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Contact Name
Mohammad Rizki Fadhil Pratama
Contact Email
mohammadrizkifadhilpratama@umpr.ac.id
Phone
+6287815093560
Journal Mail Official
bjop@umpr.ac.id
Editorial Address
Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya Building B 1st Floor, RTA Milono St. Km.1,5. Palangka Raya 73111, INDONESIA
Location
Kota palangkaraya,
Kalimantan tengah
INDONESIA
Borneo Journal of Pharmacy
ISSN : -     EISSN : 26214814     DOI : https://doi.org/10.33084/bjop
Core Subject : Health,
Borneo Journal of Pharmacy publishes various scientific articles covering Pharmacy and Pharmaceutical Sciences in the field but not limited to: Pharmacology-Toxicology, including pharmacokinetics, pharmacodynamics, pharmacotherapy, and toxicology. Pharmacognosy-Phytochemistry, including pharmacognosy, phytochemistry, ethnobotany, and ethnopharmacology. Pharmaceuticals, including biopharmaceuticals, pharmaceutical technology, formulations, and biotechnology. Analytical Pharmacy-Medicinal Chemistry, including pharmaceutical chemistry, chemical analysis, medicinal chemistry, bioinformatics, pharmacy physics, pharmaceutical analysis, and method validation. Microbiology Pharmacy, including the antibacterial, antifungal, and antiviral activity test. Natural Product Development, including testing the pharmacological activity of extracts, fractions, and plant isolates. Clinical-Community Pharmacy, including monitoring usage, side effects, counseling, and drug use evaluation. Management Pharmacy, including drug management, drug use profiles, pharmaceutical administration, and marketing.
Articles 340 Documents
Glucose-Responsive Dextran-Coated Curcumin Nanoparticles Functionalized with Glucose Oxidase for α-Amylase Inhibition Winda Trisna Wulandari; Atik Rohayati; Dela Sukma Al Febri; Gatut Ari Wardani; Firman Gustaman; Indra Indra
Borneo Journal of Pharmacy Vol. 9 No. 3 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i3.9792

Abstract

Curcumin is a natural compound with potential antidiabetic activity; however, its poor water solubility and low bioavailability limit its clinical application. This study aimed to synthesize dextran-coated curcumin nanoparticles (DCNPs) with glucose-responsive properties and evaluate their physicochemical characteristics and α-amylase inhibitory activity. DCNPs were prepared using the emulsification method with dextran as a stabilizing polymer and glucose oxidase enzyme as a glucose-sensitive agent. The nanoparticles were characterized for particle size, polydispersity index (PDI), zeta potential, morphology using transmission electron microscopy, encapsulation efficiency, and in vitro drug release in phosphate-buffered saline (PBS) with and without glucose (400 mg/dL). In addition, the α-amylase inhibitory activity was tested and compared to that of acarbose. The synthesized DCNPs exhibit a particle size of 172.1 ± 4.17 nm, PDI of 0,120 ± 0.10, and zeta potential of -18.8 ± 0.11 mV, indicating good homogeneity and moderate stability. The encapsulation efficiency reaches 95.45 ± 0.09%. The in vitro release study shows cumulative curcumin release of 40.18 ± 1.99% in PBS and 61.15 ± 3.37% in PBS with glucose after 8 hours, demonstrating glucose-responsive behavior. Furthermore, DCNPs exhibit an IC50 of 228.60 ± 2.67 ppm against α-amylase, lower than that of acarbose (399.35 ± 4.05 ppm), indicating stronger enzyme inhibition. These findings demonstrate that the developed glucose-responsive dextran-coated curcumin nanoparticles (DCNPs) meet the physicochemical criteria and exhibit significant α-amylase inhibitory activity. It indicates their potential as a dual-functional system for glucose-triggered drug release and enzymatic inhibition, and as a promising candidate for natural antidiabetic therapy.
Sacha Inchi (Plukenetia volubilis L.): From Aroma Compounds to Sensory Properties and Cosmetic Formulation Challenges Lenny Indriati; Sriwidodo Sriwidodo; Soraya Ratnawulan Mita
Borneo Journal of Pharmacy Vol. 9 No. 3 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i3.9900

