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Journal : VALENSI

Lignans from Phyllanthus niruri L. and Their Antifusarium Properties Neneng Windayani; Yaya Rukayadi; Yana Maolana Syah; Tri Cahyanto
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 8, No. 2, November 2022
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v8i2.25057

Abstract

In this study, two lignan compounds were isolated from acetone extract of Phyllanthus niruri L. nirtetralin B (1) and phyllanthin (2) using several chromatographic methods followed by molecular structure elucidation mainly based on 1D and 2D of 1H and 13C NMR spectrum. The isolated compounds were tested for their antimicrobial properties against the plant pathogenic fungus, Fusarium oxysporum, using the agar plate well diffusion method. The microdilution method determined the minimum inhibitory concentration (MIC) and the minimum fungicide concentration (MFC). In addition, the microconidia germination inhibition test was carried out using the agar diffusion method. As a result, compound 1 had MIC and MFC values of 4 and 16 μg/mL, respectively. While compound 2 showed the same MIC and MFC values of 16 μg/mL. Further testing on the inhibition of germination of F. oxysporum microconidia showed that compound 2 inhibited microconidia germination 100% at a concentration of 2 × MIC. In comparison, compound 1 at the same concentration was only able to inhibit germination by 29%. This study revealed that compound 2 is a potential new fungicide derived from local medicinal plants. However, further research is needed to identify the interaction mechanism between the test compound and the fungal pathogen F. oxysporum to develop new antifungal agents.
Co-Authors Ade Yeti Nuryantini Akila, Febiyuniesa Noorwahnov Andri, Asep Anwar, Dede Miftahul Asep Supriadin, Asep Ateng Supriatna Ateng Supriyatna Azizah, Ainun Chimayah, Mihlatal Cont, Sara Cucu Zenab Subarkah Darojah, Teja Zakiah Delima, Dila Diah Mulhayatiah Effendi, Meila N Endah Kurnia Yuningsih Fajarwati, Lusy Farida , Ida Fatmala, Trie Rizqi Fauzi, Ifan Sa'ban Ferli S. Irwansyah Firdaus, Muhammad Taufiq Hendriawan, Priyatna Herni Yuniarti Suhendi Hidayat, Robby Nur Ida Farida Iis Siti Jahro Ika Hasanah Imelda Helsy Johnson, Michael Jualiah, Siti Juwitaningsih, Tita Listiawati, Milla Md Sikin, Adi Miladanta, Algi Nurahman Mohd Rozali, Nur Anisya Faten Muhamad Nurdiansyah, Adi Mulhayatiah, Diah Navilah, Nahla Nishida, Daiki Nunung Kurniasih, Nunung Nur Hidayat, Robby Nurdin , Dian K. Nurdin, Muhamad Ali Nurlatipah, Dede Dalpa Nurunnajib, Ahfazh Fauzy Perdana, Erlangga Yoga Rahayu, Bintang Puja Rahmani, Yulpa Ratnasari Ratnasari Riri Aisyah, Riri Risa Rahmawati, Risa Romli, Siti Rashima Sa’diah, Fitri Yati Sitoresmi, Wibi Apsari Solihah, Sri Fitri Sri Adelia Sari Suhendi, Herni Yuniarti Sulaeman, Dedi Sumiati, Iis Sun Wei Sunarya, Risa Rahmawati Sundari, Citra Deliana Dewi Susan Susanti Tiana Azmi Alawiyah Tri Cahyanto Tri Cahyanto Tuti Kurniati Tuti Kurniati Ummah, Nur Fadlilah Khoerul Umusalamah, N. Dede Umusalamah, N.Dede Wan Kamarudin, Wan Saidatul Syida Wati Susilawati, Wati Wenny Bekti Sunarharum Widiastuti, Egita Wiwaha, Syahid Mujahid Wulandari, Ismi Ayu Yana Maolana Syah Yati Nurhayati Yaya Rukayadi Yulia Sukmawardani, Yulia Yuny Ernawati Zahra, Zulfa Ayu Zakwandi, Rizki Zulfikor, Ahmad