Journal Interest : Jurnal Ilmu Kesehatan Journal of Islamic Medicine Martabe : Jurnal Pengabdian Kepada Masyarakat JFL : Jurnal Farmasi Lampung Jurnal Kreativitas PKM JKM (Jurnal Kebidanan Malahayati) Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Medika Malahayati JFIOnline JFM (Jurnal Farmasi Malahayati) Jurnal Pengabdian Farmasi Malahayati (JPFM) ALKIMIA : Jurnal Ilmu Kimia dan Terapan JURNAL FARMASIMED (JFM) Jurnal Analis Farmasi Jurnal Farmamedika (Pharmamedica Journal) Jurnal Ilmiah Wahana Pendidikan JAF (Jurnal Analis Farmasi) Analit: Analytical and Environmental Chemistry JOURNAL OF Pharmacy and Tropical Issues Journal of Medical Surgical Concerns Jurnal Abdimas Kedokteran dan Kesehatan Analit: Analytical And Environmental Chemistry
Primadiamanti, Annisa
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Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Energy Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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ANALISIS EFEKTIVITAS BIAYA PENGGUNAAN INSULIN DIBANDINGKAN KOMBINASI INSULIN-METFORMIN PADA PASIEN DIABETES MELITUS TIPE 2 Primadiamanti, Annisa; Andayani, Tri Murti
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 4, No 3 (2009)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The use of metformin in insulin therapy hopefully could increase effectiveness of type 2 diabetes treatment equal with the expenditure. Non experimental research was conducted to investigate cost-effectiveness of insulin use and insulin-metormin combination. Data was taken prospectively from baseline until month 3. The measurable cost was direct medical cost which covered cost of antidiabetic drugs, cost of complication drugs, doctor’s fee, and cost of laboratory checkup. The measurable effectiveness of therapy was reduction of FPG and HbA1c level. ACER (average cost-effectiveness ratio) was calculated based on cost and effectiveness ratio in both groups. ICER (incremental cost-effectiveness ratio) was calculated based on difference of cost and effectiveness ratio in both groups. Results showed FPG level reduction in insulin group and insulin-metformin combination consecutively was 25,05% and 1,03%. Increase of HbA1c level in insulin group and insulin-metformin combination consecutively was 6,21% and 1,87%. Based on HbA1c level reduction, ACER value in insulin group and insulin-metformin combination consecutively was Rp -37.617,00 and Rp -161.729,00, ICER value was Rp 15.860,00. From the results it can be concluded that insulin-metformin combination was more cost-effective than insulin in maintaining HbA1c level. ABSTRAK Penelitian ini dirancang untuk mengetahui efektivitas biaya pada pasien DM tipe 2 yang menggunakan insulin dan kombinasi insulin-metformin. Data diambil secara prospektif dari baseline hingga bulan ke-3. Analisis efektivitas biaya dilakukan dengan perspektif ASKES. Komponen biaya yang diukur adalah biaya medik langsung, mencakup biaya antidiabetik, biaya komplikasi, biaya kunjungan ke klinik dan biaya pemeriksaan laboratorium. Efektivitas terapi yang diukur adalah penurunan kadar GDP dan HbA1c. ACER (average cost-effectiveness ratio) dihitung berdasarkan rasio biaya dan efektivitas terapi pada kedua kelompok terapi. ICER (incremental cost-effectiveness ratio) dihitung berdasarkan rasio antara selisih biaya dan efektivitas terapi pada kedua kelompok terapi. Hasil penelitian menunjukkan penurunan kadar GDP pada kelompok insulin dan kombinasi insulin-metformin berurutan adalah 25,05% dan 1,03%. Peningkatan kadar HbA1c pada kelompok insulin dan kombinasi insulin-metformin berurutan adalah 6,21% dan 1,87%. Berdasarkan penurunan kadar HbA1c, nilai ACER pada kelompok insulin dan kombinasi insulin-metformin berurutan adalah Rp -37.617,00 dan Rp -161.729,00, nilai ICER adalah Rp15.860,00. Berdasarkan hasil penelitian dapat disimpulkan bahwa kombinasi insulin-metformin lebih cost-effective dalam mempertahankan kadar HbA1c.
