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All Journal Jurnal Kesehatan Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) JOPS (Journal Of Pharmacy and Science) Media Kesehatan Politeknik Kesehatan Makassar Jurnal Mandala Pharmacon Indonesia Jurnal Promotif Preventif Jurnal Kesehatan Tambusai Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Buana Farma Journal of Experimental and Clinical Pharmacy (JECP) Jurnal EduHealth Sasambo Journal of Pharmacy Journal of Language and Health Jurnal Farmasi Sains dan Praktis Journal of Health Sciences and Medical Development Natural: Jurnal Pelaksanaan Pengabdian Bergerak Bersama Masyarakat Kunir: Jurnal Farmasi Indonesia (KJFI) Journal of Pharmascience
Farid, Nurfiddin
Univeritas Megarezky Makassar
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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AKTIVITAS SEDIAAN SHAMPO ANTIKETOMBE DAUN PEPAYA (CARICA PAPAYA L.) TERHADAP JAMUR CANDIDA ALBICANS Muhammad Akmal A Sukara; Nurfiddin Farid; Muh. Yusuf Wahyuni Hasniar
Jurnal Kesehatan Tambusai Vol. 4 No. 4 (2023): DESEMBER 2023
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v4i4.15649

Abstract

Ketombe merupakan masalah yang sering dialami di kulit kepala yang disebabkan oleh kelenjar minyak yang berlebih danmikroorganisme seperti jamur Candida albicans merupakan salah satu jamur yang menimbulkan masalah ketombe pada rambut.Tumbuhan Alam seperti Daun papaya salah satunya merupakan tanaman yang mengandung flavonoid yang bersifat sebagai antijamur. Penelitian ini bertujuan untuk mengetahui apakah ekstrak daun pepaya (Carica papaya L.) dapat diformulasikan dalam sediaan shampo antiketombe dan apakah formulasi sediaan shampo ekstrak daun pepaya (Carica papaya L.) memiliki aktivitas antiketombe terhadap pertumbuhan Candida albicans, serta mengetahui berapakah konsentrasi optimum formulasi sediaan shampo ekstrak daun pepaya (Carica papaya L.) terhadap pertumbuhan Candida albicans. Metode penelitian ini merupakan penelitian eksperimental laboratorium dengan pengujian aktivitas antijamur menggunakan metode sumuran dengan cara melihat zona bening disekitar sumuran terhadap konsentrasi 5%, 10%, 15%, kontrol negatif dan kontrol positif. Hasil penelitian sediaan shampo antiketombe ekstrak daun pepaya (Carica papaya L.) yaitu pada konsentrasi 5%, 10%, 15%, memenuhi syarat secara fisika dan kimia serta uji aktivitas antijamur terhadap jamur Candida albicans dengan zona hambat yang terbaik yaitu pada konsentrasi 15% yang dikategorikan dalam kategori sangat kuat. Dapat disimpulkan bahwa daun pepaya dapat di formulasikan sebagai shampo antiketombe yang memiliki aktivitas dalam menghambat jamur Candida albican penyebab ketombe pada konsentrasi optimum sebesar 15%.
Uji Stabilitas Sedian Lotion Antinyamuk dengan Variasi Konsentrasi Ekstrak Bunga Sukun (Artocarpus altilis) Terhadap Nyamuk Aedes Aegypti Setiawan, Prayitno; Farid, Nurfiddin; Yusuf, Muhammad; Latelay, Rio Markasi
Journal of Experimental and Clinical Pharmacy (JECP) Vol 1, No 2 (2021): August, 2021
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v1i2.242

