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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Medula Juke Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Indonesian Journal of Science and Technology Majalah Kedokteran Sriwijaya Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Jurnal Analis Kesehatan Jurnal Dunia Kesmas Jurnal Ilmu Kedokteran dan Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Aisyah : Jurnal Ilmu Kesehatan Indonesian Journal of Global Health research JK Unila (Jurnal Kedokteran Universitas Lampung) Bioscientia Medicina : Journal of Biomedicine and Translational Research JCOMENT (Journal of Community Empowerment) Jurnal Sylva Lestari Prosiding Seminar Nasional Pengabdian Kepada Masyarakat JUKEJ: Jurnal Kesehatan Jompa Majority
Betta Kurniawan, Betta
Bagian Parasitologi, Fakultas Kedokteran, Universitas Lampung
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PfCRT GENE POLYMORPHISMS IN PLASMODIUM FALCIPARUM ISOLATES FROM MALARIA PATIENTS IN MALARIA ENDEMIC AREAS USING ACT AS STANDARD THERAPY Jhons Fatriyadi Suwandi; Betta Kurniawan; Hanna Mutiara; Aila Karyus
Majalah Kedokteran Sriwijaya Vol 54, No 1 (2022): Majalah Kedokteran Sriwijaya
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/mks.v54i1.15137

Abstract

The pfcrt gene is a biomarker to determine the resistance of Plasmodium falciparum to chloroquine and amodiaquine. When chloroquine was switched to ACT, it is very likely that there will be an increase in wild type strains (pfcrt K76) due to the absence of exposure to chloroquine. Currently chloroquine has not used for malaria treatment. The aims of this study were to identify polymorphisms in the pfcrt gene and phylogenetic analysis of Plasmodium falciparum isolates from malaria patients in Pesawaran Regency, Lampung Province. This research is a laboratory research by analyzing blood samples which are stored biological materials (BBT). DNA isolation was carried out using a DNA isolation kit QIAmp DNA Mini kit from Qiagen, followed by amplification using an appropriate primer. The amplification results were followed by sequencing and then analyzed using Mega 10. The results showed that all samples had mutations in codons 76 (K76T) and 72 (C72S) of the pfcrt gene. Pesawaran isolates were closely related to other isolates. The conclusion of this study is that polymorphisms were found in codons 72 and 76 of the PfCRT gene, although chloroquine has long been abandoned as an antimalarial. The sequenced pesawaran isolates were also related to other isolates. 
UJI EFEKTIVITAS EKSTRAK MAHKOTA DEWA (Phaleria Macrocarpa) SEBAGAI REPELAN NYAMUK Aedes aegypti Rahmatullah Rayman; Hanna Mutiara; Betta Kurniawan; Jhons Fatriyadi
Jurnal Ilmu Kedokteran dan Kesehatan Vol 7, No 4 (2020): Volume 7 Nomor 4
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v7i4.3300

Abstract

Demam Berdarah Dengue (DBD) merupakan penyakit infeksi yang masih menjadi ancaman bagi beberapa daerah di Indonesia yang disebabkan oleh nyamuk Aedes aegypti. Banyak cara untuk mencegah penularan penyakit DBD salah satunya dengan menggunakan repelan. Namun repelan yang beredar di masyarakat terdiri dari bahan yang bersifat toksik bila dipakai dalam jangka waktu yang lama. Maka dari masalah ini mulai dicari bahan alami untuk dijadikan sebagai repelan. Buah mahkota dewa memiliki kandungan zat aktif yang merupakan hasil metabolit sekunder, yang alaminya berfungsi sebagai penolak hama pada buah. Tujuan penelitian ini adalah untuk mengetahui efektifitas ekstrak buah mahkota dewa sebagai repelan nyamuk Aedes aegypti. Jenis penelitian ini adalah eksperimental laboratorium dengan desain Rancangan Acak Lengkap (RAL) dengan menggunakan ekstrak mahkota dewa yang dilakukan dari bulan oktober sampai desember 2017. Nyamuk Aedes aegypti dilakukan rearing di laboratorium Zoologi Universitas Lampung dan pengujian repelan dilakukan dengan pengambilan data sebanyak 6 kali menggunakan kelinci dan dimasukkan ke dalam kurungan yang berisi 25 ekor nyamuk Aedes aegypti lalu diujikan sebagai repelan dalam bentuk lotion dengan konsentrasi 0%, 12,5%, 25%, dan 50%. Daya proteksi masing-masing konsentrasi dihitung dan estimasi konsentrasi efektif (Effective Concentration 50%) dan waktu efektif (Effective  Time 50%) dianalisis menggunakan analisis probit. Hasil penelitian menunjukkan ekstrak mahkota dewa memiliki daya proteksi pada nyamuk Aedes aegypti. Serta nilai EC50 adalah 6,830% dan nilai ET50 pada menit ke-38. Kesimpulan dari penelitian ini adalah ekstrak mahkota dewa menunjukkan memiliki aktivitas repelan pada nyamuk Aedes aegypti.
Peranan Ekosistem Hutan Mangrove pada Imunitas terhadap Malaria: Studi di Kecamatan Labuhan Maringgai Kabupaten Lampung Timur (Role of Mangrove Forest Ecosystem in Immunity to Malaria: Study in Sub-District Labuhan Maringgai District East Lampung) Agung Kartika Putra; Samsul Bakri; Betta Kurniawan
Jurnal Sylva Lestari Vol. 3 No. 2 (2015): May
Publisher : Department of Forestry, Faculty of Agriculture, University of Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (136.751 KB) | DOI: 10.23960/jsl2367-78

