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All Journal HAYATI Journal of Biosciences Smart Medical Journal Indonesian Journal of Cardiology Jurnal Respirologi Indonesia Jurnal Respirasi (JR) Health and Medical Journal World Nutrition Journal Sainstech Farma: Jurnal Ilmu Kefarmasian Cermin Dunia Kedokteran Indonesian Journal of Cancer eJournal Kedokteran Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Zaini, Jamal
National Medical Team COVID-19, The Indonesian Society Of Respirology, Jakarta, Indonesia Department Of Pulmonology And Respiratory Medicine, Persahabatan General Hospital, Faculty Of Medicine Universitas Indonesia, Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Fungal Profile in Patients with Lung Cancer Receiving First-Line Chemotherapy Faisal, Hana Khairina Putri; Aziziah, Aziziah; Pane, Irene Audrey Davalynn; Hasyim, Ammar Abdurrahman; Zaini, Jamal; Rozaliyani, Anna
Jurnal Respirasi Vol. 11 No. 3 (2025): September 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.3.2025.250-255

Abstract

Introduction: Patients with lung cancer are vulnerable to opportunistic infections, particularly fungal pulmonary infections such as those caused by Aspergillus spp., due to immunosuppression from both the disease and chemotherapy. Despite the clinical significance of these infections, data on their prevalence and associated factors in patients with lung cancer remain limited. This study aimed to determine the prevalence of Aspergillus spp. and identify associated factors in patients with lung cancer who underwent first-line chemotherapy at a national respiratory referral hospital in Indonesia. Methods: A cross-sectional study was conducted among 50 patients with lung cancer who had completed at least three cycles of chemotherapy. Sputum cultures were performed using Sabouraud dextrose agar (SDA), and serum immunoglobulin G (IgG) antibodies were tested using immunochromatographic assays. Demographic, clinical, and radiological data were collected. Bivariate and multivariate logistic regression analyses were used to identify factors associated with Aspergillus spp. infection. Results: Aspergillus spp. was detected in 92.0% of patients via sputum culture, with A. niger and A. fumigatus as the most common isolates. Over 30% showed co-colonization with other fungal species, such as Candida. Multivariate analysis revealed that a high Brinkman Index was independently associated with Aspergillus spp. colonization (p<0.05). Serum IgG antibody positivity was low (4%). Conclusion: There was a high prevalence of Aspergillus spp. colonization among patients with lung cancer undergoing chemotherapy, with smoking history emerging as a key risk factor. Targeted fungal screening is recommended, especially in heavy smokers, to facilitate early detection and improve outcomes.
Epidemiological and Clinical Features of COVID-19 Patients at National Emergency Hospital Wisma Atlet Kemayoran, Jakarta, Indonesia Susanto, Agus Dwi; Rozaliyani, Anna; Prasetyo, Budi; Agustin, Heidy; Baskoro, Hario; Arifin, Arief Riadi; Pratama, Satria; Zaini, Jamal; Hasto, Bambang Dwi; Ratmono, Tugas; Savitri, Ary Indriana; Samoedro, Erlang; Husain, Bahtiar; Nawas, Arifin; Burhan, Erlina
Kesmas Vol. 16, No. 5
Publisher : UI Scholars Hub

