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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Pertanian Indonesia ACTA VETERINARIA INDONESIANA Hemera Zoa Jurnal Sain Veteriner Jurnal Ilmu Ternak Jurnal Medik Veteriner ARSHI Veterinary Letters Jurnal Kedokteran Hewan Asian Journal of Social and Humanities Jurnal Veteriner
Anita Esfandiari
IPB University
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Earth & Planetary Sciences Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Veterinary

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Effect of Bosswelic Acid On Hematological Parameters In Sprague Dawley Rats (Rattus novergicus) Induced By Cyclophosphamide Lingga Surya Maret Daulay; Ietje Wientarsih; Anita Esfandiari; Lina Noviyanti Sutardi; Nuzul Asmilia
Asian Journal of Social and Humanities Vol. 2 No. 5 (2024): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v2i5.239

Abstract

Chemotherapy drug “cyclophosphamide (SP)” can trigger oxidative stress that causes hematotoxicity and myelotoxicity, therefore an agent that can suppress the negative effects of cyclophosphamide is needed. Boswellic acid is an herbal medicine that has anti-oxidant and anti-inflammatory effects. The aim of this study was to determine the effect of boswellic acid (BA) in hematology parameter rats induced by cyclophosphamid. Animal were allocated in to six groups, each group consists of 5 rats, the KS: healthy group, KSP: cyclophosphamide group; KSD: comparison group, and BA groups (K1;K2;K3). The treatment groups were given cyclophosphamide (SP) at dose of 150 mg/kg body weight (BW) i.p. The BA groups (K1,K2,K3) were given BA at dose of 250 mg/kg BW orally for 6 consecutive days and SP on day 1 (K1), day 4 (K2), day 6 (K3). The results showed that BA administration (K2 and K3) can help increase/maintain the amount of hematological parameters including hemoglobin, hematocrit, and erythrocytes. Administrating BA for 6 days consecutively before SP (K3) has shown best results on hematological parameters than the others including the comparison group. These results suggest that BA may have a potential herbal therapeutic agents that can mitigate cyclophosphamide-induced hematotoxicity manifestations.
Laporan Kasus: Suspek Hidronefrosis akibat Tumor Prostat pada Anjing di Rumah Sakit Hewan Pendidikan (RSHP) Sekolah Kedokteran Hewan dan Biomedis (SKHB) IPB University Wibowo, Deny Setyo; Wulansari, Retno; Esfandiari, Anita; Widhyari, Sus Derthi; Wijaya, Agus; Gunanti, Gunanti; Fitri, Arni Diana
Jurnal Sain Veteriner Vol 43, No 1 (2025): April
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.102272

Abstract

Seekor anjing jantan ras domestik berumur 16 tahun dibawa ke Rumah Sakit Hewan Pendidikan (RSHP), Sekolah Kedokteran Hewan dan Biomedis (SKHB), IPB University. Pasien datang dengan keluhan tidak mau makan hingga dua hari, berdiri dan jalan tidak stabil, muntah, nistagmus, dan sempat jatuh terguling. Pemeriksaan fisik palpasi abdomen menunjukkan adanya pembesaran serta nyeri pada kelenjar prostat. Setelah dilakukan pemeriksaan penunjang hematologi, anjing menunjukkan penurunan jumlah eritrosit, hemoglobin, hematokrit, trombosit, dan PCT. Hasil pemeriksaan kimia darah menunjukkan penurunan kadar SGOT serta peningkatan kadar BUN dan kreatinin. Hasil pemeriksaan USG menunjukkan adanya formasi kristal pada pyelum ginjal kiri, perubahan batas antara korteks dengan medula dan atrofi ginjal kanan, peningkatan ketebalan vesika urinaria, serta perubahan ekogenitas parenkim dan ukuran prostat. Hasil pemeriksaan radiografi menunjukkan adanya pembesaran pada prostat dan preputium. Hasil pemeriksaan urinalisis menunjukkan peningkatan UPC serta adanya protein, darah, kreatinin, dan leukosit. Kasus ini memiliki diagnosa banding yaitu hidronefrosis, tumor prostat, prostatitis, dan neuron injury dengan prognosis infausta. Penanganan pada kasus ini dilakukan dengan pemberian terapi berupa infus asering, suplemen, bronkodilatator, diuretik, serta antiemetik.  
Domestic Pigs as an Animal Model of Myocardial Infarction: a Comparison of Systolic and Diastolic Blood Flow Velocities of Cardiac Valves Fitri, Arni Diana; Subangkit, Mawar; Esfandiari, Anita; Gunanti; Noviana, Deni
Acta VETERINARIA Indonesiana Vol. 13 No. 1 (2025): Maret 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.1.8-15

