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Jurnal Biomedika dan Kesehatan
Published by Universitas Trisakti
ISSN : 2621539x     EISSN : 26215470     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Biomedika dan Kesehatan is an official publication of Faculty of Medicine Trisakti University. Jurnal Biomedika dan Kesehatan is a third-monthly medical journal that publishes new research findings on a wide variety of topics of importance to biomedical science and clinical practice. Jurnal Biomedika dan Kesehatan online contains both the current issue and an online archive that can be accessed through browsing, advanced searching, or collections by disease or topic.
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Articles 14 Documents
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Search results for , issue "Vol 8 No 3 (2025)" : 14 Documents clear
Potensi Sel Punca Mesenkim dalam Penyembuhan Luka Menggunakan Scaffold Nanofiber: Mini Review Purba, Priskila Natasya Rambe; Rofaani, Elrade; Astirin, Okid Parama
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.385-399

Abstract

Currently, the use of mesenchymal stem cells (MSCs) in cell therapy is growing as a means to repair damaged cells. MSCs are multipotent stem cells capable of differentiating into a variety of specialized cell types across multiple tissues. Adipose tissue, bone marrow, umbilical cord, and placenta are possible sources of MSCs. MSCs secrete a bioactive secretome that affects skin cells by mediating the actions of growth factors and cytokines. MSCs can actively contribute to wound healing through several phases, including promoting fibroblast migration, neovascularization, secreting anti-inflammatory cytokines, and re-epithelialization. To improve therapeutic effectiveness, appropriate biomaterials were incorporated into nanofiber scaffolds to mimic the natural extracellular matrix and attract fibroblasts into the skin layer. The purpose of this review is to evaluate research on the use of MSCs with various nanofiber scaffolds in the wound healing process in vitro. The review finds that several natural and synthetic polymers used as scaffold materials are biocompatible, thereby increasing the healing potential of wound tissue. MSCs, when co-cultured in nanofiber scaffolds, activate several mechanisms, including the expression of genes and growth factors related to wound healing. It is concluded that the use of biopolymers in MSC-seeded scaffold designs can contribute to the enhancement of wound healing and tissue regeneration.
Faktor Pendukung Pemanfaatan Jaminan Kesehatan Nasional Untuk Penanganan Penyakit Katastropik Di Indonesia Widayati, Hesti Prawita; Intiasari, Arih Diyaning; Rejeki, Dwi Sarwani Sri
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.374-384

Abstract

The National Health Insurance (Jaminan Kesehatan Nasional/JKN) is a nationwide program that applies social insurance principles to provide equitable access to healthcare services, including coverage for catastrophic illnesses that entail high medical expenditures. Despite its extensive coverage, the use of JKN for the management of devastating illness is influenced by various socioeconomic and health-related factors. This study aimed to identify determinants of JKN utilization for the management of catastrophic diseases in Indonesia. This systematic review was conducted using the PRISMA guidelines. Literature searches were performed across four electronic databases: PubMed, PubMed Central, Semantic Scholar, and Google Scholar. Articles were included if they discussed factors influencing the utilization of JKN or other national health insurance schemes for catastrophic illnesses. Exclusion criteria excluded studies that did not address catastrophic disease management or were not relevant to insurance utilization. The review focused on publications issued between 2015 and 2025. The initial search identified 678 articles, which were screened using title, abstract, and full-text reviews, as well as duplicate checks. A total of six articles met all eligibility criteria for final analysis. The included studies consistently showed that several factors supported JKN utilization in the management of catastrophic illness. These determinants comprised household income, family size, marital status, gender, age, medical costs, and the presence of chronic illness. Evidence indicated that low-income households, larger families, older individuals, and those with chronic diseases were more likely to rely on national health insurance due to high financial vulnerability. This review concluded that key socioeconomic and health-related factors influence the use of JKN for the management of catastrophic illness in Indonesia. Strengthening JKN policies and enhancing financial protection mechanisms are essential to reducing the economic burden of devastating diseases and ensuring the program's long-term sustainability.
Melindungi Kulit: Tinjauan Komprehensif tentang Tabir Surya Anorganik dan Perannya dalam Fotoproteksi Al-Sayed, Raghda; Ahmed, Dena; Zainulabdeen, Khalid; Waleed, Reem; Bufaroosha, Muna; Hairunisa, Nany; Lestari, Ade Dwi; Widowati, Henie; Ridwan, Alvin Mohamad; Anestessia, Ira Juliet; Yousif, Emad; Panduwati, Lira; Mayasari, Atut Cicih
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.359-373

