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All Journal Pharmasipha Pharmed: Journal of Pharmaceutical Science and Medical Research SCIENTIA JOURNAL Jambura Journal of Health Sciences and Research Jurnal Kesmas dan Gizi (JKG) JURNAL FARMASIMED (JFM) Jurnal Dunia Farmasi Jurnal Prima Medika Sains Jurnal Kesehatan Tambusai PRIMER (Prima Medical Journal) Buletin Kedokteran dan Kesehatan Prima Jurnal Pengmas Kestra (JPK)
Reh Malem br Karo
Program Studi Farmasi Klinis, Fakultas Kedokteran, Kedokteran Gigi Dan Ilmu Kesehatan Universitas Prima Indonesia Medan, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Education on The Danger of Hydroquinone in Whitening Body Lotion Products in The Community Sinurat, Jhon Patar; Br Karo, Reh Malem; Husna, Miftahul; Syarifuddin, Aminah
JURNAL PENGMAS KESTRA (JPK) Vol. 4 No. 1 (2024): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jpk.v4i1.2203

Abstract

White and bright skin is considered a symbol of beauty, success, and social status, especially in several Asian countries. This is the basis for feeling the need to care for skin, especially women. One way to care for your skin is by using whitening body lotion products so that it will produce an attractive appearance, where white and bright skin is the indicator. Finally, many women compete to use instant whitening products at low prices, but forget about the impact. Hydroquinone is an organic compound with an aromatic group that is usually added to some skin-whitening products. However, you need to pay attention to the levels and duration of use, because it can cause skin irritation and trigger cancer because it is a carcinogen. The hydroquinone level in the product is a maximum of 0.02%. This educational activity is carried out by combining methods, namely lectures, questions and answers, and discussions. PkM participants are 25 people from Lubuk Pakam. The PkM team also carried out pre and post-test activities to measure the level of knowledge of PkM participants after being given education. The PkM results provide new insight for PkM participants that some whitening products contain hydroquinone compounds at levels that exceed the limit, so PkM participants must know about the dangers of hydroquinone and how to choose safe whitening products. After being given education, PkM participants have experienced an increase in knowledge where the participants' post-test average score was 80,2 whereas the previous pre-test average score was 55,7.
Analisis kadar zat besi pada sari kedelai kemasan dengan metode spektrofotometri UV-VIS br Karo, Reh Malem; Sinurat, Jhon Patar; Fioni, Fioni; Fibrini, Dewi
Jurnal Prima Medika Sains Vol. 3 No. 2 (2021): Desember
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v3i2.2038

Abstract

Latar belakang: Kedelai adalah hasil pangan jenis kacang-kacangan yang sangat kaya akan nutrisi yang bermanfaat bagi kesehatan manusia. Tujuan: Untuk mengetahui keberadaan zat besi dan kadar zat besi dalam sari kedelai. Metode: Analisis kualitatif menggunakan pereaksi NaOH, K4[Fe(CN)6] dan K3[Fe(CN)6] dan analisis kuantitatif menggunakan spektrofotometer UV-Visibel pada panjang gelombang 248.3 nm. Hasil: Sari kedelai mengandung zat besi yang dibuktikan melalui analisis kualitatif menggunakan pereaksi NaOH, K4[Fe(CN)6] dan K3[Fe(CN)6] yang menghasilkan masing-masing endapan hijau, biru dan coklat yang artinya mengnadung zat besi. Persamaan regresi linear larutan standar besi adalah Y = 0.0154x  +  0.1555 dengan korelasi (R2) sebesar 0.9981. Kadar zat besi dalam sari kedelai adalah 56.48 mg/ml dan termasuk dalam kelompok produk yang memiliki kadar zat besi yang cukup tinggi. Kesimpulan: Sari kedelai mengandung zat zat besi dengan kadar sebesar 56.48mg/ml.
Analisis TLC terhadap senyawa flavonoid dalam ekstrak daun ciplukan (Physalis angulata L.) Cahya, Cucu Arum Dwi; Sinurat, Jhon Patar; Br Karo, Reh Malem
Jurnal Prima Medika Sains Vol. 4 No. 2 (2022): Desember
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v4i2.3258

