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All Journal Jurnal Manajemen dan Keuangan Jurnal Farmasi Indonesia Jurnal Tekinkom (Teknik Informasi dan Komputer) Jurnal Ilmiah Medicamento Business and Economic Publication Jurnal Ilmiah Multidisiplin Indonesia Journal of Social Science and Multidisciplinary Analysis Jurnal Intelek Insan Cendikia Jurnal Informatika dan Kesehatan International Journal of Contemporary Sciences (IJCS) Galen: Jurnal Ilmu Farmasi dan Kesehatan Journal Health of Indonesian Multicore International Journal of Multidisciplinary (MIJM) International Journal of Science and Society (IJSS) Mitra Jurnal Pengabdian Masyarakat Multidisiplin (MJPMM) JES-TM Social and Community Service
Chandra Arifin
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Interactive Discussion Related to the Preparation of Pharmacy Professional Work Practice at the Health Center and Health Office Saristiana, Yuneka; Prasetyawan, Fendy; Mildawati, Ratna; Marhenta, Yogi Bhakti; Kadir, Mujtahid Bin Abd; Arifin, Chandra; Rofiq, Abd; Astutik, Widhi; Rohmah, Eka Hayati
Mitra Jurnal Pengabdian Masyarakat Multidisiplin (MJPMM) Vol. 1 No. 1 (2025): Maret
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/mjpmm.v1.i1.3

Abstract

The Professional Pharmacy Practice Experience (PKPA) at Community Health Centers and Health Offices plays a crucial role in developing the professional competence of pharmacy students before they enter the actual workforce. To facilitate this preparation, an interactive discussion activity has been conducted as a means of training and collective reflection among students, supervising lecturers, and resource persons from the Health Office and community health centers. This discussion aims to enhance students' understanding of the roles and responsibilities of pharmacists within primary healthcare facilities (FKTP), while also identifying the challenges and solutions involved in the implementation of PKPA. The execution of the discussion demonstrated a high level of enthusiasm among students in exploring both the technical and non-technical aspects of the pharmacy profession, including the integration of clinical and managerial roles. The evaluation of the questionnaire reveals that over 85% of participants believe this activity significantly aids in preparing them to confront the PKPA with greater confidence. Group discussions highlight the significance of interpersonal communication skills, professional ethics, and teamwork collaboration as essential factors for the success of practice. A representative from the Health Department assessed that this activity is effective in aligning the perspectives between educational institutions and practical venues, thereby fostering ongoing synergy.
Sosialisasi Tingkat Kesadaran dan Pengetahuan Masyarakat Tentang Manfaat Teh Kombucha Dalam Mengatasi Sleep Paralysis Selama Pandemi COVID-19 Saristiana, Yuneka; Prasetyawan, Fendy; Arifin, Chandra; Rofiq, Abd; Astutik, Widhi; Azis, Asrizal; Tri Wulan, Ema
Journal of Social and Community Service Vol. 1 No. 3 (2022): July 2022
Publisher : Faculty of Engineering University of Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jestmc.v1i3.149

Abstract

This community service program aims to enhance public understanding and knowledge about sleep paralysis and the benefits of kombucha tea during the COVID-19 pandemic. Conducted throughout January 2021, the program involved various socialization activities such as presentations, workshops, and discussions. Post-activity evaluations showed a significant improvement in public understanding of sleep paralysis and the benefits of kombucha tea. Prior to the program, most respondents had limited knowledge about sleep paralysis and kombucha tea, but after participating, their understanding increased significantly. Despite facing some challenges, the overall results of this program indicate that socialization about sleep paralysis and the benefits of kombucha tea can be effective in enhancing public understanding of sleep health and nutrition during the COVID-19 pandemic.
Community Empowerment Through Increasing Knowledge About the Truth of the Drug NZT-48 as a Neurotrophic in Increasing Brain Potential: Pengabdian Masyarakat Melalui Peningkatan Pengetahuan Tentang Kebenaran Obat NZT-48 sebagai Neurotropik dalam Meningkatkan Potensi Otak Saristiana, Yuneka; Prasetyawan, Fendy; Mildawati, Ratna; Arifin, Chandra; Rofiq, Abd; Astutik, Widhi
Journal of Social and Community Service Vol. 3 No. 3 (2024): November 2024
Publisher : Faculty of Engineering University of Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jestmc.v3i3.196

Abstract

The community service aimed to bridge the gap between scientific knowledge and public perception regarding nootropics. Through a comprehensive approach involving meticulous planning, community engagement, educational activities, expert consultations, feedback collection, and evaluation, the program sought to increase awareness and understanding of cognitive enhancement substances among participants. Real-life case studies and guest lectures by renowned experts enriched the learning experience, addressing scientific, ethical, and social perspectives. The proactive involvement of community leaders and an effective awareness campaign ensured high participation and relevance. It underscored the importance of a multidisciplinary approach in addressing complex topics and highlighted the value of engaging communities in meaningful discussions about health and well-being. The program not only educated the community about the realities and myths surrounding NZT-48 and other nootropics but also promoted critical thinking and informed decision- making. By empowering the community with accurate information and fostering a culture of informed skepticism, the program contributed to the betterment of community health and well-being, setting a precedent for future public health education initiatives.
Studi Analisa Kronofarmakologi Penggunaan Obat Ibuprofen pada Pasien Covid-19 di Rawap Inap RSUD Dr. Soedomo Trenggalek Fendy Prasetyawan; Yuneka Saristiana; Faisal Akhmal Muslikh; Ratna Mildawati; Chandra Arifin; Abd Rofiq; Emma Jayanti Besan; Muhammad Nurul Fadel; Charliandri Saputra Wahab; Muhammad Alviyan Shutiawan
Jurnal Informatika dan Kesehatan Vol. 1 No. 1 (2024): IKN : Jurnal Informatika dan Kesehatan
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ikn.v1i1.3024