Abstract

Bunga sukun diketahui memiliki kandungan senyawa flavonoid yang dapat dimanfaatkan sebagai antinyamuk. Tujuan penelitian ini untuk mengetahui basis formula sediaan lotion dari ekstrak bunga sukun (Artocarpus altilis)yang stabil secara fisik sebagai antinyamuk dan untuk mengetahui efektivitas variasi konsentrasi ekstrak dari formulasi lotion ekstrak bunga sukun sebagai antinyamuk. Metode penelitian ini merupakan penelitian eksperimental. Lotion antinyamuk ekstrak dibuat dalam 4 kelompok formula yaitu kelompok formula 1 konsentrasi konsentrasi 20%, kelompok formula 2 dengan konsentrasi 30%, kelompok formula 3 konsentrasi 40%, kelompok kontrol negativ tanpa menggunakan ekstrak dan kontrol positif dengan menggunakan lotion merek (Autan). Hasil Evaluasi kestabilan fisik sediaan lotion antinyamuk pada pengujian organoleptik, pH, homogenitas tidak terjadi perubahan kestabilan selama proses sebelum dan sesudah cycling test. Uji efek lotion menggunakan 100 ekor nyamuk (Aedes aegypti) yang dibagi dalam 5 kelompok perlakuan yang terdiri dari 20 ekor nyamuk, pengujian dilakukan tiga kali pengulangan dengan selang waktu 5 menit. Hasil penelitian menunjukan lotion antinyamuk ekstrak kosentrasi 20% dapat memberikan efek daya tolak nyamuk dilihat dari uji SPSS versi 24 menunjukan p>0,05 sehingga tidak ada perbedaan secara bermakna dengan kontrol positif. Hal tersebut dapat disimpulkan ekstrak bunga sukun memilik efek sebagai antinyamuk pada konsentrasi 20% terhadap nyamuk uji.Breadfruit flowers are known to contain flavonoid compounds which can be used as a mosquito repellent. The purpose of this research is to knowing the basics of the lotion preparation formula from breadfruit flower extract (Artocarpus altilis) which is physically stable as a mosquito repellent and for determine the effectiveness of various extract concentrations from lotion formulations Breadfruit flower extract as a mosquito repellent. This research method is an experimental study. Extract mosquito-repellent lotion made in 4 groups of formulas, group formula 1  (20%) , group formula 2 (30%), group formula 3 (40%), negative control group without using extract and positive control by using brand lotion (Autan®). The results of the evaluation of the physical stability of the mosquito repellent lotion on the test organoleptic, pH, and homogeneity did not change the stability during the process before and after the cycling test. Test lotion effect using 100 mosquito (Aedes aegypti) which were divided into 5 treatment groups consisting of 20 mosquitoes, the test was carried out three times repetitions at 5-minute intervals. The results of the study showed Mosquito repellent lotion with 20% concentration extract can provide a powerful effect on mosquito repellent seen from the SPSS version 24 test shows p> 0.05 so there was no significant difference with the positive control. That matter can be concluded that breadfruit flower extract has an effect as an anti-mosquito at a concentration of 20% against test mosquitoes.
Uji Efektivitas Nyeri Ekstrak Etanol Biji Mahoni (Swietenia mahagoni) Terhadap Mencit Jantan (Mus musculus) Yang di Induksi Asam Asetat 1% Farid, Nurfiddin; Wahid, Hilmiati; Aliah, Ahmad Irsyad
Journal of Experimental and Clinical Pharmacy (JECP) Vol 1, No 2 (2021): August, 2021
Publisher : Poltekkes Kemenkes Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52365/jecp.v1i2.214

