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All Journal Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Majalah Obat Tradisional Science and Technology Indonesia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Biota JURNAL BIDAN CENDRAWASIH PALU Jurnal Pengabdian kepada Masyarakat Narra J Basic and Applied Nursing Research Journal Jurnal Kedokteran Hewan
Gemini Alam
Faculty of Pharmacy, Hasanuddin University, Makassar.
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Aktivitas Anti Mycobacterium tuberculosis Strain H37Rv dan MDR (Multi Drug Resistant) dari Ekstrak Rimpang Curcuma mangga Val.: Anti Mycobacterium tuberculosis Activity Strain H37Rv and MDR (Multi Drug Resistant) from Curcuma mangga Val. Rhizome Extract Pratiwi, Ritha; Alam, Gemini; Rante, Herlina; Massi, Nasrum
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (324.319 KB) | DOI: 10.22487/j24428744.2020.v6.i1.13102

Abstract

TB is an infectious disease caused by the bacterium Mycobacterium tuberculosis. Empirically the plants that have long been used in medicine are Curcuma mangga rhizome, which shows pharmacological activity as an anti Mycobacterium tuberculosis drug. The objective of the research is to determine the ability of hexane and methanol extracts of Curcuma mangga in inhibiting the growth of Mycobacterium tuberculosis Strain H37Rv and MDR. The extraction of Curcuma mangga rhizome was conducted by maceration methode using hexane and methanol as the solvents, respectively. Both of extracts were made in 1000 dan 500 ppm concentration, then tested for anti Mycobacterium tuberculosis activity using MODS (Microscopic Observation Drug Suspectibility) method. Determination of anti M.tuberculosis activity was based on microscopic observation on Mycobacterium tuberculosis colony in cord formation. The results showed that hexane and methanol extract in 1000 ppm concentration inhibited the growth of Mycobacterium tuberculosis Strain H37Rv dan MDR. However in 500 ppm only n-hexane extract showing the inhibiton activity. In conclusion, n-hexane extract have the ability to inhibit the growth of Mycobacterium tuberculosis Strain H37Rv dan MDR.
THE EFFECTS OF SIMVASTATIN, ROSUVASTATIN, AND FENOFIBRATE ON THE BODY WEIGHT AND LIPID PROFILES OF FEMALE RATS TREATED WITH ORAL CONTRACEPTIVES AND A HIGH-FAT DIET Putri, Dwi Anggara; Djabir, Yulia Yusrini; Bahar, Muhammad Akbar; Alam, Gemini; Rahman, Latifah; Aswad, Muhammad; Arsyad, Muhammad Aryadi
Jurnal Kedokteran Hewan Vol 16, No 3 (2022): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v16i3.22196

Abstract

This study aimed to compare the effects of simvastatin, rosuvastatin, and fenofibrate therapies on the body weight and lipid profiles of the female rats receiving a combination of oral contraceptives (COC) and a high-fat diet (HFD). Twenty female Wistar rats (130-200 g) were divided equally into four groups. The rats received a standard diet for seven days, and their baseline lipid profiles were analyzed. All rats also received COC containing 15.1 g/kg levonorgestrel/3.1 g/kg estradiol with HFD for 60 days. Starting on day 31, the rats were given the respected treatment. The control group received the vehicle, whereas the others were treated with either simvastatin (2.1 mg/kg), rosuvastatin (0.5 mg/kg), or fenofibrate (8.2 mg/kg). Blood samples were taken on days 30 and 60. The results showed that the administration of COC+HFD and vehicle for 30 days increased the rats body weight and dyslipidemia, characterized by a significant decrease in Low-Density Lipoprotein (HDL) and an increase in total cholesterol (TC) and triglycerides (TG) levels (P0.05). Among the treatments, only fenofibrate was found to be able to prevent a significant weight gain in rats. Both fenofibrate and rosuvastatin inhibited a significant rise in TG and TC levels. Meanwhile, the simvastatin administration failed to do the same. Although statistically insignificant, all treatments increased rats HDL levels. Thus, it can be concluded fenofibrate was the most effective treatment among all in reducing weight gain and improving the lipid profile of dyslipidemic rats induced by oral contraceptives and a high-fat diet.
EFEKTIVITAS PENTAGAMAVUNON-0 TERHADAP PENGHAMBATAN EKSPRESI SIKLOOKSIGENASE-2 PADA MODEL KANKER KOLON TIKUS Yulianty, Risfah; Hakim, Lukman; S, Sardjiman; Alam, Gemini; Nufika, Riska; Widyarini, Sitarina
Jurnal Kedokteran Hewan Vol 6, No 2 (2012): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v6i2.344

