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INDONESIA
Jurnal Respirologi Indonesia
Published by Perhimpunan Dokter Paru Indonesia
ISSN : 08537704     EISSN : 26203162     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Respirologi Indonesia (JRI) is an online and printed scientific publication of the Indonesian Society of Respirology (ISR). The journal is published thrice-monthly within a year (January, April, July and October). The journal is focused to present original article, article review, and case report in pulmonary and critical care medicine.
Arjuna Subject : -
Articles 9 Documents
 1 
Search results for , issue "Vol 45 No 4 (2025)" : 9 Documents clear
Combined Institutional and Telerehabilitation Programs for A Post-Tuberculosis Lung Disease Patient with Low Cardiorespiratory Endurance: A Case Report Widjanantie, Siti Chandra; Agustin, Heidy; Handayani, Diah; Burhan, Erlina; Susanto, Agus Dwi
Jurnal Respirologi Indonesia Vol 45 No 4 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497//jri.v45i4.719

Abstract

Background: Post-tuberculosis lung disease (PTLD) can lead to long-term respiratory issues and impaired lung function, which can impact quality of life. Pulmonary rehabilitation (PR) is a personalized strategy designed to address these problems and improve overall well-being. It is administered by a diverse team of experts. Case: A 28-year-old female patient with a history of tuberculosis (TB) presented with breathing difficulty. The physical examination revealed decreased chest expansion, shoulder asymmetry, a slight forward neck, and a rounded shoulder. The radiologic findings and bronchoscopy showed PTLD, atelectasis in several parts of the right lung, and regional destruction of the right lung. Discussion: The patient underwent pulmonary rehabilitation (PR), which included endurance exercises, strength training, several types of breathing exercises, breath-stacking exercises, thoracic expansion exercises, physical agents for rehabilitation modalities, education on posture correction, and energy conservation in daily activities. The patient was also monitored remotely through telerehabilitation from home. There were significant improvements in pulmonary function tests. Measurement of FVC, FEV1, the six-minute walking test (6MWT), and the PCF after two weeks of follow-up. After eight weeks of training, there were improvements in cardiopulmonary endurance, muscle endurance, and reduced dyspnea. Conclusion: Comprehensive pulmonary rehabilitation programs, including a combination of institutional and telerehabilitation synchronous approaches, can help improve cardiopulmonary endurance, muscle strength-endurance, and the overall patient's functional life who was suffering from chronic respiratory diseases, such as post-TB sequelae.
Analysis of Risk Factors for Loculated Pleural Effusion in Patients with Tuberculous Pleural Effusion at dr. Zainoel Abidin Hospital Purqan, Muhammad; Arliny, Yunita; Priyanto, Herry; Yanifitri, Dewi Behtri; Yanti, Budi
Jurnal Respirologi Indonesia Vol 45 No 4 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i4.822

Abstract

Background: Loculated pleural effusion is an effusion that has a lenticular configuration with smooth borders and is relatively homogeneous and can cause atelectasis in the surrounding lung tissue and is a result of excessive inflammation. Tuberculous pleural effusion is characterized by chronic accumulation of fluid and inflammatory cells in the pleural cavity. If not treated appropriately, a loculated pleural effusion can be life-threatening. This study aims to assess risk factors for loculated pleural effusion in TB pleural effusion patients. Method: This is an observational, analytical research with a cross-sectional design. The research sample was taken based on a consecutive sampling technique from TB pleural effusion patients treated at dr. Zainoel Abidin Hospital, Banda Aceh, from January 2024 to April 2024. Results: This study shows a relationship between age, kidney failure and diabetes mellitus on the incidence of loculated pleural effusion in TB pleural effusion patients (P<0.05). Age ≥46 years old has a 12.57 times risk, kidney failure 5.50 times and DM 14.5 times against the incidence of loculated pleural effusion. Gender, anemia, human immunodeficiency virus (HIV), pleural fluid analysis results and positive culture did not correlate with loculated pleural effusion (P>0.05). Conclusion: Age, kidney failure and diabetes mellitus are risk factors for loculated pleural effusion. The increase in age-related risk is associated with chronic inflammation, called inflammaging. Increasing age is also associated with changes in the composition and function of lung cells, making the clearance of pathogens difficult. Intense inflammation and difficulty in clearing pathogens also contribute to the association of kidney failure and diabetes mellitus with loculated pleural effusion.
Concordance Level between Impulse Oscillometry and Spirometry for Pulmonary Function Test Hapsari, Brigitta Devi Anindita; Melita , Melita; Siregar, Sihsusetyaningtyas Tiominar; Apriningsih, Hendrastutik; Adhiputri, Artrien
Jurnal Respirologi Indonesia Vol 45 No 4 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i4.920