Abstract

Sacha Inchi (Plukenetia volubilis L.) oil is a rich source of essential fatty acids and natural antioxidants, making it a promising candidate for cosmetic formulations. However, its distinctive aroma poses a significant barrier to consumer acceptance. As the first sensory attribute perceived by users, aroma plays a pivotal role in shaping perceptions of product quality and purchase intentions. This review provides a comprehensive analysis of the volatile compounds contributing to the aroma profile of P. volubilis oil, including data from both oil and seed matrices and the influence of thermal and germination treatments. This narrative review, indexed in Scopus, PubMed, and Google Scholar, covers P. volubilis oil and discusses its aroma, volatile components, potential use in cosmetics, and formulation methods. Technological strategies such as deodorization, encapsulation, microbial fermentation, enzymatic modification, and green extraction methods are examined for their potential to improve aroma without compromising bioactivity. The integration of sensory science, volatile metabolomics, affective psychology, and consumer-driven formulation is proposed as a multidisciplinary approach to developing natural oil-based cosmetics that are both biologically effective and emotionally resonant with global consumers.
Correlation between Total Phenolic Content and Total Flavonoid Content of Baeckea frutescens L. Fractions and ABTS Radical Inhibition Activity Nurkhasanah Mahfudh; Frezqa Azizah Seputri; Ichwan Ridwan Rais; Lestari Lestari; Mustofa Ahda; Awis Sukarni Mohmad Sabere
Borneo Journal of Pharmacy Vol. 9 No. 3 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i3.10286

Abstract

Baeckea frutescens L., locally known in Kalimantan as ujung atap, is a medicinal plant that grows in sandy areas of Central Kalimantan, Indonesia. It has been traditionally used and is currently recognized for its strong antioxidant potential, primarily due to its content of phenolic and flavonoid compounds. This study aimed to identify antioxidant-active fractions from B. frutescens leaf extract and evaluate the correlation between ABTS radical-scavenging activity, total phenolic content (TPC), and total flavonoid content (TFC). Its leaves were extracted by maceration with 70% ethanol, followed by successive fractionation with n-hexane, ethyl acetate, and methanol. This study showed that the methanol fraction has the highest TPC (224.532 ± 0.832 mg GAE/g) and TFC (45.452 ± 0.113 mg QE/g), along with ABTS radical-scavenging activity, with the lowest IC50 value of 23.411 ± 0.394 µg/mL, indicating the strongest antioxidant activity. Ethyl acetate and n-hexane fractions followed in descending order. All fractions demonstrated very strong antioxidant activity (IC50 < 50 µg/mL). Furthermore, this study reported a strong positive correlation between TPC and TFC (r = 0.926). In addition, the IC50 from this herb has strong negative correlations with TPC and TFC, which have r = -0.914 and r = -0.887, respectively. These results highlight the significant role of phenolic and flavonoid compounds in contributing to the antioxidant properties of B. frutescens leaf extract fractions.
Molecular Docking, Molecular Dynamics Simulation, and Antiproliferative Study of Ampelocissus thyrsiflora Compounds Targeting PARP in MCF-7 Cells Henny Sri Wahyuni; Sri Yuliasmi; Nazliniwaty Nazliniwaty; Nilsya Febrika Zebua; Gracelyn Tanaka; Pinastiara Br Napitupulu
Borneo Journal of Pharmacy Vol. 9 No. 3 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i3.10458