Abstract

One of the ecological function of mangrove forests is a habitat for mosquitoes that cause malaria (Anopheles sp.). Epidemic of malaria could increased as a result of mangrove degradation. The damage of mangrove forests stimulate Anopheles sp. migrate to other habitats such as settlements, that become malaria vector. The purpose of this research was to determine the effect of mangrove forest ecosystems both intrinsic and extrinsic factors in immunity to malaria. This research was conducted on June 2014 in the Muara Gading Mas Village, Bandar Negeri, Sriminosari, and Margasari, Sub-district Labuhan Maringgai, District East Lampung. The data were collected through interviews and survey/observations method. The impact of each variable used binary logistic regression models. Parameter optimization used software Minitab 16. The result of research have been demonstrated that there is influence both intrinsic and extrinsic factors in immunity to malaria in mangrove forest. Factors that increase resistance to malaria: (a) gender, male37.42 fold of female, (b) age, getting older every 1 year doubled to 1.17 times of originally, (c) education, the higher it is reduced to 0.001 times the originally, (d) livelihood, besides fisher 0,001 fold of fisherman, (e) the distance settlements to the health facility, each reduced to 1 meter doubled to 0.09 times the originally, (f) the distance home to mangroves, each increase of 1 meter doubled to 1,001 times the originally, (g) the dustbin, there are bins 239.71 better than none, (h) the malaria program, multiply 3.71E+05 originally than none, (i) extensive mangrove, increasing 1 m2 become 1,001 fold of originally, and (j) mangrove density, increasing 1 population/ha multiply 1.18 fold originally. Keywords: Mangrove forest, immunity to malaria, Anopheles sp.
PENINGKATAN KETERAMPILAN KADER DALAM IDENTIFIKASI KEJADIAN STUNTING PADA BALITA Otta Nur Kirana; Suharmanto; Bayu Anggileo Pramesona; Betta Kurniawan
Prosiding Seminar Nasional Pengabdian Kepada Masyarakat Vol 2 (2021): PROSIDING SEMINAR NASIONAL PENGABDIAN KEPADA MASYARAKAT - SNPPM2021
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (591.422 KB)