Abstract

Cardiovascular disease (CVD) is still the leading cause of death according to WHO in 2021. CVD generally results in myocardial infarction (MI), which occurred after tissue ischemia. Echocardiography is most likely a diagnostic tool without invasive effects. This study aimed to compare the blood flow in pig research animals treated with ligases of the circumflex arteries. Measurements were made in the mitral valve (MV), tricuspid valve (TV), semilunar pulmonary valve (SLP), and semilunar aortic valve (AO) of velocity during systole (Vs), velocity during diastole (Vd), time average peak velocity (TAMAX), and blood flow pressure at three-time points: before ligase treatment, after acute infarction (60 min), and 8 weeks after ligase treatment. All parameters in MV group increased at 60 min and decreased at 8th weeks. On TV, TAMAX and pTAMAX decreased at 60 min and week 8. In SLP, VS, pVS, and Vd decreased at 60 min and increased at 8th week. The pVd and pTAMAX parameters decreased at 60 min and 8th week, while TAMAX increased at 60 min and decreased at 8th week. In AO, the TAMAX and pTAMAX parameters increased at 60 min and 8 weeks; the other parameters were similar to MV and TV patterns.
THE EFFECTS OF AGE ON BIOCHEMISTRY PROFILES OF ACEH CATTLE BLOOD Khairita, Lia; Esfandiari, Anita; Widhyari, Sus Derthi; Winarsih, Wiwin
Jurnal Kedokteran Hewan Vol 15, No 3 (2021): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v15i3.21698

Abstract

The purpose of this study was to analyze the effects of age on the biochemistry profiles of aceh cattle, which included examinations of: total protein (TP), albumin, globulin, albumin/globulin ratio (A/G), aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), alkaline phosphatase (ALP), creatine kinase (CK), blood urea nitrogen (BUN), calcium (Ca), phosphorus (P) and magnesium (Mg) . Sixteen clinically healthy aceh cattle aged 2-4 years old, and 16 aceh cattle aged 4-6 years old were purposively selected for the study. Blood samples were drawn from the jugular vein and subjected to blood biochemistry measurements using commercial kits. The results showed that serum concentrations of TP, globulin, AST and Ca of aceh cattle were significantly (P0.05) higher in age group 4-6 years old, while ALP activity was significantly (P0.05) higher in age group 2-4 years old. In conclusion, age must be considered as a factor when interpreting the blood biochemistry profiles of aceh cattle.
Effect of Bosswelic Acid On Hematological Parameters In Sprague Dawley Rats (Rattus novergicus) Induced By Cyclophosphamide Maret Daulay, Lingga Surya; Wientarsih, Ietje; Esfandiari, Anita; Sutardi, Lina Noviyanti; Asmilia, Nuzul
Asian Journal of Social and Humanities Vol. 2 No. 5 (2024): Asian Journal of Social and Humanities
Publisher : Pelopor Publikasi Akademika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59888/ajosh.v2i5.239

Abstract

Chemotherapy drug “cyclophosphamide (SP)” can trigger oxidative stress that causes hematotoxicity and myelotoxicity, therefore an agent that can suppress the negative effects of cyclophosphamide is needed. Boswellic acid is an herbal medicine that has anti-oxidant and anti-inflammatory effects. The aim of this study was to determine the effect of boswellic acid (BA) in hematology parameter rats induced by cyclophosphamid. Animal were allocated in to six groups, each group consists of 5 rats, the KS: healthy group, KSP: cyclophosphamide group; KSD: comparison group, and BA groups (K1;K2;K3). The treatment groups were given cyclophosphamide (SP) at dose of 150 mg/kg body weight (BW) i.p. The BA groups (K1,K2,K3) were given BA at dose of 250 mg/kg BW orally for 6 consecutive days and SP on day 1 (K1), day 4 (K2), day 6 (K3). The results showed that BA administration (K2 and K3) can help increase/maintain the amount of hematological parameters including hemoglobin, hematocrit, and erythrocytes. Administrating BA for 6 days consecutively before SP (K3) has shown best results on hematological parameters than the others including the comparison group. These results suggest that BA may have a potential herbal therapeutic agents that can mitigate cyclophosphamide-induced hematotoxicity manifestations.
Profil Hematologi, Kadar Besi (Fe), dan Rasio Mieloid: Eritroid Kuda Hiperimun yang digunakan dalam Produksi Plasma Antisera Arifianto, Dinar; Esfandiari, Anita; Wibawan, I Wayan Teguh; Amrozi, Amrozi; Maharani, Maharani; Darsono, Darsono; Setiadi, Hirawan; Setiyono, Agus
Jurnal Sain Veteriner Vol 42, No 1 (2024): April
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.90681

