Article Per Year (5 Year)
p-Index From 2021 - 2026
3.323
P-Index
This Author published in this journals
All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Syntax Literate: Jurnal Ilmiah Indonesia JSFK (Jurnal Sains Farmasi & Klinis) JURNAL FARMASI GALENIKA AMALIAH: JURNAL PENGABDIAN KEPADA MASYARAKAT Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Ilmiah Farmasi Farmasyifa Science Midwifery Current Research on Biosciences and Biotechnology Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Jurnal Abdimas Kartika Wijayakusuma Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Kesehatan Bakti Tunas Husada Kartika : Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Galenika Sasambo: Jurnal Abdimas (Journal of Community Service)
Hasimun, Patonah
Fakultas Farmasi, Universitas Bhakti Kencana, Bandung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

Published : 29 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 29 Documents
Search

 1   2   3 
Efektivitas Antosianin Ekstrak Bunga Mawar Untuk Pengobatan Diabetes Mellitus Tipe 2 Wawan Kurniawan; Patonah Patonah
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v7i9.13883

Abstract

Hiperglikemia adalah suatu kondisi medis berupa peningkatan kadar glukosa darah melebihi normal yang menjadi karakteristik beberapa penyakit terutama diabetes melitus di samping berbagai kondisi lainnya. Kekayaan bunga-bunga tropis di Indonesia yang dapat dimakan telah menjadi bagian dari kuliner nusantara, secara tradisional digunakan sebagai obat, sebagai pewarna alami untuk makanan dan minuman. Antosianin merupakan senyawa turunan polifenol yang keberadaannya sangat melimpah di alam dengan keanekaragaman dalam berbagai jenis tumbuhan. Antosianin adalah komponen alami yang terakumulasi pada vakuola dan bertanggungjawab untuk warna merah, biru dan ungu pada buah, sayur, bunga dan tumbuhan lainnya. Berbagai manfaat positif dari antosianin untuk kesehatan manusia adalah sebagai antioksidan, meningkatkan kemampuan penglihatan mata, anti inflamasi, mencegah diabetes, menghambat sel tumor dan mencegah penyakit neurologis.
PENGARUH KADAR TRIGLISERIDA TERHADAP KEKAKUAN ARTERI PADA MODEL HEWAN TIKUS WISTAR JANTAN Patonah Hasimun; Hasballah Zakaria
Kartika : Jurnal Ilmiah Farmasi Vol 7 No 2 (2019)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v7i2.307

Abstract

ABSTRAK Hasil studi epidemiologi diketahui bahwa trigliserida merupakan salah satu factor resiko independent terjadinya penyakit kardiovaskular walaupun target kadar low density lipoprotein (LDL) telah tercapai dengan obat statin. Diduga terdapat hubungan antara kadar trigliserida dengan elastisitas arteri. Kekakuan arteri telah diakui berkaitan erat dengan penyakit kardiovaskular. Penelitian ini bertujuan untuk mengetahui efek hipertrigliseridemia terhadap tingkat kekakuan arteri pada model hewan tikus Wistar yang diinduksi pakan tinggi lemak dan fruktosa 25%. Sejumlah 10 ekor tikus dikelompokkan secara acak menjadi 2 kelompok terdiri dari kelompok control normal menerima pakan normal dan kelompok control positif menerima pakan tinggi lemak dan air minum fruktosa 25% selama 28 hari. Pengukuran pulse wave velocity (PWV), denyut jantung, dan kadar trigliserida serum dilakukan pada hari ke 28. Hasil menunjukkan, kelompok kontrol positif mengalami kenaikan kadar trigliserida serum yang disertai dengan meningkatnya nilai PWV dan denyut jantung yang menunjukkan terjadinya kekakuan arteri yang berbeda bermakna secara statistik terhadap kelompok kontrol normal (p<0.05). Hasil dapat disimpulkan bahwa terdapat hubungan positif antara kadar trigliserida dengan kekakuan arteri. Semakin tinggi kadar trigliserida meningkatkan kekakuan arteri sehingga resiko kardiovaskular semakin meningkat. Kata kunci : trigliserida, kekakuan arteri, denyut jantung, kardiovaskular   ABSTRACT Epidemiological studies report that triglycerides are an independent risk factor for cardiovascular disease even though the target level of low density lipoprotein (LDL) has been achieved with statin drugs. It is suspected that there is a relationship between triglyceride levels and arterial elasticity. Arterial stiffness has been recognized as being closely related to cardiovascular disease. This study aims to determine the effect of hypertriglyceridemia on arterial stiffness in animal models of Wistar rats induced by a high-fat diet and 25% fructose in drinking water. A total of 10 rats were randomly divided into 2 groups consisting of a normal control group receiving normal feed and a positive control group receiving a high-fat diet and 25% fructose in drinking water for 28 days. Measurements of pulse wave velocity (PWV), heart rate, and serum triglyceride levels were carried out on day 28. The positive control group experienced an increase in serum triglyceride levels accompanied by an increase in PWV and heart rate that was statistically significantly different (p <0.05) compared to the group normal. The results concluded that there was a positive relationship between triglyceride levels and arterial stiffness. Higher triglyceride levels increase arterial stiffness. it increases the risk of cardiovascular disease. Keywords : triglyceride, arterial stiffness, heart rate, cardiovascular
Formulasi dan Evaluasi Permen Jelly dari Ekstrak Daun Pegagan dan Rimpang Kunyit untuk Kesehatan kardiovaskular Patonah Hasimun; Deny Puriyani Azhary; Saputro, M. Ramadhan
An-Najat Vol. 2 No. 2 (2024): MEI : An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v2i2.1030