Abstract

Penelitian ini bertujuan menentukan efektivitas pentagamavunon-0 (PGV-0) terhadap penghambatan ekspresi siklooksigenase-2 (COX-2) pada kanker kolon tikus Wistar. Pada penelitian ini digunakan 20 ekor tikus Wistar jantan yang dibagi secara acak dalam 4 kelompok perlakuan. Kelompok I merupakan kontrol negatif, kelompok II kontrol positif, kelompok III diberi PGV-0 40 mg/kg BB selama 15 minggu, dan kelompok IV diberi PGV-0 40 mg/kg BB selama 25 minggu. Pemberian PGV-0 dilakukan secara oral dua kali seminggu. Induksi kanker kolon dilakukan dengan cara injeksi subkutan DMH 60 mg/kg BB, satu kali seminggu selama 15 minggu. Pada minggu ke-26, semua hewan coba dieutanasia, kolon difiksasi dalam formalin 10% untuk selanjutnya diamati perubahan makroskopik dan mikroskopik. Penilaian ekspresi COX-2 dilakukan dengan menggunakan metode Dukes stage dan skor imunoreaktivitas (IRS). Hasil penelitian ini memperlihatkan pemberian PGV-0 selama 25 minggu menurunkan jumlah nodul kanker kolon dari 5 ke 2 (berkurang 60%); diameter kanker kolon (pxl) dari 0,712 mm ke 0,0043 mm (berkurang 99,31%). Pemberian PGV-0 selama 15 minggu hanya menurunkan jumlah nodul 10% dan area kanker kolon dari 0,712 mm ke 0,0062 mm (99,07%). Skor imunoreaktivitas COX-2 diekspresikan oleh kelompok III dan IV adalah 4 dan 5. Gambaran histologis dari kolon mendukung hasil di atas. Pemberian PGV-0 efektif menurunkan jumlah dan area nodul kanker kolon melalui penghambatan ekspresi COX-2.
PPUPIK PENGEMBANGAN PROTOTIPE GINGER CANDY UNHAS: INOVASI PENCEGAH MUAL -MUNTAH DALAM RANGKA MENDUKUNG TARGET IKU 5 Sartini, Sartini; Alam, Gemini; Natsir Dijde, Nana Juniarti; Dewi Purwaningsih; Mangilep, Muhammad Agung Ady
J-ABDI: Jurnal Pengabdian kepada Masyarakat Vol. 5 No. 6 (2025): Nopember 2025
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53625/jabdi.v5i6.11768

Abstract

Jahe (Zingiberis officinale Roscoe), berdasarkan hasil-hasil penelitian diketahui banyak memiliki khasiat bagi kesehatan, antara lain : antioksidan, pereda nyeri, pereda inflamasi, pelega tenggorokan dan pencegah mual muntah. Jahe banyak digunakan dalam campuran obat tradisional dan saat ini  juga sudah banyak dalam bentuk permen. Untuk klaim kesehatan perlu dosis yang jelas per permen. Tujuan terciptanya protipe ini adalah untuk menjamin kehidupan sehat dan kesejahteraan bagi semua orang di segala usia sesuai dengan SDGs tujuan 3 dan mendukung target IKU 5 (hasil kerja dosen digunakan masyarakat). Pelaksanaan kegiatan ini, dimulai dari survey secara online mengenai produk-produk permen jahe yang ada di e-commerce, studi literatur, perancangan formula, dan produksi  skala laboratorium, dan pembuatan bisnis model canvas. Hasil kegiatan diperoleh permen jahe dalam bentuk hard candy dengan komposisi setiap jahe mengandung serbuk jahe yang setara dengan 1-2 g jahe segar, dengan tekstur keras supaya lama di mulut untuk memberikan efek pelega tenggorokan dan pencegah mual. Diharapkan Ginger Candy ini dapat dikomersialisasikan sebagai salah satu produk inovasi dari UNHAS
Co-Authors . Lukman . Mufidah . Subehan . Syamsudin Abd Halim Umar Ahmad, Mardiana Aisyah Fatmawaty Akbar Tahir, Akbar Andi Nilawati Usman Arsin, Andi A. Arsyad, Muhammad Aryadi Asarini Astuti, Ayun Dwi As’ad, Suryani Athia Kurnia Kasim Bustanul Arifin Dewi Lestari Dewi Purwaningsih Djabir, Yulia Yusrini Elly Wahyudin Enggar Fatimah Azzahra Firdaus Mubayyina Gatot S Lawrence Haeriah Haeriah, Haeriah Hasanuddin Ishak Herlina Rante Husin, Farid Indah Raya Isra Wahid Kasman Kasman Latifah Rahman Lukman Hakim M Rusdi Mangilep, Muhammad Agung Ady Marianti A Manggau Martira Maddeppungeng, Martira Matias N Kolobani Muh. Akbar Bahar Muh. Nasrum Massi Muhammad Aswad Muhammad Rasyid Ridha Natsir Dijde, Nana Juniarti Natsir Djide Poedji Hastutiek Pratiwi, Sylvia Puji Astuti Putri, Dwi Anggara Ramadhani, Nur Ridwan Amiruddin Risfah Yulianty Riska Nufika Ritha Pratiwi Sardjiman S Sartini Sartini Sitarina Widyarini Subagus Wahyuono Sudirman Nasir Tadjuddin Naid Triana Hertiani Veni Hadju Wahyu Hendrarti Yulvian Sani Yusnita Rifai, Yusnita