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All Journal JURNAL PENGABDIAN KEPADA MASYARAKAT Universa Medicina JURNAL IBNU SINA BIOMEDIKA Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Sumatera Medical Journal Abdimas Universal JURNAL ILMIAH MAKSITEK Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Kedokteran STM (Sains dan Teknologi Medik)
Delyuzar, Delyuzar
Universitas Sumatera Utara
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences

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Hubungan antara Ekspresi CD-10 dan Grading Histopatologi Karsinoma Payudara Invasif Fitri Dewi Ismida; Soekimin; Delyuzar
Majalah Patologi Indonesia Vol. 28 No. 2, Mei 2019
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

Latar belakangKarsinoma payudara invasif merupakan suatu keganasan epitelial payudara yang ditandai oleh invasi sel-selepitel ke dalam stroma. Secara global, insidensi karsinoma payudara invasif menduduki peringkat tertinggi danterus meningkat dari tahun ke tahun. Pada jaringan payudara normal, ekspresi CD-10 terlokalisir pada sel-selmioepitel dan tidak teridentifikasi pada stroma. Demikian juga, pada ductal carcinoma in situ (DCIS), CD-10tidak terekspresi pada stroma. Namun pada karsinoma payudara invasif CD-10 akan terekspresi pada stroma.CD-10 merupakan suatu cell-surface zinc-dependent metalloproteinase yang sering direkomendasikan sebagaimarker leukemia limfoblastik. Beberapa penelitian telah dilakukan untuk menilai hubungan antara ekspresi CD10 dan grading histopatologi karsinoma payudara invasif, namun sampai kini hasilnya masih kontroversi.Tujuan penelitian ini untuk menganalisis hubungan antara ekspresi imunohistokimia CD-10 dan gradinghistopatologi karsinoma payudara invasif.MetodePenelitian ini merupakan penelitian deskriptif analitik dengan pendekatan cross sectional. Sampel penelitianadalah blok parafin, berasal dari jaringan payudara yang didiagnosis secara histopatologi sebagai karsinomapayudara invasif. Sampel dipulas dengan teknik immunohistokimia menggunakan CD-10; dan kemudianekspresi CD-10 dianalisis dengan uji Kruskal-Wallis.HasilBerdasarkan analisa statistik Kruskal-Wallis terhadap 60 sampel kasus karsinoma payudara invasif mengujihubungan ekspresi imunohistokimia CD-10 dengan grading histopatologi karsinoma payudara invasif, diperolehp-value=0,0001 (p<0,05).KesimpulanEkspres
Hubungan Jumlah Sel Mast dengan Tampilan Ekspresi Vascular Endothelial Growth Factor (VEGF) pada Cutaneous Squamous Cell Carcinoma Edi Kerina Sembiring,; Delyuzar; Soekimin
Majalah Patologi Indonesia Vol. 28 No. 3, September 2019
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

