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All Journal Jurnal Teknologi Industri Pertanian Jurnal Sain Veteriner International Journal of Renewable Energy Development Tengkawang : Jurnal Ilmu Kehutanan BIOTROPIA - The Southeast Asian Journal of Tropical Biology Indonesian Journal of Forestry Research Jurnal Penelitian Hasil Hutan Jurnal Penelitian Hutan Tanaman Jurnal Riset Industri JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) BERITA BIOLOGI Indonesian Journal of Chemistry Communications in Science and Technology Jurnal Ilmu dan Teknologi Kayu Tropis Teknologi Indonesia Jurnal Penelitian Hasil Hutan Wood Research Journal : Journal of Indonesian Wood Research Society Wood Research Journal : Journal of Indonesian Wood Research Society Jurnal Sylva Lestari Makara Journal of Technology Jurnal Ilmu Kehutanan Jurnal Ilmu Kehutanan International Journal of Renewable Energy Development Jurnal Penelitian Hasil Hutan
Wasrin Syafii
Departemen Hasil Hutan, Fakultas Kehutanan, Institut Pertanian Bogor Kampus IPB Darmaga, Bogor 16680
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Electrical & Electronics Engineering Energy Engineering Environmental Science Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Public Health Veterinary

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Antifungal Activity and Identification of Active Compounds From Wood Tristaniopsis whiteana (Griff) Against Wood Rot Fungus Jemi, Renhart; Syafii, Wasrin; Febrianto, Fauzi; Hanafi, Muhammad
Wood Research Journal Vol 15, No 1 (2024): WOOD RESEARCH JOURNAL
Publisher : Masyarakat Peneliti Kayu Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51850/wrj.2024.15.1.28-35

Abstract

The aim of the study was to analyze the content of pelawan wood extractive substances (Tristaniopsis whiteana (Griff)) and to test it with the fungi Schizophyllum commune Fr and Pleurotus ostreatus. Pelawan heartwood powder was macerated with methanol. Then fractionated in stages with n-hexane, chloroform, ethyl acetate, and butanol. The resulting extract was then tested with S. commune and P. ostreatus fungi. The most active fraction was isolated using column chromatography with a gradient system, the eluent was methanol:chloroform. Sub-fractions were then tested for fungi to determine the most active sub-fractions, and the most active sub-fractions were then analyzed by 1H NMR. The results showed that the extractive content of pelawan wood was most soluble in chloroform. All extract fractions contain potential as anti-fungal. .The chloroform fraction was very active compared to the other fractions. Isolation of the chloroform fraction by column chromatography obtained 8 sub-fractions. All of these sub-fractions were able to inhibit the growth of S.commune and P.ostreatus with IC(50) = 54.55 - 64.69 mg/L and IC(50) = 54.17 - 64.44 mg/L respectively. PL.3 sub-fraction was the most active among the 8 sub-fractions. The results of 1H NMR analysis on the PL.3 subfraction were shown to be Heptanoic Acid compounds.
Antifungal Activity and Identification of Active Compounds From Wood Tristaniopsis whiteana (Griff) Against Wood Rot Fungus Jemi, Renhart; Syafii, Wasrin; Febrianto, Fauzi; Hanafi, Muhammad
Wood Research Journal Vol 15, No 1 (2024): WOOD RESEARCH JOURNAL
Publisher : Masyarakat Peneliti Kayu Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51850/wrj.2024.15.1.28-35

Abstract

The aim of the study was to analyze the content of pelawan wood extractive substances (Tristaniopsis whiteana (Griff)) and to test it with the fungi Schizophyllum commune Fr and Pleurotus ostreatus. Pelawan heartwood powder was macerated with methanol. Then fractionated in stages with n-hexane, chloroform, ethyl acetate, and butanol. The resulting extract was then tested with S. commune and P. ostreatus fungi. The most active fraction was isolated using column chromatography with a gradient system, the eluent was methanol:chloroform. Sub-fractions were then tested for fungi to determine the most active sub-fractions, and the most active sub-fractions were then analyzed by 1H NMR. The results showed that the extractive content of pelawan wood was most soluble in chloroform. All extract fractions contain potential as anti-fungal. .The chloroform fraction was very active compared to the other fractions. Isolation of the chloroform fraction by column chromatography obtained 8 sub-fractions. All of these sub-fractions were able to inhibit the growth of S.commune and P.ostreatus with IC(50) = 54.55 - 64.69 mg/L and IC(50) = 54.17 - 64.44 mg/L respectively. PL.3 sub-fraction was the most active among the 8 sub-fractions. The results of 1H NMR analysis on the PL.3 subfraction were shown to be Heptanoic Acid compounds.
Kelarutan Lignin Kayu Cepat Tumbuh dalam Ekstraksi Alkali Deded Sarip Nawawi; Adesna Fatrawana; Wasrin Syafii
Jurnal Ilmu Kehutanan Vol 15 No 1 (2021): Maret
Publisher : Faculty of Forestry Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (546.99 KB) | DOI: 10.22146/jik.v15i1.1512

