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Pharmaciana: Jurnal Kefarmasian
Published by Universitas Ahmad Dahlan
ISSN : 20884559     EISSN : 24770256     DOI : 10.12928
Core Subject : Health,
Medicine & Pharmacology
Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 808 Documents
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Immunomodulator Effect of Cnidoscolus aconitifolius Leaves Extract on CD4+ and CD8+ Expression in Salmonella typhimurium infected mice Hidayati, Sholihatil; Susanti, Dhina Ayu; Destiawan, Rian Anggia; Muflihah, Ahdiah Imroatul; Handayani, Rizka; Anggitasari, Wima
Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27050

Abstract

Typhoid fever is a common health problem in the community caused by Salmonella bacteria. The incidence rate of this infection will increase if a person's immune system is weakened. Plant extracts are generally considered to be potential immunomodulatory agents developed, which have smaller side effects. Research shows that Cnidoscolus aconitifolius leaves have medicinal properties including as hepatoprotective, antidiabetic, and anticardiovascular. The results of the antioxidant activity test show the results that Cnidoscolus aconitifolius leaves extract (CAE) has potential as an antioxidant with a very strong category. This study was conducted to determine the effect of giving Japanese papaya leaf extract on CD4+ and CD8+ expression in Babl/c mice induced by Salmonella typhimurium bacteria. The study was started by preparing 70% ethanol extract from Cnidoscolus aconitifolius leaves and preparing 30 Babl/C mice as experimental animals which were divided into 6 groups (healthy control, negative control, positive control and treatment group by giving CAE dose of 100 mg/kgbw, 200 mg/kgbw and 400 mg/kgbw). Induction was carried out by oral infection with Salmonella thypimurium bacteria. After 3 days the infected mice were treated orally once a day for 7 days. Evaluation of CD4+ and CD8+ expression was carried out using the flowcytometer method of the lymph organs. Data analysis was carried out by the Anova test followed by the post hoc test (Tukey) using the SPSS for Windows application. The results showed that giving CAE at doses of 100 mg/kgbw, 200 mg/kgbw and 400 mg/kgbw could increase the expression ratio of CD4+ and CD8+, whereas giving CAE at a dose of 400 mg/kgbw showed significantly different results (p<0.05) to the negative control. This shows that the CAE has potential as an immunomodulatory agent that can improve immune function.
Development of standardized kaffir lime fruit peel extract as a gel for antioxidant and anti-acne Darsono, Farida Lanawati; Soegianto, Lisa; Jessica, Maria Anabella
Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27076

Abstract

This study aimed to determine the effect of increasing the concentration of the condensed extract of kaffir lime fruit peel in a gel dosage form on its physical quality and effectiveness. The condensed extract was obtained by maceration with 95% ethanol as a solvent. The dosage form chosen is a hydrophilic-based gel with a modification of the addition of a penetrant enhancer (IPM) and a solubilizer (Glycerin). The concentration of the condensed extract of kaffir lime fruit peel used were F1 (10%), F2 (15%), and F3 (20%). Gel preparations were tested for physical quality and effectiveness, consisting of antioxidant activity (IC50) and antibacterial (Zone Inhibition). Furthermore, the One Way ANOVA statistical method will analyze data from parametric experiments between batches and between formulas. If there is a significant difference in the statistical analysis between the formulas, then the test is continued using the Tukey Post-Hoc test method. The experimental results showed that increasing the concentration of kaffir lime peel extract (Citrus hystrix) affected the pH value, viscosity, dispersion, and effectiveness as an anti- acne and antioxidant. It was concluded that the anti-acne gel of extract F1, F2, and F3 were physically stable during storage, and based on the physical quality and effectiveness test it was known that F3 had the greatest zone inhibition (ZI): 13.87 ± 0.18 mm and IC50 :14.9049 mg/mL
The Optimation of Fermentation Time, Antibacterial Activity and Profiling Secondary Metabolite of Symbiont Fungi from Sponge Gelliodes fibulata Rusmalina, Siska; Mahfur, Mahfur; Hasanah, Nunung; Wiyono, Mochamad Ardy; Ekayanti, Nonik Nur; Nathania, Jacinda Caroline
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.27137

