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All Journal Journal of Food and Pharmaceutical Science Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional Jurnal Farmasi Sains dan Komunitas Jurnal Pengabdian UntukMu NegeRI Jurnal Penelitian Pendidikan IPA (JPPIPA) ALCHEMY Jurnal Penelitian Kimia Jurnal Pengabdian Pada Masyarakat Majalah Farmaseutik JCES (Journal of Character Education Society) JPSCR : Journal of Pharmaceutical Science and Clinical Research PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia JKPK (Jurnal Kimia dan Pendidikan Kimia) Bubungan Tinggi: Jurnal Pengabdian Masyarakat Madaniya Jurnal Farmasi Klinik dan Sains Jurnal Pengabdian Pada Masyarakat Jurnal Pengabdian Kepada Masyarakat Itekes Bali Journal of Food and Pharmaceutical Sciences Journal of Applied Agriculture, Health and Technology
ERMAWATI, DIAN EKA
Sekolah Vokasi, Universitas Sebelas Maret, Surakarta
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Journal : Pharmaciana: Jurnal Kefarmasian

 1 
Formulation optimization and antioxidant test for Self-nano emulsifying drug delivery system of soursop leaves (Annona muricata L.) chloroform extract using candlenut oil as oil phase Anif Nur Artanti; Anggraini Febriyanty; Fea Prihapsara; Dian Eka Ermawati
Pharmaciana Vol 11, No 1 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (226.035 KB) | DOI: 10.12928/pharmaciana.v11i1.17805

Abstract

Soursop leaves (Annona muricata L.) chloroform extract has an anticancer agent that can be developed for traditional medicine preparation, even though the extract's solubility is low in the water. This study aims to generate new soursop leaves chloroform extract in the Self-Nano Emulsifying Drug Delivery System (SNEDDS). The expected result is that the solubility increases so that the drug delivery system is more effective. The extraction process of soursop leaves uses the percolation method with chloroform as a solvent. It used tween 80 and cremophore E.L. as surfactant, propylene glycol as a cosurfactant, and candlenut oil as a carrier, to make the SNEDDS formulation. Then performed a comparison between the optimal parameters for the physical properties of the SNEDDS formulation with the predictive Simplex Lattice Design (SLD) formulation with the students' t-test statistical analysis [p> 0.05]. Then carried out several tests such as loading dosage extractability, accelerated stability test, particle size, and zeta potential. Furthermore, the antioxidant test was carried out using the DPPH reagent. The optimum composition of candlenut oil, propylene glycol, a mixture of tween 80, and cremophor E.L. based on SLD is 12%: 22%: 66%, respectively. The SNEDDS optimum formulation for chloroform extract of soursop leaves produces a stable nanoemulsion, homogenous. It has a transmittance value of 90.58% ± 0.151, emulsification time of 59.44 ± 1.763 seconds, and a value of separation phase 1. The physical formulation test results showed no significant difference between observations with predictive design expert software. SNEDDS can produce 25.0 mg of soursop chloroform extract with particle size 411.4 nm, polydispersion index 0.482, and zeta potential 34.2 mV. IC50 value in 36.28 ppm indicated the antioxidant potential of the SNEDDS formulation for chloroform extract of soursop leaves is high.
The effect of propylene glycol and polyethylene glycol 400 on physicochemical properties of peel off mask of nanosilver using bioreductor Sweet Orange Peels (Citrus sinensis L. Osbeck) Dian Eka Ermawati; Fridha Angelina Pamuji; Adi Yugatama
Pharmaciana Vol 11, No 1 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (454.473 KB) | DOI: 10.12928/pharmaciana.v11i1.19663

