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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Journal of Food and Pharmaceutical Science VALENSI JURNAL KIMIA SAINS DAN APLIKASI Pharmaciana: Jurnal Kefarmasian Biology, Medicine, & Natural Product Chemistry Biopropal Industri Journal of Islamic Pharmacy JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Chimica et Natura Acta ALCHEMY Jurnal Penelitian Kimia JMM (Jurnal Masyarakat Mandiri) Journal of Pharmacopolium MATAPPA: Jurnal Pengabdian Kepada Masyarakat Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Jurnal Kreativitas PKM Molekul: Jurnal Ilmiah Kimia Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmasi Sandi Karsa Kumawula: Jurnal Pengabdian Kepada Masyarakat Jurnal Analis Farmasi Pharmacoscript Pharma Xplore : Jurnal Sains dan Ilmu Farmasi Jurnal Ilmiah Farmako Bahari Jurnal Farmagazine Agrinimal Jurnal Ilmu Ternak dan Tanaman Jurnal Farmasi dan Sains Indonesia (JFSI) JAF (Jurnal Analis Farmasi) JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Riset Rumpun Ilmu Kesehatan (JURRIKES) Jurnal Pengabdian Pada Masyarakat Media Informasi Journal of Food and Pharmaceutical Sciences Pharmaceutical Science Journal Prosiding Seminar Nasional Unimus
Richa Mardianingrum
Universitas Perjuangan Tasikmalaya
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RENDEMEN DAN SKRINING FITOKIMIA EKSTRAK KULIT MANGGIS MENGGUNAKAN METODE EKSTRAKSI DAN PELARUT BERBEDA SEBAGAI ALTERNATIF SUPLEMEN PAKAN UNGGAS Rifan Afrian Nur Walid; Andri Kusmayadi; Nurul Frasiska; Richa Mardianingrum
Agrinimal Jurnal Ilmu Ternak dan Tanaman Vol 13 No 1 (2025): Agrinimal Jurnal Ilmu Ternak dan Tanaman
Publisher : Jurusan Peternakan Fakultas Pertanian Universitas Pattimura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30598/ajitt.2025.13.1.50-56

Abstract

Kulit buah manggis (Garcinia mangostana L.) telah diketahui mengandung banyak senyawa yang memiliki aktivitas antioksidan dan antibakteri. Kulit buah manggis dalam proses ekstraksi dilakukan dengan metode ekstraksi dan pelarut yang beragam. Penelitian ini bertujuan untuk mengetahui pengaruh metode ekstraksi menggunakan pelarut berbeda terhadap rendemen dan skrining fitokimia ekstrak kulit buah manggis yang ditunjukan sebagai suplemen pakan ternak unggas. Metode penelitian ini yaitu eksperimental dengan Rancangan Acak Lengkap (RAL) pola faktorial 3x2. Faktor pertama adalah pelarut (faktor A) A1 = etanol 96%, A2 = etil asetat, A3 = n-heksan. Faktor kedua adalah metode (faktor B) B1 = metode maserasi dan B2 = metode sokletasi yang menghasilkan 6 perlakuan. Parameter yang diamati adalah persentase rendemen dan skrining fitokimia ekstrak kulit manggis. Hasil dari penelitian ini yaitu persentase rendemen menunjukkan hasil yang berbeda sangat nyata (P<0,01). Adapun pada pengujian skrining fitokimia menunjukkan adanya kandungan tannin, polifenol, dan triterpenoid. Kesimpulan dari penelitian ini yaitu metode maserasi dengan pelarut etanol 96% menunjukkan persentase rendemen yang terbaik. Hasil dari penelitian ini dapat bermanfaat sebagai antioksidan alami bagi ternak khususnya unggas. ABSTRACT Mangosteen peel (Garcinia mangostana L.) has been known to contain many compounds that have antioxidant and antibacterial activity. Mangosteen peel in the extraction process is carried out with various extraction methods and solvents. This study aims to determine the effect of extraction methods using different solvents on the yield and phytochemical screening of mangosteen peel extract which is indicated as a poultry feed supplement. This research method is experimental with a Completely Randomized Design (CRD) factorial pattern 3x2. The first factor is the solvent (factor A) A1 = 96% ethanol, A2 = ethyl acetate, A3 = n-hexane. The second factor is the method (factor B) B1 = maceration method and B2 = soxhletation method which produces 6 treatments. The parameters observed are the percentage of yield and phytochemical screening of mangosteen peel extract. The results of this study, namely the percentage of yield showed very significant results (P<0.01). The phytochemical screening test showed the presence of tannin, polyphenols, and triterpenoids. The conclusion of this study is that the maceration method with 96% ethanol solvent shows the best yield percentage. The results of this study can be useful as a natural antioxidant for livestock, especially poultry.
Studi In Silico : Aktivitas Senyawa Tanaman Kecombrang (Etlingera elatior) Sebagai Kandidat Obat Antihiperurisemia: Studi Awal Pemanfaatan Kecombrang Sebagai Terapi Alternatif Gout Muhammad Fessolsalmin; Rifda Naufalin; Putri Dian Wulansari; Susanti Susanti; Moch Herdi Nurzaman; Nitya Nurul Fadilah; Richa Mardianingrum
Jurnal Farmasi & Sains Indonesia Vol 8 No 2 (2025)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol8no2p126-135

