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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional Jurnal Farmasi Sains dan Komunitas Jurnal Pengabdian UntukMu NegeRI Jurnal Penelitian Pendidikan IPA (JPPIPA) ALCHEMY Jurnal Penelitian Kimia Jurnal Pengabdian Pada Masyarakat Majalah Farmaseutik JCES (Journal of Character Education Society) JPSCR : Journal of Pharmaceutical Science and Clinical Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia JKPK (Jurnal Kimia dan Pendidikan Kimia) Bubungan Tinggi: Jurnal Pengabdian Masyarakat Madaniya Jurnal Farmasi Klinik dan Sains Jurnal Pengabdian Pada Masyarakat Jurnal Pengabdian Kepada Masyarakat Itekes Bali Journal of Food and Pharmaceutical Sciences Journal of Applied Agriculture, Health and Technology
ERMAWATI, DIAN EKA
Sekolah Vokasi, Universitas Sebelas Maret, Surakarta
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Journal : Majalah Farmaseutik

 1 
Formulation of Anti-Acne Gel of Moringa oleifera, L. Ethanolic Extract and Antibacterial Test on Staphylococcus epidermidis Dian Eka Ermawati; Cahyarani Intan Ramadhani
Majalah Farmaseutik Vol 16, No 2 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3929.634 KB) | DOI: 10.22146/farmaseutik.v16i2.50319

Abstract

Moringa oleifera L. leaves contain flavonoid, alkaloid, and phenolic compounds which have antibacterial activity. Staphylococcus epidermidis is one of the bacteria that causes acne. The purpose of this study is to compare bacteriostatic ability of the extracts and gel for S. epidermidis bacteria and to get gel formula that can fulfills the physical properties of a good gel. Moringa leaves were extracted with maceration method using ethanol 70% in three days. HPMC 4000 was used as the polymer. Extract was added with variation concentrations of 5, 10, and 15%. Physical evaluation of gel was organoleptic, homogeneity, pH, viscosity, adhesion, and spread tests for 4 weeks. In vitro bacteriostatic activity test with 1% clindamycin gel as positive control and polymer gel as negative control. The result showed that variations concentrations of ethanolic extract of Moringa leaves affected the physical properties of gel including viscosity, pH, adhesion and spreadability. Bacteriostatic activity test of ethanolic extract of Moringa leaf was classified as strong activity, while 15% Moringa leaf ethanol extract gel was classified as moderate activity with average diameter was 9.14 mm
The Effect of Combination of Hydroxypropylmethylcellulose and Carboxymethylcellulose Sodium Polymers to The Physical Properties of Celery (Apium graveolens L.) Ethanolic Extract Patch Dian Eka Ermawati; Galuh Kartikasari
Majalah Farmaseutik Vol 16, No 2 (2020)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (3338.559 KB) | DOI: 10.22146/farmaseutik.v16i2.50358

Abstract

Celery herbs (Apium graveolens L.) contain apigenin compounds (flavonoids) that are effective as antihypertensiv. Celery herbs used in the form of decoction and oral preparations have a deficiency that is voluminous and can cause gastric irritation. Patches were chosen because it can prevent gastric irritation and reduce the frequency of drug administration because the drug is delivered over the skin with a long duration. This study aimed to know the effect of variations in the ratio of the concentrations of hydroxypropyl methylcellulose (HPMC) and carboxymethylcellulose sodium (CMC sodium) polymers to the physical properties of celery herbs ethanol extract patch.This study was conducted with maceration of celery herbs using 96% ethanol and then dispersed in patch made with variations in the concentrations ratio of HPMC and CMC sodium polymers of 3:1, 1:1, and 1:3. Patches were tested for physical properties including organoleptic, pH, thickness, weight, folding endurance, and moisture content. Statistical analysis of test data used One Way ANOVA and Paired Samples T Test.The results of statistical analysis showed that the increase concentrations ratio of CMC sodium polymer in the combination of HPMC and CMC sodium polymers could increase the thickness, weight, and moisture content of celery herbs ethanol extract patch. The best patch was formula 2 with the same concentration ratio of HPMC and CMC sodium polymers because it showed the best results with a pH 6,12-6,29, thickness 1,37-1,53 mm, weighting 2,24-2,52 gram, folding endurance more than 300 times, and the moisture content was quite stable.  
Pengaruh Kecepatan Pencampuran Terhadap Sifat Fisik Lotion Nano-Ekstrak Etanol Kulit Buah Pisang (Musa balbisiana Colla) dan Daun Teh Hijau (Camellia sinensis L. Kuntze) Dian Eka Ermawati; Alfia Andhika Putri
Majalah Farmaseutik Vol 18, No 2 (2022)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v18i2.59209

