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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Jurnal Berkala Epidemiologi Indonesian Journal of Cancer The Indonesian Biomedical Journal Health Notions Syntax Literate: Jurnal Ilmiah Indonesia MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Majalah Patologi Indonesia Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Pengabdian Masyarakat dalam Kesehatan Narra J Indonesian Journal of Cancer Jurnal Pengabdian Masyarakat Bhinneka Jurnal Pengabdian Masyarakat Bangsa Folia Medica Indonesiana
DYAH FAUZIAH, DYAH
Departemen Patologi Anatomi RS Dr. Soetomo Fakultas Kedokteran Universitas Airlangga Surabaya
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Journal : Narra J

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Correlation between interleukin-6 expression in post-mortem core liver biopsy and degree of liver injury in patients with fatal COVID-19 Maimunah, Ummi; Maharani, Andi RK.; Soegiarto, Gatot; Rahniayu, Alphania; Gunawan, Vania A.; Wiratama, Priangga A.; Djuanda, Stephanie N.; Supriadi, Supriadi; Marhana, Isnin A.; Semedi, Bambang P.; Lefi, Achmad; Kusumastuti, Etty H.; Suyanto, Edi; Lilihata, Jilientasia G.; Anggoro, Adhitri; Rinjani, Lalu GP.; Rosyid, Alfian N.; Wahyu, Dwi; Fauziah, Dyah; Rahaju, Anny S.; Kurniasari, Nila; Ariani, Grace; Nugroho, Gilang MS.; Yandi, I KR.; Nugraha, Ricardo A.
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.463

Abstract

Excessive release of interleukin-6 (IL-6) during the progression of coronavirus disease 2019 (COVID-19) induces cytokine storms, resulting in multi-organ damages including liver injury, similar in nature with mechanism of viral hepatitis. Systemic IL-6 has been associated with the incidence of liver injury among COVID-19 patients; however, studies on IL-6 expression in the liver tissue are completely lacking. The aim of this study was to measure the IL-6 expression in the liver tissues and to determine its correlation with the degree of liver injury in fatal COVID-19 patients. Through this first cross-sectional study, IL-6 expression was measured through immunohistochemical staining and the degree of liver injury was identified based on level of serum alanine aminotransferase (ALT). The Spearman correlation test was used to identify the correlation between IL-6 expression and the degree of liver injury. A total of 47 deceased COVID-19 patients were included and IL-6 expression was observed in all post-mortem liver specimens, ranging from mild to strong expression. Liver injury at various degrees (mild to severe) was found in more than half (59.5%) of the cases. The Spearman correlation analysis suggested a statistically insignificant correlation between liver IL-6 expression and the degree of liver injury (r=0.152; p=0.309). In conclusion, even IL-6 expression was observed in all post-mortem liver specimens, there was an insignificant correlation between IL-6 expression in the liver tissue with the degree of liver injury among fatal COVID-19 patients, suggesting that IL-6 was not the only main factor contributing to liver damage in COVID-19 patients.
Co-Authors Agung Dwi Suprayitno Agustin, Leonita Alpha Fardah Athiyyah Alphania Rahniayu Anak Agung Gede Sugianthara Anang Endaryanto Andi Syarti Anggoro, Adhitri Anny Setijo Rahaju, Anny Setijo Ardiansyah, Djohan Ariani, Grace Arif Satria Hardika Askandar Tjokroprawiro Barliana Barliana Budi Utomo Cindy Angelina Limantara Cita Rosita Sigit Prakoeswa Deasy Fetarayani Dewi Astuti Kurniawati Dewi Sartika A. W. Dian Yuliartha Lestari Diana Purnamasari Djuanda, Stephanie N. Dwirani Rosmala Pratiwi Dyah Erawati, Dyah Edi Suyanto Elvin Nuzulistina Emillia Wijayanti Esti Hindariati Faradila Budi Saputri Faroek Hoesin Fauzan, Rizki Ahmad Febrina Diah Puspitasari Ferdiansyah Mahyudin Fira Soraya Fitriana . Gatot Soegiarto Gilang Adi Firmansyah Gondo Mastutik Gunawan, Vania A. Hardika, Arif Satria Heriyawati, Heriyawati Hermawan Udiyanto Ilmiah, Khafidhotul Imam Susilo INDRA YULIATI, INDRA INGRID SURYANTI SURONO Khafidhotul Ilmiah Kurniawati, Yuliana Kusumastuti , Etty Hary Kusumastuti, Etty H. Kusumastuti, Etty Hari KUSUMASTUTI, ETTY HARY Lefi, Achmad Lies Mardiyana, Lies Lilihata, Jilientasia G. Machin, Abdulloh Maharani, Andi RK. Mamiek Dwi Putro MANUEL HUTAPEA MANUEL HUTAPEA, MANUEL Marhana, Isnin A. Mega Kahdina Meyta Riniastuti MUHAMMAD RIZKI YAZNIL Nabilah Puspa Utami Nasrun Bakri Nila Kurniasari Nila Kurniasari Nugraha, Ricardo A. Nugroho, Gilang MS. Nunuk Mardiana, Nunuk Prastiya Indra Gunawan Qonitatillah, Ana Rahaju, Anny S. Rahmadewi Rahmadewi Retnani, Diah Prabawati Ridholia Ridholia Ridholia Ridholia, Ridholia Rinjani, Lalu GP. Rizkie T Trisnawaty Rosyid, Alfian N. ROY YUSTIN SIMANJUNTAK ROY YUSTIN SIMANJUNTAK, ROY YUSTIN S.Pd. M Kes I Ketut Sudiana . Sarah Fauzia Sari, Aditya Sita Semedi, Bambang P. Sjahjenny Mustokoweni, Sjahjenny SUHATNO - SUHATNO -, SUHATNO Supriadi Supriadi Sutrisno Sutrisno Teguh Prakosa, Teguh Tri Wulanhandarini Ulinta Pasaribu Ummi Maimunah wahjoe djatisoesanto Wahyu, Dwi wihasto suryaningtyas Willy Sandhika Wiratama, Priangga A. Wiratama, Priangga Adi Wirawan, Putu Tanisya Putri Yandi, I KR. Yaznil, Muhammad Rizki Yetti Hernaningsih Yuliana Kurniawati Yusuf, Muhtarum