Abstract

Symbiont fungi are organisms that live in sponges tissue. Sponges are known to contain many metabolites which have the potential to be used as raw materials for medicine. Sponge Gelliodes fibulata is belongs to category demospongiae. The purpose of this study was to determine the optimal time to obtain the best secondary metabolite profile results in the sponge symbiont fungus Gelliodes fibulata. This research is included in experimental research. Beginning with the fungi culture of the sponge Gelliodes fibulata. Followed by a fermentation process with variations in time 2, 4, 6, 8, 10, 12, and 14 days to get the secondary metabolites produced. A liquid extraction process is carried out to obtain secondary metabolites produced during fermentation. The final stage is to carry out qualitative analysis with TLC and antibacterial testing with the well-diffusion method. The results obtained show that the long fermentation time influences the secondary metabolites obtained, and the metabolites possessed influence their antibacterial activity. The profile of secondary metabolites from TLC showed that the 10th day of fermentation had the most complex secondary metabolites and the highest yield 0.086%. The results of antibacterial activity showed that the 10th day of fermentation had the largest inhibition zone with 7.75 ± 0.44 mm compared to the other days of fermentation.
Repurposing drugs in endometrial cancer using genomic variants database Darmawi, Darmawi; S, Donel; Suhandri, Wiwin; Winarto, Winarto; Adikusuma, Wirawan; Irham, Lalu Muhammad; Fidiawati, Wiwit Ade; Razali, Renardy Reza; Nathania, Auren; Zahra, Leina Putri
Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27201

Abstract

Endometrial cancer (EC) is the fourth most frequent gynecological cancers, and its incidence and mortality rates have increased over the last decade. Cytotoxic therapy with carboplatin and paclitaxel is the recommended first-line treatment for EC patients. However, the options for following therapy are limited. The latest advances in molecular studies have uncovered the nature of genetic alterations in EC, compelling methods for further research into the treatment of EC since they may disclose to tailored pharmacological therapy. The aim of this study to identify novel drug candidates in treating EC using genomics variants and biological pathway. The genomic variants of  EC were downloaded from cBioportal database. We established connection between the biological EC risk genes from cBioportal database and the DrugBank database. Finally, we used Connectivity Map (CMap) analysis to identify possible drugs whose mechanisms coincided with therapeutic targets and rank them based on the scoring system. We identified novel potential candidate drugs for EC, they are Bosutinib and Nilutamide which exhibit robust scores in the CMap analysis compare to paclitaxel. We also discovered BCR-ABL1 and AR as potential biomarker-driven therapy in EC. This study demonstrates the possibility of using genetic network analysis combined with bioinformatics to repurpose drugs for the treatment of EC. Further study will investigate the mechanisms of using BCR-ABL1 and AR targeting in the treatment of EC.
Interprofessional education applied in first-year and third-year health students: cross-sectional study Perwitasari, Dyah Aryani; Baroroh, Faridah; Sari, Andriana; Novitasari, Putri Rachma; Kodriati, Nurul; Matahari, Ratu; Purwanto, Barkah Djaka
Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27253

Abstract

Health professions work together to provide the best service in health care facilities by collaborating with patients, families, worker and the community. Interprofessional education (IPE) were practice of collaboration between two or more students from different health profession programs. The purpose of study was to compare IPE results from first and third year batches. The two batches included 345 first-year students and 460 third-year students, from three different health disciplines, including medicine, pharmacy, and public health. These students met for four weeks to increase interprofessional collaboration, improve communication skills, foster respect and increase knowledge of the various roles each discipline, especially case management, conflict management and team work. Before IPE program, the students were given pre-questionnaire to assess their prior understanding of IPE. Each group of first-year students presented the outcomes of their discussions in the fourth week, while the third-year students created a poster about the subject and presented it in the second week. The students complete the program and post-questionnaire after their presentation. The International Collaborative Competencies Attainment Survey served the development the IPE questionnaire (ICCAS). The result of pre-IPE domains’ score revealed substantial disparities in the team work domain, with third-year students score was lower than the first students, whereas first-year students had the highest score in the most of IPE categories, unless collaboration and conflict management (p>0.05). The post-IPE domains’ score showed significant differences in all of the domains. Most of the IPE domains had higher score in first year students, excluding communication and team work.
Ethanol-based solvent system for recovery antioxidant activity Centella asiatica L. Urban and its application in sleep-deprived Rats Wardatun, Sri; Sofihidayati, Trirakhma; Afifah, Nida; Juhroh, Juju
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.27277

