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All Journal Publikasi Pendidikan Jurnal Kesehatan Jurnal Aisyah : Jurnal Ilmu Kesehatan Jurnal Pengabdian Kepada Masyarakat Ungu ( Abdi Ke Ungu) Jurnal Ilmiah Wahana Pendidikan JIFI (Jurnal Ilmiah Farmasi Imelda) JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) Journal of Innovative and Creativity International Journal of Contemporary Sciences (IJCS)
Suswidiantoro, Vicko
Universitas Aisyah Pringsewu
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Education Electrical & Electronics Engineering Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Synergistic Antihyperglycemic Effects of Soursop Leaves and Garlic in Alloxan-Induced Rats Suswidiantoro, Vicko; Safutri, Wina; Pratiwi, Mida; Putri, Diah Karika; Dwiningrum, Riza; Lestari, Fina Aulika
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 12 (2024): October 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v1i12.12038

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder characterized by elevated blood glucose levels due to impaired insulin production. Natural remedies, such as soursop leaves (Annona muricata) (SL) and garlic (Allium sativum) (GAR), are known for their antihyperglycemic properties. This study aimed to investigate the effects of SL and GAR extracts, individually and in combination, on reducing blood glucose levels in alloxan-induced diabetic rats. A total of 24 male Wistar rats were divided into six groups, receiving treatments of either metformin, SL, GAR, or their combination for seven days following alloxan administration to induce hyperglycemia. Blood glucose levels were measured before and after induction, and post-treatment on day 15. The results showed that the combined extracts exhibited better antihyperglycemic activity compared to individual treatments, with the most effective dose being 26.3 mg/kg BW SL + 31.5 mg/kg BW GAR.
The Caffeine Analysis in Tea Bag and Robusta Coffee Using UHPLC Methods Sutomo, Ahmad; Ridwan, Muhammad; Suswidiantoro, Vicko; Pisacha, Iga Mayola; Daskar, Annajim; Rosanti, Afi Sania
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 12 (2024): October 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v1i12.12040

Abstract

Caffeine, a natural psychostimulant, enhances arousal by inhibiting the effects of adenosine on the dopamine pathway. This study aimed to analyze and compare caffeine concentrations in seven robusta coffee samples (coded RC) and five black tea bags (coded BT) using both qualitative and quantitative methods. Qualitative tests employed Dragendorff reagents for coffee and Parry reagents for tea, confirming caffeine presence through colorimetric changes. Quantitative analysis utilized reverse-phase UHPLC, with a mobile phase of aquabidestilata and methanol (60:40), a C18 stationary phase at 40°C, and detection at 272 nm. Validation parameters demonstrated strong performance, with an RSD of 0.573%, a linear correlation coefficient of 0.998 for concentrations between 100–250 ppm, a LoD of 1.02 ppm, a LoQ of 3.10 ppm, and 99.88% accuracy. Results showed robusta coffee sample RC3 contained the highest caffeine concentration at 26.00 mg/serving, while black tea sample BTB3 exhibited 2.44 mg/serving. Despite higher caffeine levels in robusta coffee compared to black tea, both remained below the SNI threshold of 50 mg/serving, confirming their safety for consumption.
UJI AKTIVITAS ANTIFUNGI KOMBINASI EKSTRAK UMBI BAWANG PUTIH (Allium sativum L) DAN DAUN SIRIH MERAH (Piper ornatum N.E.Br) TERHADAP PERTUMBUHAN Candida albicans Artadevy, Nadhila Fahira; Daskar, Annajim; Suswidiantoro, Vicko; Safutri, Wina
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 1 (2025): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i1.2001