Abstract

The dissolution of wood lignin in the alkali solution were analyzed for two fast growing species, sengon (Paraserianthes falcataria) dan leda (Eucalyptus deglupta). Wood samples were extracted in 1% sodium hydroxide solution in cold and hot temperatures for 24 and 1 h, respectively. Extractable substances content, permanganate consumption (expressed as assumed lignin content) were analyzed from the filtrates, lignin content and diastereomeric of β-O-4 structure were analyzed from the wood residue after alkali extraction. The extracted substances from both of wood in hot alkali was higher than in cold alkali solution, although the time of cold alkali extraction was much longer that hot alkali extraction. Assumed lignin content in the extract was quite high in both samples which were 34.4-42.9% and 35.5-39.8% including 2,15-2,29% dan 1,04-1,32% of lignin for cold and hot alkali extraction, respectively. The changes in stereo isomeric form, erythro and threo, of β-O-4 structure of lignin in wood residue indicated that partial depolimerization of lignin was takec place during alkali treatment.
Antidiabetic Activities of Agarwood (Aquilaria malaccensis) Leaf Extracts via Enhanced Insulin Secretion in BRIN-BD11 Pancreatic Beta-Cells Prayogo, Yanico Hadi; Sari, Rita Kartika; Hamidi, Zikri; Syafii, Wasrin; Harlina, Eva; Prasetyo, Bayu Febram
Jurnal Sylva Lestari Vol. 13 No. 3 (2025): September
Publisher : Department of Forestry, Faculty of Agriculture, University of Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jsl.v13i3.1197

Abstract

Agarwood leaves (Aquilaria malaccensis), a non-timber forest products, shows significant potential as a source of antidiabetic compounds. This study aims to evaluate the antidiabetic activity of agarwood leaves and their cytotoxicity on pancreatic beta-cells, as well as predict their compound bioactivity through an in silico approach. The leaves were extracted using ethanol, water, and a mixture of ethanol–water with the assistance of ultrasound irradiation. The extracts were then tested in vitro for their antidiabetic potential by assessing their ability to inhibit the alpha-glucosidase enzyme and their effect on insulin secretion, as well as their cytotoxicity on BRIN-BD11 pancreatic beta-cells. The phytocompounds in the extract were identified using liquid chromatography-mass spectrometry, and their binding behavior was studied by in silico molecular docking. Among the three, the ethanol–water extract showed the highest extraction yield. Cytotoxicity assays revealed that the ethanol–water extract was cytotoxic at high concentrations (1000 µg/mL), but safe at lower concentrations. The alpha-glucosidase inhibition was relatively weak. Nevertheless, the extracts significantly stimulated insulin secretion in BRIN-BD11 cells up to fivefold compared to untreated cells. In silico studies indicated that xanthone glycoside, flavonoid glycoside, and coumarin compounds exhibit strong binding affinities to multiple insulin-secretion-related proteins. These findings suggest that agarwood leaf extract, particularly ethanol–water extract, possesses promising antidiabetic activity through an insulinotropic mechanism. Keywords: agarwood, alpha-glucosidase, insulinotropic, molecular docking
BIOMASSA SEBAGAI MATERIAL ELEKTRODA SUPERKAPASITOR Nur Adi Saputra; Wasrin Syafii; Gustan Pari; Deded Sarip Nawawi; Akhiruddin Maddu
Jurnal Penelitian Hasil Hutan Vol. 40 No. 3 (2022): Jurnal Penelitian Hasil Hutan
Publisher : BRIN Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20886/jphh.2022.40.3.189-202