Abstract

Nanosilver (AgNPs) can be synthesized using plant extracts that safe, simple, and environmentally friendly. Sweet orange contains flavonoids and citric acid, which can be a bioreductor and capping agent in silver biosynthesis to increase antimicrobial activity. AgNPs are then dispersed in a gel for acne treatment through a peel-off mask preparation. Humectants provide moisture, prevent skin irritation and regulate the viscosity of the preparation. Propylene Glycol (PG) and Polyethylene Glycol 400 (PEG 400) are humectants combined to obtain good physicochemical properties of the preparation. This study aims to determine the character of AgNPs and the effect of humectant combinations on the physicochemical properties of peel-off mask preparations. AgNPs characterization was performed using UV-VIS Spectrophotometry, Particle Size Analysis, and Scanning Electron Microscope. The PG-PEG 400 combinations are F1 (0: 100%); F2 (25%: 75%); F3 (50%: 50%); F4 (75%: 25%) and F5 (100%: 0). The physical-chemical test for 28 days included organoleptic, viscosity, dry time, and pH. The biosynthesis results produced AgNPs with maximum absorption of nanoparticles at 435 nm, rod morphological shapes measuring 106 ± 10.6 nm, and PI 0.26 ± 0.06. Statistical analysis showed that the PG-PEG 400 combination significantly affected the viscosity, dispersibility, and dry time of the preparation but affected nothing to pH. The combination of PG-PEG 400 decreased the viscosity and increased the dispersibility of peel-off mask preparation. The higher concentration of propylene glycol caused the dry time of preparation to become longer. Formulas with PG-PEG 400 combination of 25%: 75% and 75%: 25% meet the requirements of viscosity, dispersibility, dry time, and pH and not significant changes during 28 days of storage at room temperature.
Cox-2 inhibition activities of creams containing anguilla bicolor and sea cucumbers extract on croton oil induced inflammation in mice Heru Sasongko; Waliyyin Razan Qanit; Raka Sukmabayu W.S; Agung Putu S.P.Kristyawan; Nining Sugihartini; Wisnu Kundarto; Dian Eka Ermawati
Pharmaciana Vol 10, No 3 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (284.015 KB) | DOI: 10.12928/pharmaciana.v10i3.14823

Abstract

The fatty acids, like EPA and DHA, were known as anti-inflammation. It works on inflammatory tissue, brought by edema plasma, and changed into resolvins, protectins, and maresins by the enzyme reaction. Anguilla bicolor and Sea cucumber fish are known to contain EPA and DHA. This study analyzes the inhibition Cox-2 effect of the combination of Anguilla bicolor oil with Sea cucumber extract as an active ingredient in a cream preparation. This experiment used 7 groups of male BALB/C strain mice: normal control; negative control; positive control; A. bicolor oil cream; H. leucospilota extract cream; a combination of A. bicolor : H. leucospilota (2:1) cream; a combination of A. bicolor : H. leucospilota (1:2) cream. The anti-inflammatory activity was evaluated by the amount of inflammatory cell, the thickness epidermis, and the amount of cell expression COX-2  on mice's back skin tissue induced by croton oil (0,1 %). After 3 days, histopathological skin tissues were made. The data were analyzed statistically by One Way ANOVA followed by LSD to know each group's differences at a significance level of 0.05. The experiment results showed that the formula with the best anti-inflammatory activities is the combination of A. bicolor and H. leucospilota (2:1) cream.  The decrease of the amount of inflammatory cell (75.97%), the thickness of the epidermis (43.88%), and the amount of COX-2 cell expressions (60.52%) from the formula did not differ significantly with the positive control (p>0,05). It can be concluded that A. bicolor and H. leucospilota have anti-inflammation activity based on the experiment results.
The effect of zinc oxide and Curcuma heyneana Val. combination on stability and sun protection factor (SPF) of lotion Dian Eka Ermawati; Dita Yuli Budiasih
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (485.054 KB) | DOI: 10.12928/pharmaciana.v12i3.23380

Abstract

Indonesian people risk-averse effects of Ultraviolet (UV) exposure, so they need skin protection agents. Zinc Oxide (ZnO) is an effective UV reflection, but at a concentration of more than 10%, it can cause skin irritation. Combining ZnO with other UV protective agents is necessary, so its concentration can be reduced but still effective. The flavonoid in C. heyneana has potential as a sunscreen because chromophore groups can absorb UV B and UV A light. This study aims to examine the effect of the combination of ZnO and C. heyneana on the stability and SPF value of lotion. The lotion is made in five variations of the composition of ZnO and C. heyneana, F1 of 100: 0%; F2 of 0:100%; F3 of 50:50%; F4 of 25:75%; and F5 of 75:25% respectively. Test parameters include organoleptic, pH, spreadability, viscosity, and SPF. The test is recorded before and after the cycling test. Statistical analysis using Paired Sample T-Test. The combination of ZnO and C. heyneana affected organoleptic, viscosity, spreadability, and SPF value but did not affect pH. The higher concentration of ZnO will increase the viscosity, pH, and SPF but decrease the spreadability. The formula with a combination of ZnO and C. heyneana of 50%:50% is selected because it has an SPF value of 13.24 and; a viscosity of 48.67 d.Pas; pH of 7.1; and spreadability of 3.81 cm. 
The effect of temperature solubility on particle size and antibacterial activity of nanosilver of gembili’s inulin Dian Eka Ermawati; Hayunda I'zaaz Fajrin; Sholichah Rohmani; M. Nur Dewi Kartikasari
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (800.08 KB) | DOI: 10.12928/pharmaciana.v13i1.23185