Abstract

Candida infection caused by Candida albicans is a common health problem, especially in the skin and female reproductive organs. In Indonesia, the prevalence of candidiasis is around 20–25%, with a predominance in the hair, skin, mucous membranes, mouth, and esophagus. In Lampung Province, candidiasis incidents include severe intertrigo (56%), mild intertrigo (44%), axillary candidiasis (52%), and breast candidiasis (20%). This study aimed to evaluate the antifungal activity of a combination of garlic bulb (Allium sativum L.) and red betel leaf (Piper ornatum N.E.Br) extracts against the growth of Candida albicans. This study used a laboratory experimental method with a Completely Randomized Design (CRD), consisting of a negative control (distilled water), a positive control (fluconazole), and a combination of extracts with a ratio of 20%:20%, 20%:40%, and 40%:40%. The extract was obtained through maceration method, and antifungal activity was measured based on the inhibition zone. Phytochemical tests showed the presence of active compounds such as saponins, flavonoids, alkaloids, tannins, and steroids that act as antifungals. The results of the disc diffusion test showed the average diameter of the inhibition zone as follows: 0 mm (negative control), 6.49 ± 1.05 mm (positive control), 2.9 ± 0.26 mm (P1, weak), 4.15 ± 1.57 mm (P2, weak), 5.68 ± 2.73 mm (P3, moderate), and 6.81 ± 1.92 mm (P4, moderate). Statistical tests showed significant differences between negative and positive controls and treatments 2 and 3. In conclusion, the combination of garlic and red betel leaf extract, especially P4, has antifungal potential against Candida albicans.
The Correlation Between Mothers’ Knowledge Level And Polio Immunization Coverage At Dahlia Integrated Healthcare Center Of Datarajan saputra, adi; Suswidiantoro, Vicko; Aulika Lestari, Fina; Kartika Putri, Diah
JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) Vol. 4 No. 3 (2025): JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI)
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/js.v4i3.4306

Abstract

Polio is a dangerous contagious disease that continues to threaten children, with recent cases re-emerging in Indonesia due to low immunization coverage. A lack of maternal knowledge has been identified as one of the main barriers to the success of polio immunization programs. This study aims to analyze the correlation between mothers’ knowledge level and polio immunization coverage among children at Dahlia Integrated Healthcare Center of Datarajan Village. A quantitative cross-sectional study was conducted from February to April 2025 in Datarajan Village of Tanggamus Regency, involving 47 respondents. Data were collected using a questionnaire on mothers’ knowledge and children’s immunization status and analyzed using univariate and bivariate methods. The results showed that most mothers had a “Moderate” level of knowledge (53%), while the majority (91%) of children had received complete polio immunization. Statistical analysis revealed no significant correlation between mothers’ knowledge level and completeness of polio immunization p value 0,071. The high coverage of complete immunization despite varying knowledge levels highlights the important role of reminders provided by local midwives in ensuring immunization completion. Factors such as a child’s illness were cited as reasons for incomplete immunization. In conclusion, no significant correlation was found between mothers’ knowledge level and polio immunization coverage. The completeness of immunization was more strongly influenced by the proactive role of healthcare workers in reminding parents of immunization schedules.
Optimization of Lip balm Formulation Containing Beetroot Extract (Beta Vulgaris L.) With a Combination of Grapeseed oil and Avocado oil Using the Simplex Lattice Design Method ananda, ardini; Rosanti, Afi Sania; Dwiningrum, Riza; Suswidiantoro, Vicko
JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) Vol. 4 No. 3 (2025): JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI)
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/js.v4i3.4318

Abstract

Lip balm, as a semi-solid preparation, can be used to moisturize and protect the lips from dryness and chapping. The use of natural colorants and emollients derived from natural sources is considered safer and more environmentally friendly. Beetroot (Beta vulgaris L.) contains betacyanin as a natural pigment, while grapeseed oil and avocado oil provide emollient properties that help moisturize and nourish the lips. This study aimed to optimize the lip balm formulation containing beetroot extract, grapeseed oil, and avocado oil using Design Expert software version 13 through the Simplex Lattice Design (SLD) method. Ten formulations were produced and evaluated for pH, spreadability, and adhesiveness. The results showed that variations in composition affected the physical characteristics of the lip balm. Grapeseed oil improved spreadability, while avocado oil influenced pH and enhanced adhesiveness. The combination of the three ingredients exhibited synergistic and antagonistic interactions on the physical properties depending on the proportion of each component. The optimum formula was obtained in formulation 5, with a composition of 10% beetroot extract, 10% avocado oil, and 5% grapeseed oil, yielding a desirability value of 1.000. Validation results showed good agreement between predicted and experimental data. Statistical validation using the Wilcoxon test and one-sample t-test indicated p-values > 0.05,suggesting no significant differences. Thus, the model was validated and considered reliable for predicting formulation outcomes. This study successfully optimized a natural lip balm formulation with desirable physical properties, highlighting the potential of beetroot extract as asafe natural colorant in combination with emollient oils.
Antibacterial Effectiveness Test on the Combination of Kersen Leaf (Muntingia calabura L.) and Jackfruit Leaf (Artocarpus heterophyllus L.) Extracts Against The Growth of Staphylococcus aureus Bacteria Mahendri, Adelia Citra; Suswidiantoro, Vicko; Pratiwi, Mida; Pisacha , Iga Mayola
JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI) Vol. 4 No. 3 (2025): JURNAL KESEHATAN, SAINS, DAN TEKNOLOGI (JAKASAKTI)
Publisher : LPPM Universitas Dhyana Pura