Abstract

Hyperuricemia is a metabolic disorder caused by an increase in uric acid levels, which is at risk of ausing gout. The plant kecombrang (Etlingera elatior) is known to contain bioactive compounds that have the potential to act as xanthine oxidase inhibitors. This study aims to evaluate 50 compounds from kecombrang as antihyperuricemia candidates using an in silico approach. The analysis includes toxicity and pharmacokinetics (ADMET) predictions, Lipinski's rule of five, molecular docking, and molecular dynamics simulations. The docking results of selected compounds Aduncetin E (-8.93 kcal/mol) and Methyllinderatin (-8.78 kcal/mol) show the best affinity for xanthine oxidase enzyme with lower binding energy compared to allopurinol (-6.26 kcal/mol). Molecular simulations support the stability of the ligand-receptor complex the MMGBSA results indicate that Aduncetin E (13.4048 kcal/mol) and Methyllinderatin (-30.3009 kcal/mol) have potential that can be developed as antihyperuricemia drug candidates.
Studi In Silico Senyawa 1,4-Naphthalenedione-2-Ethyl-3-Hydroxy sebagai Antiinflamasi dan Antikanker Payudara Richa Mardianingrum; Kamiel Roesman Bachtiar; Susanti Susanti; Aas Nuraisah Aas Nuraisah; Ruswanto Ruswanto
ALCHEMY Jurnal Penelitian Kimia Vol 17, No 1 (2021): March
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.17.1.43979.83-95

