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Journal : Universa Medicina

Scurrula atropurpurea increases nitric oxide and decreases malondialdehyde in hypertensive rats Nour Athiroh AS; Erna Sulistyowati
Universa Medicina Vol. 32 No. 1 (2013)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2013.v32.44 - 50

Abstract

BACKGROUNDHypertension is the most prevalent chronic disease and has an impact on one billion people. Production of superoxide radicals and endothelial dysfunction are involved in hypertension. Scurrula atropurpurea (BL.) Dans. is a tea plant parasite. This study aimed to evaluate the role of Scurrula atropurpurea (BL.)Dans. on nitric oxide (NO) as a marker of endothelial dysfunction and malondialdehyde (MDA) as a marker of oxidative stress in hypertensive rats.METHODSThis study subjected rats to deoxycorticosterone acetate (DOCA)-induced hypertension. The experimental groups consisting of the control group and 3 hypertension groups receiving Scurulla  tropurpurea extract at a dosage of 50; 100; and 200 mg/KgBW. Scavenging activity of Scurrula atropurpurea (BL.) extract was analyzed by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method. The levels of arterial nitric oxide (NO) and pulmonary  malondialdehyde (MDA) were analyzed by spectrophotometry. ANOVA and a post hoc test were applied to find the difference of arterial NO and pulmonary MDA levels between groups.RESULTSThe level of arterial NO was significantly decreased in the hypertension groups as compared with the control group, while the level of pulmonary MDA was significantly increased (p<0.05). Scurulla atropurpurea significantly increases the NO level at a dosage of 200 mg/KgBW, compared with the hypertension groups (p<0.001). Scurulla atropurpurea significantly decreases pulmonary MDA level at a dosage of 100 and 200 mg/KgBW compared with the hypertension groups (p<0.05).CONCLUSIONScurulla atropurpurea extract increases arterial NO and decreases pulmonary MDA in hypertensive rats, thus playing an important role in endothelial dysfunction and oxidative stress.
Co-Authors Abdur Rohman Wahid Ahmad Baidarus Ahmad Taufiq Aisyah Aisyah Aldina, Devana Rahma Andini, Saskia Ade Hutami Fery Anita Puspa Widiyana Anna Fathiah Annisatul Hakimah Ar Rahmah, Mumtazunnisa As Sufiyah Argus Argus Argus Mahyan Ari Hayati Ari Hayati Arina Roikhana Ariski Vevi Liswandari Ayu Pertiwi, Chintya Baidarus, Ahmad Dea Fatimatu Zahroh Devi Qurroti A'yun Dewi Qurrot &#039;Aini Dewi Qurrot 'Aini Doti Wahyuningsih Durrotul Hasanah Dwi Mareta Nur hidayati Dyan Aprillia Susanti Eka Kumalasari Eko Noerhayati Erna Sulistyowati Erna Susanti fahmiy, Rakhmawati Faisal Faisal Fajrin, Siti Awaliah Fatimah Abdul Sammad Fatimah Fatimah fatimah Fatimah Fatur rohman Rohman Forrela Zahwa Salamah Gatra Ervi Jayanti Gemilang, Satria Hari Santoso Hari Santoso Hari Santoso hari santoso Hari Santoso Hari Santoso Hasan Zayadi Hatif Khusnin Nida' Herlinda Rahayu Husain Latuconsina Husain Latucosina Husain, Muhammad Hafizh Istirochah Pujiwati Jadid Mubarakati, Nurul Jihan Farah Zakia Laili Mihmidati Lestari, Tengku Anggun Luluk Rofiatul Mafluhah M. Abdul Qodir Jailani M. Mas’ud Said Ma'ruf, Muhammad Mahanem Mat Noor, Mahanem Mat Mahyantika, Seftya Putri Maidhatul Rosidha Widyanti Majida Ramadhan Malia Anjani Mardhiyah, Mardhiyah Masyhuri Masyhuri Mihmidati, Laili Mohammad Mabrur Mubarokati, Nurul Jadid Muhammad Fahmi Hidayatullah Nafisa Nafisa Nafisa, Nafisa Nia Novita Nurrohmah Nirwana, Linggar Nur hidayati, Dwi Mareta Nur Mufida Nur Permatasari Nur Shofiyah Munawaroh Nur Shofiyah Munawaroh, Nur Shofiyah Nurrohmah, Nia Novita Nurul Jadid Mubarakati Nurul Jadid Mubarakati Nurul Jadid Mubarakati Nurul Jadid Mubarokati Oktaviana, Nimas Ajeng Rahayu Dwi Lestari Rahmawati, Rizka Dwi Rakhmawati fahmiy Ramadhan, Majida Ramadhani, Mieta Widya Ratna Djuniwati Lisminingsih Ratna Juniwati Lisminingsih Rizki Kusuma Hantika Saimul Laili Salamah, Forrela Zahwa Saputri, Syntia Diyah Hayu Ria Savana, Amartya Gesit Shinta mayangsari Sholikha alaiya Sholikha alaiya, Sholikha Silfi hamidatul lailiyah Silvia, Putri Azizatul Siti Asmaniyah Mardiayani Siti Awaliah Fajrin Siti Imama Khoiriyah Siti Qurrotul Aini Suroyya, Mariyam Susanti, Dyan Aprillia Tengku Anggun Lestari Umu Intan Kinasih Uyunul Hikmah Wahidah, Shinta Nuriyah Yudi Purnomo Zahroh, Dea Fatimatu Zakia, Jihan Farah