Abstract

Gembili Tuber (Dioscorea esculenta L.) is an Indonesia local tuber that reported to have potential as a source of inulin. Inulin is one of fiber types and carbohydrates sources derived from plants and has prebiotic and antibacterial activity. However, inulin long chain has low solubility in water, so it is necessary to modify the solubility in the biosynthetic process. In this study, the biosynthetic process was carried out using inulin as bioreducer of silver ions to help increase the absorption of gembili inulin. Gembili inulin was mixed with silver nitrat solution at variation temperature at 25 ℃ and 60 ℃ of biosynthetic process, in order to produce the expected particle size and antibacterial activity against bacteria Staphylococcus aureus and Eshcerichia coli. The results of this study indicate that variations in solubility temperature of inulin in nanosilver biosynthetic produce particle size of 12-49 nm with round shape. Whereas the temperature of inulin solubility did not show any significant difference towards AgNO3 control in the antibacterial activity test against S.aureus and E.coli bacteria. FTIR spectra showed that interaction between functional groups of silver nitrate and gembili inulin. Inulin only acts as a capping agent of nanosilver biosynthetic and does not induce antibacterial activity of nanosilver.
The effect of syrup simplex concentration on the physicochemical stability of Gembili’s inulin (Dioscorea esculenta (Lour.) Burkill) nanosilver colloid Ermawati, Dian Eka; Hanuriansyah, Yavi
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.26569

Abstract

Gembili tuber's inulin is a successful bioreductor agent that forms a nanosilver with a size of 481.4 nm and is stable for 30 days at 4 °C storage. That nanosilver has immunomodulatory activity and is proven safe from the results of acute toxicity tests at a dose of 4 mg/kgBB. However, a drug delivery system is needed to be developed as a supplement product. The syrup was chosen because it is free of alcohol, has a better taste, measured dose, and stability of the active substance compared to elixir, solution, and suspension. Simplex syrup as a syrup base affects stability because it has the potential to form crystals during storage. This research aims to determine the effect of simplex syrup concentration on the stability of nanosilver syrup. The research was conducted with the biosynthesis process using gembili's inulin, nanosilver characteristic, modified syrup formula, and stability test. Nanosilver syrup was prepared by modifying the simplex syrup concentration of 20%, 40%, and 60%. Nanosilver was added at 4 mg/KB b.w, then tested the physicochemical; stability, including organoleptic, pH, and viscosity, before and after storage with temperature variations of 4 °C and 40 °C for six cycles. The best formula then analysis of sugar reduction content and FT-IR. Data analysis using SPSS 21.0 Windows with One-way ANOVA test, Post Hoc, and Paired T-Test. The results showed that the concentration of simplex syrup affected consistency, pH, and viscosity. The simplex syrup concentration of 60% met the requirement with a medium thick consistency, pH 5.25±0.03, a viscosity of 92±2.6 cps, reducing sugar content was 20.59% ±0.002, and the FTIR profile showed that it still contained nanosilver which was indicated by the presence of Ag-N groups compared to silver nitrate solution.
The effect of syrup simplex concentration on the physicochemical stability of Gembili’s inulin (Dioscorea esculenta (Lour.) Burkill) nanosilver colloid Ermawati, Dian Eka; Hanuriansyah, Yavi
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.26569