Abstract

Inflamasi merupakan suatu respon dari tubuh terhadap adanya cedera maupun infeksi yang ditandai dengan timbulnya kemerahan, demam, bengkak, nyeri dan hilangnya fungsi. Inflamasi berkontribusi terhadap ketidakseimbangan sekresi sitokin yang akan menghambat terjadinya apoptosis pada sel kanker sehingga menyebabkan hiperproliferasi sel. Kanker payudara merupakan salah satu penyakit kanker dengan prevalensi tertinggi di urutan ke dua di dunia. Penelitian terdahulu melaporkan pemberian minyak atsiri rimpang bangle (Zingiber purpureum Roxb.) secara topikal mampu memberikan penghambatan inflamasi yang lebih tinggi daripada triamcinolone, namun spesifik senyawa yang berpotensinya belum diketahui. Tujuan dari penelitian ini, yakni mencari senyawa aktif hasil analisis GCMS minyak atsiri rimpang bangle yang berpotensi sebagai antiinflamasi dan antikanker payudara secara in silico. Metode yang digunakan berupa screening Lipinski’s rule of Five, farmakokinetika dan toksisitas senyawa hasil analisis GC-MS, serta penambatan molekul dan dinamika molekular. Hasil screening dan simulasi penambatan molekul menunjukkan bahwa senyawa 1,4-naphthalenedione-2-ethyl-3-hydroxy dapat berikatan dengan reseptor COX-1 (antiinflamasi), dan hERα (antikanker payudara), namun lebih selektif terhadap reseptor COX-1 dengan nilai energi bebas (ΔG) yang lebih kecil yakni sebesar -7,20 kkal/mol, dibandingkan dengan interaksinya terhadap reseptor Erα yang bernilai -6,00 kkal/mol. Hasil simulasi dinamika molekular menggunakan metode kalkulasi MM-GBSA menunjukkan bahwa kompleks (1,4-naphthalenedione-2-ethyl-3-hydroxy)-(COX-1) memiliki nilai ∆GTOTAL sebesar -24,22 kkal/mol. Nilai ini lebih kecil dibandingkan dengan ∆GTOTAL kompleks (1,4-naphthalenedione-2-ethyl-3-hydroxy)-(hErα) sebesar -8,92 kkal/mol). Hal ini menunjukkan bahwa tingkat afinitas 1,4-naphthalenedione-2-ethyl-3-hydroxy terhadap COX-1 diprediksi lebih baik dan lebih poten sebagai antiinflamasi dibandingkan sebagai antikanker payudara.In Silico Study of 1,4-Naphthalenedione-2-Ethyl-3-Hydroxy Compounds as Anti-inflamation dan Breast Anticancer. Inflammation is a response from the body to injury or infection which is characterized by redness, fever, swelling, pain, and loss of function. Inflammation contributes to the imbalance of cytokine secretion which will inhibit apoptosis in cancer cells, causing cell hyperproliferation. Breast cancer is one of the cancer diseases with the second-highest prevalence in the world. The pioneering works reported that topical application of Bangle (Zingiber purpureum R) was able to provide a higher inhibition of inflammation than triamcinolone, however, the specific potential of the compound was unknown. The purpose of this study is to find active compounds that have the potential to be anti-inflammatory and anti-cancer in the breast using in silico approach. The methods used are screening Lipinski’s Rule of Five, pharmacokinetics and toxicity of compounds from GC-MS analysis and molecular docking, and molecular dynamics. The screening and molecular docking simulation results showed that the compound 1,4-naphthalenedione-2-ethyl-3-hydroxy can bind to COX-1 (anti-inflammatory), and ERα (Estrogen Reseptor α), but was more selective towards COX-1 receptor with a binding affinity (ΔG) -7.20 kcal/mol, compare to its interaction with ERα which is -6.00 kcal/mol. The results of molecular dynamics simulation using the MM-GBSA calculation method show that the complex (1,4-naphthalenedione-2-ethyl-3-hydroxy)-(COX-1) has a value of ∆GTOTAL of -24.22 kcal/mol). This value is smaller than ∆GTOTAL of the complex (1,4-naphthalenedione-2-ethyl-3-hydroxy)-(hErα) of -8.92 kcal/mol. The results indicate that the affinity level of 1,4-naphthalenedione-2-ethyl-3-hydroxy to COX-1 was predicted to be better and more potent as an anti-inflammatory than as an anti-breast cancer.
Antibacterial Activity of Streptococcus mutans from Saga Herbaceous Plant (Abrus precatorius): In Silico Study Richa Mardianingrum; Neta Ekayanti Suganda; Srie Rezeki Nur Endah; Ruswanto Ruswanto
ALCHEMY Jurnal Penelitian Kimia Vol 19, No 2 (2023): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.19.2.67780.177-189