Abstract

Electrical storage and distribution devices become important in next generation to help integrate more renewable energy intothe electricity grid. Supercapacitor technology is considered the most promising alternative to Li-ion batteries, which have limitedLithium material. However, the low energy density is a weakness of supercapacitors, even though they have a high-power density.Activated carbon-based supercapacitor electrodes have ideal potential for development. The inherent attributes of activated carbon,pore properties, and functional groups, are responsible for improving the performance of supercapacitors. The main challenge for theresearchers is the pore size distribution, micro (<2nm), meso (2–50 nm), and macro (>50 nm), which varied in activated carbon.Micro pores have an impact on increasing the value of specific capacitance values which will encourage an increase in energy density.Meso pores have an impact on the overall accessibility of the electrode surface by electrolyte ions. Future studies will emphasize oncarbonization and activated carbon activation techniques to improve the surface quality of activated carbon.
PENGARUH ZAT EKSTRAKTIF KAYU GAMAL (Gliricidia sepium Jacq.) TERHADAP NILAI KALOR Rahmi Mauladdini; Wasrin Syafii; Deded Sarip Nawawi
Jurnal Penelitian Hasil Hutan Vol. 40 No. 2 (2022): Jurnal Penelitian Hasil Hutan
Publisher : BRIN Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20886/jphh.2022.40.2.125%E2%80%93134

Abstract

The development of gamal wood (Gliricidia sepium Jacq.) aims to meet the needs of biomass energy in rural areas. Manystudies on extractives of gamal wood have been carried out, but there is very little information about the effect of extractives on thecalorific value. The effect of extractives on the calorific value can be determined by analyzing extractives compounds contained in thewood. This study aimed to determine the extractives compounds that affect the wood calorific value. The sawdust of gamal bark andwood was extracted by successively maceration by using solvents with different polarities. The free-extractives sawdust was thenmeasured for its calorific value. To ascertain the effect of extractives on the calorific value, the extract of the gamal bark and woodwas added to the oil palm sawdust, then the increase in calorific value was measured. The results showed that the extractives ingamal bark and wood affect the change of calorific value. The removal of extractives by using different solvents caused a differentdecrease in calorific value. The highest decrease in calorific value (4.03%) was obtained by non-polar (n-hexane) soluble extractiveof the gamal bark. The addition of gamal wood extracts to oil palm sawdust also causes an increase in the calorific value.Phytochemical and LC-MS/MS analysis of n-hexane soluble extractives from gamal bark detected groups of terpene compounds,amides alkaloids, flavonoids, coumarins, and benzopyrans. Based on the results of this study, the n-hexane soluble compounds wassuspected to have the most influence on the calorific value.
KAJIAN STRUKTUR ARANG-PIROLISIS, ARANG-HIDRO DAN KARBON AKTIF DARI KAYU Acacia mangium Willd. MENGGUNAKAN DIFRAKSI SINAR-X Saptadi Darmawan; Wasrin Syafii; Nyoman J Wistara; Akhirudin Maddu; Gustan Pari
Jurnal Penelitian Hasil Hutan Vol. 33 No. 2 (2015): Jurnal Penelitian Hasil Hutan
Publisher : BRIN Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20886/jphh.2015.33.2.81-92

Abstract

Activated carbon has been used widely for various applications. Hydro-char which is hydrothermally carbonized from biomass could be used as an alternative precursor for activated carbon manufacture, which is commonly obtained from pyrolized-char. This paper observes crystalline structure of Acacia mangium’s pyrolized-char and hydro-char using XRD (X-raydiffraction). The mangium wood was carbonized in 200°C and 300°C and depth analysis was conducted based on activated carbon product. Result shows carbon maturity index and aromaticity from both precursors (conventional and alternative) tends to increase after being activated; interlayer spacing (d002) is getting closer; meanwhile, crystallinity is greater; and the number, height as well as width of aromatic layers are increasing. Hydro-char exhibited crystallinity degree, maturity and aromaticity lower than those of the pyrolized-char obtained at 300°C carbonization, with the greater volatile content. Both types of char perform carbon structure with amorphous texture. The greatest iodine adsorption is achieved by hydro-char which was carbonized at 300°C. In general, XRD analysis on low temperature carbonization of pyrolized-char and hydro-char could predict the porosity of activated carbon.
SIFAT DAN MUTU ARANG AKTIF TEMPURUNG KEMIRI Mody Lempang; Wasrin Syafii; Gustan Pari
Jurnal Penelitian Hasil Hutan Vol. 30 No. 2 (2012): Jurnal Penelitian Hasil Hutan
Publisher : BRIN Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20886/jphh.2012.30.2.100-113

