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All Journal International Journal of Public Health Science (IJPHS) Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Pendidikan Biologi Undiksha Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Medula Indonesian Journal of Urology Bioeksperimen: Jurnal Penelitian Biologi Jurnal Penelitian Pertanian Terapan Paediatrica Indonesiana Jurnal Biologi Tropis Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Kesehatan Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) BIO-EDU: Jurnal Pendidikan Biologi Jurnal Ilmu Medis Indonesia Bioma : Jurnal Biologi dan Pembelajaran Biologi IJIS Edu : Indonesian Journal of Integrated Science Education JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai Jurnal Agromedicine Unila: Jurnal Kesehatan dan Agromedicine
Hendri Busman
Jurusan Biologi Fakultas Matematika dan Ilmu Pengetahuan Universitas Lampung
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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The Effect of Black Pepper (Piper nigrum L.) Extract on Morphology and number of Mice (Mus musculus L.) Spermatozoa Induced by Progestin Hormone Indriyani; Sutyarso; Busman, Hendri; Nurcahyani, Nuning; Setyaningrum, Endah
Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Vol. 11 No. 2 (2024)
Publisher : Department of Biology Faculty of Mathematics and Natural Sciences Universitas Lampung in collaboration with The Indonesian Association of Biology (PBI) Lampung Branch.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jbekh.v11i2.384

Abstract

The progestin hormone is used as male hormonal contraception. Giving progestin to normal men can  suppress libido and testicular function effectively, and reduce testosterone levels so that it can interferer with the spermatogenesis process. This study is about the effectiveness of black pepper (Piper nigrum L.) extract on morphology and number of spermatozoa in mice (Mus musculus L.)  induced by progestin. This study used a completely randomized design (CRD) which has divided into four treatment groups, each group contained 5 mice and treated according to the experimental design. Group P0 as a control (given H2O), P1 (induced by 1,25 mg progestin), P2 (induced by 1,25 mg progestin and 3.33mg/Kg BW ethanol extract of black pepper), and P3 (induced by 1,25 mg progestin and 3.33mg/Kg BW distilled water extract of black pepper). The Progestin hormone is given twice (week 1 and week 2). Black pepper extract was given daily for 35 days. Data were analyzed by one-way ANOVA and continued with the LSD test with a level of 5%. The result showed that giving of ethanol extract and distilled water extract from black pepper could improve the normal morphology and number of spermatozoa in mice after induced by progestin hormone so that fertility in men increases.
A Case Report: Multidrug-Resistant Tuberculosis in A 53-Year-Old Patient Mustofa, Syazili; Ananta, Yoga; Ginting, Bisart; Septiani, Linda; Busman, Hendri
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 2 (2025): Volume 12 Nomor 2
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i2.18173

Abstract

A 53-year-old man with multidrug-resistant tuberculosis (MDR-TB) presented with clinical symptoms such as cough with yellow-white sputum for a month, shortness of breath, fever, night sweats, and weight loss. After completing six months of TB treatment in 2010, he developed MDR-TB, proven by resistance to rifampicin. Initial diagnosis by chest X-ray showed signs of pulmonary TB and right pleural effusion, while the sputum test confirmed Mycobacterium tuberculosis with moderate bacterial load. Laboratory results showed anemia, leukocytosis, and hypoalbuminemia. The patient's therapy included a combination of bedaquiline, levofloxacin, linezolid, clofazimine, cycloserine, and vitamin B6, along with additional treatments such as antibiotics, symptomatic therapy, and nutritional support. The medical team conducted regular monitoring and consultation with pulmonary, psychiatry, and nutrition specialists to ensure treatment compliance. This case highlights the challenges in managing MDR-TB, especially in patients with a history of TB. Early detection of drug resistance and prompt implementation of appropriate therapy are essential to improve treatment outcomes and prevent further spread. This report emphasizes the need for a multidisciplinary approach and close monitoring in the management of MDR-TB.
Uji Daya Hambat Ekstrak Daun Bakau Lindur (Bruguiera gymnorrhiza) Terhadap Pertumbuhan Bakteri Pseudomonas aeruginosa Syarif, Muhammad Reza; Kurniawaty, Evi Kurniawaty; Busman, Hendri; Rahmanisa, Soraya Rahmanisa
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 3 (2025): Volume 12 Nomor 3
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i3.18963

Abstract

Pseudomonas aeruginosa adalah bakteri Gram-negatif oportunistik yang menyebabkan infeksi nosokomial berat. Virulensinya didukung oleh pembentukan biofilm dan resistansi antibiotik, sehingga diperlukan terapi alternatif. Bruguiera gymnorrhiza (bakau lindur) diketahui memiliki senyawa bioaktif dengan sifat antibakteri. Penelitian ini menggunakan ekstrak etanol daun bakau untuk menguji aktivitas antibakteri terhadap Pseudomonas aeruginosa. Ekstraksi dilakukan dengan metode maserasi, dan uji fitokimia dilakukan untuk mengidentifikasi senyawa aktif. Aktivitas antibakteri dianalisis melalui uji zona hambat dan evaluasi statistik. Ekstrak menunjukkan efek antibakteri bergantung konsentrasi dengan zona hambat 12,82 mm; 14,18 mm; dan 15,34 mm masing-masing untuk konsentrasi 50%, 75%, dan 100%. Senyawa aktif seperti flavonoid dan saponin merusak membran sel bakteri dan metabolisme, berkontribusi pada hasil yang diamati. Meski efektif, ekstrak menunjukkan daya hambat lebih rendah dibandingkan antibiotik standar karena perbedaan dalam kemurnian dan konsentrasi. Temuan ini menegaskan potensi ekstrak bakau sebagai agen antibakteri alami yang membutuhkan optimalisasi lebih lanjut. Ekstrak etanol daun Bruguiera gymnorrhiza menunjukkan aktivitas antibakteri signifikan terhadap Pseudomonas aeruginosa, memberikan dasar untuk pengembangan terapi berbasis tanaman.
Laboratory and Clinical Manifestation Correlation of Neonatal Sepsis in Abdul Moeloek Hospital Ervina, Leni; Berawi, Khairunnisa; Busman, Hendri; Irawan, Bambang; Azizah, Nailul; Yolanda, Jennifer Ester
Jurnal Ilmu Medis Indonesia Vol. 4 No. 2 (2025): Maret
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/jimi.v4i2.4250