Abstract

Breast cancer remains the most frequently diagnosed cancer worldwide, and the severe adverse effects associated with conventional chemotherapy underscore the urgent need to discover safer, natural anticancer agents with fewer side effects. This study aimed to investigate the anticancer potential of Ampelocissus thyrsiflora (Blume) Planch, a North Sumatran medicinal plant rich in flavonoids. Initially, in silico analyses were conducted to identify potential bioactive compounds and their molecular targets. The ethanol extract was found to contain seven distinct flavonoid compounds, identified by LC-HRMS. Network pharmacology analysis identified 259 proteins associated with breast cancer. Among these, one compound showed a high interaction score (0.742) with poly (ADP-ribose) polymerase (PARP), a protein that plays a critical role in DNA repair and is highly relevant in breast cancer, highlighting it as a key therapeutic target. Molecular docking revealed strong binding affinities of the compounds to PARP, involving key amino acid residues TYR907, GLY863, SER904, TYR889, ALA898, and LYS903. Molecular dynamics simulations further confirmed stable ligand–protein interactions over a 100-ns trajectory. Subsequently, in vitro validation was performed to confirm the computational findings. The MCF-7 breast cancer cell line was selected for its well-established expression of hormone-responsive pathways and its relevance to studying PARP-associated DNA repair mechanisms in breast cancer. Treatment with the extract resulted in a dose- and time-dependent decrease in cell proliferation. These findings highlight the potential of A. thyrsiflora flavonoids as promising natural candidates for targeted breast cancer therapy.
Phytochemical Characterization and Antibacterial Potential of Ethanolic Extract of Durio zibethinus Murr. Albedo Ritha Pratiwi; Nadia Stevani; Syariful Anam; Amalia Purnamasari Zainal; Dyah Ratna Ayu Puspita Sari; Muhammad Azwar AR; Alyaan Siddiqui; Paula Mariana Kustiawan; Mahfuzun Bone; Wa Ode Sitti Musnina
Borneo Journal of Pharmacy Vol. 9 No. 3 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i3.11119

Abstract

Bacterial resistance to conventional antibiotics has become a major global health challenge, prompting the exploration of natural antibacterial agents derived from plant materials. Durian (Durio zibethinus Murr.) albedo, an abundant agricultural by-product, has received limited attention despite its potential as a source of bioactive compounds. This study aimed to determine the total phenolic and flavonoid contents of ethanolic durian albedo extract, characterize its functional groups using Fourier Transform Infrared (FTIR) spectroscopy, and evaluate its antibacterial activity against Staphylococcus aureus and Escherichia coli. Fresh albedo of the Montong cultivar was extracted by maceration using 96% ethanol. Total phenolic and flavonoid contents were determined using the Folin–Ciocalteu and aluminum chloride colorimetric methods, respectively. Functional groups were identified by FTIR spectroscopy, while antibacterial activity was assessed using the agar disc diffusion method at extract concentrations of 15%, 25%, 35%, and 45%. The extract contained 0.52 ± 0.06 mg GAE/g extract of total phenolics and 0.034 ± 0.001 mg QE/g extract of total flavonoids, indicating the predominance of phenolic compounds. FTIR analysis revealed characteristic functional groups associated with phenolic-rich phytochemicals, including hydroxyl, carbonyl, aromatic, and C–O groups. The extract exhibited concentration-dependent antibacterial activity, with the largest inhibition zones observed at 45% against S. aureus (15.6 ± 0.7 mm) and E. coli (12.4 ± 0.6 mm). The greater susceptibility of S. aureus suggests higher effectiveness against Gram-positive bacteria. These findings demonstrate that durian albedo possesses promising antibacterial potential associated with its phytochemical composition and support its valorization as a sustainable source of natural antibacterial agents.
Integrated LC–MS Profiling, In Vitro Antioxidant Activity, and Exploratory Molecular Docking of Selected Mangifera odorata Fruit Extract Constituents with KEAP1 Mashuri Mashuri; Zairin Noor; Eko Suhartono; Husna Dharma Putera; Nia Kania; Ristaniah Rose Effendy; Iskandar Iskandar
Borneo Journal of Pharmacy Vol. 9 No. 3 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i3.12172

