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Peningkatan Pengetahuan pada Kader Posyandu tentang Imunisasi di Kecamatan Ulubelu, Tanggamus, Lampung Alvin Widya Ananda; Fitria Saftarina; Betta Kurniawan; Dian Isti Angraini
MAJORITY Vol 9 No 2 (2020): MAJORITY
Publisher : Majority

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Abstract

The coverage of infant immunization in 2017 in Lampung province in the form of BCG immunization was 99.88%, DPT1 was 100% and measles was 100%. However, there are still districts that do not reach the target of measles immunization (
Dampak Infeksi SARS-Cov-2 Terhadap Penderita Hipertensi Haekal Alfhad; Fitria Saftarina; Betta Kurniawan
MAJORITY Vol 9 No 1 (2020): MAJORITY
Publisher : Majority

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Abstract

Coronavirus disease 2019 (COVID-19) is the first viral outbreak pneumonia in Wuhan, China, in December 2019, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2). WHO reported 2.241.359 positive cases of COVID-19 patients worldwide, with a cumulative death toll of 152.551 men by April 19, 2020. As in 18 April 2020, Indonesia itself hit 6.248 positive cases with a total of 535 deaths, according to the Indonesian Health Ministry. SARS-Cov-2 is a coronaviral (β) beta group virus. In order to enter the target cell, SARS-CoV 2 uses the ACE Angiotensin conversion enzyme (ACE) 2. This can reduce the function of ACE2 which changes Angiotensin 2 into Angiotensin (1-7). The disrupted production of Angiotensin (1-7) can cause a vasodilator effect that is not optimal, so the condition of people with hypertension can be worsen. The risk of SARS-Cov-2 infection is higher among those suffering from hypertension with the drug Renin-Angiotensin-Aldosterone System inhibitor, due to the expression of ACE2. Overexpression of ACE2 may make it easier for SARS-CoV-2 to penetrate the body.
Pengaruh Pemberian Injeksi Intramuskular Sel Punca Mesenkimal Tali Pusat Manusia Terhadap Gambaran Histopatologi Ginjal Pada Tikus Putih (Rattus norvegicus) Galur Sprague dawley yang diinduksi Aspirin Cahaya Carla Bangsawan; Evi Kurniawaty; Utari Gita Mutiara; Betta Kurniawan
MAJORITY Vol 11 No 1 (2022): MAJORITY
Publisher : Majority

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Abstract

Uncontrolled use of aspirin can cause several complications and various damaged to organs, including kidney injury. Mesenchymal stem cells as an alternative therapy is an important source for repair and regeneration of damaged tissue. The purpose of this study is to determine the effect of intramuscular injection of human umbilical chord on kidney tissue impairment of rats (Rattus norvegicus) with aspirin induction. This study was a laboratory experimental study with a post test only control group design with 27 white rats (Rattus norvegicus) Sprague dawley strain which divided into three groups. The control group (KK) was given regular drink and food, P1 was given 200 mg/kgBW aspirin orally for 14 days, P2 was given 200 mg/kgBW aspirin orally for 14 days and treated with intramuscular injection of 0.75 mL extracted human cord mesenchymal stem cells. Data were observed by Kruskal-Wallis Non-Parametric Test, obtained p=0,001 (p<0,05), then get a meaningful result which means Ho is rejected. The statistical results with Mann-Whitney test obtained are also find significant differences in each groups, but P1 with P2 (p=0,497) has no significant differences.
Co-Authors A.A. Ketut Agung Cahyawan W Abda Abda Abigail Pheilia Ade Triajayanti Ade Yonata, Ade Aditya Permana Agung Kartika Putra Agung Kartika Putra Agung Kurnia, Ahmad Fadila Agustine Sesunan, Dyah Surya Aila Karyus Ali Rahmat Alvin Widya Ananda Andriana, Bibin B. Anggi Setiorini Anggraeni Janar Wulan, Anggraeni Janar Anggraeni, Liza Anniza Agustina Apga Repindo Arief Darmawan Asep Sukohar Bayu Anggileo Pramesona Cahaya Carla Bangsawan Centya Cheirini Christine Wulandari Dewayanti, Wahyu Dian Isti Angraini Dwi Indria Anggraini Dwita Oktaria Dyah Wulan Sumekar Rengganis Wardani Efrida Warganegara Endah Setyaningrum Etty Widyastuti Ety Apriliana Evi Kurniawaty Fadli, Muhammad Yogie Firdha Yossi Chani Fitria Saftarina Fitria, Saftarina Giska Tri Putri Hadibrata, Exsa Haekal Alfhad Hamzah, Muhammad Syafei Hanna Mutiara Hanna Mutiara Hanna Mutiara Hanna Mutiara, Hanna Hendra Tarigan Hijami, Nurul 'Afifah Husna, Ismalia I Wayan Dika Aditia Darma Ika Yunidasari Indah Anita Dewi Jausal, Anisa Nuraisa Jermsittiparsert, Kittisak Jhons Fatriyadi Suwandi Kartika, Juspeni Keisha Azzahra Tetadrian Khairun Nisa Kirche, Agnes Angelina Kurnia, Yogi Kurniawaty, Evi Laila Puspita M. Ridho Ulya M. Yusran Merry Indah Sari Muatiara, Hanna Muhammad Aditya, Muhammad Muhammad Iqbal Muhammad Ricky Ramadhian Muhammad Yusran Muhartono Muhartono Nainggolan, Hotman Natama Nani Indah Hardiyanti Novita Carolia Nuning Nurcahyani Nurmumpuni, Dwita Nurul Islamy Nurul Sahana Rahmadhini Nurul Utami Nurul Utami Otta Nur Kirana Rahmatullah Rayman Rani Himayani Reni Zuraida Ria Rizki Jayanti Rika Lisiswanti Risal Wintoko Risti Graharti Riyan Wahyudo Rizki Hanriko Rizqa Atina Rodiani - Rofiqul Umam Ronalda Budyantara Sa'diyah, Isma Fadlilatus Samsul Bakri Samsul Bakri Samsul Bakri Selvi Marcellia Septilia Sugiarti Septyne Rahayuni Putri Sri Janahtul Hayati Sri Puji Hartini Suharmanto Suharmanto Suharmanto Susianti Susianti, Susianti Sutyarso Sutyarso Sutyarso Suwandi, Jhons F. Suwandi, Jhosn Fatriyadi Suyatno Suyatno Syaka, Muthiiah Khodista Syazili Mustofa Tri Umiana Soleha Tri Umiana Soleha Triyandi, Ramadhan Ulima Mazaya Ghaisani Utari Gita Mutiara Wardani, Ika Novianna Widianningrum, Wahyu Zahra Dewi Hasna Difa