Abstract

Sunscreens are topical agents that protect the skin from the damaging effects of ultraviolet (UV) radiation, a major contributor to premature aging and skin cancer. These products are typically categorized into two main types: physical (inorganic or mineral) and chemical (organic) sunscreens. Physical sunscreens primarily consist of zinc oxide (ZnO) and titanium dioxide (TiO₂), which reflect and scatter UV rays, thereby providing broad-spectrum protection. Compared with chemical sunscreens, which absorb UV radiation and convert it into heat, inorganic agents are associated with a lower risk of systemic absorption and skin irritation, making them particularly suitable for sensitive skin and pediatric use. This review explores the fundamental mechanisms of action, formulation challenges, and comparative effectiveness of inorganic sunscreens. Special attention is given to their photostability, which contributes to longer-lasting protection, and to their safety profiles in both acute and chronic use. Additionally, recent innovations in nanoparticle technology have enhanced the aesthetic appeal of these agents by reducing visible residue. However, this has also raised new concerns about nanoparticle penetration and environmental impact. Finally, the review addresses public health considerations, including regulatory updates, consumer preferences, and the role of education in promoting informed use of sunscreen.
Hubungan Usia Menarche dengan Kejadian Kanker Payudara pada Wanita Dewasa Balgahoom, Najwa; Surjadi, Lily Marliany; Kurniawan, Febriyanto
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.263-273

Abstract

Background Breast cancer is a non-communicable disease that is a health problem worldwide. Based on breast cancer prevalence data according to the World Health Organization (WHO) in 2020, 2.3 million women have been diagnosed, and 685,000 of them have died from breast cancer. Several factors can increase the risk of possible breast cancer incidence, some of which are age of menarche, nulliparity (never giving birth), and obesity. The purpose of this study was to determine the relationship between age at menarche, body mass index (BMI), and nulliparity with the incidence of breast cancer in adult women. Methods This cross-sectional study was conducted at Dharmais Cancer Hospital, Jakarta, with 104 respondents aged 19-59 years with breast complaints during March-May 2024. By excluding respondents with consecutive non-random sampling techniques. Data analysis using the Mann-Whitney test with a probability level (p < 0.05). Results The data showed that 98 respondents had breast cancer, and over 80% of them had the no special type (NST) breast cancer. Meanwhile, 6 respondents were not diagnosed with breast cancer. There were 62 respondents with normal menarche age (>12 years), with a p-value of 0.979. Additionally, 91 respondents had multiparity, with a p-value of 0.891. Furthermore, 74 respondents had an excessive body mass index (BMI), with a p-value of 0.336. Conclusions Based on statistical analysis, it can be concluded that there is no significant relationship between menarche age, body mass index (BMI), and parity with breast cancer in adult women.
Endometriosis pada Luka Operasi Seksio Sesarea: Suatu Laporan Kasus Yastani, Deasyka; Wirawan, Jimmy Panji; Anastasya, Karina Shasri; Faradilla, Meutia Atika; Xavierees, Endrico; Yohana, Yohana; Suweino, Suweino; Rahmansyah, Mulia; Mahardieni, Karlina; Ferina, Mutiara
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.329-333

Abstract

Caesarean scar endometriosis is a rare form of extra pelvic extrapelvic or extra-pelvic endometriosis that often presents with nonspecific symptoms, leading to diagnostic challenges. We report the case of a 41-year-old woman who presented with a painful subcutaneous mass at the site of a previous caesarean section, noted eight months post-surgery. MRI imaging revealed a mass suggestive of cutaneous endometriosis, and a wide excision was performed. Histopathological analysis confirmed the diagnosis by identifying endometrial glands and stroma within the cutaneous tissue. We report the case of a 41-year-old woman with a painful subcutaneous mass at the site of a previous cesarean section. The mass was detected eight months after the cesarean section. Following magnetic resonance imaging (MRI), which demonstrated a mass characterized as cutaneous endometriosis, the patient underwent wide excision. Histopathological analysis confirmed the diagnosis by demonstrating endometrial glands and stroma within the cutaneous tissue. Caesarean scar endometriosis is often associated with Pfannenstiel incisions, with a latency period of symptom onset averaging over two years. While imaging, such as MRI, is useful for preoperative assessment, surgical excision remains the definitive treatment. Recurrence is uncommon but can occur. Iatrogenic seeding of endometrial cells during surgery is a likely etiological factor, highlighting the importance of proper surgical technique and wound cleaning. Cesarean scar endometriosis is often associated with a Pfannenstiel incision, with an average latency period of more than two years. Although imaging such as MRI is useful for preoperative assessment, surgical excision remains the definitive treatment. Recurrence is rare but can occur. Iatrogenic endometrial cell seeding during surgery is a likely etiologic factor, highlighting the importance of proper surgical technique and wound cleansing. The conclusion was although rare, cutaneous endometriosis should be considered in women presenting with cyclical pain and masses at surgical scars post-caesarean - cyclic pain and masses in their post-cesarean scars. Early recognition and surgical intervention are key to effective management and prevention of cutaneous endometrosis recurrence.
Perbandingan Kualitas Hidup berdasarkan Hasil Nilai SNOT-22 pada Penderita Rinosinusitis Kronik sebelum dan sesudah Terapi Irigasi Nasal dengan Larutan NaCl 0,9% TR, Teuku Husni; Zakiaturrahmi, Zakiaturrahmi; Syakirah, Raihan
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.274-284