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36002/js.v4i3.4366

Abstract

Kersen leaves (Muntingia calabura L.) and jackfruit leaves (Artocarpus heterophyllus L.) are tropical plants that grow in Indonesia. The phytochemical content of kersen leaves and jackfruit leaves include flavonoids, tannins and saponins. Flavonoids have antibacterial properties because they can fight bacteria in several ways. These substances can interfere with the formation of bacterial genetic material (nucleic acids), damage cell membranes that maintain the contents of bacterial cells, and inhibit the processes used by bacteria to produce energy. This study aims to determine the effectiveness of secondary metabolite compounds against the growth of Staphylococcus aureus bacteria contained in kersen leaves and jackfruit leaves. The research method used is experimental. The sample in this study was a combination of 96% ethanol extract of kersen leaves (Muntingia calabura L.) and jackfruit leaves (Artocarpus heterophyllus. L). The yield of extracts obtained in kersen leaves amounted to 32.1% and avocado leaves 25.42%. Phytochemical screening showed that both samples contained secondary metabolites such as flavonoids, tannins and saponins. The combination of kersen leaf and jackfruit leaf extracts at a concentration ratio of 80:50% and has an average inhibition zone with high effectiveness of 11.10 mm which is classified as strong. This shows that there is a difference, the inhibition zone is better than ampicillin in inhibiting Staphylococcus aureus bacteria.
Uji Aktivitas Antioksidan Kombinasi Ekstrak Buah Tomat (Solanum Lycopersicum L.) Dan Buah Pepaya (Carica Papaya L.) Menggunakan Metode DPPH Vicko Suswidiantoro; Novi Ana Nurlaili; Indah Safitri; Amanda Tirtasena; Kiki Ariska; Mela Annisa; Mela Kurniasari; Wina Safutri; Riza Dwiningrum
Journal of Innovative and Creativity Vol. 5 No. 2 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i2.1675

Abstract

Free radicals are unstable molecules that can cause cell damage and trigger various degenerative diseases. One effort to inhibit the adverse effects of free radicals is to use antioxidants. Tomato fruit (Solanum lycopersicum L.) and papaya fruit (Carica papaya L.) are known to contain various antioxidant compounds such as lycopene, vitamin C, flavonoids, and phenolics. The purpose of this study was to determine the antioxidant activity of a combination of tomato and papaya fruit extracts using DPPH (2,2-diphenyl-1-picrylhydrazyl) method and determine the best value of IC₅₀ from three comparisons of extract combinations. This type of research is a qualitative and quantitative experimental study. Tomato and papaya fruits were extracted using maceration method with 96% ethanol. The result of this study was that in three comparisons the combination of tomato and papaya extracts, 25%:75%, 50%:50%, and 75%: 25% based on IC50 parameters showed very strong antioxidant activity. The ratio of 25%: 75% resulted in the value of IC50 of 2.44 ° 0.003 ppm, the ratio of 50%: 50% of 2.14 ° 0 ppm, and the ratio of 75%: 25% of 2.4710 ° 0.003 ppm. The conclusion of this study is that in the statistical test comparison of the combination of tomato and papaya extracts, the three comparisons have a very strong antioxidant activity and there is no significant difference, with a significance value of p = 1,000.
Formulasi Sediaan Krim Tabir Surya Ekstrak Etanolik Daun Leunca (Solanum Nigrum L.) Dan Uji Sun Protection Factor (SPF) Vicko Suswidiantoro; Dila Cindy Reptiana; Haikal Nur Islam; Hazballah Asy Syifa; Miftah Khoirun Nissa; Audya Zahra; Eva Nurul Baity; Wulan Cahya Indah; Wina Safutri; Riza Dwiningrum; Mida Pratiwi; Iga Mayola Pisacha
Journal of Innovative and Creativity Vol. 5 No. 2 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i2.1873