Abstract

The global COVID-19 pandemic has presented unprecedented challenges to global health. The Dr. Soedomo Regional General Hospital in Trenggalek has been at the forefront of managing COVID-19 patients, with a primary focus on the use of ibuprofen to alleviate symptoms such as fever and pain. Despite the widespread use of ibuprofen, knowledge regarding its interaction with the circadian rhythm, especially in COVID-19 patients, remains limited. This study employed an analytical observational approach with a Cross-Sectional design to analyze the use of ibuprofen in COVID-19 patients at Dr. Soedomo Regional General Hospital in Trenggalek. The study included 100 patients, emphasizing body temperature at three different times. Data analysis revealed a significant decrease in body temperature after therapy, particularly at 4:00 PM. These findings lay the foundation for the development of more targeted and personalized treatment strategies by understanding the body's response patterns to therapy at different times.   Abstrak Pandemi global COVID-19 telah menciptakan tantangan kesehatan global yang belum pernah terjadi sebelumnya. Rumah Sakit Umum Daerah Dr. Soedomo di Trenggalek telah menjadi pusat perhatian dalam menangani pasien COVID-19. Fokus utama adalah penggunaan ibuprofen untuk mengelola gejala, seperti demam dan nyeri. Meskipun ibuprofen umum digunakan, pengetahuan tentang interaksi dengan siklus sirkadian tubuh, terutama pada pasien COVID-19, masih terbatas. Penelitian ini menggunakan pendekatan observasional analitik dengan desain Cross Sectional untuk menganalisis penggunaan ibuprofen pada pasien COVID-19 di RSUD Dr. Soedomo Trenggalek. Hasil penelitian melibatkan 100 pasien, dengan fokus pada suhu tubuh pada tiga waktu berbeda. Analisis data menunjukkan penurunan suhu tubuh yang signifikan setelah terapi, terutama pada pukul 16.00 WIB. Hasil ini memberikan dasar untuk pengembangan strategi pengobatan yang lebih terarah dan personalisasi, dengan memahami pola respons tubuh terhadap terapi pada waktu yang berbeda.
Prediction of Sinensetin from Kumis Kucing (Orthosiphon aristatus) as Aspulvinone Dimethylallyltransferase Inhibitor for Anticancer Agent Prasetyawan, Fendy; Arifin, Chandra; Astutik, Widhi; Rohmah, Eka Hayati; Kadir, Mujtahid Bin Abd; Ariawan, M Wahyu; Marhenta, Yogi Bhakti; Mildawati, Ratna; Saristiana, Yuneka; Rofiq, Abd
Multicore International Journal of Multidisciplinary (MIJM) Vol. 1 No. 1 (2025): May
Publisher : Marasofi International Media and Publishing (MIMP)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64123/mijm.v1.i1.3

Abstract

Sinensetin, a polymethoxylated flavone found in Orthosiphon aristatus (commonly known as Kumis Kucing), was evaluated in silico for its potential inhibitory activity against Aspulvinone Dimethylallyltransferase, an enzyme implicated in cancer-related biosynthetic pathways. The SMILES structure of sinensetin was retrieved from PubChem and analyzed using the PASS online prediction tool (www.way2drug.com). The results showed a high probability of activity (Pa = 0.865) and a very low probability of inactivity (Pi = 0.016), indicating that sinensetin is likely to act as a potent inhibitor of the enzyme. These findings suggest that sinensetin could be a promising anticancer agent candidate by targeting Aspulvinone Dimethylallyltransferase. Further studies are recommended to validate this prediction through molecular docking and biological assays.
The Comparative Effectiveness of Angiotensin II Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors in Outpatient Hypertensive Patients at Community Health Centers Prasetyawan, Fendy; Yuneka Saristiana; Faisal Akhmal Muslikh; Wisnu Haryo Widyoko; Chandra Arifin; Abd Rofiq
International Journal of Contemporary Sciences (IJCS) Vol. 1 No. 3 (2024): January 2024
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijcs.v2i1.8346