BackgroundThe most common non-melanocytic skin cancers are basalioma and squamous cell carcinoma. Squamouscell carcinoma is a malignancy of squamous epithelium. Mast cells stimulate neovascularization andangiogenesis in multiple tumors. One of the main factors of angiogenesis in squamous cell carcinoma isthe Vascular Endothelial Growth Factor (VEGF). The aim of this study is to investigate the associationbetween number of mast cells with the expression of VEGF of cutaneous squamous cell carcinoma.MethodsThis is an analytical descriptive study with cross sectional approach. The sample of this study are paraffinblocks of skin tissue which diagnose histopathologically as squamous cell carcinoma. Then the sampleswill be stained with immunohistochemistry CD117 (Novocastra®) to count the number of mast cells andVEGF (Dako®) to see angiogenesis. Their expression will be analyzed with Fisher’s Exact Test statisticalanalysis to investigate the association between number of mast cells with expression of VEGF ofcutaneous squamous cell carcinoma.ResultsThe number of mast cells ≥15 cells were 7 cases (23.3%). Expressed VEGF positive expression in 30cases (100%). Suitability test Fischer's Exact Test has value not significant (p> 0.05).ConclusionThere is no conformance relationship between the number of mast cells with VEGF expression of p-value.
Hubungan Ekspresi Imunohistokimia Cyclooxygenase-2 (COX-2) dengan Derajat Histopatologi Meningioma Indri Mahrani; Delyuzar; Joko S. Lukito
Majalah Patologi Indonesia Vol. 28 No. 3, September 2019
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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BackgroundMeningioma is the most common intracranial primary neoplasm in adults, which arise from arachnoid cap(meningothelial) cells. Histological appearance of a meningioma is an important predictor of tumor behavior.Cyclooxygenase-2 (COX-2) enzyme is overexpressed in different types of tumors and is known to beassociated with malignant behavior of tumors. The aim of this study was to evaluate cyclooxygenase-2 (COX-2)immunoreactivity in meningioma and to find association with histopathologic grading of meningioma.MethodsThis is an analytical descriptive study with cross sectional approach. The histopathologic grading of 22 samplesof meningioma were determined and stained with COX-2 immunohistochemistry. The color intensity: 1 (mild), 2(moderate), 3 (strong). Percentage of positive cells: 0 (0%), 1 (<10%), 2 (10-50%), 3 (>50%). The evaluationwas the sum of color intensity and percentage of positive cells: positive (>4), negative (<4).ResultsTwnty two cases of meningioma: mean age=41 years, 90.9% females, meningothelial=22.7%, grade I=77.3%).COX-2 expression: negative: 17 cases (77,3%) all was first degree of malignancy. COX-2 positive: 5 cases(22,7%): 4 cases of second degree and 1 case of third degree of malignancy. The expression of COX-2 inmeningioma cells was associated with WHO histopathologic grading (p=0.001).ConclusionThis study showed a relationship between COX-2 immunohistochemical expression and histopathologic gradingof meningioma, where COX-2 was more expressed in grades II and III.
Identifikasi Polimorfisme Gen CYP1A1 pada Karsinoma Sel Skuamosa dan Adenokarsinoma Serviks Hilda Fitriyani; Delyuzar; Hidayat
Majalah Patologi Indonesia Vol. 29 No. 2, Mei 2020
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i2.410

Abstract

BackgroundCervical cancer is the third most common cancer in women with risk factor of smoking, high parity, long term use of oralcontaception that are associated with chemical carcinogenesis. Chemical carcinogenesis require biotransfor-mation of lipophilicsubstrates to hydrophilic metabolites, therefore facilitating their secretion from the human body. Cytochrome P450 (CYP) is one ofgenes that have important role in this process. Benzo[α]pyrene and estrogen have a common biotransformation process which ismetabolized by CYP, particularly CYP1A1. The objectives to identify the frequency and distribution of CYP1A1 gene polymorphismin squamous cell carcinoma and adenocarcinoma of the cervix.MethodsThis is an analytical descriptive study with cross sectional approach. CYP1A1 gene polymorphism (3801T/C or Ile462Val) wasanalyzed using PCR-RFLP method followed by gel electrophoresis.ResultsCYP1A1 gene polymorphisms (3801TC) in squamous cell carcinoma were 50% heterozygote T/C, 36% wild-types T/T and 14%homozygote C/C. CYP1A1 gene polymorphisms (3801TC) in adenocarcinoma were 60% heterozygote T/C and 40% wild-types T/T.CYP1A1 gene polymorphisms (Ile462Val) in squamous cell carcinoma were 97.2% heterozygote Ile/Val, and 2.8% homozygoteVal/Val. CYP1A1 gene polymorphisms (Ile462Val) in adenocarcinoma were 100% heterozygote Ile/ValConclusionThe most common type of CYP1A1 gene polymorphism (3801TC and Ile462Val) in squamous cell carcinoma and adenocarcinomaof the cervix were heterozygote.
Analisis Gambaran Morfologi Limfadenitis Tuberkulosis Menggunakan Metode Biopsi Aspirasi Jarum Halus dan Polymerase Chain Reaction Dedy Suryadi; Delyuzar; Soekimin
Majalah Patologi Indonesia Vol. 29 No. 2, Mei 2020
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i2.419