Abstract

Activated charcoal is charcoal product obtained through activating process which possesses better adsorption properties and wider uses than charcoal. The common sources of activated charcoal feedstocks are coal, wood and agricultural by-products such as nutshells and fruitpits. This research was carried out to develop processing technology of cundienut shell activated charcoal. Candlenut shell (Aleurites moluccana Willd) were carbonised in drum kyln to produce charcoal, then the charcoal was activated in electrical retort beating duration of 90 and 120 minuts at temperatur of 550 C, 650 C and 750 C. Properties evalnation were assessed in a accord with the Indonesia National Standard (SNI) 06-3730-1995. Results indicated that the activation treatment bad direct affect on the activated charcoal properties. The activated charcoal that efforded highest adsorption capacity on lodine number of 758,70 mg/g wat optained by steaming activation could meet at temperatur of 750 C. This activated charcoal properties the requirements of SN106-3730-1995,
FIBER DISRUPTION OF BETUNG BAMBOO (Dendrocalamus asper) BY COMBINED FUNGAL AND MICROWAVE PRETREATMENT Fatriasari, Widya; Syafii, Wasrin; Wistara, Nyoman; Syamsu, Khaswar; Prasetya, Bambang; Anita, S Heris; Risanto, Lucky
BIOTROPIA Vol. 22 No. 2 (2015): BIOTROPIA Vol. 22 No. 2 December 2015
Publisher : SEAMEO BIOTROP

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1200.375 KB) | DOI: 10.11598/btb.2015.22.2.363

Abstract

Combined microwave pretreatment is an effective method to modify carbohydrate and lignin structures of fungal and lignocellulosic materials, thereby improving the hydrolysis process for bioethanol conversion. This study aimed to evaluate the structural changes in carbohydrate and lignin components of betung bamboo following a combined biological–microwave pretreatment. Based on previous findings, a 30-day incubation using 5% and 10% (w/v) inoculum loading of the white-rot fungus Trametes versicolor—which showed the highest delignification selectivity—was selected as the fungal pretreatment. Microwave irradiation was then applied for 5, 10, and 12.5 minutes at 330 W. Characterization of structural changes was conducted using FTIR spectroscopy, X-ray diffraction (XRD), and scanning electron microscopy (SEM). FTIR analysis revealed that the combined pretreatment affected only the intensity of absorption bands without altering the functional groups. A decline in peak intensity occurred at 1,736 cm⁻¹ (C=O in xylan), 1,373 cm⁻¹ (C–H deformation in cellulose and hemicellulose), 1,165 cm⁻¹ (C–O–C vibration in cellulose and hemicellulose), and 895 cm⁻¹ (β-glycosidic linkage in cellulose). The pretreatment reduced hydrogen bonding in cellulose and weakened lignin–carbohydrate linkages associated with bamboo cellulose crystallinity. A slight increase in crystallinity index was observed due to cleavage of the amorphous fraction. SEM imaging confirmed the disruption of fiber structure, showing increasing degradation with longer microwave exposure durations.
In-vitro, In-vivo, and In-silico Studies of Insulinotropic Activity and Cytotoxicity of Mahagony Seed Extracts and Its Nanophytosome Hamidi, Zikri; Sari, Rita Kartika; Prayogo, Yanico Hadi; Syafii, Wasrin; Kasmi, Adinda Zahra Marissa; Prasetyo, Bayu Febram; Harlina, Eva; Wahyudi, Setyanto Tri
Communications in Science and Technology Vol 10 No 2 (2025)
Publisher : Komunitas Ilmuwan dan Profesional Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21924/cst.10.2.2025.1676