Abstract

Abstract Stunting is a major threat to the quality of Indonesian people, as well as a threat to the nation's competitiveness. This is because stunted children are not only disturbed by their physical growth, but also impaired brain development, which of course will greatly affect their ability and achievement in school, productivity and creativity in productive ages. The number of stunting cases in Indonesia in 2013 reached 37.8%, while in 2019 it decreased to 27.67%. The purpose of this activity is to improve the skills of cadres in identifying stunting in toddlers through measuring height and weight. This activity is one of the efforts to increase screening for toddlers who are stunted. The target of this activity is a cadre of 16 people. The activity will be held on October 2, 2021 at 13.00-16.00 WIB in the Karang Anyar Public Health Center, South Lampung. The method used in this activity consists of providing material, discussion and training. The evaluation carried out to assess the success of this activity consists of an initial evaluation, process evaluation and final evaluation. The community service team involved are lecturers and students in the Master of Public Health Study Program. The result of this activity is an increase in the skills of the cadres regarding the identification of stunting in toddlers. Suggestions that can be given to Public Health Center are to create programs that can maintain and improve cadre skills regarding stunting identification such as anthropometric measurements in infants and toddlers. Abstrak Stunting merupakan ancaman utama terhadap kualitas manusia Indonesia, juga ancaman terhadap kemampuan daya saing bangsa. Hal ini dikarenakan anak stunted, bukan hanya terganggu pertumbuhan fisiknya saja, melainkan juga terganggu perkembangan otaknya, yang mana tentu akan sangat mempengaruhi kemampuan dan prestasi di sekolah, produktivitas dan kreativitas di usia-usia produktif. Jumlah kasus stunting di Indonesia pada tahun 2013 mencapai 37,8% sedangkan tahun 2019 menurun menjadi 27,67%. Tujuan kegiatan ini adalah meningkatkan keterampilan kader dalam mengidentifikasi stunting pada balita melalui pengukuran tinggi dan berat badan. Kegiatan ini merupakan salah satu upaya untuk meningkatkan skrining balita yang mengalami stunting. Sasaran kegiatan ini adalah kader berjumlah 16 orang. Kegiatan dilaksanakan pada tanggal 2 Oktober 2021 pukul 13.00-16.00 WIB di Aula Puskesmas Karang Anyar Lampung Selatan. Metode yang digunakan dalam kegiatan ini terdiri dari pemberian materi, diskusi dan pelatihan. Evaluasi yang dilakukan untuk menilai keberhasilan kegiatan ini terdiri dari evaluasi awal, evaluasi proses dan evaluasi akhir. Tim pengabdian masyarakat yang dilibatkan adalah dosen dan mahasiswa pada Program Studi Magister Kesehatan Masyarakat. Hasil kegiatan ini adalah meningkatnya keterampilan para kader tentang identifikasi stunting pada balita. Saran yang dapat diberikan bagi Puskesmas adalah membuat program yang dapat mempertahankan dan meningkatkan keterampilan kader tentang identifikasi stunting seperti pengukuran antropometri pada bayi dan balita.
THE DIFFERENCES OF COMMUNITY KNOWLEDGE BETWEEN BEFORE AND AFTER HEALTH EDUCATION OF MALARIA Sa'diyah, Isma Fadlilatus; Wardani, Dyah Wulan Sumekar Rengganis; Kurniawan, Betta; Soleha, Tri Umiana
JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan" Vol. 8 No. 2 (2020): JAMBI MEDICAL JOURNAL Jurnal Kedokteran Dan Kesehatan
Publisher : FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS JAMBI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (187.22 KB) | DOI: 10.22437/jmj.v8i2.10209

Abstract

Background: Sukajaya Lempasing village is a malaria-endemic area with the increasing of Annual Parasitic Incident from 2015, which is 1.7 per 1,000 population to 2.2 per 1,000 population in 2016. The village has a higher Annual Parasite Incidence with a national Annual Parasite Incidence in Indonesia of 0.84 per 1,000 population. Various efforts have been made to prevent malaria, such as early diagnosis, prompt treatment, vector surveillance and control. However, the program has not been effective in reducing the number of malaria due to the lack of society’s knowledge about Malaria. Methods: This research uses the quasi-experimental method. The sampling technique is a total sampling. The study was conducted from April to June 2017, located in Sukajaya Lempasing Village, Pesawaran, Lampung. The samples obtained were 25 people. Data obtained from questionnaires. Results: The results of univariate analysis obtained abnormal distribution data with the p-value of pretest = 0.03 and p posttest = 0.00. Because the data is abnormally distributed, the bivariate analysis of the non-parametric Wilcoxon test is used which shows the value of p = 0.00. Conclussion: The conclusion of this research is the difference in knowledge about malaria before and after health education in the community of Sukajaya Lempasing Village. Keywords: Malaria, Health Education, Knowledge.
Hubungan Usia, Paritas, Penyakit Infeksi Dan Status Gizi Ibu Terhadap Kejadian Kelainan Kongenital Mayor pada Janin Zahra Dewi Hasna Difa; Khairun Nisa; Betta Kurniawan; Nurul Islamy; Rodiani -
Medula Vol 13 No 3 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i3.668