Abstract

Antibacterial is a substance that can inhibit growth or can even kill bacteria that cause infection. One of them is infection with Streptococcus mutans bacteria that cause damage to teeth, such as dental caries. Dental caries is a disease that affects many adults and children, permanently damaging the tooth layer and forming small holes in the teeth. The purpose of this study was to find active compounds from the herb Saga plant (Abrus precatorius), which has the potential to be antibacterial of S. mutans in silico. The methods used are pharmacokinetics and toxicity screening, Lipinski's Rule of Five, as well as simulations of molecular docking and molecular dynamics. The Abruquinone D (-6.43) and Abruquinone F (-7.08) were predicted to have stable interactions and be similar to amoxicillin (-7.69) and native ligand (-8.56 kcal/mol) based on the results of screening and molecular docking simulations of active compounds from Saga herbaceous (Abrus precatorius) against deoxycytidylate deaminase receptors. Molecular dynamics findings confirmed by MMGBSA methods that Abruquinone D (-41.3876 kcal/mol) had a lower energy value than Abruquinone F (-24.8521 kcal/mol). It can be inferred that Abruquinone D has a higher potential as an antibiotic (S. mutans) than Abruquinone F.
Kuersetin: Penghambat Uridin 5-Monofosfat Sintase sebagai Kandidat Antikanker Ruswanto Ruswanto; Imam Mustaqim Garna; Lilis Tuslinah; Richa Mardianingrum; Tresna Lestari; Tita Nofianti
ALCHEMY Jurnal Penelitian Kimia Vol 14, No 2 (2018): September
Publisher : UNIVERSITAS SEBELAS MARET (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/alchemy.14.2.14396.236-254