Abstract

Human skin is a very important organ because it is located on the outside of the body and functions to receive external stimuli such as touch, pain, and other influences. One cause of damage is ultraviolet (UV) rays. Leunca leaves (Solanum nigrum L.) have high antioxidant activity, which is associated with their flavonoid content, especially quercetin and kaempferol. The purpose of this study was to determine the characteristics of sunscreen cream preparations from ethanolic extract of leunca leaves (Solanum nigrum L.) and to determine the concentration of ethanolic extract of leunca leaves (Solanum nigrum L.) in cream preparations that provide good sunscreen potential based on the Sun Protection Factor (SPF) value. The method used was experimental in making sunscreen cream preparations with concentrations F1 (0.05%), F2 (0.10%), F3 (0.20%) and F4 (0.30%). Physical quality tests, organoleptic tests, homogeneity tests, Ph tests, spreadability tests, and adhesion tests were carried out. protection power test, viscosity test, cream type test and SPF value test. In the four formulations meet the physical quality test requirements that distinguish them are in the Sun Protection Factor (SPF) value. The best is in formulation 4, which is 2.19, which is included in the minimum protection
Evaluasi Pelayanan Informasi Obat Terhadap Kepuasan Pasien di Instalasi Farmasi Rumah Sakit Ibu dan Anak Restu Bunda Teluk Betung Tahun 2025 Elsya Azis Suryani; Vicko Suswidiantoro; Mida Pratiwi; Diah Kartika Putri; Riesce Octa Verantika
Journal of Innovative and Creativity Vol. 5 No. 2 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i2.2147

Abstract

Pemberian informasi obat memiliki peranan penting dalam memperbaiki kualitas hidup dari pasien dan menyediakan pelayanan yang bermutu bagi pasien sehingga menurunkan ketidakpatuhan pasien. Kelengkapan pelayanan informasi obat pada pasien sangatlah berpengaruh terhadap kepuasan pasien, kepuasan pasien dapat dipengaruhi oleh beberapa hal diantaranya adalah pemberian informasi yang baik, keramahan tenaga kefarmasian, kecepatan pelayanan, ketersediaan obat, kebersihan ruang tunggu, serta ketersediaan media sebagai informasi obat. Tujuan penelitian ini untuk mengetahui pelayanan informasi obat, Tingkat kepuasan pasien, dan hubungan pelayanan informasi obat terhadap kepuasan pasien rawat jalan di Instalasi Farmasi Rumah Sakit Ibu dan Anak Restu Bunda Teluk Betung Tahun 2025. Penelitian ini merupakan penelitian analitik dengan metode pendekatan kuantitatif. Populasi pada penelitian ini adalah pasien rawat jalan di RSIA Restu Bunda Teluk Betung Tahun 2025. Teknik sampling yang digunakan adalah purposive sampling dengan jumlah sampel 110 pasien. Pengumpulan data menggunakan kuisioner. Analisis data menggunakan uji non-parametrik chi square untuk mengetahui hubungan antar variable. Hasil penelitian pelayanan informasi obat yang diberikan dengan kategori baik sebanyak 89 pasien (80,9%), Tingkat kepuasan pasien tergolong pasien merasa puas sebanyak 88 pasien (80%) Dan didapatkan hasil korelasi pearson signifikansi sebesar 0,021 (p 0,05). Berdasarkan hasil tersebut terdapat hubungan pelayanan informasi obat dengan kepuasan pasien di Instalasi Farmasi Rumah Sakit Ibu Dan Anak Restu Bunda Teluk Betung Tahun 2025.
Formulasi dan Evaluasi Sediaan Body Scrub Kombinasi Ekstrak Daun Salam (Syzygium polyanthum (Wight.) Walp. dan Beras Putih (Oryza sativa L. ) Sebagai Antioksidan Riza Dwiningrum; Mida Pratiwi; Vicko Suswidiantoro; Clarissa Helmavicha Amanda
Journal of Innovative and Creativity Vol. 5 No. 2 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i2.2247