Abstract

Hipertensi merupakan penyakit tidak menular yang menjadi salah satu penyebab kematian di dunia. Hipertensi diawali dengan meningkatnya tekanan darah secara terus menerus. Kombinasi dari tanaman pegagan dan kunyit mampu menekan tekanan darah sistolik dan diastolik serta mampu memperbaiki kekakuan arteri. Tujuan penelitian ini mengetahui stabilitas formulasi sediaan sediaan permen jelly dari ekstrak daun pegagan dan rimpang kunyit. Formula permen jelly dibuat menjadi 3 formula dengan konsentrasi penambahan ekstrak daun pegagan dan rimpang kunyit sebesar 3,5 g dengan variasi penggunaan karagenan. Penelitian dianalisis statistik Kruskal wallis. Pengujian permen jelly meliputi uji organoleptis, uji kadar air (metode oven), uji keseragaman bobot, dan uji kesukaan (metode hedonik). Uji organoleptik ketiga formula memiliki warna coklat dengan aroma khas tutty frutty, formula I memiliki rasa manis sedikit pahit dan formula II dan III memiliki rasa manis, formula I dan III memiliki tekstur kenyal sedangkan formula II memiliki tekstur agak kenyal, uji kadar air formula I 3,5%, formula II 4,6% dan formula III 5%, uji keseragaman bobot ketiga formula memenuhi persyaratan uji keseragaman bobot menurut FI III. Dari ketiga formula, formula III memiliki tekstur dan rasa yang disukai responden dengan persentase kadar air sebesar 5% dan memenuhi persyaratan keseragaman bobot.
POTENSI RIMPANG BANGLE HANTU (Zingiber ottensii Val.) SEBAGAI ANTIHIPERGLIKEMIA PADA MODEL HEWAN DIABETES YANG DIINDUKSI FRUKTOSA Patonah Hasimun; Agus Sulaeman; Nova Freena Dewi
JURNAL FARMASI GALENIKA Vol 4 No Edisi Khus (2017): Jurnal Farmasi Galenika Volume 4 Edisi Khusus SemNas Tanaman Obat Indone
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar belakang : Diabetes melitus (DM) dicirikan dengan intoleransi glukosa yang menghasilkan terjadinya hiperglikemia dan gangguan dalam metabolisme lipid dan protein. DM tipe 2 adalah jenis DM yang paling sering dijumpai dan pada umumnya diawali oleh gangguan fungsi insulin (resistensi insulin) yang mana selain dapat meningkatkan kadar glukosa darah juga dapat meningkatkan kadar trigliserida. Penelitian ini dilakukan untuk mengetahui aktivitas ekstrak bangle hantu (Zingiber ottensii Val.) sebagai antihiperglikemia dan dosis efektif ekstrak rimpang bangle hantu (Zingiber ottensii Val.) yang dapat menurunkan kadar glukosa darah pada model hewan yang diinduksi fruktosa Metode : Penelitian ini menggunakan desain true experimental in vivo pada hewan coba tikus yang diinduksi dengan fruktosa dan propiltiourasil (PTU). Hewan coba dibagi menjadi 6 kelompok (n = 6), yaitu kelompok normal, kelompok pembanding, kelompok induksi dan 3 kelompok ekstrak dengan dosis 50 mg/kg BB, 100 mg/kg BB dan 150 mg/kg BB. Hasil : Terjadi penurunan kadar glukosa darah tikus selama test toleransi glukosa yang dilakukan pada hari ke 8, 15, dan 22 serta kadar trigliserida yang diuji pada hari ke 22. Kesimpulan : Ekstrak rimpang bangle hantu (Zingiber ottensii Val.) memiliki potensi sebagai antihiperglikemia terhadap model hewan diabetes yang diinduksi fruktosa dan memiliki aktivitas maksimal sebagai antihiperglikemia secara in vivo pada dosis 100 mg/kg BB.
Inhibition of HMG CoA Reductase and Lipid Peroxidation in The Rats Liver by Selected Zingiberaceae Hasimun, Patonah; Sulaeman, Agus; Putra, Hendra Mahakam; Lindasari, Heni
Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v8i2.9430