Abstract

Kulit pisang kepok (M. balbisiana Colla) dan daun teh hijau (C. sinensis L. Kuntze) memiliki aktivitas antioksidan. Teh hijau mengandung katekin 20-30% meliputi epikatekin, epikatekin-3-galat, epigalokatekin, dan epigalokatekin-3-galat dengan nilai IC50 21,44 µg/mL. Kulit pisang kepok mengandung galokatekin, epikatekin, dan katekin. Aktivitas antioksidan pisang kepok yaitu 94,25% dengan nilai IC50 64,03±2,78 ppm yang tergolong sangat aktif. Pemakaian ekstrak sebagai zat aktif kosmetik memiliki pharmaceutical elegance rendah, sehingga ekstrak diformulasikan dalam SNEDDS (Self Nano-Emulsifying Drugs Delivery System). Maserasi kulit pisang kepok dan daun teh hijau menggunakan pelarut etanol 96%. Komponen formula SNEDDS (minyak kemiri : tween 80 : PEG 400) perbandingan 1:6:1; 1:7:1 dan 1:8:1. Orientasi ekstrak yang ditampung dalam sistem antara 100-500 mg. SNEDDS dengan loading ekstrak maksimal didispersikan dalam basis lotion kemudian dilakukan pecampuran dengan variasi kecepatan pencampuran (mortir, homogenizer kecepatan 500 dan 1000 rpm). Pengamatan sifat fisik dan kimia lotion meliputi viskositas, pH, daya sebar dan daya lekat. Analisa statistik menggunakan One Way Anova. Pengujian lotion dilakukan selama 12 hari dan data dianalisa menggunakan Paired T-Test. Hasil analisa statistik menunjukkan bahwa variasi kecepatan pencampuran berpengaruh signifikan terhadap daya sebar dan daya lekat, namun tidak berpengaruh terhadap viskositas dan pH lotion. Homogenizer dengan kecepatan 1000 rpm merupakan metode terbaik untuk lotion nano ekstrak etanol kombinasi kulit pisang kepok dan daun teh hijau karena memenuhi persyaratan sifat fisik dan kimia yang baik selama penyimpanan.
The Effect of Carrageenan Concentration on the Physical and Chemical Properties of Gummy Turmeric Acid Jamu Nurul Rochmawati; Dian Eka Ermawati
Majalah Farmaseutik Vol 17, No 2 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v17i2.63615

Abstract

Turmric acid Jamu is an Indonesian herbal drink that made from turmeric and tamarind. The herbal medicine industry in Sleman Yogyakarta produces Turmric acid Jamu, but the concentration of curcuminoid has not been determined. Consumers of Turmric acid Jamu are limited to women and adults. Children rarely want to consume jamu, even though the curcuminoid in turmeric can increase appetite, especially for todler. Innovation is needed to process Turmric acid Jamu into products that more desirable and efficacious. Gummy is made with the addition of a gelling agent so that the texture is chewy. Carrageenan is a gelling agent made from seaweed and is safe for food products. The purpose of this study was to determine the effect of variations in carrageenan concentrations on physical and chemical properties, also to determine the optimum concentration of carrageenan in gummy Turmric acid Jamu according to the Indonesian National Standard on soft candy. This research is an experimental laboratory with variations in the concentration of carrageenan (7.5%; 8.0%; 8.5%) and Turmric acid Jamu as the main ingredient. The test include organoleptic, pH, weight uniformity, water content, disintegration time and the respondent acceptance test. The concentration of curcuminoid using spectrophotometry UV-VIS method and statistical analysis. The results showed that carrageenan concentration affected organoleptic, weight uniformity, moisture content, and disintegration time, but did not affect pH. The curcuminoid concentration of Turmric acid Jamu was 1.47% and the gummy was 0.03% (w/w). The carrageenan concentration of 8.0% is the optimum formula because it meets the quality requirements of the gummy and is the most preferred by the respondents.
The Effect of Combination of Polyvinyl alcohol and Alfa-cellulose on Physical and Chemical Properties Salam Leaves Ethanolic Extract Patch (Syzygium polyanthum (wight) walp.) Dian Eka Ermawati; Novi Andriani
Majalah Farmaseutik Vol 18, No 4 (2022): in press
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v18i4.73257

Abstract

Salam leaves contain the flavonoid as an anti-inflammatory at a dose of 2.1% w/w. Topical anti-inflammatory was chosen because it is easier to apply. A patch can release the active substance continuously for a long time, compared to gels and creams. Polymers are the main component of patch to control the speed of drug release. Polyvinyl alcohol and alpha-cellulose are polymers that can increase the rate of drug diffusion and form a strong film layer. This study aims to determine the effect of the combination of PVA and Alpha-cellulose on the physicochemical properties of the salam leaves ethanolic extract patch. This research was carried out by maceration of salam leaves using ethanol 96% then dispersed in a patch that was made with variations ratio of PVA and alpha-cellulose, namely 1:1; 3:1; 1:3. The patches were tested for physicochemical properties including organoleptic, pH, thickness, weight, folding endurance, and humidity. Statistical analysis of the test data used One Way ANOVA and Paired Samples T-Test with a confidence level of 95%. The results showed that the combination of PVA and alpha-cellulose polymer in the patch preparation had a significant effect on the weight, thickness, and moisture test, but did not affect an organoleptic, folding endurance, and pH test. Based on the parameters of the physicochemical properties test, the chosen formula was a patch with a ratio of PVA and alpha-cellulose 7:3 because it met the requirements for the patch preparation including the weight of 1.96-2.06 grams, thickness 1.15-1.18 mm, folding endurance >300 times, humidity 25.75 – 30.17% and pH 6.3 – 7.1. The selected formula contains flavonoids based on qualitative analysis using the TLC method.
Transport Test of Total Flavonoid Model of Strawberry Emulgel (Fragaria vesca L.) Through Shed Snakeskin Membrane Dian Eka Ermawati; Suwaldi Martodiharjo; T.N Saifullah Sulaiman
Majalah Farmaseutik Vol 19, No 2 (2023)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/farmaseutik.v19i2.78129

