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TOTAL BACTERIA AND IDENTIFICATION OF PROTEOLYTIC RUMINAL AND RETICULUM BACTERIA FROM LOCAL KACANG GOAT Safika, Safika; Darmawi, Darmawi; Ramadhani, Fitria Sari; Nurhaspika, Nurhaspika; Moliwati, Moliwati
Jurnal Kedokteran Hewan Vol 12, No 1 (2018): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v12i1.9288

Abstract

This study aimed to calculate the total bacteria and to identify the proteolytic bacteria in rumen and reticulum of local Kacang goat. The samples used were the rumen and reticulum fluids of five goats at abattoirs in Banda Aceh. Isolation of proteolytic bacteria was carried out using skim milk agar with pour plate method and incubated at 39 C for 48 hours. The bacterial colonies morphology was observed and the total bacterial count was recorded. DNA of the widest proteolytic index colony was isolated, amplified, and sequenced. The results showed that the dominant colonies morphology was white with position inside the agar. The average of total proteolytic bacteria in goat rumen fluid and reticulum fluid were 6.416x106 CFU/mL and 2,382x107 CFU/mL, respectively. Isolates with the widest proteolytic index was Ru3 (2.5 mm) in the rumen which homology and phylogenetic tree analysis of 16S rRNA showed 93% sequence similarity with Bacillus subtilis, while in reticulum was Re1 (2.0 mm) which has 92% sequence similarity to Tatumella. It is concluded that the number of proteolytic bacteria in reticulum is greater than the number of proteolytic bacteria in the rumen of local kacang goat. Homology analysis in this study proved that the Ru3 and Re1 isolate were probably either a new species or unconfirmed species.
Uji Kekerasan Terhadap Alumunium dan Baja Karbon Rendah Hasil Rendaman Media Konsentrasi Asam Klorida 3% MS, Firdaus; Bayin, Darmawi; Yuliani, Yuliani; Saud, Eddy; Prasetyo, Sugeng; Mukamal, M. Farda Insan
TURBO [Tulisan Riset Berbasis Online] Vol 13, No 1 (2024): TURBO : Jurnal Program Studi Teknik Mesin
Publisher : Universitas Muhammadiyah Metro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24127/trb.v13i1.3285

Abstract

Penelitian ini bertujuan untuk meneliti pengaruh perendaman media Asam klorida konsentrasi 3% terhadap kekerasan Alumunium dan Baja karbon. Bahan yang digunakan dalam penelitian ini adalah baja karbon rendah AISI 1018, aluminium 6061, asam klorida (HCl) 3 %, air. Uji kekerasan menggunakan Mesin Rockwell (HRC type C). Hasil uji kekerasan menunjukan baja karbon rendah lebih keras dibandingkan alumunium. Sebab kedua spesimen memiliki perbedaan struktur mikro dan kepadatannya. Dan juga hasil diatas menunjukan bahwa benda uji yang telah direndam dilarutan HCl tingkat kekerasannya berkurang sebab telah terjadi proses korosi dan pelunakan struktur mikronya.
Diagnosis and medical treatment of otitis externa in a ragdoll cat: A case report Usrina, Nora; Habibie, Maulana; Darmawi, Darmawi; Amiruddin, Amiruddin; Zulkifli, Baidillah; Yusriani, Yenni
The International Journal of Tropical Veterinary and Biomedical Research Vol 8, No 2 (2023): Vol. 8 (2) November 2023
Publisher : The Faculty of Veterinary Medicine of Syiah Kuala University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/ijtvbr.v8i2.35836

Abstract

Otitis is a disease that is often found due to the cat's ears being unclean and causing earwax to build up along with fluid. Otitis is caused by inflammation of the epithelium of the ear canal and also surrounding structures such as the external auditory meatus and pinna. A 3-month-old Ragdoll cat, male, with white and black hair on the ears, was examined with complaints of head tilting and frequent head shaking, pus in the ears, and inflammation. Clinical examination revealed erythema. The ear wax swab examination results showed an Otodectes cynotis mite infection. The results of the bacterial culture examination showed the presence of Klebsiella sp bacterial infection. The animal was diagnosed with otitis externa. Treatment for otitis externa is given by Dexamethasone, Erlamycetin (Chloramphenicol 1%), Ivermectin, and lidocaine. The accumulated earwax is also cleaned using a cotton bud and saline. Five days after therapy the cat showed recovery.
The Influence of Gadgets on the Morals of Teenagers in Sarolangun Jambi Province Darmawi, Darmawi; Kamaludin, Saman; Angraini, Nani; Suparno, Suparno; Ofiani, Oktawini
Al Qalam: Jurnal Ilmiah Keagamaan dan Kemasyarakatan Vol. 19, No. 6 : Al Qalam (November 2025)
Publisher : Sekolah Tinggi Ilmu Al-Qur'an (STIQ) Amuntai Kalimantan Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35931/aq.v19i6.5115