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Abstract

The emergency hospital is intended to prevent transmission of COVID-19 in the community by isolating patients without symptoms, with mild or moderate symptoms. This study evaluated the clinical characteristics and outcomes of COVID-19 patients who were admitted to this facility. This retrospective study re-viewed data of patients treated at the National Emergency Hospital Wisma Atlet Kemayoran in Jakarta, Indonesia, from March 23 to April 30, 2020. Patient characteristics (clinical symptoms, laboratory test results, Chest X-Ray, SARS-CoV-2 immunoserology, and RT-PCR results from nasopharyngeal/ oropharyngeal preparations) were compared between severity groups. There were 413 COVID-19 cases analyzed, of which 190 (46%) were asymptomatic, 93 (22.5%) were mild, and 130 (31.5%) were moderate cases. Most asymptomatic cases were male, with young age, and without comorbidity. Mild cases were dominated by female and young patients, while most moderate cases were male and older patients. The number of patients with comorbidities was higher in mild and mod-erate cases. The patient’s overall outcome was good and did not differ based on the severity of symptoms. Despite the many challenges, patients with moderate symptoms can be safely treated in the emergency hospital.
Diagnostic Value of Saliva RT-PCR Test within Suspected SARS-CoV-2 Cases in Indonesia Putra, Andika Chandra; Zaini, Jamal; Ridwanuloh, Asep Muhammad; Nugroho, Herjuno Ari; Setyawan, Ryan Haryo; Idris, Idris; Setiawan, Ruby; Sushadi, Pangda Sopha; Wulandari, Ari Sulistyo; Zannati, Anky; Indriawati, Indriawati; Erdayani, Eva; Wahyuni, Wahyuni; Agustiyanti, Dian Fitria; Wisnuwardhani, Popi Hadi; Saniyyah, Zahrah; Azika, Wira Norman; Haryanto, Budi; Utomo, Ahmad Rusdan Handoyo; Ningrum, Ratih Asmana
Health and Medical Journal Vol 6, No 2 (2024): HEME May 2024
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v6i2.1494

Abstract

Introduction: The ongoing SARS-CoV-2 pandemic has profoundly emphasized the pressing need for accurate and reliable diagnostic procedures. Given the potential health risks associated with nasopharyngeal swabs, there has been growing interest in seeking alternative diagnostic mediums. In this context, our study delved into evaluating saliva as a potential diagnostic tool, simultaneously assessing its efficiency in relation to patient demographics and their exhibited clinical symptoms. Methods: Spanning from May to December 2020, we conducted a comprehensive cross-sectional analysis. We meticulously examined medical records to gather insights on patient characteristics, existing health conditions, onset of symptoms, clinical manifestations, and compared the results obtained from both salivary and nasopharyngeal RT-PCR tests for SARS-CoV-2. Results: Among the individuals suspected of SARS-CoV-2 infection, the mean age stood at 52.4 years, with males representing 60.3% of this group. Interestingly, a significant 76.9% reported underlying health conditions, predominantly hypertension and diabetes. The most commonly reported symptoms encompassed respiratory challenges, notably coughing and shortness of breath, succeeded by symptoms like nausea, fever, and a general sense of fatigue. The performance of saliva tests, in terms of accuracy, appeared to be significantly influenced by the timing of symptom emergence. Conclusion: The RT-PCR tests utilizing saliva samples demonstrated considerable promise, especially during the early stages of symptom manifestation, providing a reliable alternative to traditional nasopharyngeal swabs. The findings suggest a superior diagnostic sensitivity when utilizing saliva during the initial phases of a SARS-CoV-2 infection.
Indonesian Society of Respirology Position Paper on Lung Cancer Control in Indonesia Andarini, Sita; Santoso, Andintia Aisyah; Arfiansyah, Mochammad Aris; Syahruddin, Elisna; Zaini, Jamal; Putra, Andika Chandra; Kurniawan, Ferry Dwi; Ermayanti, Sabrina; Soeroso, Noni Novisari; Munir, Sri Melati; Infianto, Andreas; Setijadi, Ana Rima; Setyawan, Ungky Agus; Wulandari, Laksmi; Haryati, Haryati; Jasminarti, Ida Ayu; Hidayat, Moulid; Santoso, Arif
Jurnal Respirologi Indonesia Vol 44 No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.884