Abstract

Kuda merupakan salah satu hewan yang penting dalam produksi plasma antisera sebagai bahan baku pembuatan serum. Akhir abad ke-19 kuda berperan krusial dalam pengembangan serum pertama terhadap penyakit difteri manusia. Hingga saat ini kuda masih digunakan untuk memproduksi berbagai serum anti-venom, anti-rabies, anti-tetanus, hingga anti-SARS CoV-2. Proses produksi plasma antisera diawali dengan injeksi imunogen pada kuda yang disebut dengan hiperimunisasi. Antibodi dalam jumlah besar yang terbentuk dikoleksi kemudian dipurifikasi untuk digunakan pada manusia. Hiperimunisasi menimbulkan berbagai efek samping, diantaranya adalah penimbunan fibril amiloid pada berbagai jaringan yang dapat mengganggu fisiologi dan fungsi organ tubuh. Sebanyak 12 ekor kuda digunakan dalam penelitian ini dan dibagi menjadi 4 kelompok. Kuda kontrol (n=3) terdiri atas kuda yang belum pernah mendapatkan perlakuan hiperimunisasi, sedangkan 9 kuda lainnya dikelompokkan berdasarkan lamanya waktu produksi plasma antisera dengan metode hiperimunisasi (masing-masing kelompok berjumlah 3 ekor). Kelompok I terdiri atas kuda dengan masa produksi 2-3 tahun, kelompok II terdiri atas kuda dengan masa produksi 4-5 tahun, dan kelompok III terdiri atas kuda dengan masa produksi 6-7 tahun. Sampel darah, serum, dan aspirasi sumsum tulang dianalisis utuk menghitung niali eritrosit, Hb, PCV, trombosit, profil besi (besi serum, UIBC, TIBC, saturasi transferin), rasio mieloid:eritroid (M:E) dan persentase retikulosit. Analisis statistik menunjukkan bahwa terdapat perbedaan yang signifikan pada parameter eritrosit dan rasio M:E (P<0,05), sedangkan niali Hb, PVC, trombosit, prosentase retikulosit, dan profil besi tidak ditemukan perbedaan yang signifikan (P>0,05). Data tersebut menunjukkan bahwa perlakuan hiperimunisasi menyebabkan penurunan eritrosit dan peningkatan nilai rasio mieloid:eritroid (M:E) pada kuda penghasil plasma antisera.
Hematological Profile of Macaca nemestrina Across Different Age Groups Sri Wahyuni; Fitriya Nur Annisa Dewi; Anita Esfandiari; Suryo Saputro; Huda Shalahudin Darusman
Acta VETERINARIA Indonesiana Vol. 13 No. 3 (2025): November 2025
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avi.13.3.217-223

Abstract

Macaca nemestrina, also known as the pigtail macaque, plays a crucial role in drug development and serves as a highly valuable animal model for studying various human diseases due to its phenotypic similarities to humans, including those related to the aging process. Hematology is a critical component of clinical assessments for this spesies, serving both as a diagnostic tool to determine their health status and to characterize disease models, including degenerative and geriatric diseases. As anemia is a common phenomenon in the elderly, it is also important to determine whether M. nemestrina exhibit a similar condition with age. The aim of this study was to determine the hematological profiles of clinically healthy female M. nemestrina across young, adult, and elderly age groups, particularly related to anemia parameters. This study was conducted at the Primate Research Center, IPB University, Bogor, Indonesia. The animals were part of a breeding colony and were divided into three groups based on age: young (5–7 years), adult (12–14 years), and elderly (18–21 years). Following anesthesia with ketamine, a physical examination was performed to determine clinical status, and blood samples were collected for a complete blood count (CBC) evaluation using an automated analyzer. The results showed that total erythrocytes, hemoglobin concentration, hematocrit value, and mean corpuscular hemoglobin (MCH) were significantly different (P<0.05) in the elderly group compared to the other groups. Additionally, the red cell distribution width (RDW) percentage and leukocyte count differed significantly between the adult and elderly groups. The results showed that the erythrogram differs with age in clinically healthy M. nemestrina, suggesting the importance of determining appropriate baseline reference values in macaques of different ages.
Ragam Jenis Caplak di Lingkungan Kampus Institut Pertanian Bogor Dramaga dan Potensinya Sebagai Vektor Penyakit Padang, Ardy Armando; Supriyono, Supriyono; Hadi, Upik Kesumawati; Soviana, Susi; Esfandiari, Anita
Jurnal Veteriner Vol. 27 No. 1 (2026)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/