Abstract

Nyeri adalah perasaan sensorik dan emosional yang tidak nyaman, berkaitan dengan adanya kerusakan jaringan. Biji mahoni (Swietenia mahagoni), mengandung senyawa flavanoid yang mampu memberikan efek analgetik dengan menghambat biosintesis prostaglandin sehingga mengurangi rasa nyeri, penelitian ini bertujuan untuk mengetahui aktivitas analalgetik ekstrak etanol biji mahoni pada mencit jantan (Mus musculus) yang di induksi asam asetat 1%. Penelitian yang dilakukan adalah penelitian eksperimental dengan desain penelitian Posttest Only Control Group Design. Hewan uji dibagi menjadi tiga kelompok, masing-masing perlakuan terdiri dari lima ekor mencit jantan (Mus musculus) dengan pemberian kontrol yang berbeda-beda, Mencit 1 (Na CMC 0,5% kontrol negatif), mencit 2 (Ekstrak etanol biji mahoni dosis 100 mg), mencit 3 (Ekstrak etanol biji mahoni dosis 200 mg), mencit 4 (Ekstrak etanol biji mahoni dosis 400 mg) dan mencit 5 (Ibuprofen 400mg kontrol positif). Hasil penelitian yang diperoleh ekstrak biji mahoni memiliki khasiat sebagai analgetik pada dosis 100 mg 37,79%, dosis 200 mg 57,40% dan ekstrak etanol biji mahoni dosis 400 mg 70,80%. Hasil terbaik diperoleh pada konsentrasi 400 mg yaitu 70,80%, semakin tinggi dosis ekstrak biji mahoni (Swietenia mahagoni) semakin besar pula daya analgetiknya.Pain is an uncomfortable sensory and emotional feeling, associated with tissue damage. Mahogany seeds (Swietenia mahagoni), contains flavonoid compounds that can provide analgesic effect by inhibiting prostaglandin biosynthesis reduce pain, this study aims to determine the activity of analgesia of mahogany seed ethanol extract in male mice (Mus musculus) induced by 1% acetic acid. The research conducted is experimental research with Posttest Only Control research design Group Design. The test animals were divided into three groups, each treatment consisted of five male mice (Mus musculus) with administration of different controls, Mice 1 (Na CMC 0.5% control negative), mice 2 (ethanol extract of 100 mg mahogany seeds), mice 3 (Mahogany seed ethanol extract dose of 200 mg), mice 4 (Ethanol extract of seeds mahogany dose 400 mg) and mice 5 (ibuprofen 400 mg positive control). The results of the study obtained that mahogany seed extract has an efficacy as an analgesic at a dose of 100 mg 37.79%, a dose of 200 mg 57.40% and mahogany seed ethanol extract dose of 400 mg 70.80%. Best results obtained at a concentration of 400 mg which is 70.80%, the higher the dose of seed extract mahogany (Swietenia mahagoni) the greater the analgesic power.
Formulasi dan Uji Efektivitas Sediaan Lip cream dari Ekstrak Etanol Biji Buah Merah (Pandanus conoideus L) sebagai Pewarna Alami dengan Menggunakan Metode DPPH (1,1-Difenil-2-Pikrihidrazil) Primadani, Nur Baetty; Alyidrus, Rugayyah; Farid, Nurfiddin; Auliah, Nielma
JURNAL FARMASI DAN MAKANAN Vol 7 No 1 (2023): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v7i1.4173