Abstract

This present study set out with the objective of evaluating the effect of ethanol–water solvent composition on extraction yield, insulinotropic activity (IA), cytotoxicity, and phytochemical profile (PP) of mahogany (Swietenia mahagoni) seed (MS) extracts. It also sought to study in silico and encapsulate the best extract, and to assay the antidiabetic of the extract and its nanophytosome. The extraction of MSs was achieved through the utilization of ethanol, ethanol–water (1:1), and water through ultrasound–assisted extraction. The extracts of IA and cytotoxicity were assayed in vitro using BRIN–BD11 cell lines and analyzed using LC-MS. The most effective extract was identified for its active compounds using molecular docking, encapsulation, characterization, and testing for its antidiabetic properties in vivo. The highest yield was observed in the water extract (MW), followed by the ethanol–water extract (MEW) and the ethanol extract (ME). MEW and MW demonstrated low level of cytotoxicity, with MEW exhibiting the highest level of IA. An in silico study identified four key antidiabetic compounds through the IA mechanism. The study demonstrated that MEW and its nanophytosome (250 mg/kg mouse weight) effectively reduced blood glucose level, and enhanced both erythrocyte function, and insulin secretion. This finding provides a new perspective in the development of natural-based antidiabetic agents through the nanophytosome formulation of mahogany seed extract.
Co-Authors Abdul Aziz Darwis Achmad Achmad Achmad Achmad Adesna Fatrawana Adesna Fatrawana Akhiruddin Maddu Akhirudin Maddu Akhirudin Maddu Akhirudin Maddu Amril Aman Anak Agung Istri Sri Wiadnyani Ani Suryani Anne Carolina Bambang Prasetya Bambang Prasetya Bayu Febram Prasetyo Bintang C. H. Simangunsong Buchari Buchari Deded Sarip Nawawi Deded Sarip Nawawi Denny Irawati Desi Melianti Dewi R Agungpriyono E Gumbira Sa, E Gumbira Eka Novriyanti Eka Novriyanti Eko Budi Santoso Eko S Pribadi Elis Nina Herliyana ENDANG SUHENDANG Erdy Santosa Erdy Santosa Eva Harlina Evie Nihayah Fabianus Ranta Fahriya Puspita Sari Faizatul FALAH Fathul Yusro Fauzi Febrianto Gunawan Pasaribu Gunawan Pasaribu Gustan Pari Gustan Pari Gustan Pari Gustan Pari Gustan Pari Gustan Pari Gustan Pari Gustan Pari Gustan Pari Gustan Pari Gustan Pari Gustan Pari Gustini Syahbirin Hamidi, Zikri Herman Siruru Herman Siruru Hikma Yanti Hiroyuki Yamamoto Husni Y Rosadi, Husni Y I MADE ARTIKA I Nyoman Jaya Wistara IGK Tapa Darma Illah Sailah Imam Wahyudi Indrawan, Imam Wahyudi Irmanida Batubara Irnayuli R. Sitepu Irnayuli R. Sitepu Iskandar Z Siregar Istie Rahayu Izza Firdausi Hadiyanto Jemi, Renhart Juliasman Juliasman Karliati, Tati Kasmi, Adinda Zahra Marissa Khaswar Syamsu Kosei Yamauchi Kurnia Sofyan Kurnia Sofyan Kurnia Sofyan Laela N. Anisah Laela Nur Anisah Latifah K. Darusman Latifah K. Darusman Lucky Risanto M. Daud Maggy T Suhartono Maggy T Suhartono Maman Turjaman Maman Turjaman Maya Ismayati Mody Lempang Mody Lempang Mody Lempang Mody Lempang Muflihati Muflihati Muhammad Adly Rahandi Lubis Muhammad Fadli Muhammad Hanafi Nissa Nurfajrin Solihat Norman Razief Azwar Nugraha, Arifin Budiman Nur Adi Saputra Nur Adi Saputra Nur Azizah Prayogo, Yanico Hadi Pudja Mardi utomo Pudja Mardi utomo Purwoko, Agus Rahmi Mauladdini Rahmi Mauladdini Renhart Jemi Rita K Sari Rita Kartika Sari Romi Irka Putra S Heris Anita, S Heris Saat Egra Santiyo Wibowo Santiyo Wibowo Santiyo Wibowo Saptadi DARMAWAN Saptadi Darmawan Saptadi Darmawan Setyanto Tri Wahyudi Simon Taka Nuhamara Simon Taka Nuhamara Siruru, Herman Siti Maemunah Siti Sa&#039;diah Siti Sa'diah Soetrisno Hadi Soetrisno Hadi Sri Familasari Suminar A Achmadi Suminar S Achmadi Syamsul Arifin Tohru Mitsunaga Umi Cahyaningsih Widya FATRIASARI Widya FATRIASARI Yanico Hadi Prayogo Yanotama T Laksana Yanti Hikma Yusup AMIN