Abstract

The development of information technology has had a significant impact on the lives of adolescents, including in Sarolangun Regency, Jambi Province. The massive use of gadgets affects various aspects of adolescent life, one of which is morality because morality is a person's behavior or attitude that arises from within, which is based on moral and ethical values. This article aims to analyze the influence of gadget use on adolescent morality in Sarolangun using a qualitative descriptive approach. Data were collected through literature studies from various journals, mass media, and academic books. The results of the analysis show that gadget use has both positive and negative influences on adolescent morality in Sarolangun, Jambi Province. Positive influences include access to educational information and the development of digital skills as well as facilitating access to lessons, while negative influences include decreased social interaction, increased aggressive behavior, and decreased compliance with social norms regarding parents and prevailing social norms in society. This requires the active role of parents, educators, and the community in guiding the wise use of gadgets to shape adolescent morality that is good and beneficial for themselves and society.
Culturally Responsive Humanistic Islamic Education among the Anak Dalam Indigenous Community Darmawi, Darmawi; Warsah, Idi; Fakhruddin, Fakhruddin
Journal La Edusci Vol. 6 No. 5 (2025): Journal La Edusci
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallaedusci.v6i5.2627

Abstract

This study explores the implementation of Islamic Religious Education within the Suku Anak Dalam communities of Bukit Duabelas by examining how a humanistic approach enables religious learning to unfold in ways that honor cultural identity and everyday lived experience. Using a qualitative case study design, the research draws on in depth interviews, participatory observations, and document analysis to understand how Islamic teachings are introduced, interpreted, and gradually internalized in communities shaped by semi nomadic movement, strong ancestral traditions, and an oral knowledge system. The findings reveal that religious learning emerges most meaningfully when educators adopt flexible and dialogical strategies such as storytelling, modeling, and culturally grounded conversations that align with the emotional pace and social rhythms of the community. These approaches allow Islamic values to intersect naturally with local wisdom related to solidarity, ecological ethics, and kinship obligations. The study also identifies persistent challenges, including low literacy levels, the enduring authority of adat, and limited access to formal educational resources, which require educators to negotiate teaching with sensitivity and patience. Despite these constraints, observable social transformations indicate growing familiarity with Islamic practice, particularly among children and women. The study concludes that a humanistic and culturally responsive orientation is essential for fostering inclusive and sustainable religious education in indigenous settings and contributes to broader discussions on the development of contextually grounded Islamic pedagogy in multicultural societies
Ki-67 Expression and Histopathological Type, Metastatic Status, and Risk Factors in Lung Cancer Khairani, Muhammad; Munir, Sri Melati; Darmawi, Darmawi; Yovi, Indra; Esha, Indi; Fauzi, Zarfiardy Aksa; Zahtamal, Zahtamal
Jurnal Respirasi Vol. 12 No. 1 (2026): January 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.1.2026.35-43

Abstract

Introduction: Lung cancer remains a leading cause of cancer-related morbidity and mortality worldwide. In Indonesia, the incidence and death rates associated with this disease remain alarmingly high. Ki-67 is a potential biomarker for assessing cellular proliferation and metastatic potential. However, its clinical application in lung cancer remains inconsistent. This study aimed to analyze the association between Ki-67 expression and histopathological subtype, metastatic status, and clinical risk factors in patients with lung cancer. Methods: This study enrolled 42 patients diagnosed with lung cancer at Arifin Achmad General Hospital, Pekanbaru, Indonesia. Statistical analysis used the Chi-square or Fisher’s exact test (non-parametric tests) for categorical data and the Kolmogorov-Smirnov test, depending on the data characteristics. Participants were selected based on predefined inclusion criteria, complete medical documentation, and available Ki-67 immunohistochemistry results. Results: Among the 42 patients analyzed, 34 (80.9%) exhibited metastasis. The findings revealed a significant correlation between Ki-67 expression and metastasis (p=0.0038), whereas no significant associations were observed with age, sex, smoking status, or histopathological classification. Most patients (approximately 69%) had low Ki-67 expression. Conclusion: Ki-67 expression was associated with metastatic status in patients with lung cancer and might serve as a prognostic biomarker. Further studies with larger sample sizes are needed to validate these findings.
Bioinformatics Analysis of Potential Targets of Betulinic Acid Against Virulence Factors of Chlamydia trachomatis Nurani, Erla; Roza, Putri Diana; Darmawi, Darmawi; Irham, Lalu Muhammad; Adikusuma, Wirawan; Anggraini, Dewi
Jurnal Ilmiah Kesehatan (JIKA) Vol. 7 No. 3 (2025): Volume 7 Nomor 3 Desember 2025
Publisher : Sarana Ilmu Indonesia (Salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v7i3.1465