Abstract

Antioxidants have the ability to eliminate free radicals by donating electrons to oxidants. Preclinical and clinical studies show that Centella asiatica L. Urban has antioxidant activity. Ethanol was the best solvent for extracted antioxidant compounds from Centella asiatica L. Urban. The concentration of ethanol solvents effect to the compounds extracted and its antioxidant activities. The objective of study to determine ethanol based solvent systems for best recovery of antioxidant activities and in vivo antioxidant activity of the most active extract using stress induced sleep-deprived rats with glutathione (GSH) concentration parameters. Ethanol based solvent system show different recovery antioxidant activity of Centella asiatica L. Urban. Ethanol 70% had the highest recovery of antioxidant activity with an IC50 value of 76.76 ppm. Ethanol 70% Centella asiatica L. Urban extract given in sleep-deprived rats at 300 mg/kg were not significantly different in glutathione levels from those group rats that received the positive control solution (ascorbic acid). The 70% ethanol extract of C. asiatica L. Urban has the potential to ameliorate the stress induced by sleep deprivation.
Antibiotic consumption and resistance: a 3-years ecological study for four critical groups of bacteria in a general regional hospital Sanjaya, Dwi Arymbhi; Siada, Nyoman Budiartha; Juanita, Rr Asih; Mahaputra, I Putu Yudistira; Kamalia, Made Gek Adisti; Meriyani, Herleeyana
Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27321

Abstract

Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae are the most critical groups of multi-drug resistant (MDR) bacteria that cause a threat in hospitals. This study identified the trend of antibiotic consumption, antibiotic resistance pattern, and the relationship between antibiotic consumption and antibiotic resistance in a critical group of bacteria in a general regional hospital. This ecological study was based on retrospective data from inpatient databases in a general regional hospital over three years (2017-2019). The trend for annual antibiotic consumption over 2017-2019 was defined as defined daily doses/100 bed-days. The relationship between total antibiotic consumption and the percentage of antibiotic resistance among four isolated critical bacteria was explored in time series analysis and linear regression. The most frequently used antibiotic was ampicillin (220.33 DDD/100 bed-days), ciprofloxacin (126.86 DDD/100 bed-days), and ampicillin-sulbactam (126.34 DDD/100 bed-days). There was a significant relationship between antibiotic consumption (ampicillin, ampicillin-sulbactam, ceftazidime, gentamicin, amikacin, and ciprofloxacin) in DDD/100 bed-days and antibiotic resistance in E. coli, K. pneumoniae, and P. aeruginosa (p<0.05) but not statically significant in A. baumannii (p=0.062). The annual usage fluctuated or remained stable, with no statistically significant trends change. The relationship between antibiotic consumption and antibiotic resistance was significant in three out of four critical groups of bacteria.
Study of kinetic and adsorption isotherm of ibuprofen on mcm-41 synthesized with rice husk Hartono, Olyvia Azzahra Putri; Purnomo, Frida Octavia; Waluyo, Dyah Ayuwati; Alam, Tunas; Madiabu, Mohammad Jihad
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.27393