Abstract

Cardiovascular disease is the leading cause of death worldwide. One of the major risk factors for cardiovascular disease is hyperlipidemia. This study aimed to determine the potential of Zingiberaceae (10 species) as inhibitor of HMG-CoA reductase enzyme activity and lipid peroxidation. This study was conducted by 2 methods including assay of HMG CoA reductase inhibition and lipid peroxidation test. The study was performed by in vitro method, using 20% rat liver homogenate. The inhibition of HMG CoA reductase enzyme was done by reacting liver homogenate, HMG CoA substrate, which added the Zingiberaceae extract compared with simvastatin as standard drug. The absorbance of the mixture was measured by a Microlab 300 spectrophotometer at a 340 nm wavelength. Lipid peroxidation assay was induced by the FeSO4.7H2O solution. The absorbance value measured using a spectrophotometer at a 532 nm wavelength. Lipid peroxidation inhibition was characterized by absorbance of the test extract, compared with the control group. The obtained data was calculated as percent of inhibition and was used to calculate IC50 extract test. The results showed that the 10 ethanolic extracts of Zingiberaceae rhizomes have activity as enzyme inhibitor HMG-CoA reductase with IC50 value range 65.8±4.1 – 203.3±15.2 ppm, and inhibition of lipid peroxidation with IC50 value range 13.5±5.0 – 219.6±4.3 ppm. This study can be concluded that the Zingiberaceae rhizomes have potential role as antihyperlipidemic agents through inhibition of HMG CoA reductase enzyme activity and preventing lipid peroxidation.
Review: Zebrafish (Danio Rerio) Sebagai Model Obesitas dan Diabetes Melitus Tipe 2 Hardianti, Mira; Yuniarto, Ari; Hasimun, Patonah
JSFK (Jurnal Sains Farmasi & Klinis) Vol 8 No 2 (2021): J Sains Farm Klin 8(2), Agustus 2021
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.8.2.69-79.2021

Abstract

Zebrafish (Danio rerio) yang sebelumnya disebut Brachydanio rerio merupakan spesies ikan air tawar tropis yang berukuran kecil yang berasal dari Asia Selatan dan Sungai Gangga di India. Zebrafish bisa diaplikasikan pada model obesitas dan diabetes melitus tipe 2 (DMT2). Obesitas merupakan pemicu terjadinya DMT2. Tujuan dari review artikel ini dapat memberikan informasi dan meningkatkan pemahaman pembaca bahwa zebrafish merupakan model yang ideal untuk obesitas dan DMT2. Metode penulisan review artikel ini dilakukan dengan penelusuran artikel ilmiah terpublikasi bertaraf nasional dan internasional dengan menggunakan kata kunci berupa “Obesity, zebrafish, model”, “Hyperglycemia, zebrafish, model” atau “zebrafish for hyperglycemia” dan “Diabetes melitus type 2, zebrafish, model”. Zebrafish model obesitas dan DMT2 yang diinduksi makanan dan obat menunjukkan keunggulan menjadi obesitas seperti pada manusia dan mamalia lain. Selain itu, zebrafish yang diinduksi dengan metode perendaman glukosa diperoleh hasil meningkatnya kadar glukosa darah dan gangguan respon terhadap insulin eksogen. Pemberian alternatif terapi dari bahan alam seperti GTE, palmaria mollis, diosgenin, bubuk kayu manis pada zebrafish memberikan hasil yang cukup baik sehingga bisa dipertimbangkan sebagai alternatif model hewan lain.
Impact of Black Garlic extract on cardio-renal protection in hypertensive animal models Hasimun, Patonah; Putra, Hendra Mahakam; Choerunnisa , Fitriani
Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i1.24513