Abstract

Skrining flavonoid menggunakan pereaksi FeCl3 5%, uap amoniak, shinoda, pereaksi basa dan timbal asetat mengkonfirmasi bahwa daun ciplukan mengandung senyawa flavonoid. Ekstrak metanol daun ciplukan yang diproses melalui metode maserasi diperoleh ekstrak sebesar 200 g. Kemudian partisi dilakukan terhadap ekstrak daun ciplukan menggunakan pelarut etil asetat dan n-heksana sehingga menghasilkan ekstrak sebesar 32.12 gram. Ekstrak kering daun ciplukan dipersiapkan untuk analisis TLC dengan cara dilarutkan menggunakan pelarut metanol. Fase diam yang digunakan adalag silica gel 60F254 Merck dan fase gerak yang digunakan adalah eluen (kloroform : metanol). Hasil analisis TLC menggunakan eluent kloroform : metanol (80:20 v/v) menunjukkan munculnya noda yang berwarna kuning kehitaman yang mengartikan bahwa ada senyawa flavonoid dalam ekstrak daun ciplukan dengan nilai Rf sampel adalah 0.76 yang dibandingkan dengan Rf Standart quercetin adalah 0.92.
Penentuan kadar total fenolik, total flavonoid, dan uji aktivitas antibakteri ekstrak etanol daun kerai payung (Filicium decipiens) terhadap bakteri Propionibacterium acnes dan Staphylococcus epidermis Hoswari, Cindy Natasya; Br Karo, Reh Malem; Yudha, M
Jurnal Prima Medika Sains Vol. 5 No. 1 (2023): Juni
Publisher : Program Studi Magister Kesehatan Masyarakat Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jpms.v5i1.3699

Abstract

Tanaman kerai payung (Filicium decipiens) merupakan salah satu jenis tanaman yang dapat digunakan sebagai bahan alternatif dalam pembuatan obat. Tanaman ini mengandung berbagai senyawa metabolit sekunder seperti senyawa fenolik, flavonoid, tanin, alkaloid, saponin dan terpenoid. Adapun tujuan penelitian ini adalah untuk menentukan kadar total fenolik, total flavonoid ekstrak etanol daun Filicium decipiens serta aktivitasnya terhadap bakteri Propionibacterium acnes dan Staphylococcus epidermis. Ekstrak etanol daun Filicium secipiens diperoleh melalui metode ekstraksi secara maserasi dengan pelarut etanol. Kadar total fenolik dan flavonoid ekstrak etanol daun Filicium decipiens ditentukan dengan menggunakan metode spektrofotometri UV-Visible. Penentuan kadar total fenolik dan flavonoid masing-masing menggunakan pereaksi Folin-Ciocalteau dan . Ekstrak dibuat dalam variasi konsentrasi (25%,50%%,100%) dan dilakukan pengujian aktivitas antibakteri dengan menggunakan metode difusi cakram. Berdasarkan pada hasil penelitian diperoleh bahwa kadar total fenolik dan flavonoid ekstrak etanol daun Kerai Payung masing-masing adalah 234,79 mg/GAE/g dan 4,5905 mg/QE/g. Hasil uji aktivitas antibakteri pada berbagai variasi konsentrasi ekstrak terhadap bakteri Propionibacterium acnes dan Staphylococcus epidermis diperoleh masing-masing zona hambat terbesar pada konsentrasi ekstrak 100% yaitu 17,72 mm untuk Propionibacterium acnes dan 18,18 mm untuk Staphylococcus epidermis. Zona hambat yang dihasilkan tersebut tergolong kuat.
Socialization of the Existence of Saccharin in Packaged Beverage Products in the Lubuk Pakam Area Sinurat, Jhon Patar; Br Karo, Reh Malem; Yanti, Dian Anggri; Ginting, Wira Maria; Harahap, Rahmat Ali Putra; Batubara, Khairunnisa; Telova, Yurizki
JURNAL PENGMAS KESTRA (JPK) Vol. 4 No. 2 (2024): Jurnal Pengmas Kestra (JPK)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M) Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jpk.v4i2.2418