Abstract

Strawberries contain antioxidants, including quercetin-3-β-D-glucoside, coenzyme Q10, anthocyanins pelargonidin-3-O-glucoside, and cyanidin-3-glucoside. The amount of anthocyanins and flavonoids in fruit tends to decrease by 40-50% after the formulation process, so it is necessary to develop a formula to be applied as a topical preparation. The combination of emulsifiers can stabilize the active substance and increase the permeation of the preparation. This study aims to determine the total flavonoid permeation profile of strawberry fruit emulgel preparations with a combination of emulsifiers. This study used a total flavonoid model from strawberry emulgel. Emulgel was prepared with a combination of emulsifier span 80: croduret 50: propylene glycol at a ratio of 2: 4: 2. The permeation test was carried out using a modified vertical Franz diffusion cell equipped with Shed Snakeskin membrane. The permeation test results showed that the cumulative amount of total flavonoids transported across the shed snakeskin membrane was 117.14 g/cm2 out of a total of 2.24 mg of strawberries in the emulgel formula for 5 hours. The permeability of the snakeskin shed membrane was 2.84x10-5 g/cm2, and the flux value was 6.6x10-5 g/sec. The release kinetics follow the Higuchi kinetic model with the diffusion mechanism.
Co-Authors Adi, Lutfan Prastyo Aditya, Shafira Nur Agung P. Surya Agung Putu S.P.Kristyawan Aini S., Aini Alfia Andhika Putri Amaris Susanto, Nindita Clourisa Andini, Bimar Putri Anggraini Febriyanty Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti, Anif Nur Anjani, Niki Putri Aprilia Saefanan Shofa Cahyarani Intan Ramadhani Cahyarani Intan Ramadhani Damayanti, Avina Kusuma Darojati, Ulfa Afrinurfadhilah Daswati Daswati Dewi, Aptika Oktaviana Trisna Dita Yuli Budiasih Diyah Tri Utami Dyah Ayu Ambarwati Ediati Sasmito Esha ND., Pramitha Farida, Yeni Fea Prihapsara Fea Prihapsara Fea Prihapsara Fea Prihapsara, Fea Fridha Angelina Pamuji Galuh Kartikasari H., Muchammad Hanifah, Fitria Lidini Hanuriansyah, Yavi Hayunda I'zaaz Fajrin Heni Utami Prilantari Heru Sasongko Heru Sasongko Heru Sasongko Heru Sasongko Hidayati, Astri Husna, Hanna Miftahul Indah Purwantini Indrajati, Dyah Yekti KD, Anggi Kundarto, Wisnu Kuntari, Tabita Putri M Fiqri Zulpadly M. Fiqri Zulpadly M. Fiqri Zulphadly M. Nur Dewi Kartikasari M. Nur Dewi Kartikasari Megasari, Anis Laela Meitasari, Annisa Diyah Meitasari, Annisa Diyan Muchammad H., Muchammad mufrod mufrod Nafisa, Fadhila Dian Nailul Maghfiroh ND., Pramitha Esha Niken Rosyana Dewi Septini Nindita Clourisa Amaris Susanto Nining Sugihartini Noveri, Priscilla Novi Andriani Novi Andriani, Novi Nugraha Mas'ud Nuraini, Putri Indah Nurul Rochmawati Prastia, Echa Hana Putri, Hapsari Duanda Putriana, Susanti Putro, David Sarono Putu UA., Ni Qutratu'ain, Syahla Rahmat S, Anang Kuncoro Raka Sukmabayu W.S Ramadhani, Cahyarani Intan Rochmani, Sholichah Rohmani, Sholicha S., Aini Saifullah Sulaiman Salsabila, Fitri Samrotul Jannah Setyowati, Tri Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani, Sholichah siti nurkhasanah Susanto, Nindita Clourisa Amaris Sutarno Sutarno Suwaldi Martodiharjo T.N Saifullah Sulaiman Tambunan, Rido Rohana UA., Ni Putu Ul Millah, Nida untari, meta kartika Utami, Diyah Tri Villian Septiana Waliyyin Razan Qanit Wisnu Kundarto Wisnu Kundarto Wisnu Kundarto Wisnu Kundarto Wulandari, Wening Yeni Farida Zulpadly, M. Fiqri Zulpadly, M.Fiqri Zulpadly, Muhammad Fiqri Zulphadly, M.Fiqri