Abstract

Gembili tuber's inulin is a successful bioreductor agent that forms a nanosilver with a size of 481.4 nm and is stable for 30 days at 4 °C storage. That nanosilver has immunomodulatory activity and is proven safe from the results of acute toxicity tests at a dose of 4 mg/kgBB. However, a drug delivery system is needed to be developed as a supplement product. The syrup was chosen because it is free of alcohol, has a better taste, measured dose, and stability of the active substance compared to elixir, solution, and suspension. Simplex syrup as a syrup base affects stability because it has the potential to form crystals during storage. This research aims to determine the effect of simplex syrup concentration on the stability of nanosilver syrup. The research was conducted with the biosynthesis process using gembili's inulin, nanosilver characteristic, modified syrup formula, and stability test. Nanosilver syrup was prepared by modifying the simplex syrup concentration of 20%, 40%, and 60%. Nanosilver was added at 4 mg/KB b.w, then tested the physicochemical; stability, including organoleptic, pH, and viscosity, before and after storage with temperature variations of 4 °C and 40 °C for six cycles. The best formula then analysis of sugar reduction content and FT-IR. Data analysis using SPSS 21.0 Windows with One-way ANOVA test, Post Hoc, and Paired T-Test. The results showed that the concentration of simplex syrup affected consistency, pH, and viscosity. The simplex syrup concentration of 60% met the requirement with a medium thick consistency, pH 5.25±0.03, a viscosity of 92±2.6 cps, reducing sugar content was 20.59% ±0.002, and the FTIR profile showed that it still contained nanosilver which was indicated by the presence of Ag-N groups compared to silver nitrate solution.
Co-Authors Adi, Lutfan Prastyo Aditya, Shafira Nur Agung P. Surya Agung Putu S.P.Kristyawan Aini S., Aini Alfia Andhika Putri Amaris Susanto, Nindita Clourisa Andini, Bimar Putri Anggraini Febriyanty Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti Anif Nur Artanti, Anif Nur Anjani, Niki Putri Aprilia Saefanan Shofa Cahyarani Intan Ramadhani Cahyarani Intan Ramadhani Damayanti, Avina Kusuma Darojati, Ulfa Afrinurfadhilah Daswati Daswati Dewi, Aptika Oktaviana Trisna Dita Yuli Budiasih Diyah Tri Utami Dyah Ayu Ambarwati Ediati Sasmito Esha ND., Pramitha Farida, Yeni Fea Prihapsara Fea Prihapsara Fea Prihapsara Fea Prihapsara, Fea Fridha Angelina Pamuji Galuh Kartikasari H., Muchammad Hanifah, Fitria Lidini Hanuriansyah, Yavi Hayunda I'zaaz Fajrin Heni Utami Prilantari Heru Sasongko Heru Sasongko Heru Sasongko Heru Sasongko Hidayati, Astri Husna, Hanna Miftahul Indah Purwantini Indrajati, Dyah Yekti KD, Anggi Kundarto, Wisnu Kuntari, Tabita Putri M Fiqri Zulpadly M. Fiqri Zulpadly M. Fiqri Zulphadly M. Nur Dewi Kartikasari M. Nur Dewi Kartikasari Megasari, Anis Laela Meitasari, Annisa Diyah Meitasari, Annisa Diyan Muchammad H., Muchammad mufrod mufrod Nafisa, Fadhila Dian Nailul Maghfiroh ND., Pramitha Esha Niken Rosyana Dewi Septini Nindita Clourisa Amaris Susanto Nining Sugihartini Noveri, Priscilla Novi Andriani Novi Andriani, Novi Nugraha Mas'ud Nuraini, Putri Indah Nurul Rochmawati Prastia, Echa Hana Putri, Hapsari Duanda Putriana, Susanti Putro, David Sarono Putu UA., Ni Qutratu'ain, Syahla Rahmat S, Anang Kuncoro Raka Sukmabayu W.S Ramadhani, Cahyarani Intan Rochmani, Sholichah Rohmani, Sholicha S., Aini Saifullah Sulaiman Salsabila, Fitri Samrotul Jannah Setyowati, Tri Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani Sholichah Rohmani, Sholichah siti nurkhasanah Susanto, Nindita Clourisa Amaris Sutarno Sutarno Suwaldi Martodiharjo T.N Saifullah Sulaiman Tambunan, Rido Rohana UA., Ni Putu Ul Millah, Nida untari, meta kartika Utami, Diyah Tri Villian Septiana Waliyyin Razan Qanit Wisnu Kundarto Wisnu Kundarto Wisnu Kundarto Wisnu Kundarto Wulandari, Wening Yeni Farida Zulpadly, M. Fiqri Zulpadly, M.Fiqri Zulpadly, Muhammad Fiqri Zulphadly, M.Fiqri