Abstract

Food quality needs to be considered, especially for the nutrition and chemical content contained therein. One of these chemicals can act as a sweetener which can enhance the taste and aroma of a product. The artificial sweetener is saccharin, which is generally added to packaged food and beverage products. However, the permitted use of saccharin in a product is around 0.005 - 0.03%. If the quantity of saccharin exceeds the threshold, it will cause health problems such as nervous diseases, hypertension, and cancer. This socialization activity aims to educate the public to be more concerned about health by carefully reading the composition of packaged beverage products before consuming them. The Community Service activity was carried out through socialization which was attended by 20 participants, namely residents around the Lubuk Pakam sub-district. The procedure for this activity includes a pre-test, provision of materials, discussion, questions and answers, and a post-test. The increase in participant knowledge is measured based on the pre-test and post-test scores of the participants. The Community Service results showed that several packaged beverage products actually contained saccharin in amounts that exceeded the threshold. In addition, this socialization also further increases awareness and presents a more careful attitude in participants in reading the composition of packaged beverage products before consuming them. Then the results showed that there was an increase in the knowledge of Community Service participants who initially dominated the category of knowledge that was not good and quite good to good and very good. The Community Service activities through this socialization have proven to be useful in increasing participants' knowledge regarding the presence of saccharin in packaged beverage products.
Squamous cell carcinoma of the kidney: A case report Lina, Juliana; Karo, Reh Malem br; Theresia, Yohani; Fadillah, Qori
Buletin Kedokteran & Kesehatan Prima Vol. 4 No. 1 (2025): March
Publisher : Fakultas Kedokteran, Kedokteran Gigi, dan Ilmu Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/bkkp.v4i1.6544

Abstract

Primary renal squamous cell carcinoma (SCC) is a rare neoplasm strongly associated with a history of nephrolithiasis. Renal SCC is reported to have high morbidity and mortality rates, especially in the elderly population. Clinical manifestations of renal SCC are generally characterized by hematuria, flank pain, and a palpable mass in the retroperitoneal area. Histopathological examination reveals the infiltration of squamous cell nests that destroy the stroma. These cells show nuclear pleomorphism, an increased nuclear/cytoplasmic ratio, irregular nuclear membranes, coarse chromatin, prominent and dense basophilic nucleoli, and eosinophilic cytoplasm. These histopathological findings confirm the diagnosis of squamous cell carcinoma. The uniqueness of this case lies in the diagnosis of renal SCC in a relatively young age group, making it a distinct clinical concern. Further immunohistochemical examination, including CK5/6, p63, p40, and CK14 panels, is needed to determine the prognosis and appropriate treatment strategy. This case report emphasizes the importance of understanding kidney stone disease as a preventive measure against the development of renal SCC.
ANALYSIS OF RHODAMIN-B CONTENTS IN CHILI SAUCE AROUND OF THE TANJUNG MORAWA TRADITIONAL MARKET WITH UV-VIS SPECTROPHOTOMETER Sinurat, Jhon Patar; Ayuningsari, Laras; Br Karo, Reh Malem
JURNAL KESMAS DAN GIZI (JKG) Vol. 6 No. 1 (2023): Jurnal Kesmas dan Gizi (JKG)
Publisher : Fakultas Kesehatan Masyarakat Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jkg.v6i1.1956