Abstract

Major congenital abnormalities refer to medical and cosmetic abnormalities that require surgery and are a leading cause of mortality among children under the age of five in Indonesia. Several risk factors contribute to congenital abnormalities, including the mother’s age, parity, infectious diseases, nutritional status, environment, education, and employment. This study aims to determine the relationship between age, parity, infectious diseases, and nutritional status of mothers and the occurrence of major congenital abnormalities. Secondary data from medical records of mothers who received treatment in the delima room at RSUD Dr. H. Abdul Moeloek were analyzed using an observational analytic method and a cross-sectional approach. The chi-square test and odds ratio values were used to test the major congenital abnormalities' relationship with the risk factors. Results showed that there was a significant association between nutritional status, infectious diseases, and parity with the incidence of major congenital abnormalities (p = 0,004; OR = 0,086; 95% CI = 0,016-0,468), (p = 0,034; OR = 6,816; 95% CI = 1,288 – 36,062) and  (p = 0,005; OR = 9,567; 95% CI = 1,549 – 30,206), but not with maternal age (p = 0,724; OR = 1,333; 95% CI = 0,322 – 5,526). The incidence of major congenital abnormalities is related to nutritional status, infectious diseases, and parity, but not to maternal age. 
Peningkatan Pengetahuan pada Kader Posyandu tentang Imunisasi di Kecamatan Ulubelu, Tanggamus, Lampung Alvin Widya Ananda; Fitria Saftarina; Betta Kurniawan; Dian Isti Angraini
MAJORITY Vol 9 No 2 (2020): MAJORITY
Publisher : Majority

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The coverage of infant immunization in 2017 in Lampung province in the form of BCG immunization was 99.88%, DPT1 was 100% and measles was 100%. However, there are still districts that do not reach the target of measles immunization (
Dampak Infeksi SARS-Cov-2 Terhadap Penderita Hipertensi Haekal Alfhad; Fitria Saftarina; Betta Kurniawan
MAJORITY Vol 9 No 1 (2020): MAJORITY
Publisher : Majority

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Abstract

Coronavirus disease 2019 (COVID-19) is the first viral outbreak pneumonia in Wuhan, China, in December 2019, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2). WHO reported 2.241.359 positive cases of COVID-19 patients worldwide, with a cumulative death toll of 152.551 men by April 19, 2020. As in 18 April 2020, Indonesia itself hit 6.248 positive cases with a total of 535 deaths, according to the Indonesian Health Ministry. SARS-Cov-2 is a coronaviral (β) beta group virus. In order to enter the target cell, SARS-CoV 2 uses the ACE Angiotensin conversion enzyme (ACE) 2. This can reduce the function of ACE2 which changes Angiotensin 2 into Angiotensin (1-7). The disrupted production of Angiotensin (1-7) can cause a vasodilator effect that is not optimal, so the condition of people with hypertension can be worsen. The risk of SARS-Cov-2 infection is higher among those suffering from hypertension with the drug Renin-Angiotensin-Aldosterone System inhibitor, due to the expression of ACE2. Overexpression of ACE2 may make it easier for SARS-CoV-2 to penetrate the body.
Pengaruh Pemberian Injeksi Intramuskular Sel Punca Mesenkimal Tali Pusat Manusia Terhadap Gambaran Histopatologi Ginjal Pada Tikus Putih (Rattus norvegicus) Galur Sprague dawley yang diinduksi Aspirin Cahaya Carla Bangsawan; Evi Kurniawaty; Utari Gita Mutiara; Betta Kurniawan
MAJORITY Vol 11 No 1 (2022): MAJORITY
Publisher : Majority

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Abstract

Uncontrolled use of aspirin can cause several complications and various damaged to organs, including kidney injury. Mesenchymal stem cells as an alternative therapy is an important source for repair and regeneration of damaged tissue. The purpose of this study is to determine the effect of intramuscular injection of human umbilical chord on kidney tissue impairment of rats (Rattus norvegicus) with aspirin induction. This study was a laboratory experimental study with a post test only control group design with 27 white rats (Rattus norvegicus) Sprague dawley strain which divided into three groups. The control group (KK) was given regular drink and food, P1 was given 200 mg/kgBW aspirin orally for 14 days, P2 was given 200 mg/kgBW aspirin orally for 14 days and treated with intramuscular injection of 0.75 mL extracted human cord mesenchymal stem cells. Data were observed by Kruskal-Wallis Non-Parametric Test, obtained p=0,001 (p<0,05), then get a meaningful result which means Ho is rejected. The statistical results with Mann-Whitney test obtained are also find significant differences in each groups, but P1 with P2 (p=0,497) has no significant differences.
Hubungan Profil Lipid Terhadap Kontrol Glikemik DM Tipe 2 Peserta Program Pengelolaan Penyakit Kronis (Prolanis) di fasilitas Kesehatan Provinsi Lampung Tahun 2021 Suyatno, Suyatno; Kurniawan, Betta; Suharmanto, Suharmanto
Jurnal Analis Kesehatan Vol. 10 No. 1 (2021): JURNAL ANALIS KESEHATAN
Publisher : Department of Health Analyst, Politeknik Kesehatan, Kementerian Kesehatan Tanjungkarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26630/jak.v10i1.2719