Abstract

Background Chronic rhinosinusitis (CRS) is an inflammatory disease of the nasal mucosa and paranasal sinuses that lasts for 12 weeks or more. This disease often causes physical, emotional, and social disturbances in patients. CRS requires proactive treatment; therefore, nasal irrigation using 0.9% NaCl is considered a supportive therapy that can help manage CRS. This study aimed to evaluate changes in quality of life using the Sinonasal Outcome Test-22 (SNOT-22), a 22-question questionnaire, administered to CRS patients before and 10 days after nasal irrigation therapy with  0.9% NaCl solution. Methods This study was an observational analytic cross-sectional study involving 36 adult patients (18–60 years old) diagnosed with CRS at Zainoel Abidin Regional General Hospital, Banda Aceh. Data were obtained through the SNOT-22 questionnaire before and 10 days after nasal irrigation therapy. Results Statistical analysis showed a significant difference in SNOT-22 scores between before and 10 days after nasal irrigation therapy with 0.9% NaCl (p-value <0.05). This decrease in SNOT-22 scores reflects improvements in physical symptoms, such as nasal congestion and facial pain, as well as improvements in the patients' emotional and social well-being. Conclusions The average SNOT-22 scores of chronic rhinosinusitis patients before nasal irrigation therapy with 0.9% NaCl solution were high. This reflects the significant severity of chronic rhinosinusitis symptoms, both physical and psychosocial, before receiving the intervention.
Pengaruh Nitrogen Cair terhadap Morfologi dan Jumlah Fibroblas pada Tendon Patela Tikus Wistar Jantan Isma, Satria Pandu Persada; Norahmawati, Eviana; Irsan, Istan Irmansyah; Asmiragani, Syaifullah; Phatama, Krisna Yuarno; Adiwignyo, Dandy Drestanto; Pratama, Yudit Alfa`
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.308-316

Abstract

Background Cryoablation with liquid nitrogen has shown promise in treating bone sarcomas, but its effects on fibroblast morphology and viability in ligament tissue remain unclear. This study aims to evaluate the effects of liquid nitrogen on fibroblasts in the patellar tendon ligament of male Wistar rats. Methods This experimental study used 24 male Wistar rats (6 months old, 300-400 grams), randomly divided into four groups. The control group was not exposed to liquid nitrogen, while the experimental groups were exposed for 1, 5, and 10 minutes, respectively. After 7 days of acclimatization, the rats were exposed to liquid nitrogen and then euthanized. The patellar tendon ligaments were collected for histological analysis, stained with Hematoxylin-Eosin, and examined under a microscope. Statistical analysis was performed using One-Way ANOVA, followed by Tukey post hoc tests to determine significant differences among exposure times. Results Significant changes in fibroblast morphology and count were observed with increasing exposure time. One-way ANOVA revealed significant differences (p < 0.001) in fibroblast count and morphological alterations across exposure groups. Tukey post hoc tests showed that a 10-minute exposure resulted in substantial reductions in fibroblast count and viability, accompanied by progressive morphological changes as exposure time increased. Discussion Exposure to liquid nitrogen significantly affects fibroblast cells, and longer exposure times lead to more severe cellular damage. Exposure duration should be carefully controlled during cryotherapy to optimize therapeutic benefits. Conclusions Exposure to liquid nitrogen adversely affects fibroblast cells in the patellar tendon ligament, with prolonged exposure resulting in decreased cell viability and morphological changes.
Anemia Berat pada Pembawa Sifat Thalasemia dengan Tuberkulosis Peritoneal: Sebuah Laporan Kasus Salsabila, Diva Azura; Farsyah, Muhammad Athar; Amelia, Ade; Fadilah, Tubagus Ferdi
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.350-358