Abstract

Body scrub is a cosmetic that acts as an exfoliator, which has the ability to remove dead skin cells and provide protection to the skin from free radical attacks. One of the natural ingredients that can be used as raw material for body scrub is bay leaf (Syzygium polyanthum (Wight.) Walp) and white rice (Oryza sativa L.) with flavonoids, tocopherols, and tocotrienols that act as natural antioxidants. The study purpose was: This study aims to determine the physical quality characteristics and antioxidant activity of bay leaf and white rice extract body scrub preparations using UV-Vis spectrophotometry. Materials and methods. The method used in the study was experimental in the laboratory by making three formulations of body scrub concentrations FI (3%,10%), FII (6%,10%), and FIII (9%,10%). Results: The results of the study stated that the three formulas met the requirements of the physical quality test, but did not meet the protective power test and the preparations had different antioxidant values, where the best formula that had a very strong antioxidant activity value was in formula III with an IC50 value obtained of 45.452, which was included in the very strong category. Conclusions. The research conducted is expected to be an initial reference for further researchers to conduct pharmacological activity tests such as antibacterial or anti-inflammatory in vivo to support the further benefits of the preparations made.
Co-Authors Abdul Mun'ím Abdul Mun’im Adi Saputra Afi Sania Rosanti Ahmad Zul Khoiri Aini, Sarifatul Amanda Tirtasena ananda, ardini Andika Wahyu Saputra Anggun Fitria Annajim Daskar Annies Surya Utami Annisa Zahra Artadevy, Nadhila Fahira Audya Zahra Aulika Lestari, Fina Bastian, Arif Alexander Bayu Satriawan, Ahmad Clarissa Helmavicha Amanda Damayanti Abdul Karim, Dewi Daskar, Annajim Deswita, Dwi Diah Kartika Putri Diah Kartika Putri Dila Cindy Reptiana Dimas Thoriq Muhammad Iqbal Edy Syamsuri Eka Pratiwi Yunianti Eka Selviyana Elsya Azis Suryani Eva Nurul Baity Fadia Zahra, Alya Fadlina Chany Saputri Fikriya Ridlawati Gustianing, Defy Haikal Nur Islam Hazballah Asy Syifa Iga Mayola Pisacha iga mayola pisacha Iga Mayola Pisacha Indah Safitri Jelita Kartika Juliatika Kurniawati Kaka Widi Rahayu Kartika Putri, Diah Katika Putri, Diah Kiki Ariska Lestari, Fina Aulika Linatul Arifah M.Syarif Alhauri Mahendri, Adelia Citra Mayola Pisacha, Iga Mela Annisa Mela Kurniasari Mida Pratiwi Mida Pratiwi Miftah Khoirun Nissa Miftausakina, Taufiki Miko Nanda Kusuma Muhammad Ridwan Mun'im, Abdul Novi Ana Nurlaili Nurazizah, Amalia Siti Pisacha , Iga Mayola Pisacha, Iga Mayola Pratama, Dimas Feriza Pratama Puspita, Cici Chandra Putri, Diah Karika Putri, Diah Kartika Riesce Octa Verantika Riska Reza Novita Riza Dwiningrum Riza Dwiningrum Riza Dwiningrum, Riza Rosanti, Afi Sania Safitri, Indah Salsa Della Ananta Putri Saputra, Cahya Agung Sari, Yuhana Satriawan, Ahmad Bayu Septiana, Elen Suci Humayroh Sucipto, Ajeng Afriliana Sutomo, Ahmad Syaifurrahman, Amir Tanjung, Salsabila Adelia Tias Eka Rahmawati Triyani Anggun Sari Sari Turisma Alfi Arizona Vera Tri Anjani Wibowo, Catur Ari Wina Safutri Wina Safutri Wulan Cahya Indah Yanti, Erna Yeni Aryanti