Abstract

Current developments in food processing technology have made many food producers create variations in food products. Variations can include adding attractive food colorings so that consumers become enthusiastic. This good development is also disrupted because there are still some food producers who add synthetic food coloring which is not permitted to be used in food products. This happens because of a lack of knowledge and the desire of producers to make more profits, without thinking about the health impacts on the community. Synthetic dyes have a bad impact on human health, especially if they are not intended as food additives. Rhodamine-B is a synthetic dye that gives a bright red color to most cosmetic products. Rhodamine-B can irritate the gastric mucosa, eyes, skin, and respiratory tract, and trigger liver cancer. This type of research is quantitative using experimental methods in the laboratory. The samples tested were chili sauces with 5 different brands circulating in the Tanjung Morawa traditional market. Qualitative analysis using TLC was used to identify the presence of rhodamine-B in chili sauce. Comparative rhodamine-B levels and chili sauce were measured using a UV-Vis spectrophotometer at a maximum lambda of 545 nm. Chili sauces A, B, and D contain rhodamine-B dye as proven by TLC stains with Rf 0.92; 0.95; and 0.92. The linear regression equation obtained from the relationship between standard concentration and absorbance data is y = 0.0091x-0.009 with a coefficient of determination (R2) of 0.9988. Rhodamine-B levels in each chili sauce A, B, and D include 0.548; 0.505; and 0.496 mg/g. Regulation Number 722/Menkes/Per/IX/88 emphasizes that rhodamine-B is not permitted in food products because it is dangerous for body health.
Analysis of Hydroquinone Compounds in Whitening Body Lotion Preparations Circulating in The Community Sinurat, Jhon Patar; Husna, Miftahul; Br Karo, Reh Malem; Syarifuddin, Aminah
JURNAL KESMAS DAN GIZI (JKG) Vol. 6 No. 2 (2024): Jurnal Kesmas dan Gizi (JKG)
Publisher : Fakultas Kesehatan Masyarakat Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jkg.v6i2.2123

Abstract

Skin care has become an important part for today's women. Whitening body lotion is very necessary in maintaining skin when doing activities outside and indoors. Many Indonesian women desire to have white, clean and bright skin so they can appear attractive. An attractive appearance is very necessary in society. To achieve this, many women choose skin care products at affordable prices without paying attention to the dangers of the chemical content in them. One of the skin whitening ingredients that is often used in beauty products is the compound hydroquinone. The hydroquinone compound plays a role in preventing skin pigmentation. However, if the levels exceed 0.02% in the preparation, it will cause skin irritation, kidney function disorders and cancer. The type of research is a mixed type, namely qualitative and quantitative. Qualitatively, it will obtain data on the presence of hydroquinone and quantitatively in the form of hydroquinone levels. The samples were 5 whitening body lotion preparations circulating in Lubuk Pakam which were determined randomly and were coded A, B, C, D, and E. Qualitative analysis was carried out using the TLC method and quantitative analysis was carried out using the UV-spectrophotometric method. Visible. The results of qualitative analysis show that samples A, C, and D contain hydroquinone compounds which are characterized by the appearance of blackish brown spots with respective Rf values of 0.89; 0.96; and 0.89. Meanwhile, when qualitative analysis was carried out, the levels obtained for the three samples were 44.56% each; 5,604%; and 5,612%. Based on regulations issued by BPOM RI in 2022, it is stated that hydroquinone levels in beauty products must not exceed 0.02%. So it can be concluded that whitening body lotion preparations with sample codes A, C, and D are not recommended for use because the use limit for hydroquinone is classified as unsafe. It is recommended that people, especially women, be more selective in choosing and using beauty products.
Analisis Kandungan Pemanis Sakarin Dalam Minuman Serbuk Instan Di Sekitaran Lubuk Pakam Sinurat, Jhon Patar; Br Karo, Reh Malem; Telova, Yurizki; Rizki, Nadya
Pharmed: Journal of Pharmaceutical Science and Medical Research Vol. 7 No. 2 (2024)
Publisher : Universitas PGRI Madiun