Abstract

Caplak sebagai ektoparasit memiliki berbagai macam inang, serta memiliki peran yang signifikan sebagai vektor penyakit. Caplak menularkan berbagai jenis patogen termasuk bakteri. Penelitian ini bertujuan mengidentifikasi ragam jenis caplak di lingkungan kampus IPB serta mendeteksi bakteri patogen yang terdapat pada caplak. Sampel dikoleksi dengan dua metode, yaitu flagging dan secara langsung pada hewan dengan total waktu tiga bulan. Metode flagging dilakukan di beberapa pekarangan rumput di dalam kampus IPB, seperti pekarangan Rumah Sakit Hewan Pendidikan (RSHP), Unit Reproduksi dan Rehabilitasi (URR) dan sebagainya. Koleksi caplak dilakukan pada lima titik di area dengan waktu kurang lebih 10 menit pada setiap titik area. Kecepatan koleksi sama dengan kecepatan normal berjalannya manusia biasa dengan ukuran bendera 60 x 90 cm. Koleksi dilakukan sekali dalam dua minggu selama tiga bulan. Metode koleksi langsung pada hewan, dilakukan pada beberapa jenis hewan peliharaan seperti ayam, anjing dan kucing yang berada di dalam kampus IPB dan dilakukan secara manual menggunakan tangan dibantu dengan pinset. Jumlah caplak yang berhasil dikoleksi dalam periode penelitian adalah sebanyak 16, dimana 7 berasal dari metode flagging, dan 9 berasal dari metode koleksi langsung. Caplak hasil koleksi diidentifikasi berdasarkan morfologi kemudian dideteksi terhadap adanya bakteri Rickettsia dan Anaplasma dengan metode Polymerase Chain Reaction (PCR). Caplak yang berhasil ditemukan dengan flagging yaitu Rhipicephalus (R.) microplus dan R. sanguineus, sedangkan pada hewan ditemukan R. sanguineus dan Haemaphysalis (H.) wellingtoni. Caplak hasil koleksi dengan metode flagging ditemukan di satu lokasi, yaitu URR. Koleksi caplak secara langsung pada hewan, ditemukan 7 caplak pada 2 ekor anjing, dan 2 caplak pada 2 ekor ayam. Hasil deteksi molekular terhadap bakteri Rickettsia dan Anaplasma menunjukkan hasil yang negatif. Sehingga, caplak yang dapat diidentifikasi di dalam lingkungan kampus IPB Dramaga yaitu R. sanguineus, R. microplus, dan H. wellingtoni dimana tidak ada satupun caplak dalam penelitian yang membawa patogen Rickettsia dan Anaplasma.
Citra ultrasonografi dan profil hematologi kasus pyometra pada kucing di Klinik Hewan Cimanggu Rr Soesatyoratih; Anita Esfandiari
ARSHI Veterinary Letters Vol. 6 No. 4 (2022): ARSHI Veterinary Letters - November 2022
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.6.4.61-62