Abstract

Natural products remain important sources of antioxidant compounds, particularly among underexplored tropical fruits. This study evaluated the antioxidant potential of Kweni (Mangifera odorata) fruit extract by integrating LC–MS profiling, in vitro assays, and molecular docking. Putative compounds were annotated by spectral-library matching. Hydroxyl radical (•OH) and hydrogen peroxide (H₂O₂) scavenging and metal-ion chelating activities were measured, and the corresponding half-maximal inhibitory concentrations (IC₅₀) were determined. Five flavonoid-related candidates (eriodictyol, astilbin, apigetrin, naringenin, and genistein) were selected for docking against Kelch-like ECH-associated protein 1 (KEAP1). The extract showed measurable activity in all three assays, with IC₅₀ values of 67.240 µg/mL for metal-ion chelation, 83.03 µg/mL for H₂O₂ scavenging, and 84.17 µg/mL for •OH scavenging. Among the selected candidates, astilbin and the tentatively annotated apigetrin produced the most favorable Vina scores (−10.2 kcal/mol) and predicted contacts within the modeled KEAP1 pocket. Because the compounds were putatively annotated and the assays used the whole extract, the observed activities cannot be assigned to individual constituents. The docking results indicate possible ligand–KEAP1 interactions but do not demonstrate KEAP1 inhibition, disruption of KEAP1–NRF2 binding, or NRF2 activation. Authentic standards, isolated compounds, biochemical binding assays, and cellular studies are required for confirmation.
Formulation of Liquid Body Wash Containing Ethanol Extract of Sarang Semut (Myrmecodia tuberosa Jack) Tuber from Central Kalimantan Rezqi Handayani; Fera Sartika; Salsabila Aura
Borneo Journal of Pharmacy Vol. 9 No. 3 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i3.12239

Abstract

The skin is a vital organ that protects the internal body from physical and mechanical stressors, thermal variations (heat or cold), radiation or ultraviolet (UV) rays, and pathogens. Skin protection is essential and is often maintained through the use of cosmetic products such as soap. Sarang Semut (Myrmecodia tuberosa Jack), native to Central Kalimantan, is a medicinal plant widely utilized in traditional medicine. Previous studies have indicated that Sarang Semut tubers contain secondary metabolites, including alkaloids, flavonoids, saponins, tannins, and steroids, which possess antibacterial and antioxidant properties. These bioactive compounds provide significant potential for the development of liquid soap dosage forms. This study aims to formulate a liquid bath soap using the ethanol extract of Sarang Semut tuber as the active ingredient with varying extract concentrations: F0 (control/without extract), F1 (2.5 grams), and F2 (5 grams). An experimental research method was employed, focusing on physical property evaluations, which included organoleptic, homogeneity, foam height, pH, and viscosity tests. The results demonstrated that the ethanolic extract of Sarang Semut tuber can be successfully formulated into a liquid soap. Furthermore, physical property evaluations confirmed that all formulations of the Sarang Semut tuber ethanol extract liquid soap met the established requirements for physical quality standards.
Free Radical Scavenging and In Vitro Anti-inflammatory Activities of the n-Hexane Fraction of Rhizophora mucronata Leaves from South Kalimantan, Indonesia Sutomo Sutomo; Arnida Arnida; Fadlilaturrahmah Fadlilaturrahmah; Rezky Akbar; Novia Pratiwi; Tanto Budi Susilo; Yulianto Yulianto; Amar Vijai Nasrulloh
Borneo Journal of Pharmacy Vol. 9 No. 3 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i3.12316

Abstract

Free radicals can cause tissue damage that can be prevented by antioxidant compounds. An anti-inflammatory is a compound that can suppress inflammation caused by oxidative stress. One of the wetland plants from South Kalimantan that has the potential as an antioxidant and anti-inflammatory is mangrove (Rhizophora mucronata). This study aims to determine the radical-capturing and anti-inflammatory activities of the n-hexane fraction of the ethanol extract of R. mucronata leaves. Extraction was performed by the maceration method, and fractionation by the liquid-liquid method. Qualitative test of radical scavenging using the thin layer chromatography method, while a quantitative test using UV-Vis spectrophotometry. Anti-inflammatory test using the protein denaturation inhibition method. Extraction of 750 g of R. mucronata leaf powder with 96% ethanol yielded 51.72 g (6.9%), and from 10 g of the 96% ethanol extract, the n-hexane fraction was 12.65 g (63.3%).  The n-hexane fraction test showed the presence of several compounds with potential as free-radical scavengers qualitatively, and quantitatively yielded an IC50 of 77.0925 ppm, which falls in the strong category. The anti-inflammatory test results showed an IC50 value of 64.902 ppm, which falls within the strong category. This study demonstrated that the n-hexane fraction of R. mucronata leaves exhibited promising preliminary in vitro free-radical-scavenging and anti-inflammatory activities.
Effectiveness of Digital Pharmaceutical Care Intervention on Medication Adherence in Hypertensive Patients: A Quasi-Experimental Study in Banjarmasin, South Kalimantan Yugo Susanto; Andi Hermansyah; Muhammad Ashar; Saybah Humairah; Devi Ristian Octavia; Long Chiau Ming; Muhammad Junaid Farrukh; Zaheer-Ud-Din Babar; Ronny Faslah; Abdul Rahem; Yuni Priyandani; Gusti Noorrizka Veronika Achmad
Borneo Journal of Pharmacy Vol. 9 No. 3 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i3.12742