Abstract

Background: The most widely used lung function test, spirometry, requires constant coaching and more effort. An alternative modality of impulse oscillometry (IOS) was introduced, which is simpler than spirometry, requiring only basic tidal breathing and less cooperation, but with less stringent standards. Methods: This research was a diagnostic test research with medical records data of patients who underwent spirometry and oscillometry procedures within the same period. The study was conducted in Sebelas Maret University General Hospital from March to September 2024. Results: A total of 77% of examinations gave the same results, namely restriction in 32 people (30.8%) and obstruction in 48 people (46.2%). Meanwhile, as many as 23% of IOS examinations gave different results compared to spirometry examinations (discordance). Six normal results from spirometry showed the impression of obstruction in IOS. The agreement between the IOS examination and spirometry was moderately significant (P=0.0001). Conclusion: Impulse oscillometry is a useful adjunct to spirometry, which is still the gold standard, especially for patients who are incapable of performing forced maneuvers.
Effectiveness of the 4-7-8 Breathing Technique in Enhancing Sleep Quality for COPD Patients Satria, Orita; Nasution, Nurromsyah; Apriani, Fitri; Andriani, Rizki; Damayanti, Siti; Permatasari Tarigan, Amira
Jurnal Respirologi Indonesia Vol 45 No 4 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i4.948

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a disease that is a health problem throughout the world. COPD sufferers can experience problems with decreased oxygen levels. This incidence can cause COPD sufferers to experience decreased sleep quality. Poor sleep quality will have an impact on the sufferer's physiology. Therefore, COPD sufferers can do breathing exercises, such as the 4-7-8 breathing exercises, which play a role in maximizing oxygen in the respiratory system. This study was conducted to determine the effect of 4-7-8 breathing exercises on improving sleep quality in patients with COPD Method: This study used a quasi-experimental design with a pretest-posttest without a control. This research was conducted on 45 samples, which were recruited in Cut Nyak Dhien Regional Hospital's pulmonary polyclinic, from February 29 to March 18, 2024. The main interventions carried out are the 4-7-8 breathing technique, and the study tool is the Pittsburgh Sleep Quality Index (PSQI) questionnaire. The data analysis method used was the Wilcoxon statistical test. Results: There is a decrease from 13.33 (pre-intervention) to 4.93 (post-intervention) for the mean score of the breathing exercise 4-7-8. There is a significant influence between influence of the 4-7-8 breathing exercise on improving sleep quality in COPD patients (P=0.001). Conclusion: There is a significant effect of breathing exercise 4-7-8 on improving sleep quality in COPD patients.
Galactomannan Test in Suspected Invasive Pulmonary Aspergillosis Patients: An Evidence-Based Case Report Rahmiati, Lina; Mubarokah , Mubarokah; Prasetyo, Dimas Seto
Jurnal Respirologi Indonesia Vol 45 No 4 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i4.954

Abstract

Background: Invasive pulmonary aspergillosis is a severe fungal infection with a high mortality rate. However, because the clinical and radiological images are non-specific, and culture results take a long time and yield unsatisfactory results, rapid, high-accuracy tests are needed. Consequently, the diagnosis of invasive pulmonary aspergillosis remains difficult. The objective of this study was to assess the galactomannan (GM) test as a diagnostic tool for patients with suspected invasive pulmonary aspergillosis. Methods: Articles were searched through three databases (PubMed, Embase, and Cochrane) using keywords based on PICO components related to suspected invasive pulmonary aspergillosis and the GM test. Titles and abstracts were screened, duplicates were removed, and articles were filtered according to inclusion and exclusion criteria. The critical appraisal was performed using methods recommended by the Center for Evidence-Based Medicine at the University of Oxford. Results: Three studies reported serum GM test sensitivities ranging from 71% to 88%, suggesting that this assay may be suitable as a screening tool due to its adequate true positive detection rate. The specificity values in these studies ranged from 89% to 98%, indicating good accuracy in correctly identifying true negative cases. However, considerable heterogeneity was observed across the studies. Conclusion: The GM test is a promising rapid diagnostic tool for suspected invasive pulmonary aspergillosis, enabling earlier and more accurate antifungal treatment. However, further studies are needed to standardize its cut-off values and interpretation to ensure consistent clinical application.
Immunology of Drug-Resistant Tuberculosis (DR-TB):A Literature Review Oinike, Irene; Wijaya, Dewi
Jurnal Respirologi Indonesia Vol 45 No 4 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i4.958

Abstract

Drug-resistant tuberculosis (DR-TB) poses significant challenges to control efforts due to its complex pathogenesis and limited treatment options. DR-TB arises through primary infection with resistant strains or secondary resistance during the course of treatment. Secondary resistance is divided into intrinsic and acquired. In intrinsic resistance, infection is caused by TB germs that have evolved, causing resistance through several mechanisms, namely reducing cell membrane permeability, drug reflux, degradation and target modification, while acquired resistance is caused by chromosomal mutations in target genes during the treatment process. Resistance is driven by chromosomal mutations in key genes such as rpoB, katG, inhA, pncA, emb, gyrA/gyrB, rrs and others, leading to reduced drug susceptibility. This review summarizes immunological mechanisms relevant to resistance and current treatment approaches.
Comparative Diagnostic Accuracy of LF-LAM TB Antigen and Xpert MTB/RIF in Pulmonary Tuberculosis among Underweight Patients Eksa, Dwi Robbiardy; Hendarto, Gatot Sudiro; Sinaga, Fransisca TY; Dilangga, Pad; Herdato, M. Junus Didiek; Infianto, Andreas; Ekawati, Diyan; Gozali, Achmad; Ajipurnomo, Adhari
Jurnal Respirologi Indonesia Vol 45 No 4 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/7brxv447

