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Lili Andriani
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Aktivitas koagulan ekstrak dan fraksi daun Sembung Rambat (Mikania micrantha Kunth.) Perawati, Santi; Andriani, Lili; Pratama, Septa; Humayroh, Humayroh
Chempublish Journal Vol. 4 No. 1 (2019): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.712 KB) | DOI: 10.22437/chp.v4i1.6909

Abstract

ABSTRAK Sembung Rambat (Mikania micrantha Kunth) merupakan tumbuhan yang tumbuh merambat mengandung zat aktif dalam bentuk metabolit sekunder seperti alkaloid, saponin, flavonoid, steroid, tanin, terpenoid dan kaya akan senyawa fenolik. Penelitian ini dilakukan untuk mengetahui kemampuan ekstrak dan fraksi dari daun sembung rambat sebagai koagulan. Ekstraksi daun segar sembung rambat menggunakan metode maserasi dengan pelarut etanol 96% , ekstrak etanol difraksinasi menggunakan metode ekstrak cair-cair dengan pelarut n-heksan, etil asetat dan n-butanol. Aktivitas koagulan diukur dengan cara melihat waktu terbentuk benang fibrin dan waktu henti darah pada hewan uji Mencit Putih Galur (Deutschland, Denkenand and Yoken). Ekstrak dengan dosis 60mg/20g BB mencit menunjukkan hasil aktivitas koagulan yang terbaik dibandingkan dengan variasi dosis lain dengan waktu terbentuk benang fibrin (77 detik) dan waktu henti darah (86 detik). Pada fraksi etil asetat memiliki aktivitas koagulan terbaik dibandingkan dengan ekstrak dan fraksi lain dengan waktu terbentuk benang fibrin (64 detik) dan waktu henti darah (86 detik). Ekstrak dan fraksi daun sembung rambat pada dosis 60mg/20g BB mencit memiliki aktivitas koagulan yang baik. Kata kunci: Koagulan, Sembung Rambat (Mikania micrantha Kunth.) ABSTRACT Sembung Rambat (Mikania micrantha Kunth.) Is a climbing plant containing alkaloids, saponins, flavonoids, steroids, tannins, terpenoids and rich in phenolic compounds. This aim was to determine the ability of extracts and fractions of sembung rambat leaves as coagulant. Extraction of fresh leaves of used maceration method with ethanol 96% as a solvent, ethanol extract fractionated used liquid-liquid extract method with n-hexane, ethyl acetate and n-butanol. Coagulant activity was measured by looking at the time of formation of fibrin yarn and the time of blood stops in theanimals test of White Mice (Deutschland, Denkenand and Yoken). Extracts with a dose of 60 mg / 20 g BB mice showed the best results of coagulant activity compared to other dose variations with the time of formation of fibrin yarn 77 seconds and blood stop time 86 seconds. The ethyl acetate fraction has the best coagulant activity compared to extracts and other fractions with fibrin yarn formed time 64 seconds and blood stop time 86 seconds. In conclusion, the extracts and fractions of sembung rambat have coagulant activity. Key words: Coagulant, Mikania micrantha Kunth
Co-Authors 'Aliyah, Siti Hamidatul Ade Rahima Afrila, Diliza Agustina, ria Ahmad Yunus Ara Ofiana Ardila, Eti Arfiah, Besek Arif Rahim armini hadriyati, armini Astridawati, Indah Atmaja, Anggito Surya Awaliatuwelda Aziza, Aziza Azizah Azizah Barmi Hartesi Budiningtyas, Dwi Putri Dahlia, Dimbi Desi Sagita Entianopa, Entianopa Erlina Zahar Eryunita, Putri Evi Adriani, Evi Fadila, Aulia Febriyenti, 0la Fitria Fitria Haflin Haflin Haflin, Haflin Handayani, Ayu Mustika Harbeng Masni, Harbeng Hasanah, Rifdatul Humayroh, Humayroh Hutabarat, Zuhri Hutabarat, Zuhri Saputra Jhony Hendra Juwita, Agnes Lia Anggresani M. Henityo Agung As'adi Mahadma Bhima Whinata Marisdayana, Rara Medina, Fhatia Melyawati Melyawati, Melyawati MORI SAPUTRA, DEKA ISMI Myson Myson, Myson Nadia Putri Nova Hari Santhi Novika, Revi Gama Hatta Nur Mila Sari Nursaya'bani, Dimas Saad Padli, Husni Palupi, Retno Maria Pamungkas, Satriyo Pratiwi, Heni Putri Mariska, Ruri Putri Pratiwi Rahmadevi Rahmawati, Rahmawati Randa, Muhammad Rini Mustikasari Kurnia Pratama Risnawati, Ida Rizky Yulion Rolita, Rolita Ruri Putri Mariska Santi Perawati Santi Perawati, Santi Sari, Jihan Kartika Sartika, Diza Sembiring, Benar Sembiring, Rinawati Septiany, Dwi Setiawan, Egi Silvia, Melinda Siregar, M Ridho Afandy Siregar, Ulica Elidawati Siti Hamidatul 'Aliyah Sudirman Sudirman Sujoko Sujoko Susi Widiawati, Susi Sutrisno , Deny Syafitri, Eka Tahta Kirana, Sahla Tara, Firman Vera Hendriani wati, Misna Whinata, Mahadma Bhima Wijanarko, Ardi Yulianis Yuliawati Yuni Andriani Yuniansyah, Lutfhi Suci Zaitun Zaitun Zulhen, Annisa ‘Aliyah, Siti Hamidatul