Abstract

Hypertension remains a major public health challenge in Indonesia, where suboptimal adherence to antihypertensive therapy contributes to poor blood pressure control and avoidable cardiovascular risk. Pharmacist-led digital care offers a promising strategy to enhance medication adherence. This study aimed to evaluate the effectiveness of SatuObat, a Pharmacist-led digital care app, in improving medication adherence among hypertensive patients in community pharmacy practice. A quasi-experimental study with a non-equivalent control group pre-test and post-test design was conducted at community pharmacies in Banjarmasin, Indonesia. A total of 102  patients were recruited using consecutive sampling and assigned to either a control group (receiving usual care, n=52) or an intervention group (receiving usual care plus SatuObat app, n=50). The intervention comprised structured digital reminders, two-way chat with pharmacists, and tailored educational messages delivered through the app over 4 weeks. Medication adherence was measured using the validated Indonesian version of the MARS-5 questionnaire. Data were analyzed using the Wilcoxon signed-rank test and the Mann-Whitney U test. Adherence did not change significantly in the control group (p = 0.532), whereas the intervention group showed a significant increase in adherence scores (Δ = 7.20; p < 0.001). Post-intervention adherence was significantly higher in the intervention group than in the control group (p < 0.001). These findings indicate that integrating SatuObat into pharmacist-led care can substantially enhance medication adherence among hypertensive patients in community pharmacy settings and support the wider adoption of digital pharmaceutical care in low- and middle-income countries.
Cover, Content, and Editorial Note from Borneo J Pharm Vol. 9 No. 3 September 2026: Bridging Indigenous Bioactives and Advanced Drug Delivery: From Local Botanical Wealth to Functional Pharmaceutical Innovations Mohammad Rizki Fadhil Pratama
Borneo Journal of Pharmacy Vol. 9 No. 3 (2026): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v9i3.14400

Abstract

Assalamu'alaikum Wr. Wb. Alhamdulillahirabbil 'alamin. The next edition of Borneo Journal of Pharmacy (Borneo J Pharm) has been published in September 2026. This edition contains twelve articles spanning: Pharmacology-Toxicology, Pharmacognosy-Phytochemistry, Pharmaceutical, Analytical Pharmacy-Medicinal Chemistry, Microbiology Pharmacy, Natural Product Development, and Clinical-Community Pharmacy. This edition includes writings from four countries: Indonesia, Malaysia, Qatar, and the United States. The authors come from several institutions, including Universitas Pakuan, Universitas Lambung Mangkurat, Universitas Padjadjaran, Universitas Tadulako, George Mason University, Universitas Muhammadiyah Kalimantan Timur, Universitas Mulawarman, Universitas Ahmad Dahlan, Sukamara District Health Office, International Islamic University Malaysia, Universitas Gadjah Mada, National Research and Innovation Agency of The Republic of Indonesia, Universitas Muhammadiyah Palangkaraya, Universitas Bakti Tunas Husada, Universitas Sumatera Utara, Universitas Tjut Nyak Dhien, Universitas Muhammadiyah Banjarmasin, Universitas Airlangga, Universitas Negeri Malang, Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin, Universitas Muhammadiyah Lamongan, Sunway University, UCSI University, Qatar University, and Politeknik Negeri Banjarmasin. The editorial board is fully aware that there is still room for improvement in this edition; hence, with all humility, we are willing to accept constructive suggestions and feedback to improve the publication in future editions. The editorial board would like to thank all editors, reviewers, and contributors of the scientific articles who have provided the repertoire in this issue. We hope that all parties, especially the contributors, will participate again in the publication of the next edition, scheduled for December 2026. Wassalamu'alaikum Wr. Wb.

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