Abstract

Thalassemia is a heterogeneous group of inherited hemoglobin disorders characterized by reduced or absent synthesis of globin chains, leading to varying degrees of ineffective erythropoiesis and chronic anemia. Thalassemia trait is usually regarded as a benign carrier state, often presenting with mild, asymptomatic microcytic anemia that does not require transfusion. In contrast, tuberculosis is a chronic infectious disease that commonly causes anemia of chronic disease through persistent inflammation, cytokine-mediated bone marrow suppression, and hepcidin-driven disturbances in iron metabolism. When these two conditions coexist, the resulting anemia may be more severe than expected from either condition alone.This report describes a unique case in which thalassemia is complicated by peritoneal tuberculosis, resulting in an unusually severe anemic state not typical for a carrier. A 15-year-old female receiving ongoing treatment for peritoneal tuberculosis presented with severe anemia (hemoglobin 7.43 g/dL). Physical examination revealed classic thalassemia signs, including facies cooley and splenomegaly. Laboratory findings confirmed severe microcytic, hypochromic anemia, and HPLC analysis showed elevated HbF and Hb Bart's, consistent with a thalassemia trait. The patient was managed with packed red cell (PRC) transfusions and folic acid, which successfully resolved the acute symptoms. As a conclusion, the severe anemia in this patient was likely due to multifactorial causes: an underlying thalassemia trait compounded by anemia of chronic disease (ACD) from tuberculosis. This case highlights the critical need to investigate comorbidities in thalassemia carriers with atypical presentations.
Polusi Udara dan Risiko Penyakit Akut pada Telinga, Hidung, dan Tenggorok: Studi Cross-Sectional di Jakarta Barat Tjhin, Purnamawati; Melati, Tiara; Agustawan, Dwi; Abdillah, Fauzan
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.285-297

Abstract

Background Air pollution, particularly in urban areas such as West Jakarta, is a major public health concern. Longterm exposure to pollutants, including particulate matter (PM) 2.5, can lead to respiratory problems, including acute otolaryngologic diseases. Outdoor workers, such as those involved in urban infrastructure maintenance, are more vulnerable to these conditions. This study aimed to assess the relationship among air pollution levels, mucociliary clearance function, and the prevalence of acute otolaryngologic diseases among outdoor workers in West Jakarta. Methods A cross-sectional study was conducted among 120 Public Infrastructure and Facility Maintenance (PPSU) workers in the Cengkareng, Rawa Buaya, and Cengkareng Timur sub-districts. Air quality was assessed using data from nearby monitoring stations, measuring PM2.5 levels and the Air Quality Index (AQI). Health assessments included anamnesis, patient-reported outcome questionnaires, saccharin transit test, and otorhinolaryngologic endoscopic assessments. Results The average PM2.5 level was 57.58 μg/m³ (high risk for respiratory issues), and the AQI was 144.71 µg/m³ (unhealthy). The saccharin transit time test averaged 427.29 seconds, with a mean nasal floor length of 63.76 mm. The prevalence of acute rhinopharyngitis was 59.2%, rhinosinusitis 8.3%, occupational rhinitis 9.2%, and vitamin D insufficiency 67.5%. However, no significant correlation was found between air pollution exposure, mucociliary function, and acute otolaryngologic diseases (p > 0.05). Conclusions Despite high exposure to air pollution, no significant relationship was observed between air pollution, mucociliary clearance, and acute otolaryngologic diseases among PPSU workers. Further studies with larger sample sizes and longitudinal designs are needed.
Embolisasi Pra Operatif Untuk Angiofibroma Nasofaringeal Abdillah, Fauzan; Nugroho, Dwi Agustawan; Fadillah, Ibnu Harris; Mashabi, Yasmine; Hairunisa, Nany; Yousif, Emad
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.334-349

Abstract

Background: Juvenile nasopharyngeal angiofibroma (JNA) is a rare benign vascular tumor that almost exclusively affects adolescent males. Despite its benign nature, JNA demonstrates locally aggressive behavior and is associated with significant intraoperative bleeding. Preoperative embolization has become an important modality to reduce tumor vascularization and minimize intraoperative blood loss. The Objective of this case report is to discuss the role of preoperative embolization in the management of JNA, including relevant vascular anatomy, embolic materials, benefits and limitations, as well as local case experiences in Indonesia. Methods: A literature review was conducted on the external carotid artery anatomy, etiology, epidemiology, histopathology, tumor spread and staging, and preoperative embolization techniques using various materials such as gelfoam, polyvinyl alcohol, ethanol, and microspheres. Additionally, two cases of JNA at Cipto Mangunkusumo Hospital were reported, both treated with preoperative embolization using gelfoam prior to transpalatal tumor resection. Results: In both cases, embolization successfully reduced tumor vascularity. However, due to surgical delay beyond 48 hours after embolization, intraoperative bleeding remained significant (800–1000 mL). Both patients recovered uneventfully without postoperative complications, and histopathological findings confirmed JNA. Conclusion: Preoperative embolization is effective in reducing intraoperative blood loss during JNA surgery and should ideally be performed within 24–48 hours before resection. This approach facilitates safer tumor removal, although its optimal success depends on timing, embolization technique, and operator expertise.

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