Abstract

A strong link exists between arterial stiffening and cardiovascular conditions, particularly hypertension. Hypertension, a significant contributor to mortality rates, particularly affects elderly populations. The processed form of Allium sativum, known as black garlic, is renowned for its medicinal properties, including its ability to lower blood pressure. This study examined the blood pressure-lowering effects of black garlic extract, employing male Wistar rats aged two to three months.The experiment involved six distinct rat groups, each comprising of four animals. The two groups served as controls, whereas the remaining four underwent different treatments. Captopril was administered to one group at a dose of 2.5 mg/kg, whilst the remaining three groups were given black garlic extract as BG50, BG100, and BG200. All groups, with the exception of the control normal, underwent a 28-day induction protocol that included 25% fructose in drinking water, cholesterol (200 mg/kg), and propylthiouracil (12.5 mg/kg). The test substances were administered starting on day 14 concurrently with the induction phase. The evaluated parameters included blood pressure, arterial stiffness, nitric oxide (NO) levels, and renal histopathology. Black garlic extract significantly lowered blood pressure, enhanced arterial elasticity, and increased NO levels (p < 0.05) compared with the controls. Renal histopathological analysis revealed protective effects, suggesting prevention of kidney damage. These findings suggest that black garlic may have cardiorenal protective effects and could be useful for managing hypertension and arterial stiffness.
Edukasi Kesehatan dan Pemanfaatan Herbal untuk Pencegahan dan Pengelolaan Hipertensi di Kabupaten Bandung Patonah Patonah; Aris Suhardiman; Lia Marliani; Purwaniati Purwaniati; Mamay M Sobandi; Jajang Japar Sodik
Sasambo: Jurnal Abdimas (Journal of Community Service) Vol. 6 No. 4 (2024): November
Publisher : Lembaga Penelitian dan Pemberdayaan Masyarakat (LITPAM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/sasambo.v6i4.2128

Abstract

Program pengabdian masyarakat ini berfokus pada edukasi kesehatan dan pemanfaatan herbal untuk pencegahan dan pengelolaan hipertensi di Kabupaten Bandung. Program ini dirancang untuk mengatasi tingginya prevalensi hipertensi melalui pendekatan promotif dan preventif. Kegiatan edukasi meliputi seminar kesehatan interaktif, demonstrasi praktis penggunaan herbal, serta skrining kesehatan yang mencakup pengukuran tekanan darah, glukosa, kolesterol, dan asam urat. Hasilnya menunjukkan peningkatan signifikan dalam pengetahuan masyarakat, di mana persentase peserta dengan pemahaman memadai tentang hipertensi meningkat dari 19% menjadi 72%. Selain itu, peserta mulai menerapkan perilaku hidup sehat, seperti mengurangi konsumsi garam dan meningkatkan aktivitas fisik. Pengenalan herbal seperti jahe, kunyit, dan seledri memberikan alternatif strategi pengendalian tekanan darah yang mengintegrasikan kearifan lokal dengan ilmu pengetahuan modern. Inisiatif ini menunjukkan efektivitas intervensi berbasis komunitas secara holistik dalam meningkatkan hasil kesehatan masyarakat dan pentingnya program edukasi kesehatan yang berkelanjutan. Health Education and Herbal Utilization for Hypertension Prevention and Management in Bandung Regency This community service program focused on health education and herbal utilization for the prevention and management of hypertension in Bandung Regency. The program was designed to address the high prevalence of hypertension through promotive and preventive approaches. Activities included interactive health seminars, practical demonstrations on herbal utilization, and health screenings for blood pressure, glucose, cholesterol, and uric acid levels. The results showed a significant improvement in community knowledge, with the percentage of participants with adequate understanding of hypertension increasing from 19% to 72%. Additionally, participants adopted healthier behaviors, such as reducing salt intake and increasing physical activity. The introduction of herbal remedies, including ginger, turmeric, and celery, offered alternative strategies for blood pressure control, integrating local wisdom with modern science. This initiative demonstrated the effectiveness of holistic community-based interventions in improving public health outcomes and underscored the importance of sustainable health education programs.
Establishment of a Medical Team in Girimekar Village, Bandung District Fenti Fatmawati; Patonah Patonah; Dedep Nugraha; Wempi Budiana; Yanyan Mulyani; Supriyatni Kartadarma
Warta Pengabdian Andalas Vol 31 No 1 (2024)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.31.1.128-134.2024