ANALISIS EFEKTIVITAS BIAYA PENGGUNAAN INSULIN DIBANDINGKAN KOMBINASI INSULIN-METFORMIN PADA PASIEN DIABETES MELITUS TIPE 2 Primadiamanti, Annisa; Andayani, Tri Murti
Jurnal Farmasi Indonesia Vol 4, No 3 (2009)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v4i3.21

Abstract

The use of metformin in insulin therapy hopefully could increase effectiveness of type 2 diabetes treatment equal with the expenditure. Non experimental research was conducted to investigate cost-effectiveness of insulin use and insulin-metormin combination. Data was taken prospectively from baseline until month 3. The measurable cost was direct medical cost which covered cost of antidiabetic drugs, cost of complication drugs, doctorâ??s fee, and cost of laboratory checkup. The measurable effectiveness of therapy was reduction of FPG and HbA1c level. ACER (average cost-effectiveness ratio) was calculated based on cost and effectiveness ratio in both groups. ICER (incremental cost-effectiveness ratio) was calculated based on difference of cost and effectiveness ratio in both groups. Results showed FPG level reduction in insulin group and insulin-metformin combination consecutively was 25,05% and 1,03%. Increase of HbA1c level in insulin group and insulin-metformin combination consecutively was 6,21% and 1,87%. Based on HbA1c level reduction, ACER value in insulin group and insulin-metformin combination consecutively was Rp -37.617,00 and Rp -161.729,00, ICER value was Rp 15.860,00. From the results it can be concluded that insulin-metformin combination was more cost-effective than insulin in maintaining HbA1c level. ABSTRAK Penelitian ini dirancang untuk mengetahui efektivitas biaya pada pasien DM tipe 2 yang menggunakan insulin dan kombinasi insulin-metformin. Data diambil secara prospektif dari baseline hingga bulan ke-3. Analisis efektivitas biaya dilakukan dengan perspektif ASKES. Komponen biaya yang diukur adalah biaya medik langsung, mencakup biaya antidiabetik, biaya komplikasi, biaya kunjungan ke klinik dan biaya pemeriksaan laboratorium. Efektivitas terapi yang diukur adalah penurunan kadar GDP dan HbA1c. ACER (average cost-effectiveness ratio) dihitung berdasarkan rasio biaya dan efektivitas terapi pada kedua kelompok terapi. ICER (incremental cost-effectiveness ratio) dihitung berdasarkan rasio antara selisih biaya dan efektivitas terapi pada kedua kelompok terapi. Hasil penelitian menunjukkan penurunan kadar GDP pada kelompok insulin dan kombinasi insulin-metformin berurutan adalah 25,05% dan 1,03%. Peningkatan kadar HbA1c pada kelompok insulin dan kombinasi insulin-metformin berurutan adalah 6,21% dan 1,87%. Berdasarkan penurunan kadar HbA1c, nilai ACER pada kelompok insulin dan kombinasi insulin-metformin berurutan adalah Rp -37.617,00 dan Rp -161.729,00, nilai ICER adalah Rp15.860,00. Berdasarkan hasil penelitian dapat disimpulkan bahwa kombinasi insulin-metformin lebih cost-effective dalam mempertahankan kadar HbA1c.