Abstract

Hypertension, often termed "The Silent Disease" due to its asymptomatic nature, remains a global health concern. This study investigates the comparative effectiveness of Angiotensin II Receptor Blockers (ARBs) and Angiotensin-Converting Enzyme Inhibitors (ACEIs) in managing hypertension, focusing on Valsartan and Candesartan (ARBs) and Ramipril and Captopril (ACEIs). Analyzing retrospective data from Community Health Centers in Solo City, the research aims to provide nuanced insights into outpatient care scenarios. The meticulous statistical analysis, utilizing SPSS and t-tests, uncovers notable differences, particularly favoring Valsartan and Ramipril within their respective drug classes. These findings carry substantial implications for healthcare practitioners, aiding in the development of precise treatment guidelines. Understanding the comparative clinical effectiveness, safety profiles, and tolerability of ARBs and ACEIs ensures a more personalized approach to hypertension management
Frekuensi Penggunaan Obat Antivirus Pada Pasien SARS-CoV-2 dengan Penyakit Ginjal Kronis di Instalasi Farmasi Rawat Inap Rumah Sakit Fendy Prasetyawan; Yuneka Saristiana; Faisal Akhmal Muslikh; Ratna Mildawati; Chandra Arifin; Abd Rofiq
Jurnal Intelek Insan Cendikia Vol. 1 No. 1 (2024): Maret 2024
Publisher : PT. Intelek Cendikiawan Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pandemi COVID-19 telah menimbulkan tantangan global yang signifikan sejak munculnya virus SARS-CoV-2 pada tahun 2020. Pengendalian penyakit ini menjadi prioritas kesehatan utama mengingat dampaknya yang luas. Indonesia juga terpengaruh dengan laporan kasus pertama COVID-19 pada Maret 2020, membutuhkan perhatian serius dalam penanganannya. Salah satu komorbiditas yang sering terjadi pada pasien COVID-19 adalah penyakit ginjal kronis (CKD), yang meningkatkan risiko komplikasi medis. Pemahaman yang lebih mendalam tentang penggunaan obat antivirus pada pasien CKD yang terinfeksi COVID-19 menjadi penting, mengingat potensi toksisitas obat dan interaksi yang mungkin terjadi. Meskipun obat antivirus seperti favipiravir dan remdesivir telah menjadi strategi penting dalam penanganan COVID-19, perhatian khusus diperlukan saat memberikannya kepada pasien CKD karena risiko akumulasi dan toksisitas yang lebih tinggi. Studi potong lintang yang dilakukan di RSUD Dr. Soedomo Trenggalek bertujuan untuk mengevaluasi penggunaan obat antivirus pada pasien COVID-19 dengan CKD. Hasilnya menunjukkan bahwa mayoritas pasien menerima favipiravir (64%) dibandingkan dengan remdesivir (36%). Namun, penggunaannya perlu disesuaikan dengan fungsi ginjal pasien untuk menghindari toksisitas. Penelitian lebih lanjut diperlukan untuk memahami perbandingan efektivitas antara kedua jenis obat antivirus ini pada pasien CKD, sehingga dapat memberikan pedoman pengobatan yang lebih tepat bagi populasi pasien yang rentan ini
Pharmacokinetic Prediction Of Apigenin From Celer (Apium Graveolens L.) Using Pkcsm Lusiana Aprillia; Fendy Prasetyawan; Yuneka Saristiana; Ratna Mildawati; Chandra Arifin; Abd Rofiq
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 1 No. 1 (2025): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v1i1.3

Abstract

Celery (Apium graveolensL.) is a plant that has various pharmacological activities. One of the main bioactive compounds in celery is apigenin. Understanding the pharmacokinetic properties of apigenin is very important in evaluating its effectiveness and safety as a drug candidate. This study aims to predict the pharmacokinetic properties of apigenin using the pkCSM computational approach. The prediction results show that apigenin has good intestinal absorption, but low water solubility. Distribution ability is moderate, with limited penetration into the central nervous system. Apigenin is not a major substrate of CYP2D6 and CYP3A4 enzymes, but can inhibit CYP1A2 and CYP3A4. The elimination rate is moderate. Apigenin is not mutagenic, not hepatotoxic, and does not cause cardiotoxic effects. Apigenin has low toxicity toT. pyriformisand safe in acute doses with an LD50 of 2,432 log mM.
Co-Authors Abd Rofiq Abdul Halim Mukti Nasution Anis Akhwan Dhafin Astutik, Widhi Azis, Asrizal Besan, Emma Jayanti Charliandri Saputra Wahab Dewi Retno Puspitosari Eka Hayati Rhomah Elisabeth Penti Kurniawati Elsa Mahardika Putri Emma Jayanti Besan Faisal Akhmal Muslikh Febriana, Laela Fendy Prasetyawan Gunawan Pamudji Widodo Ivan Junius Mesak Kadir, Mujtahid Bin Abd Lusiana Aprillia M. Wahyu Ariawan Marhenta, Yogi Bhakti Mildawati, Ratna Muhammad Alviyan Shutiawan Muhammad Nurul Fadel Nida Fadhilah Oktadiana, Isma Paskah Ika Nugroho Ratna Mildawati Rhomah, Eka Hayati Rofiq, Abd Rohmah, Eka Hayati Roriq, Abd Saut P Tamba Sri Indriani Tri Wijayanti Tri Wulan, Ema Tsamrotul Ilmi Widhi Astutik Wisnu Haryo Widyoko Yuneka Sarisitiana Yuneka Saristiana