Abstract

Formulation and Effectiveness Test of Lip Cream Preparations from Ethanol Extract of Red Fruit Seeds (Pandanus conoideus L) as A Natural Dye Using The DPPH (1,1-Diphenyl-2-Pikrihidrazil) Method. Red fruit seeds are botanical specimens that possess keratenoid chemicals, specifically b-carotene and a-carotene, which exhibit antioxidant properties. The objective of this study is to develop a stable Lipcream formulation and measure the IC50 value of the lipcream prepared from the ethanol extract of red fruit seeds (Pandanus conoideus L), which has antioxidant properties. An experimental research approach utilizing a solvent maceration technique with a solvent concentration of 96%. The obtained concentrated extract was subjected to rotation, followed by the fabrication of solutions with concentrations of 2%, 4%, and 6%, utilizing beeswax as a thickening agent. Kaolin is used as a texturizer. The emollients used are castor oil, cetyl alcohol, and dimethicon. Methyl paraben and propyl paraben are utilized as preservatives. Titanium dioxide serves as a pigment. The scent of vanilla. The preparation was evaluated by a cycling test consisting of 6 cycles over a period of 12 days. Organoleptic observations revealed a semi-solid texture, cream-like form, and a vanilla scent. The homogeneity test yielded consistent results, with pH measurements exceeding 0.05p, spreadability test results surpassing 0.05p, and adhesiveness test results meeting the specified standards. In addition to doing antioxidant testing, the DPPH method is employed using a UV-Vis spectrophotometer. The research findings indicate that the ethanol extract derived from red fruit seeds (Pandanus conoideus L) can be effectively made into a stable lip cream formulation, both in terms of its physical and chemical properties. The IC50 values obtained from the lip cream formulation including the ethanol extract of red fruit seeds (Pandanus conoideus L) were 59,496 ppm, 52,817 ppm, and 5,581 ppm, respectively. Formula 3 contains the most potent antioxidant value among all lip cream preparations.
Penyuluhan dan Pemberian Obat Cacing Sebagai Upaya Pencegahan Kecacingan Bagi Siswa Kelas IV/A di UPT SPF SD Negeri Pannara Tamzil Azizi Musdar; Nurfiddin Farid; Hilmiati Wahid
Natural: Jurnal Pelaksanaan Pengabdian Bergerak bersama Masyarakat. Vol. 2 No. 1 (2024): February : Natural: Jurnal Pelaksanaan Pengabdian Bergerak bersama Masyarakat
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/natural.v2i1.449

Abstract

Intestinal diseases caused by transmission from worms as a source of helminthiasis generally occur in areas with subtropical and tropical climate conditions which have a wet climate and lack of awareness among the public regarding maintaining health and sanitation of the surrounding environment. Around 60 percent of Indonesians experience worm infections. The largest age group is 5-14 years old. The prevalence figure is 60 percent, 21 percent of which attack elementary school age children. This disease can be spread by eggs in human waste found in soil and water, therefore awareness of clean and sanitary living is very influential, the process or pattern of feces disposal is also very influential in the spread of this worm. The high rate of soil contamination by Ascaris, which reaches >70%, can also be caused by feces that are thrown anywhere, such as in bushes or around houses close to where you live. Preventing recurrent infections is very important by practicing clean and healthy living habits such as avoiding contact with soil that may be contaminated with human feces, washing hands with soap and water before handling food, protecting food from soil and washing or heating food that falls on the floor. Several researchers have shown that school age is a group that is often affected by worm infections because they are often in contact with soil. Apart from the government, the role of teachers and parents is very important in providing understanding or knowledge about worms so that they are more disciplined. The aim of community service is to provide knowledge and understanding to class IV/A students at SD N Pannara regarding the dangers of worms and how to prevent them and administer worm medicine.
Formulasi dan Uji Efektivitas Sediaan Aromaterapi Minyak Atsiri Bunga Melati (Jasminum sambac) Sebagai Antidepresan pada Mencit Jantan Putih (Mus Musculus) Alifah, Dwi Yulianti; Siradjuddin, Mutmainnah; Idris, Zulfiah; Farid, Nurfiddin; Setiawan, Prayitno; Suhenro, Suhenro; Azima, Annisa
KUNIR: JURNAL FARMASI INDONESIA Vol 2 No 2 (2024): NOVEMBER
Publisher : Program Studi Farmasi (S-1), Fakultas Ilmu Kesehatan, Universitas Bhamada Slawi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36308/kjfi.v2i2.633