Co-Authors A.A. Ketut Agung Cahyawan W Abdul Aziz Abdul Hamid Alfikri Ade Maria Ulfa Adilio Sangfirgus Triananda Afri Asia Nata Nyaman Agung, Rahmat Aini, Fadhilah Aji Putra Rosmiawan Amabel, Deby Andrianti, Windi ANGIN, MARTIANUS PERANGIN Anisah Febrianti Anjar Jaulin Apriliana, Sukma Ardiela, Putri Agil Ariza Setya Ningrum Ariza, Angga Dwi Arja, Andria Dhesvia Atmaja, Yorano Auliya Nurrahmah Ayu Rai Saputri, Gusti Ciecilia Dewi, Mentari Cucu Ria Savita Dalita, Rama Dananta Tri Hani Umpuan davit muhamad muslim Destri Lina Sari Dewa Ayu Ketut Devi Diandini, Alvina Trisna Dwi Difa Aryan Maulana Dila Yuni Antika Dimas Rizki Oktavian Dira Yuniar, Trisia Dwi Mentari Dwi Susanti Dwiyanti, Made Endah Lestari, Yovita Entin Rositasari Erdina Erdina Erika Indah Safitri Erisandy, Fika Eustacia Evelline Oktaviani Fadilla, Aliza Nur Farra Hayka Salsabila Faskal Nadi Alim Fegy Seftia Ferry Pratama Fitri Amalia Fitri Yanti Gusti Ayu Putri Mei Restuti Gusti Ayu Rai Saputri Gusti Ayu Rai Saputri Habib Abdul Muiz Hayka Salsabila, Farra Hermawan, Dessy Hersa Novitasari Hidayaturahmah, Rizky Iga Jelita Budiono Indah Safitri, Erika Intan Marisa Joko Sunowo, Joko Kartini, Qhory Cahya Putri Kh, Miftakhul Kumalasari, Fadila Isti Lia Amura Lidia Dwi Oktarianti Linda Safitri Malinda, Yun Maria Ulfa, Ade Marina, Cici Marleni Irama Juita Martianus Perangin Angin Martianus Perangin Angin Meithia, Artha Mutiara, Mutiara Oktarima Niken Feladita Niken Feladita Niken Feladita Niken Feladita Santoso Nikhita Anindya Salsabilla Ninuk Tri Meilina Nirwan Fachrozi, Muhammad Nofita Nofita Nofita, Nofita Nopiyansyah, Nopiyansyah Noviyanti, Fadhila Nur Alfi Mufida Hasni Nurul Huda Oktarima, Mutiara Oktavia Rudi, Renna Oktavia, Maria Maya Eka Peranginangin, Martinus Purnama, Robby Candra Putri Amalia Putri Anggraini Putri, Tiara Aprilia Putri, Vivit Millani Rahayu Septia Ayuni Rahmat Agung Rai Saputri, Gusti Ayu Rama Cahya Pranayudha Ramadhani, Muhammad Rani Juliana Ranti Mailinda Sari Ratih Dwi Pramana Saraswati Ratna Silvi Sundari Reni Erlisa Renna Oktavia Rudi Retnaningsih, Agustina Riza Aulia Rizky Hidayaturahmah Rizky, M. Ali Robby Chandra Purnama Rokhimah, Intan Ainur Rr Salwa Zasya Aura Kharisma Rusmini, Hetti S, Septi Nurhaliza Samino Samino Samino Samino Samor, Vania Amanda Saputri, Gusti Ayu Rai Sari, Septi Widya Sekar Pratiwi, Arum Selvi Marcellia Septi Susanti Shelina, Shelina Shinta Wulandari Shinta Wulandari, Shinta Sigit Sukmawan Sitepu, Debora Egyita Siti Khamidaturrohmah Siti Khamidhaturrohmah Suri, Nurma Syahrul, Fadhila Hasana Tenisia Artianti Tri Murti Andayani Triananda, Adilio Sangfirgus Trisia Dira Yuniar Tutik Tutik Ummi, Eiga Auliya Utami, Yolanda Putri Uvit Sarimanah Vani Wahyudiningrum Vida Elsyana Vika Imroatul Qoni'ah Visca Nabella Wahid Datul Awalliyyah Winahyu, Diah Astika Yunda Taqqiyah Ramadhana Zasya Aura Kharisma, Rr Salwa