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Journal : INDONESIAN JOURNAL OF PHARMACY

SYNTHESES AND ANTIOXIDANT ACTIVITIES OF SOME HYDROXY DIMETHOXY CHALCONE DERIVATIVES VH, Elfi Susanti
INDONESIAN JOURNAL OF PHARMACY Vol 25 No 1, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (467.23 KB) | DOI: 10.14499/indonesianjpharm25iss1pp17

Abstract

Four (4) hydroxy dimethoxy chalcones derivatives were synthesized by Claisen-Schmidt condensation of hydroxyacetophenone with 3,4-dimethoxybenzaldehyde using conventional method and grinding technique. The synthesized compounds were characterized by spectroscopy (IR, 1H-NMR and 13C-NMR). Synthesis of the hydroxy dimethoxy chalcone using grinding method is better than the conventional method. The synthesis using grinding method require a low concentration base, shorter reaction (15min) and higher yield (70-84%).  The antioxidant activity of the compounds was determined by DPPH method, showed that  2,5-dihydroxy-3,4-dimethoxy chalcone have the highest antioxidant activity.Key word: hydroxy dimethoxy chalcone, Claisen-Schmidt condensation, grinding, DPPH method
PHYTOCHEMICAL SCREENING AND ANALYSIS POLYPHENOLIC ANTIOXIDANT ACTIVITY OF METHANOLIC EXTRACT OF WHITE DRAGON FRUIT (Hylocereus undatus) VH, Elfi Susanti; Utomo, Suryadi Budi; Syukri, Yandi; Redjeki, Tri
Indonesian Journal of Pharmacy Vol 23 No 1, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (233.544 KB) | DOI: 10.14499/indonesianjpharm23iss1pp60-64

Abstract

White dragon fruit  is  a well  known  and  widely  used  herbal medicine,  especially  in  Asia,  which  contains  several  interesting bioactive constituents and possesses health promoting properties. The  aim  of  this  study  was  to  analyze  for  the  bioactive compounds,  evaluate  total  phenolic  contents  and  antioxidant capacities  of  methanolic  extract  of  white  dragon  fruit.  The antioxidant  activity  was  determined  by  the  1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity assay. Total phenolic  content  were  determined  by  Folin-Ciocalteu  method. Phytochemical  screening  of  the  white  dragon  fruit  showed the  presence  of  triterpenoid,  alkaloid,  flavonoid  and  saponin. The  extract  exhibited  strong  antioxidant  activity  with  IC50 of 193 μg/mL, and total phenolic content of 246 μg/mL in 1 Kg dry extract.Key words: antioxidant activity, total phenolic, DPPH, white dragon fruit
Co-Authors Adi, Yulia Kristi Agustin Wulandari Anastasia Diaz Pramesti Anastasia Diaz Pramesti Ari Syahidul Shidiq Ashadi, . Asna, Lilis Sofiyatul Aufa Vib Mitsalina Bayu Antrakusuma Catur Saputro, Agung Nugroho Dwi Retno Sari Endang Susilowati Endang Susilowati Fajar Rakhman Wibowo Hartantia, Restika Maulidina Iis Alviah Imam Sri Nugroho Juniar Fauziatul Azizah Lestari, Nova Dwi Lintang Nur Agia Luthfiana, Eva Magdalena, Octaviany Maria Ulfa Martini, Kus Sri Melati Kusuma Wardani Mohammad Masykuri Muhammad Hizbul Wathon Mulatsari, Desi Mulyani, Bakti Mulyani, Sri Mustofa Mustofa Muzzazinah Muzzazinah Nastiti, D. Ninda Dwi Cahya Devi Nurma Yunita Indriyanti Nurma Yunita Indriyanti Nurma Yunita Indriyanti Nurman Perdana, R. Pramesthi, Hilda Nita Rahardjo, S. B. Rahmawati, Ani Ramandika, Muhammad Gunawan Dwi Redjeki, Tri Redjeki, Tri Redjeki, Tri Sabirin Matsjeh Safitri, Nadia Indri Salim, Eko Nur Samodra, Imam Saputro, Agung Nugroho Catur Saputro, Sulistyo Sastika, Agasta Ria Sentot Budi Raharjo Setiawan, Dwi Arief Setiyani Setiyani Sri Mulyani Sri Mulyani Sri Mulyani Sri Mulyani Sri Retno Dwi Ariani Sri Retno Dwi Ariani Sri Retno Dwi Ariani Sri Retno Dwi Ariani Sri Retno Dwi Ariani Sri Retno Dwi Ariani Sri Yamtinah Sugiharto, Sugiharto Sulistyo Saputro Suryadi Budi Utomo Suryadi Budi Utomo Suryadi Budi Utomo Suryani, Adik Annisa Fitri Suryanto, Eko Tonang Dwi Ardyanto Totiana, Fian Tri Prianti Tri Redjeki Tutik Dwi Wahyuningsih Utami, Budi Utomo, Suryadi Budi Widiastuti Agustina Eko Setyowati Wulandari, Lilis Yandi Syukri Zulkarnaen, Rizmoon Nurul