Abstract

Rice husk is one of the abundant wastes, especially in agricultural countries. Rice husk waste has asilica content of 95.80%, where the silica content can be utilized to make an adsorbent. One of theadsorbents that can be made is Mobil Composition of Matter 41 (MCM-41), a material with ahexagonal structure with a surface area to adsorb ibuprofen. Based on the results of the research thathas been done, MCM-41 synthesized with rice husk has the same characterization results as MCM-41synthesized with commercial materials tetraethyl orthosilicate (TEOS). Fourier Transform InfraredSpectroscopy (FTIR) characterization results show the absorption peak is at wave number 1068.58 cm1 which shows asymmetric Si-O-Si stretching vibrations and at 799.60 cm-1region is symmetric Si-OSi stretching vibrations. X-ray diffraction (XRD) characterization results show an hexagonal crystalform at 20 = 20o-30o. Scanning Electron Microscope (SEM) characterization results show particle of2,664 um. Based on the results of the research that has been done MCM-41 synthesized from rice huskcan adsorb ibuprofen with Langmuir isotherm approach and Pseudo Second Order kinetics, and themaximum adsorbing capacity is 34.48 mg/g
Cytotoxicity of Zingiber officinale var. rubrum on HeLa cells and prediction of anti-proliferative activity via the jak2/stat3 and hedgehog pathways using a molecular docking approach Rofida, Siti; Nurani, Laela Hayu; Utami, Dwi; Edityaningrum, Citra Ariani
Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v13i3.27482

Abstract

Cervical cancer is one of the second-leading causes of death in women. The discovery of cancer drug candidates continues to be carried out due to the resistance that occurs in cervical cancer therapy. Plant metabolite compounds are one of the sources used to explore new drug candidates. Red ginger rhizome is a candidate plant that has anti-cervical cancer activity. This study aims to determine the cytotoxicity of an ethanol extract of red ginger rhizomes on the growth of HeLa cancer cells and predict anti-proliferative activity via the jak2/stat3 and hedgehog pathways. The sample (red ginger rhizome simplicia) was extracted by remaceration using 75% ethanol. The MTT assay method is used to test the cytotoxicity and anti-proliferation of metabolite compounds using Autodock 4.2 software. The receptors used in the jak2, stat3, and smo pathways were obtained from the Protein Data Bank with the codes 6VGL, 6NUQ, and 5L7I, respectively. The ethanol extract produced is a thick yellowish brown extract with an aromatic smell and spicy taste, with an extract yield of 18.63% w/w. 75% ethanol extract of red ginger rhizomes has cytotoxic activity in HeLa cancer with an IC50 of 104.22 ± 6.18 µg/mL and an IC50 of cisplatin of 38.61 ± 3.66. Prediction of antiproliferative activity via the jak2 pathway shows a binding energy and Ki value of -7.47 kcal/mol, -7.48 kcal/mol, and 3.33 uM, 3.27 uM, as shown by alpha-cedrol and beta-eudesmol compounds. The highest inhibition on the stat3 and smo pathways was shown by the beta compound eudesmol, with binding energy and Ki values of -6.05 kcal/mol, -7.57 kcal/mol, and 36.48 uM, respectively; 2.81 uM.
Enzymatic virgin coconut oil effect on urea and creatinine levels of hypercholesterolemia-diabetics induced Wistar male rats Dewi, Niluh Puspita; Alaydrus, Syafika; Nadila, Nadila; Magfirah, Magfirah; Tandi, Joni; Anggi, Viani; Astria, Nani
Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i1.27489

Abstract

Coconut (Cocos nucifera) is an Indonesian commodity that has high economic value tall. Virgin Coconut Oil (VCO) is one of the processed coconut products whose selling value is very high, because The composition of VCO consists of medium-chain fatty acids that can maintain a healthy body and prevent various diseases. The process of making VCO used in This research is an enzymatic method using pineapple weevil as a bromelain enzyme. This study aims to determine the effect of enzymatic administration of VCO and an enzymatic dose of VCO which is effective in reducing urea and creatinine levels in hypercholesterolemic-diabetic male white rats (Rattus norvegicus). This study was an experimental laboratory with a modified pretest and posttest randomized controlled group design using 30 test animals which were divided into 6 treatment groups. Each group consisted of 5 test animals, namely normal control, negative control, and positive control, with doses of 0.2, 0.4, and 0.8 mL/kg BW. The data obtained were analyzed using a One Way Anova and non- parametric statistical test by Kruskal Wallis. test and followed by a further Mann Whitney test to determine differences between treatments. The results showed that enzymatic VCO at a dose of 0.8 mL/kg BW was an effective dose in reducing urea and creatinine levels with an average decrease of 17.40 mg/dL and 0.36 mg/dL. The novelty in this study showed that the enzymatic VCO had an effect on reducing urea and creatinine levels in diabetic hypercholesterolemic male white rats.

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