Abstract

Bhakti Kencana University (BKU) community service activities were conducted in Girimekar Village, Bandung Regency. This activity involved BKU lecturers from various disciplines, such as Midwifery, Nursing, Public Health, and Pharmacy. This activity was carried out by forming a medical team, which was an effort to empower the community, especially the youth of the local group. This activity aims to socialize emergency treatment measures that must be carried out as soon as possible before residents are taken to the community health center or hospital. This will help the community care more about their health. Girimekar Village has topography and land contours in the form of highlands and lowlands at an altitude of between 400 meters above sea level and 600 meters above sea level, with an average temperature ranging from 19°C to 37°C. Girimekar Village consists of 5 hamlets, 22 RWs, and 79 RTs. Based on the topography, most areas outside the forest area are slopes or peaks with varying heights. Most RWs are located outside forest areas. Conditions like this are the background for the formation of this medical team. The method for forming a medical team was carried out by identifying the number of young people in the area and then carrying out preliminary outreach by educating them about the importance of emergency treatment before residents are taken to the hospital. After the socialization, the medical team was given training on first aid in the form of basic life support. The formation of the medical team was carried out by first identifying the number of youth. This activity, which was carried out for one month, produced a medical team from among the youth who were expected to be at the forefront in assisting. First, to residents before taking them to the health center or hospital. 26 Girimekar residents attended it, and the long-term plan for this activity is to hold first aid training for the medical team at least once every six months.
ARTICLE REVIEW: EFFECTIVENESS OF COMBINATION OF PLANT EXTRACTS AS ALTERNATIVE HYPERTENSION THERAPY Almasih, Royan; Hasimun, Patonah; Solihah, Nurlaella
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 2 (2025)
Publisher : Universitas Muhammadiyah Ahmad Dahlan Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i2.1704

Abstract

Hypertension is a global health problem requiring effective and safe management. Conventional therapies often face challenges, such as drug resistance, side effects, and patient non-compliance, increasing the need for alternative therapies. This article aims to review the effectiveness of plant extract combinations as antihypertensive therapies. This study used a literature review approach to studies published in the last 10 years, focusing on the mechanism of action, effectiveness, and synergistic potential of plant combinations. The results showed that combinations such as Anredera cordifolia (ten.) v. Steenis and Sonchus arvensis L. provided a decrease in systolic blood pressure (SBP) by 27.95 mmHg and diastolic blood pressure (DBP) by 33.89 mmHg, approaching the effectiveness of standard drugs such as valsartan. The main mechanisms include the inhibition of angiotensin-converting enzyme (ACE), vasodilation through the release of nitric oxide (NO), and diuretic effects. The combination of plant extracts shows potential as a safe and effective alternative; however, further clinical trials are needed to strengthen these findings. Keywords: Combination of Plant Extracts, Antihypertensive, Alternative Therapy.
Co-Authors Afief, Arief R. Agus Sulaeman Agus Sulaeman Agus Sulaeman Almasih, Royan Aris Suhardiman Aulia Nurfazri Istiqomah Avianningsih, Reformia Choerunnisa , Fitriani Choirunnisa, Zulfy Dadang Juanda Dedep Nugraha Deny Puriyani Azhary Dewi, Nova Freena Dian Eka Fakhira Fatmawati, Eva Fenti Fatmawati Garnadi Jafar, Garnadi Hardianti, Mira Hendra Mahakam Putra Hendra Mahakam Putra Heni Lindasari Ika Kurnia Sukmawati Irma Yulianti Jajang Japar Sodik Lia Marliani Lindasari, Heni Lindasari, Heni Mamay M Sobandi Maulana, Mamay Maya Rosdiana Muzaki, Yoga Adi Restu Nova Freena Dewi Purwaniati, Purwaniati Putra, Hendra Mahakam Putra, Hendra Mahakam Putriyanti, Al-fira Rukmana, Aan Rukmana Sabarudin, Cecep Saputro, M. Ramadhan Sintia Veronika Purba Siti Nurjanah Siti Pandanwangi TW Sodik, Jajang Japar Solihah, Nurlaella Suhardiman, Aris Sukmawati, ika kurnia Sulaeman, Agus Sumarna, Rendi Supriyatni Kartadarma WAWAN KURNIAWAN Wempi Budiana Yani Mulyani Yani Mulyani Yanyan Mulyani Yuniarto, Ari Zahra, Nadhira Aulia Zakaria, Hasballah Zulfy Choirunnisa Zuniarto, Ahmad Azrul