Abstract

Depresi merupakan gangguan mental yang pada kondisi tertentu dapat menjadi kronis hingga berulang dan mampu mengganngu aktivitas seseorang dan paling parahnya dapat menyebabkan bunuh diri. PDSKJI pada tahun 2020 menyebutkan bahwa dari 2.364 responden di 34 provinsi yang ada di Indonesia, terdapat 67% mengalami depresi, 77% mengalami trauma psikologis serta sejumlah 49% responden mengalami depresi berat (berpikir tentang kematian). Bunga Melati merupakan bagian dari melati yang memiliki banyak manfaat selain sebagai antibakteri juga antidepresan karna mengandung banyak metabolit sekunder seperti flavonoid dan benzil asetat. Penelitian ini bertujuan untuk memformulasi aromaterapi dari minyak atsiri bunga melati (Jasminum sambac) dan untuk mengetahui apakah aromaterapi minyak atsiri bunga melati (Jasminum sambac) memiliki efek sebagai antidepresan pada mencit jantan putih (Mus musculus) serta konsentrasi paling efektif sebagai antidepresan pada mencit jantan putih (Mus musculus). metode destilasi digunakan untuk mengambil minyak atsiri bunga melati (Jasminum sambac). Formula aromaterapi yang telah dibuat dievaluasi terhadap sediaan, dan diuji efektivitas antidepresannya dengan metode force swimming test. Hasil penelitian pada pengujian evaluasi sediaan, uji organoleptik, uji homogenitas, uji pH, uji kejernihan dan uji iritasi sesuai dengan parameter sediaan aromaterapi dan memiliki efek sebagai antidepresan serta memiliki konsentrasi paling efektif pada konsentrasi 6%.
Uji Efektivitas Anthelmintik Formula Suspensi Biji Mentimun (Cucumissativus L.) Terhadap Cacing Gelang (Ascaris Lumbricoides) : The effectiveness Test of Cucumber Seeds Suspension Formula (Cucumissativus L.) Towards Roundworms (Ascaris Lumbricoides) as Anthelmintic Farid, Nurfiddin; Syamsu, Andi Suparlan Isya; Aliah, Ahmad Irsyad; Murdi, Anna Muthmainna
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (506.057 KB) | DOI: 10.22487/j24428744.2020.v6.i1.14307

Abstract

The Effectiveness Test of Cucumber Seeds Suspension Formula (Cucumis sativus L) towards Roundworms (Ascaris lumbricoides) as in Vitro Anthelmintic, It has been conducted research to know cucumber seeds powder (Cucumis sativus L) can be made into form of suspension stock and to know stock of cucumber seeds suspension (Cucumis sativus L) can give effect of anthelmintic toward roundwoms Ascaris lumbricoides. The research was conducted by using experimental method. Powder of cucumber seeds (Cucumis sativus L) were made into suspension stock with 3 concentratios such as 5%, 10%, 15% concetrations and suspension without powder of cucumber seeds (Cucumis sativus L) with different addition subtance concentration. Test animal used was roundworm (Ascaris lumbricoides) that was taken by pig’s intestine. Treatment group consisted into five categories such as 125 mg positive control of pamoat pirantel (Combantrin®), negative control of suspension without powder of cucumber seeds (Cucumis sativus L), and category of cucumber seeds suspension (Cucumis sativus.L) as 5%, 10%, and 15%. Each group was soaked with 40 ml test ingredient into petri dish. Then it was observed and writte the number of died worms in every minute. 100% observation of died worm was group of positive control at 405 minutes, negative control at 1710 minutes, 5% concetration of cucumber seeds suspension stock at 540 minutes, 10%concentration at 465 minutes and 15% concentration at 420 minutes. The result of research showed that cucumber seeds (Cucumis sativus L) can be made into suspension stock and effective as anhelmintic toward roundworms Ascaris lumbricoides.
Evaluasi Kesesuaian Penyimpanan High Alert Medication di Instalasi Farmasi Rumah Sakit Kontesa, Emiliana Ansika; Farid, Nurfiddin; Ahmad, Fitriani Fajri
Journal of Language and Health Vol 6 No 2 (2025): Journal of Language and Health
Publisher : CV. Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jlh.v6i2.6718