Abstract

Background: In 2023, the global incidence of tuberculosis (TB) reached 8.2 million cases. It is the highest on record due to delayed diagnoses and a rising number of TB patients. Tuberculosis is more prevalent among patients with compromised immune systems, including those with HIV and malnutrition (BMI <18.5 kg/m2), who exhibit increased vulnerability to infection. The challenge of sputum expulsion impedes diagnosis, requiring a rapid, cost-effective early-detection technique. The lateral flow lipoarabinomannan TB antigen (LF-LAM TB-Ag) assay provides an alternate method for identifying lipoarabinomannan in urine, a constituent of the Mycobacterium tuberculosis cell wall. This study assessed the effectiveness of the LF-LAM TB-Ag assay compared with the Xpert MTB/RIF assay for TB diagnosis. Methods: A comparative cross-sectional study was conducted at Abdul Moeloek Hospital, Lampung Province, from January 2023 to June 2024. A total of 52 suspected pulmonary TB patients with HIV-negative status and underweight BMI were evaluated using both the LF-LAM TB-Ag and Xpert MTB/RIF assays. Results: Chi-square tests were used to compare the performance of LF-LAM TB-Ag with Xpert MTB/RIF. The LF-LAM TB-Ag test had a sensitivity of 79.59% and a specificity of 100% (P=0.002). Conclusion: This study underscores the necessity for early detection of pulmonary TB in underweight individuals. The integration of LF-LAM TB-Ag with Xpert MTB/RIF improves detection, especially in high-risk populations, enabling prompt treatment and enhanced disease management.
Effects of Active Hexose Correlated Compound (AHCC®) on Clinical and Laboratory Response of Pulmonary Tuberculosis Patients Madolangan, Jamaluddin; Yusuf, Irawan; Wahyudin, Elly; Djaharuddin, Irawaty
Jurnal Respirologi Indonesia Vol 45 No 4 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i4.820

Abstract

Backgrounds: Active hexose correlated compound (AHCC), an α-glucan extracted from Lentinula edodes, is known for its immunomodulatory properties. It is suspected that the strong nutrients contained in AHCC are very safe and without side effects, including in tuberculosis patients. This study evaluated the effect of AHCC on clinical and hematologic responses in pulmonary tuberculosis (TB) patients Methods: A double-blind randomized controlled trial was conducted involving 60 pulmonary TB patients receiving standard anti-TB therapy. Participants were randomly assigned to receive either AHCC (3 g/day) or a placebo for six months. Clinical and laboratory parameters were assessed before and after treatment. Results: Patients in the AHCC group showed greater improvement in clinical symptoms (reduced cough, improved appetite, and weight gain) and significant enhancement of hematological and immunological markers compared with placebo (P<0.05). AHCC supplementation significantly increased CD4⁺ and CD8⁺ lymphocyte counts, suggesting improved immune recovery and modulation of host defense against Mycobacterium tuberculosis infection. Conclusion: AHCC supplementation alongside standard anti-TB therapy improves clinical outcomes and immune responses in patients with pulmonary tuberculosis.
Correlation Between Predicted Maximal Oxygen Uptake (VO2 max) from The Six-Minute Walk Test and Reaction Time in Male Security Guards Noor, Amira Ismi; Soehardiman, Dicky; Taufik, Feni Fitriani
Jurnal Respirologi Indonesia Vol 45 No 4 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i4.1015

Abstract

Background: Reaction time, the interval between stimulus and motor response, reflects alertness and is critical in professions such as security guards. Maximal oxygen uptake (VO₂ max), a standard measure of cardiorespiratory fitness, has been linked to improvements in cognitive performance. This study examined the relationship between predicted VO2 max values from the six-minute walk test and reaction time in security guards. Methods: A cross-sectional study was conducted among 33 male security guards at Persahabatan National Respiratory Center between October and November 2024. Participants completed physical activity questionnaires, the six-minute walk test, and audio-visual reaction time assessments. Results: The mean predicted VO2 max was 18.3±2.9 ml/kg/min (metabolic equivalents/METs: 5.2±0.8). Body mass index significantly influenced VO₂ max (p = 0.002). Auditory reaction time was significantly faster than visual reaction time (172.6±25.7 ms vs. 199.8±33.1 ms, p < 0.001). A weak negative correlation was found between predicted VO₂ max and visual reaction time (r = –0.340, p = 0.048), but not with auditory reaction time (r = –0.245, p = 0.169). Conclusion: Higher cardiorespiratory fitness, as reflected by predicted VO₂ max, was not strongly associated with visual reaction time among security guards.

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