Abstract

BackgroundIndonesia is the 2nd largest of tuberculous (TB) cases in the world. Therefore, TB must be controlled by increasing the capacity anddeveloping universal access needed for TB diagnose accurately and quickly. Progression in controlling TB and decreasing theconsequence can be accelerated through early detection and promt treatment. This study used PCR test as gold standard, albeitthe high cost. Thus, quick, accurate and low cost diagnostic method is needed. In this case morphologic features requirementinclude the existence of epithelioid and necrosis in FNAB smears. Objective was to analyze morphologic features of tuberculosislymphadenitis using FNAB and PCR methods.MethodsThis study is a cross sectional analysis. N samples are all kind of lymphadenitis tuberculosis. Morphologic features in FNABcytology must be confirmed using PCR test and performing chi-square test respectively.ResultsEpitheloid and necrosis features of TB lymphadenitis on FNAB showed 100% positive on PCR methods. This study divided intothree groups. Statistic analyses between group I and II, group II and III showed in significant differences (p=0.074); while betweengroup I and III showed significant differences (p<0.05).ConclusionsPCR method could confirmed morphologic features (epitheloid and necrosis) of TB lymphadenitis
Nilai Numerik Sitomorfometri Keliling dan Densitas Inti pada Fibroadenoma, Karsinoma Duktus dan Karsinoma Lobular Payudara fitriani Lumongga; Muhammad Nadjib D Lubis; Delyuzar
Majalah Patologi Indonesia Vol. 19 No. 1 (2010)
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

ABSTRAKLatar BelakangPemeriksaan sitologi biopsi aspirasi jarum halus penting dalam diagnosa preoperatif lesi payudara. Sampai saatini interpretasi sediaan sitologi sering bersifat subjektif. Untuk mendapatkan diagnosa yang lebih objektif,diperlukan aplikasi tambahan dengan menggunakan komputer melalui images analysis. Morfometri yangdilakukan dengan komputerisasi dan analisa gambar dapat digunakan untuk menghitung ukuran sel, sepertikeliling inti (perimeter) dan densitas inti.TujuanTujuan studi ini membandingkan ukuran perimeter dan densitas inti antara fibroadenoma, karsinoma duktus dankarsinoma lobular payudara dengan menggunakan image analysis.Bahan dan CaraPenelitian menggunakan studi potong lintang dengan jumlah sampel 10 pada setiap kelompok. Sediaan hasilbiopsi aspirasi diwarnai Diff-Quik dan dilakukan pengukuran morfometri dengan pewarnaan Fuelgen. Penilaianmorfometri inti menggunakan MCID Analysis software pada 50 sel tiap slide dan dinyatakan dengan angka yangdapat dipindahkan ke dalam bentuk histogram. Perbedaan beberapa variabel diuji statistik dengan tesBonferroniHasilRata-rata keliling inti fibroadenoma mammae: 0,513 µm, karsinoma duktus : 0,887 µm, karsinoma lobular: 0,634µm. Rata-rata densitas inti fibroadenoma 0,45006: Relative optical density (ROD) dan karsinoma duktus: ROD.0,5338KesimpulanPada hasil penelitian terdapat perbedaan rata-rata keliling inti pada lesi fibroadenoma, karsinoma duktus dankarsinoma lobular payudara serta terdapat perbedaan densitas inti lesi payudara fibroadenoma dan karsinomaduktus dengan menggunakan pewarnaan Fuelgen.
Ekspresi AgNOR dan Ekspresi Ki-67 pada Grading Adenokarsinoma Prostat Roza Rita; Delyuzar; Lidya Imelda Laksmi
Majalah Patologi Indonesia Vol. 29 No. 3, September 2020
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v29i3.446

Abstract

BackgroundProstate cancer is the second most common cancer and fifth most common cancer cause of death in males. Tissue biopsy is a goldstandard examination to diagnose prostate cancer. One of the hallmarks of cancer is increased activity of cell proliferation. Thisactivity can be detected with Ki-67 and AgNOR (Argyrophilic nucleolar organizing region). The aim of this study is to analyzedcorrelation between AgNOR and Ki-67 expression in grading of prostated adenocarcinoma.MethodsThis analytic cross-sectional study was held in Laboratory of Anatomical Pathology of Medical Faculty of USU/ RSUP H. AdamMalik Medan. Thirty paraffin blocks diagnosed with prostate adenocarcinoma were stained with H&E and p63 immunohistochemistrythen evaluated based on Gleason’s histopathological grading and stained with Agnor and Ki 67.ResultsAgNOR expression yang diperoleh pada grading adenokarsinoma prostat group 1, 2, 3, 4, dan 5 berturut-turut adalah 43; 32,40(±14,54); 64,29 (±28,2); 59,5 (±28,32); 69,22 (±29,26). Ekspresi Ki-67 pada setiap grading adenokarsinoma prostat group 1, 2, 3, 4,dan 5 secara berurutan adalah 43; 32,4 (±14,53); 64,29 (±28,2), 59,5 (±28,31); 69,22 (±29,26). Statistical analyses showed thatthere was no significantly correlation between grading of prostate adenocarcinoma and AgNOR expression (p=0.065), and Ki-67expression (p=0.18). Nevertheless, a significantly correlation between KI-67 expression and grading of prostate adenocarcinomawas found (p=0.34).ConclusionKi-67 could be used as prognostic indicator for prostate adenocarcinoma.
Relationship of the Number of Black Dots in the Nuclei of Argyrophilic Nucleolar Organizing Regions (AgNORs) Expressed Epithelial Cells with Nottingham Grading System in Invasive Breast Carcinoma of No Special Type (IBC-NST) Mohd. Yuwanda Basrul; Delyuzar Delyuzar; T. Kemala Intan; Soekimin Soekimin; T. Ibnu Alferraly
Majalah Patologi Indonesia Vol. 35 No. 1, Januari 2026
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i1.669