Abstract

Seekor kucing betina bernama Berlin datang ke Klinik Hewan Cimanggu dengan keluhan hewan lesu, kurang nafsu makan dan mengeluarkan cairan merah dari bagian belakang tubuhnya. Hasil pemeriksaan fisik kucing bernama Berlin didapatkan adanya leleran lendir yang berwarna merah keluar dari vulva. Dari hasil anamnesa dan temuan klinis, kucing Berlin diduga menderita pyometra. Pyometra merupakan suatu gangguan reproduksi pada hewan betina yang ditandai dengan adanya penimbunan nanah pada uterus. Dari gejala klinis yang tampak, pyometra yang diderita kucing Berlin adalah pyometra terbuka. Hasil pemeriksaan penunjang ultrasonografi dan pemeriksaan darah terkonfirmasi kucing Berlin menderita pyometra.
Extra-hepatic biliary duct obstruction pada anjing ras Dachshund Nicolas Edward Christanto Kartjito; Siti Aisyah Rahmalia Effendi; Gamelita Rizkawandi Solinda; Setyo Widodo; Sus Derthi Widhyari; Retno Wulansari; Agus Wijaya; Fitriya Nur Annisa Dewi; Deny Setyo Wibowo; Anita Esfandiari
ARSHI Veterinary Letters Vol. 7 No. 2 (2023): ARSHI Veterinary Letters - Mei 2023
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.7.2.25-26

Abstract

Anjing jantan ras dachsund (Teckel) berwarna hitam, berusia 4 tahun dengan bobot badan 7,5 kg dibawa pemiliknya datang ke klinik hewan dengan keluhan muntah berulang. Hasil pemeriksaan hematologi menunjukkan polisitemia, leukositosis dan jumlah granulosit yang tinggi. Hasil uji biokimia darah menunjukkan peningkatan pada aktivitas SGPT/ALT, GAMA-GT, total bilirubin, total protein, albumin, rasio ALB/GLOB dan rasio BUN/CRE. Hasil radiografi menunjukkan adanya bentukan membulat radiolucent didekat organ hati. Diagnosa kasus klinis pada anjing ini yaitu extrahepatic biliary duct obstruction dan terapi simptomatik dilakukan dengan memberikan gastroprotektan, antiemetik, serta obat-obatan untuk membantu memperbaiki fungsi hati. Pengobatan dilakukan selama 2 minggu dan menunjukan perbaikan pada organ hati berdasarkan hasil pemeriksaan biokimia darah, diikuti dengan tidak ada dilatasi kantung empedu pada radiogram.
Co-Authors . Herlina . Suryono Aditia Dwi Cahyono Agus Lelana Agus Setiyono Agus Wijaya Agus Wijaya Agus Wijaya Ali Hujarat Amrozi Arief Purwo Mihardi Arief Purwo Mihardi Arif Purwo Mihardi Arifianto, Dinar Arni Diana Fitri Azzahrah, Putri Bambang Pontjo Priosoeryanto Bayu Febram Bayu Firmala Kusuma Bintang Nurul Iman Chusnul Choliq Chusnul Choliq Damiana Rita Ekastuti Darsono Darsono Deni Noviana Deny Setyo Wibowo Dewi, Fitriya Nur Annisa Dondin Sajuthi Dwi Utari Rahmiati Erni Sulistiawati Fitri, Arni Diana Fitriya Nur Annisa Dewi Friska Mery Montolalu Gagah Hendra Wijaya Gamelita Rizkawandi Solinda Gunanti Gunanti . Henny Nuraini Huda Shalahudin Darusman I Ketut Sutama I wayan Teguh Wibawan Ida Zahidah Irfan IETJE WIENTARSIH Joan Elviyanti Joesoef, Jayusman Arsiyanti Kathirina Beatrik Riwu Wolo Khairita, Lia Kusumawati, Nina Tri Leni Maylina Lia Khairita Lina Noviyanti Sutardi Lingga Surya Maret Daulay Madyastuti, Rini Maharani Maharani, Maharani Maret Daulay, Lingga Surya Mohamad Yamin Nicolas Edward Christanto Kartjito Nina Kusumawati Ningtias, Putri Indah Nuzul Asmilia Nuzul Asmilia Padang, Ardy Armando Retno Wulansari Rizal Arifin Akbari Rizal Rahadian Ramdhany Robby Wienanto Robby Wienanto Rr Soesatyoratih Safitria Wulandari Setiadi, Hirawan Setyo Widi Nugroho Setyo Widodo Setyo Widodo Setyo Widodo Setyo Widodo Siti Aisyah Rahmalia Effendi sri murtini . Sri Wahyuni Subangkit, Mawar Supriyono Supriyono Suryo Saputro Sus Derthi Widhyai Sus Derthi Widhyari Sus Derthi Widhyarti Susi Soviana Tiara Widyaputri Upik Kesumawati Hadi Virgilius Martin Kelake Kedang Virgilius Martin Kelake Kedang Wasmen Manalu Wiwin Winarsih Wolo, Kathirina Beathrik Riwu