Abstract

Lung cancer is a major health concern in Indonesia due to its increasing prevalence, late-stage diagnosis, younger population, and high mortality. Addressing this issue requires nationwide implementation of comprehensive lung cancer control, which includes risk reduction and prevention strategies, focusing on tobacco control and air pollution mitigation. Screening with low-dose computed tomography (LDCT) and early detection in symptomatic patients, along with TB screening programs and all non-communicable diseases, is strongly recommended to enhance early case findings, treatment effectiveness, and overall patient outcomes. A multidisciplinary team (MDT) approach is important to ensure accurate diagnosis and comprehensive care. Moreover, the integration of palliative care at the early stages of advanced lung cancer is vital, focusing on symptom management and enhancing the quality of life for patients. While national guidelines are available for the diagnosis and treatment of lung cancer, significant disparities in healthcare access remain across Indonesia. Thus, it is essential to improve universal health coverage and referral systems to guarantee equal access to lung cancer care for patients at all levels through advocacy and ease of access.
Co-Authors Abul A'la Al Maududi Achmad Hudoyo Agus Dwi Susanto Agustin, Heidy Agustiyanti, Dian Fitria Ahmad Hudoyo Ainun Wulandari Ana Rima Ana Rima Setijadi Andarini, Sita Andreas Infianto Anky Zannati Anna Rozaliyani Anwar Jusuf Arfiansyah, Mochammad Aris Arief Riadi Arifin Arif Santoso Arif Santoso Arifin Nawas Arifin Nawas Arifin, Arief Riadi Ary Indriana Savitri Astrid B Rase Azika, Wira Norman Aziza Ghanie Aziziah, Aziziah Bahtiar Husain Baiq Amalia Utami Bambang Dwi Hasto Baskoro, Hario Budhi Antariksa Budi Haryanto Budi Prasetyo Budi Prasetyo Cipuk Muhaswitri Dea Putri Audina Denny Grecius Siregar Dini Rizkie Wijayanti Drupadi Dillon Elisna Syahruddin Erdayani, Eva Erlina Burhan Ermayanti, Sabrina Ermayanti, Sabrina Erni Mudhiati Fairuzia Fiyanti Putri Faisal Yunus Faisal Yunus Faisal, Hana Khairina Putri Fariz, Nurwidya Fathiyah Isbaniyah Ferry Dwi Kurniawan Findra Setianingrum Ginindha Izzati Sabila Hana Khairina Putri Faisal Hana Khairina Putri Faisal Hario Baskoro Harris Abdullah Haryati Haryati Haryati Haryati Hasto, Bambang Dwi Hasyim, Ammar Abdurrahman Herawati Hidajat Herjuno Ari Nugroho, Herjuno Ari Hidayat, Moulid Hilma Nur Faiza Husain, Bahtiar Ida Ayu Jasminarti Idris Idris INDRA YOVI Indriawati, Indriawati Infianto, Andreas Isbaniah, Fathiyah Jasminarti, Ida Ayu Kemal Akbar Suryoadji Kemalasari Nas Darisan Kezia Alicia Theresia Manik Kurniawan, Ferry Dwi Laksmi Wulandari Lisnawati Lisnawati Mia Elhidsi Muammar Emir Ananta Muhamad Rizqy Fadhillah Muhamad Rizqy Fadhillah Muhamad Rizqy Fadhillah Mulyati Tugiran Nathaniel Aditya Noni Novisari Soeroso Pane, Irene Audrey Davalynn Popi Hadi Wisnuwardhani, Popi Hadi Prasenohadi Prasenohadi Putra, Andika Chandra RATIH ASMANA NINGRUM Ridhawati Sjam Ridwanuloh, Asep Muhammad Ririen Razika Ramdhani Robiatul Adawiyah Romi Baginta Rudi Kurniawan Samoedro, Erlang Samuel S Kamalle Saniyyah, Zahrah Santoso, Andintia Aisyah Sarah Fitriani Satria Pratama Satria Pratama Savitri, Ary Indriana Seira Putri Boru Rambe Septiyani Monalisa Setiawan, Ruby Setyawan, Ryan Haryo Setyawan, Ungky Agus Shanty R. Kusumawardani Sita Andarini Sita Andarini Sita Andarini Sita Laksmi Andarini Siti Syahral Ain Sri Melati Munir Sri Melati Munir Sushadi, Pangda Sopha Tugas Ratmono Tugas Ratmono, Tugas Utomo, Ahmad Rusdan Handoyo wahyuni wahyuni Westi ATW Wulandari, Ari Sulistyo Yayi DB Susanto Yoga Yuniadi Yuwono, Edho Zahrah Annisa