Abstract

Background Breast cancer is a malignant disease in women. The high number of breast cancer cases is caused by multiple factors, including barriers to early detection of breast cancer, socio-economic and geographical factors, and the difficulty of affordable, timely and effective health services. IBC-NST has the highest incidence among breast cancer cases with a 10 year survival rate (65-78%). AgNORs parameters have been shown to represent a reliable tool for determining the clinical outcome of cancer diseases, being an independent prognostic factor in many types of tumors.   Method Descriptive analytics research was carried out on slides from 31 patients with IBC-NST. Each slide was stained with H&E stainning to assess the Nottingham grading system and stained with AgNORs to assess the number of black dots in epithelial cell nuclei that expressed AgNORs. All clinicopathological data were taken from medical records/pathology archives. Logistic regression test (p<0.005) was used to assess the relationship between the number of black dots in epithelial cell nuclei expressing AgNORs and the Nottingham grading system in IBC-NST.   Results The highest cases were in the age group ≤40-50 years (range: 50.1 years), the highest grading was in grade 3 of the Nottingham grading system (48.8%), the lowest number of black dots was 576 dots and the highest was 1,036 dots (mean 798.80, median 710.0 and standard deviation 144.71) and the highest number of black dots was in grade 3 of the Nottingham grading system.   Conclusion Assessment of the number of black dots in the nuclei of epithelial cells expressing AgNORs associated with Nottingham grading system can be used as an indication of prognosis in patients with IBC-NST.
Co-Authors Ainun Mardiah Alamanda, Intan Nefia Alferraly, T. Ibnu betty betty Chairani, Rizki Chrestela, Jessy Chrestella, Jessy CINDY CLARA AWE Dedy Suryadi DITA ANNISA DIARA NASUTION Edi Kerina Sembiring, Edy Fachrial Eka Airlangga Emita Sabri Endang Sjamsudin Feby Yanti Harahap Fiandani, Fatma Fitri Dewi Ismida fitriani Lumongga Harahap, Rini Syahrani HENDRA SUTYSNA Hidayat Hidayat Hidayat Hilda Fitriyani Humairah Medina Liza Lubis Ibnu Alferally Indri Mahrani Indriani Saragih, Septina Intan, T. Kemala Jessy Chrestella Joko S. Lukito Kadri, Sayed Muhammad Kharismawaty, Dina Laksmi, Lidya Imelda Lidya Imelda Laksmi Lita Feriyawati Lokot Donna Lubis Lubis, Fahrurrozi Lubis, Nenni Dwi Aprianti Lukito, Joko S Lukito, Joko S. M. Nadjib D. Lubis Mariedina, Causa Trisna Mohd. Yuwanda Basrul Muhammad Nadjib D Lubis Muhammad Ramli Nadjib Dahlan Lubis Nasution, Annio Indah Lestari Nurcahaya Sinaga Nurlela Nurlela P. Poida B. Gurning Ren Astrid Allail Siregar Reza Aditya Digambiro Rita Juliana Pohan Riza, Ahyar Rizki, Diana Roza Rita S Lukito, Joko S. Lukito, Joko Sihotang, Marisi Cintya Debby sinambela, Roy Herbon Soekimin Soekimin Soekimin Soekimin Soekimin Soekimin Soekimin, Soekimin Sri Amelia, Sri Sufitni Sunarti Sunarti Syafruddin Ilyas T Kemala Intan T. Ibnu Alferally T. Ibnu Alferally T. Ibnu Alferraly T. Kemala Intan tengku ibnu alferraly Tri Widyawati Urip Harahap Utami, Tania Mulia