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Journal : Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)

Relationship Between Micronutrient Ferritin, Vitamin D, And Calcium With The Severity Of Diabetic Foot Based On The Wagner-Meggitt Criteria At Adam Malik Hospital Amalia Puspita Dewi; Mardianto; Nasution, Melati Silvanni
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 2 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

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Abstract

Background: Diabetic foot is a significant complication for Type 2 Diabetes Mellitus’s (T2DM) patients. Previous studies have linked diabetic foot to micronutrients such as ferritin, vitamin D, and calcium, but there have been no follow-up studies in Medan. Objective: This study aimed to analyze the relationship between levels of ferritin, vitamin D, and calcium with the severity of diabetic foot, as measured by the Wagner-Meggit criteria, in T2DM patients at Adam Malik Hospital. Method: A cross-sectional study with 48 T2DM patients at Adam Malik Hospital from December 2022 to December 2023. Micronutrient levels were measured, and the severity of diabetic foot was assessed using the Wagner-Meggitt classification. Result: The majority of participants (64.6%) were female. High ferritin levels were observed in 91.6% of patients, while 93.75% had low levels of calcium and vitamin D. Bivariate analysis revealed no significant correlations between ferritin, corrected calcium, or vitamin D levels and Wagner grades 2-5 (p=0.515, p=0.646, p=0.377, respectively). Non-parametric correlation analysis showed significant relationships between corrected calcium (p=0.022) and vitamin D (p=0.027) with Wagner grades. Discussion: Among the 48 subjects, bivariate testing found that ferritin levels above 150 ng/ml were not linked to diabetic foot severity. Low calcium levels (below 8.5 ng/dl) were significantly associated with increased severity of diabetic foot (p < 0.03). 93.75% of participants had low vitamin D levels, which also correlated significantly with foot severity (p=0.027). Conclusion: The study concluded that calcium and vitamin D levels correlate with the severity of diabetic foot, whereas ferritin levels do not.
RELATIONSHIP BETWEEN C-REACTIVE PROTEIN AND IL-6 LEVELS AND EJECTION FRACTION IN HEART FAILURE PATIENTS AT ADAM MALIK HOSPITAL Pratiwi, Harvinda Arya; Refli Hasan; Lubis, Masrul; Mardianto
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 7 No. 3 (2025): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v7i3.20467

Abstract

Background: Heart failure (HF) is a progressive condition markedby anatomical and functional cardiac defects. Inflammation is amajor factor in HF development. While some research implies a linkbetween elevated CRP and IL-6 levels and lower ejection fraction(EF), the results are inconsistent. This study aims to evaluate therelationship between C-reactive protein, IL-6 levels, and EF in heartfailure patients.Method: This cross-sectional analytic observational study wasconducted at Adam Malik Hospital to assess the relationshipbetween CRP and IL-6 levels and left ventricular EF (LVEF) in HFpatients. Result: The findings showed no significant connection betweenCRP and LVEF (p=0.391), implying that CRP does not directlyreflect systolic dysfunction. Conversely, IL-6 levels have asubstantial inverse connection with LVEF (p=0.001), indicating agreater link between systemic inflammation and cardiacperformance. Conclusion: These findings underline the importance of amultimodal approach to HF care, including the use of inflammatorymarkers for risk classification in this population. While CRP maynot be as accurate a predictor of systolic dysfunction, IL-6 appearsto be more closely related to heart failure severity. Keywords: CRP, Ejection fraction, Heart failure, IL-6.