Abstract

Kesalahan dalam pemberian obat di rumah sakit masih menjadi masalah serius yang berdampak pada keselamatan pasien, terutama ketika menyangkut obat-obatan yang tergolong high alert medication (HAM). Obat-obatan ini memiliki risiko tinggi menyebabkan cedera serius jika terjadi kesalahan dalam penyimpanan atau penggunaan. Penelitian ini bertujuan untuk mengevaluasi kesesuaian penyimpanan HAM di Instalasi Farmasi Rumah Sakit Khusus Daerah (RSKD) Dadi Provinsi Sulawesi Selatan berdasarkan standar dari Permenkes No. 72 Tahun 2016 dan Peraturan BPOM No. 4 Tahun 2018. Metode penelitian yang digunakan adalah deskriptif kualitatif dengan pendekatan observasional dan dokumentasi. Observasi dilakukan pada tiga unit instalasi farmasi, yaitu Apotek, Gudang, dan Depo OK. Hasil penelitian menunjukkan tingkat kesesuaian penyimpanan HAM sebesar 90% di Apotek, 83,33% di Gudang, dan 85% di Depo OK. Beberapa ketidaksesuaian ditemukan, seperti ketiadaan jarak antar obat, belum adanya daftar HAM yang ditempel, dan pelabelan yang belum menjangkau satuan terkecil. Hasil ini menunjukkan perlunya perbaikan dalam infrastruktur penyimpanan dan peningkatan kompetensi tenaga farmasi melalui pelatihan berkala. Penelitian ini memberikan kontribusi penting dalam upaya peningkatan keselamatan pasien melalui pengelolaan penyimpanan obat berisiko tinggi yang lebih aman dan sesuai standar.
Pemanfaatan Minyak Atsiri Kulit Jeruk Bali (Citrus maxima) Sebagai Alternatif Antibakteri Staphylococcus epidermidis dan Staphylococcus aureus Pada Deodoran spray Octaviani, Dilha; Farid, Nurfiddin; Syarifuddin, Surya
Jurnal Farmasi & Sains Indonesia Vol 8 No 1 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no1p1-6

Abstract

Cleanliness and body odor are major and important factors of personal hygiene and appearance. If a person's body smells good, their self-confidence will be higher. Using soap and water as a body wash when bathing is relatively ineffective in preventing body odor. So several other alternative actions can be taken, such as using anti-body odor cosmetic preparations (deodorant). This research aims to determine whether grapefruit peel (Citrus maxima) essential oil can be formulated as a spray deodorant that meets physical quality requirements and to determine its antibacterial effectiveness on Staphylococcus epidermidis and Staphylococcus aureus. The method used in this research is experimental with a formula design divided into four formulas, F0 without essential oil, F1 with the addition of 0.5% essential oil, F2 with the addition of 1% essential oil, and F3 with the addition of 1.5% essential oil. The finished doedorant preparation was then subjected to organoleptic testing, homogeneity, pH, dry time, spraying pattern, cycling test for 6 cycles, and antibacterial activity test. The results of this research show that grapefruit peel (Citrus maxima) essential oil can be made into a spray deodorant that meets physical quality requirements. The results of the research show that the formulation has antibacterial activity against Staphylococcus aureus bacteria, with an F1 inhibition zone of 0.5% 3.8 mm (weak), F2 1% 4.5 mm (weak), F3 1.5% 15.2mm (strong). In Staphylococcus epidermidis bacteria, the inhibition zone is F1 0.5% 3.5 mm (weak), F2 1% 4.6 mm (weak), and F3 1.5% 14.8 mm (strong).
Isolasi dan Uji Aktivitas Antibakteri dari Bakteri Endofit Daun Matoa (Pometia pinnata J.R. & G. Forst.) terhadap Staphylococcus aureus dan Escherichia coli Rusli, Nurul Azmi; Wahyuningsih, Sri; Irwan, Irwan; Farid, Nurfiddin
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.590