Abstract

Kanker adalah pembentukan jaringan baru yang abnormal dan bersifat ganas. Efek toksisitas yang ditimbulkan pada setiap senyawa obat antikanker selalu menjadi problem dalam pengobatan kanker dengan cara kemoterapi, maka dari itu perlu dicari alternatife lain untuk mengatasi kanker. Kuersetin telah diketahui mempunyai aktivitas sitotoksik pada sel kanker tapi belum diketahui mekanisme kerjanya. Pada penelitian ini telah dilakukan penelitiaan in silico untuk mengetahui target reseptor dari senyawa kuersetin melalui identifikasi target reseptor melalui http://lilab.ecust.edu.cn/pharmmapper/ dan studi interaksi melalui metode docking. Hasil menunjukkan bahwa kuersetin memiliki aktivitas pada target reseptor proto-onkogen protein-tirosin kinase dan uridin 5-monofosfat sintase. Berdasarkan nilai energi bebas (∆G) dari hasil docking dapat disimpulkan kuersetin memiliki aktivitas terbaik pada protein target uridin 5-monofosfat sintase dengan nilai energi binding affinity sebesar -8,28617 kkal/mol dan berinteraksi dengan residu asam amino yang sesuai dengan active site dari protein target reseptor uridin 5-monofosfat sintase yaitu membentuk 2 ikatan hidrogen dengan residu Tyr 432 dan Gly 450 dan kontak bagian hidrofobik dengan residu Asn 312, Met 371, pro 417.Quersetine: Uridine 5-Monophosphate Synthase Inhibitor as Anticancer Candidate. Cancer is the abnormal formation of new tissue and malignant. Toxicity effects inflicted on any anti-cancer drug compounds has always been a problem in the treatment of cancer by chemotherapy, therefore it is necessary to find other alternatives to treat cancer. Quercetin has been known to have cytotoxic activity on cancer cells but unknown mechanism of action. This study has been conducted in silico to determine the receptor target of the quercetin compound through the identification of target receptors by http://lilab.ecust.edu.cn/pharmmapper/ and interaction studies through docking methods. The results showed that the quercetin has activity on the receptor target proto-oncogene protein-tyrosine kinase and uridine 5- monophosphate synthase. Based on free energy value (ΔG) of the docking results we can conclude the quercetin has the best activity of the receptor target uridine 5- monophosphate synthase with a binding affinity energy value of -8.28617 kcal/mol and interacts with the amino acid residues to the active site of the receptor target 5-uridine monophosphate synthase which form two hydrogen bonds with Tyr 432 and Gly 450 and the hydrophobic contact with Asn 312, Met 371, and pro 417.
Co-Authors Aas Nuraisah Aas Nuraisah Aas Nuraisah Adinda Putri Amanda Afriliani, Sindy Aguslina Kirtishanti Agustien, Gina Septiani Ai Teni Siti Robi`ah Amelia, Widya Puspitasari Andri Kusmayadi Arif Budiman Arry Yanuar AYU RAHMAWATI Bachtiar, Kamiel Roesman Delis Susilawati Diah Lia Aulifa Dudi Nurmalik Elis Nurul Ikhlas Elsi Eryanti Fajar Setiawan Feri Sandria Gatut Ari Wardani Gina Septiani Agustien Gina Septiani Agustien Gina Septiani Agustien Ginna Sri Nuryani Gramita, Widya Siva Hadiwijaya, Nathannael Adrya Harfiah Nur Aini Hartono, Sugianto Ayudha Ikram, Nur Kusaira Khairul Imam Mustaqim Garna Indah Cantika Indri Rahmawati Irma Andriani Isti Daruwati Jhoni, I Made Kamiel Roesman Bachtiar Korry Novitriani, Korry Kuncoro, Aditiya Kurniawan, Rian Liawardi, Petra Pahlawanda Chrisanto Lilis Tuslinah Lilis Tuslinah Lilis Tuslinah, Lilis Lina Rahmawati Rizkuloh Makiyatuzahro, Dede Avissa Mardhiah Mardhiah Mardhiah Mardhiah Mas'ud, Ibnu Meylany Sity Rossy Lestary Mia Nurfazriah Mida Hamidah Moch Herdi Nurzaman Mochamad Herdi Nurzaman Monikasari, Hesti Muchtaridi Muchtaridi Muhammad Fessolsalmin Nahariyah, St. Rohmani Napitupulu, Gloria Naser Fahmi Muhamad Neta Ekayanti Suganda Nisa Uswatun Khasanah Nitya Nurul Fadilah Nitya Nurul Nitya Nurul Fadilah Nofianti, Tita Nofriyaldi, Ali Nur Aji Nur Aji Nur Ihsani Pertiwi Nur Laeli Dwi Hidayati Nur Laili Dwi Hidayati Nur Rahayuningsih Nur Rahayuningsih, Nur Nurlaila, Putri Saniah Nurmalik, Dudi Nurmalik, Dudi Nursuhud Nursuhud Nursuhud Nurul Frasiska Oktariani, Anisa Pertiwi, Nur Ihsani Pratama, Rizki Pratita, Anindita Tri Kusuma Pratomo, Muhammad Fadhil Putri Dian Wulansari Renadi, Sedin Rifan Afrian Nur Walid Rifda Naufalin Rizgy Anggia Ruswanto Ruswanto Ruswanto Ruswanto Ruswanto, Ruswanto Ryan Apriandi Sa'banah, Nonah Sarwatiningsih, Yunia Sarwatiningsih, Yunia Septian, Ade Dwi Setyawati, Luthfi Utami Sindy Afriliani Siswandono, Siswandono Srie Rezeki Nur Endah Srie Rezeki Nur Endah Suhardiana, Eddy Suharyani, Ine Suharyani SUSANTI Susanti Susanti Susanti Susanti Susanti Susanti Susanti Susanti Susanti Syifa Alifia Lukman Syifa Sri Rahmawati Tammy Riyanda Julianti Tati Herlina Tifa Nofianti Tita Nofianti Tita Nofianti Tita Nofianti, Tita Tresna Lestari Tresna Lestari, Tresna Tsalma Dwi Juliani Fasya Tuslinah, Lilis Unang Supratman Vikandari, Sonya Nurizki Winda Trisna Wulandari, Winda Trisna Wirantono, Sebastian Nathanoel Yanti Yanti Yuliawati, Sri Yunia Sarwatiningsih Yuniarti Falya