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All Journal Journal of Islamic Pharmacy Journal of Islamic Medicine JMM (Jurnal Masyarakat Mandiri) Jurnal Kesehatan Islam : Islamic Health Journal AL-ULUM: JURNAL SAINS DAN TEKNOLOGI Bioscientist : Jurnal Ilmiah Biologi Pharmaceutical Sciences and Research (PSR) FARMASAINKES Journal Medical Informatics Technology Journal of Pharmaceutical Science and Clinical Pharmacy (PSCP) PharmaCine: Journal of Pharmacy, Medical and Health Science Jurnal Farmasi Islam Kalimantan ABDINE :Jurnal Pengabdian Masyarakat
Rizki Rahmadi Pratama
Fakultas Farmasi, Universitas Islam Kalimantan Muhammad Arsyad Al Banjari Banjarmasin
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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ANTIDEPRESSANT ACTIVITY TEST OF RED BETEL LEAF ETHANOL EXTRACT (Piper crocatum) ON MALE WHITE MICE (Mus musculus) USING THE FORCED SWIM TEST METHOD Triswanto Sentat; Anita Apriliana; Siti Lili Rizki Sari; Novi Milasari; Ghina Adhila; Rizki Rahmadi Pratama; M. Hasan Andryanto
AL-ULUM: JURNAL SAINS DAN TEKNOLOGI Vol 11 No 2 (2025)
Publisher : UPT Publication and Journal Management, Islamic University of Kalimantan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/jst.v11i2.18542

Abstract

Red betel leaves (Piper crocatum) contain flavonoids, alkaloids, polyphenols, tannins, and which is known for its antidepressant properties. The purpose of this study was to determine the effect of antidepressant activity of ethanol extract of red betel leaves on male white mice (Mus musculus) orally. The method used in testing antidepressants is the Forced Swim Test. Fifteen mice were divided into five groups: a positive control group receiving 3.5 mg/kg BW amitriptyline, a negative control group, and three groups receiving 200, 400, and 800 mg/kg BW of the extract. The antidepressant effect was measured by observing the immobility of mice during swimming. The results of the study using paired sample t-Test analysis showed that there was a difference in immobility before and after, in the 400 mg/kg BW extract and 3.5 mg/kg BW amitriptyline dose groups had significant differences.
Co-Authors Ahsana, Dina Al-Hasyimi, Said Muhammad Amelia Putri, Irena Andika Andika Andre Septianto Anita Apriliana Anita Apriliana Ardiansyah, Seno Aulia Aris Fadillah Aulia Ramadhan Auliana Auliana Burhan Ma'arif Burhan Ma’arif Ciara Fitri Pribadi Della Primalia Septiani Dewi Sapitri Didi Susanto Erlianti, Karina Faisal Akhmal Muslikh Faisal Akhmal Muslikh Fauzi Rahman Fitri Apriliany, Fitri Fuzi Maulana Ash’ari Ghina Adhila Halimah Halimah Hasniah Indah Fajarwati, Jelita Indradewa, Rhian Juwita Ramadhani Karina Erlianti M. Hasan Andryanto Ma'arif, Burhan Marisca Evalina Gondokesumo Marisca Evalina Gondokesumo, Marisca Evalina Maximus M. Taek Meily, Alfisyahriatunnida Melisa Intan Barliana Muhammad Aulia Rahman Muhammad Fauzi Muhammad Fauzi Nily Sua’ida Nor Syipa Hayati Novi Milasari Nur Aini Nur ‘Azah Nurwijayanti Puji Rahmawati, Dwi Purwitasari, Neny Rasida, Rima Rida Rida Said Muhammad Al Hasyimi Septianto, Andre Siti Lili Rizki Sari Syahputra Wibowo Syarifah Nazila Fitriani Al-Hasany Syarifah Rugayah TIANA MILANDA Triswanto Sentat Triswanto Sentat Yanu Andhiarto Yulistia Budianti Soemarie Yuniarti Falya