Abstract

Chlamydia trachomatis is an obligate intracellular pathogen responsible for trachoma and sexually transmitted infections, with rising antibiotic resistance posing a major therapeutic challenge. Natural compounds such as betulinic acid, a pentacyclic triterpenoid with broad-spectrum antimicrobial and anti-inflammatory properties, offer potential as alternative therapeutic agents. This study aimed to analyze the potential targets of betulinic acid against C. trachomatis virulence factors using bioinformatics approaches. Protein–compound interaction prediction was performed using STITCH v5.0, while virulence classification was analyzed through VICMpred and VirulentPred. BepiPred v2.0 was employed to identify B-cell epitopes, and PSORTb v3.0 was used to predict subcellular localization. The results identified five proteins targeted by betulinic acid, including DNA topoisomerase IV subunit B (parE), DNA topoisomerase IV subunit A (parC), DNA gyrase subunits (gyrA and gyrB), and sulfite reductase (cysJ). Among these, three were classified as virulence factors: parE (0,2959), parC (0,1754), and cysJ (0,4018). Subcellular localization analysis showed that parE and parC are cytoplasmic proteins essential for DNA replication, while cysJ is associated with the cytoplasmic membrane and metabolic processes. Betulinic acid showed strong potential as an antimicrobial compound targeting key virulence proteins of C. trachomatis. These findings provide foundational insight for further experimental studies to develop betulinic acid–based therapeutic strategies against chlamydial infections.
Co-Authors A, Yufrizal Ademi, Gressha Vionalle Aini, Sabrina Ambiyar, Ambiyar Amiruddin Amiruddin Anas, Marnisyah Aneka Firdaus Angraini, Nani Angreini, Meliyantika Annisa, Aiza Apriyan, Dian Arenja, Regina Trisya Arman Sayuti Arsih, Ulfi Widi Arwizet Arwizet, Arwizet Awaluddin Awaluddin Beočanin, Anđelija Budi Syahri budianto panjaitan Chatarina Umbul Wahyuni Dewi Anggraini Dion, Selin Dwinna Aliza Dwisnu, Erlian Erianza, Dava Erwin Erwin Esha, Indi Etriwati E Fadhil Fuad Rachman Fakhruddin Fakhruddin Ferdian, Riyan Giovani, Edo Habibie, Maulana Hasan, Denny Irmawati Hasan, Maryatun Helmi, T. Zahrial Heni Pujiastuti Husni Hidayat Idi Warsah INDRA YOVI Irwin Bizzy Jamil, Kurnian Fitri Kamaludin, Saman Khairani, Muhammad Khairussyifa, Najmi Kurnia F. Jamil Kusuma, Herwin Wijaya Lalu Muhammad Irham Liansyah, Tita M. M Amin Indra Putra M. Nur Salim M. Syukri Ismail Maimun Syukri, Maimun Maryanti, Yossi Moliwati, Moliwati MS, Firdaus Mukamal, M. Farda Insan Muslim Akmal N. Nazaruddin Nathania, Auren Ningrum, Sania Devita Nora Usrina Nurani, Erla Nurhaspika, Nurhaspika Nuzul Asmilia Ofiani, Oktawini Pangaribuan, Machyuddin Tumpak Marojahan Prawana, Yogi Ramadhani, Fitria Sari Razali Daud Razali, Renardy Reza Roza, Putri Diana S, Donel Safika S, Safika Saud, Eddy Setiawan, Sepdirama Sibuan, Sibuan Siti Aisyah Solly Aryza Sri Melati Munir Sugeng Prasetyo Sugito - Suhandri, Wiwin Sukma, Zahwa Tamara Sumanto Sumanto Suparno Suparno Syafruddin Syafruddin Tabrani, Tabrani Taufiq Taufiq Ummu Balqis Usman, Said Wenny Novita Sari Winarto Winarto Wirawan Adikusuma Wiwit Ade Fidiawati Yenni Yusriani Yuliani Yuliani Zahra, Leina Putri Zahtamal Zahtamal Zamzami, Rumi Sahara Zarfiardy Aksa Fauzi Zikra, Izza Fattalia Zulkifli, Baidillah Zuraidawati Zuraidawati, Zuraidawati