Abstract

Diabetes Melitus (DM) masih menjadi permasalahan dunia. International Diabetes Federation (IDF) memperkirakan ada peningkatan prevalensi DM di tahun 2030 sebanyak 576 juta orang, dan meningkat menjadi 700 juta pada tahun 2045. Menurut Organisasi Kesehatan Dunia (WHO) DM dapat menyebabkan kecacatan dan kematian secara dini. Faktor resiko pada DM diantaranya adalah karteristik dan profil lipid. Tujuan penelitian untuk mengetahui korelasi karketeristik dan kadar lipemik dengan penyakit Diabetes Melitus peserta prolanis. Rancangan penelitian adalah analitik dengan pendekatan crosssectional. Sampel adalah pasien DM dengan pemeriksaan HbA1C dan profil Lipid pada priode bulan Februari sampai Maret tahun 2021. Analisa univariat untuk melihat distribusi frekuensi karakteristik, status kontrol Diabetes Melitus, status kadar kholesterol, Trigliserida, HDL dan LDL. Uji penelitian didapatkan rata-rata responden berumur 51-60 tahun, perempuan, dari perkotaan. Rata-rata kadar HbA1C 8,67, Kholesterol 210,82, trigliserida  178,19, HDL 94 dan LDL 125,55. Dari uji bivariat menunjukan terdapat hubungan yang bermakna antara kontrol glikemik dengan kadar trigliserida dengan p value=0,000, namun tidak bermakna dengan profil lipid yang lain. Peningkatan trigliserida erat kaitannya dengan kebisaaan pola makanan. gaya hidup sehat dapat mengurangi terjadinya DM
Co-Authors A.A. Ketut Agung Cahyawan W Abigail Pheilia Ade Triajayanti Agung Kartika Putra Agung Kartika Putra Agustine Sesunan, Dyah Surya Aila Karyus Ali Rahmat Alvin Widya Ananda Andriana, Bibin B. Anniza Agustina Arief Darmawan Bayu Anggileo Pramesona Cahaya Carla Bangsawan Christine Wulandari Dewayanti, Wahyu Dian Isti Angraini Dwita Oktaria Dyah Wulan Sumekar Rengganis Wardani Evi Kurniawaty Fitria Saftarina Giska Tri Putri Haekal Alfhad Hanna Mutiara Hanna Mutiara Hanna Mutiara, Hanna Husna, Ismalia Indah Anita Dewi Jermsittiparsert, Kittisak Jhons Fatriyadi Suwandi Khairun Nisa Kirche, Agnes Angelina Kurnia, Yogi Laila Puspita Lia Puspitasari M. Yusran Merry Indah Sari Muhammad Iqbal Muhammad Ricky Ramadhian Nainggolan, Hotman Natama Novita Carolia Nuning Nurcahyani Nurul Islamy Nurul Sahana Rahmadhini Nurul Utami Otta Nur Kirana Rahmatullah Rayman Rani Himayani Rika Lisiswanti Riyan Wahyudo Rodiani - Rofiqul Umam Ronalda Budyantara Sa'diyah, Isma Fadlilatus Samsul Bakri Samsul Bakri Samsul Bakri Septilia Sugiarti Sri Janahtul Hayati Suharmanto Suharmanto Suharmanto Suyatno Suyatno Syaka, Muthiiah Khodista Syazili Mustofa Tri Umiana Soleha Tri Umiana Soleha Triyandi, Ramadhan Ulima Mazaya Ghaisani Utari Gita Mutiara Wardani, Ika Novianna Widianningrum, Wahyu Zahra Dewi Hasna Difa