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25273/pharmed.v7i2.21925

Abstract

Minuman merupakan salah satu produk yang paling banyak dikonsumsi oleh masyarakat. Minuman dengan cita rasa yang baik juga akan mampu menghilangkan rasa haus. Zat pemanis berperan dalam meningkatkan cita rasa dan aroma pada minuman. Pemanis buatan seperti sakarin menjadi salah satu jenis pemanis buatan yang diizinkan penggunaannya di Indonesia dengan ketentuan jumlah antara 0,005-0,03%. Jenis penelitian ini merupakan penelitian deskriptif yang mana dapat menentukan keberadaan sakarin dalam produk minuman serbuk instan. Sampel merupakan 5 buah minuman serbuk instan yang beredar di lubuk pakam. Sampel diawali dengan proses preparasi, analisis kualitatif menggunakan resorsinol, dan penentuan kadar sakarin menggunakan spektrofotometer UV-Visibel. Sampel minuman serbuk instan dengan kode C dan E terbukti mengandung pemanis sakarin saat diuji menggunakan resorsinol. Panjang gelombang maksimum 268 nm digunakan untuk mengukur absorbansi seri baku dengan rentang 0,2111 hingga 0,4437. Persamaan regresi linear yang diperoleh yaitu y = 0,006x + 0,093 dengan koefisien determinasi sebesar 0,9987. Kadar Sakarin dalam sampel C dan E adalah masing-masing sebesar 1,37% dan 0,72% yang mana jumlah ini melebihi ambang batas yang ditentukan oleh BPOM No. 11 Tahun 2019 yaitu sebesar 0.03% sehingga kurang baik untuk dikonsumsi.
Isolation and Structural Elucidation of Flavonoid Compounds from Ciplukan (Physalis angulata L.) Leaf Extract Cahya, Cucu Arum Dwi; Sinurat, Jhon Patar; Br Turnip, Nur Ulina M.; Br Karo, Reh Malem
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2667

Abstract

The exploration and utilization of herbal medicines continue to expand due to the presence of plant-derived secondary metabolites, which have been proven to prevent and treat various diseases with minimal side effects. One plant widely recognized for its medicinal properties is Physalis angulata L. (commonly known as ciplukan). Despite its frequent use in traditional medicine, particularly its leaves, limited studies have focused on the isolation of flavonoid compounds from this part of the plant. The isolation and structural elucidation of these flavonoids are essential to identify the bioactive compounds responsible for the plant's pharmacological effects. This study aimed to isolate and elucidate the chemical structure of flavonoid compounds from P. angulata leaf extract. The powdered leaves were subjected to maceration, solvent partitioning, phytochemical screening, thin-layer chromatography (TLC), and compound isolation using column chromatography. The isolated compounds were then characterized using UV-Visible (UV-Vis) spectroscopy, Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR), and mass spectrometry (MS). The flavonoid compound isolated in this study was identified as quercetin (C??H??O?), a member of the flavonol subclass. It exhibited a molecular mass of 302 g/mol and showed maximum absorbance at wavelengths of 372.5 nm and 305.5 nm. Spectroscopic analyses revealed the presence of functional groups including C–O, C=C, C=O, CH, and OH, as well as 10 hydrogen and 15 carbon atoms in the NMR spectra. Based on these data, the isolated compound was confirmed to be 3,3',4',5,7-pentahydroxyflavone, commonly known as quercetin, with the molecular formula C??H??O?.
Co-Authors Afri Abdiansyah Afri Abdiansyah Andri Hidayat, Andri Asyrun Alkhairi Lubis Ayuningsari, Laras Br Sihite, Rani Marselina Br Turnip, Nur Ulina M. Cahya, Cucu Arum Dwi Christine, Yesina Duha, Kristin Berlianta Elfia Neswita Erida Novriani etha tesalonika tamba Fadillah, Qori Fibrini, Dewi Fioni, Fioni Ginting, Wira Maria Harahap, Rahmat Ali Putra Hoswari, Cindy Natasya Husna, Miftahul Khairunnisa Batubara Lina, Juliana Manao, Merlianasari Meutia, Rena Nasution, Ali Napiah Nasution, Sri Lestari Ramadhani Natali, Oliviti Neswita, Elfia purba, marina novelly br Razoki Razoki Razoki, Razoki Rizki, Nadya Sembiring, Novitaria Br. Simanjuntak, Nerly Juli Pranita Sinurat, Jhon Patar Sirait, Reni Aprinawaty Suci Wulandari Syarifuddin, Aminah Syarifuddin, Shofian Tampubolon, Regina Elianda Tanamal, Claudia Telova, Yurizki Theresia, Yohani Wardah Fitria Tanjung Wardah Fitria Tanjung Windi Wildani Windi Wildani Yanti, Dian Anggri Yudha, M