Abstract

Daun matoa mengandung metabolit sekunder yang memberikan aktivitas antibakteri terhadap Staphylococcus aureus dan Escherichia coli. Tanaman tingkat tinggi mengandung bakteri endofit yang mampu menghasilkan metabolit sekunder yang sama dengan tanaman inangnya. Penelitian ini bertujuan untuk mendapatkan isolat bakteri endofit dari Daun Matoa (Pometia pinnata J.R. & G. Forst.) dan aktivitas antibakteri terhadap Staphylococcus aureus dan Escherichia coli serta jenis isolat bakteri endofit tersebut. Metode penelitian merupakan eksperimental laboratorium, isolasi bakteri endofit Daun Matoa dilakukan dengan metode penanaman langsung. Isolat yang dihasilkan diuji aktivitas antibakterinya terhadap Staphylococcus aureus dan Escherichia coli menggunakan metode difusi agar dengan paper disk. Identifikasi bakteri endofit dilakukan secara makroskopik, mikroskopik, media selektif dan uji biokimia. Hasil penelitian menunjukkan bahwa Daun Matoa menghasilkan 4 isolat bakteri endofit yaitu BE 1, BE 2, BE 3, dan BE 4. Keempat isolat bakteri endofit memiliki aktivitas antibakteri terhadap Staphylococcus aureus dan Escherichia coli. Dimana rata-rata diameter zona hambat terhadap Staphylococcus aureus pada isolat BE 1, BE 2, BE 3 dan BE 4 berturut-turut yaitu 23,6 mm, 25,3 mm, 28,3 mm dan 30,3 mm yang termasuk dalam kategori sangat kuat. Sedangkan terhadap Escherichia coli pada isolat BE 1, BE 2, BE 3, dan BE 4 berturut-turut sebesar 19,6 mm, 20 mm, 23 mm dan 24,6 mm yang masuk kedalam kategori kuat hingga sangat kuat. Jadi, Daun Matoa mengandung bakteri endofit yang memiliki aktivitas antibakteri terhadap Staphylococcus aureus dan Escherichia coli. Isolat BE 1 merupakan Escherichia sp., BE 2 yaitu Staphylococcus sp., sedangkan BE 3 dan BE 4 merupakan Pseudomonas sp.
Co-Authors Abda Abda Ahmad, Fitriani Fajri Aliah, Ahmad Irsyad Alifah, Dwi Yulianti Alyidrus, Rugayyah Andi Bibit Utari Rahayu Andi Ulfiana Utari Auliah, Nielma Azima, Annisa Dian Islamiah Dwi Rantisari Thayeb, Andi Meinar Hilmiati Wahid Hilmiati Wahid Idris, Zulfiah Ika Lismayani Ilyas Inda sari Irwan Irwan Jangga Kontesa, Emiliana Ansika Latelay, Rio Markasi Muh. Yusuf Wahyuni Hasniar Muhammad Akmal A. Sukara Muhammad Arman Muhammad Yusuf Muhammad Yusuf Muhammad Yusuf Murdi, Anna Muthmainna Musdalifa Musdalifa Muzayyidah Muzayyidah Muzayyidah Nasrawati Basir Nurfitria Junita Nurhikma Awaluddin Nurjannah Bachri Nurul Inayah Octaviani, Dilha Primadani, Nur Baetty Putri Indah Sari Rahmania Rahmania Rugayyah Alyidrus Rusli, Nurul Azmi Saleh, Adriandy Setiawan, Prayitno Siradjuddin, Mutmainnah Sri Wahyuningsih Sriyanty Sadsyam Suhartina Hamzah Suhenro, Suhenro Suhrah Febrina Karim Sulfiani, Sulfiani Syamsu, Andi Suparlan Isya Syarifuddin, Surya Tamzil Azizi Musdar Ummu Kalsum Ummu Kalsum Wahid, Hilmiati Wahyuli, Resky Wahyuni Irianti Wira Anugrah Yustikawati Yustikawati Yustisi, Juaella