Abstract

Purpose: The prognosis of neonatal sepsis critically depends on early detection; however, its nonspecific clinical signs and variable laboratory findings often complicate the timely diagnosis. This study aimed to assess the correlation between clinical manifestations and laboratory results in neonatal sepsis cases, focusing on patients at Abdul Moeloek Hospital. Methodology/approach: A cross-sectional approach was used to analyze the medical records of neonates diagnosed with sepsis between January and June 2024. All neonates admitted to the neonatal unit with suspected sepsis during this period were included in the study. Results/findings: The majority of patients were male (65.1%) and 1 week old (58.7%). Hyperthermia (44.4%) was the most common symptom, followed by a normal heart rate (68.3%) and respiratory rate (81%). Most patients had normal hemoglobin (55.6%) and leukocyte levels (71.4%), low platelet counts (50.8%), and negative culture results (74.6%). Statistically significant correlations were found between heart rate (OR=0.4) and respiratory rate (OR=0.3) and laboratory findings (p<0.05), although the strength was weak to moderate. No significant correlation was observed with body temperature (p=0.412). Conclusions: Heart and respiratory rates were significantly associated with sepsis-related laboratory results, whereas body temperature was not. Most affected neonates were male, one week old, and presented with hyperthermia but otherwise normal vital signs and blood cell counts. Limitations: The limited sample size and study duration suggest the need for further research. Contribution: These findings provide insights into improving the early detection and management of neonatal sepsis, particularly in pediatric care settings in Indonesia.
INFEKSI SALURAN KEMIH AKIBAT PENGGUNAAN KATETER PADA PASIEN RAWAT INAP DI RUMAH SAKIT Ananta, Yoga; Mustofa, Syazili; Septiani, Linda; Busman, Hendri
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1436

Abstract

Urinary tract infection (UTI) is a disorder caused by microorganisms that multiply in the urinary tract, which is normally sterile from bacteria. Risk factors for UTI include age, gender, medical procedures such as catheterization, hygiene, and duration of catheter use. Catheter-related UTI is the most common type of nosocomial infection, with a prevalence of up to 80% in patients who use catheters. The main cause of UTI is gram-negative bacteria, such as Escherichia coli (48.44%) and Klebsiella pneumoniae. In women, the risk is higher because the urethra is shorter and closer to the anus. UTI is divided into lower and upper urinary tract infections, where symptoms vary from pain during urination to serious complications such as pyelonephritis and urosepsis. The pathophysiology of UTI often involves the colonization of microorganisms on the catheter or urinary tract. The risk of infection increases with the duration of catheter placement, reaching 5–10% per day. Diagnosis of UTI involves history taking, physical examination, and urine culture, although modern methods such as flow cytometry are increasingly used for efficiency. Prevention involves personal hygiene, aseptic technique during catheter insertion, and prophylactic antibiotic use in selected cases. Treatment of UTI includes empiric antibiotics such as trimethoprim-sulfamethoxazole, fluoroquinolones, or nitrofurantoin, depending on the severity and causal pathogen. Appropriate preventive and treatment approaches can reduce the incidence of UTI, improve patient quality of life, and decrease the rate of complications. Keywords: Trigger Factors, Urinary Tract Infection (UTI), Catheter
The Effectiveness of Breadfruit Leaf Ethanol Extract to Reduce Level of Blood Glucose Levels in Mice that Induced by Alloxan Indriyani, Indriyani; Sarasati, Filia; Nurcahyani, Nuning; Sutyarso, Sutyarso; Busman, Hendri
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9734

Abstract

Severe hyperglycemia symptoms can be brought on by elevated blood glucose levels. Diabetes mellitus will result if this occurs consistently over a period of years. The aim of this study was to determine the effects of breadfruit leaf extract on blood glucose reduction and the effects of alloxan on mice's weight. Data analysis using ANOVA at 5% confidence interval and LSD (Least Significant Difference) test. The research results showed that the K+ group (which was only induced by alloxan) experienced a significant decrease in blood glucose levels when breadfruit leaf extract was administered. Blood glucose level of mice was found to decrease by 61% (87.60 ± 1.07) at an effective dose of 22.4 mg/grbw/day (P3), which was almost the same as the blood glucose level of K (-) on day 0; in addition, the body weight of mice increased after a hyperglycemic episode when the ethanol extract of breadfruit leaves was administered.
EFFECT OF RED GINGER (Zingiber officinale Rosc. Var Rubrum) ETHANOL EXTRACT OR SILDENAFIL IN LIBIDO: A COMPARATIVE STUDY USING MALE WHITE RATS (Rattus norvegicus) MODEL WITH DIABETES MELLITUS Hadibrata, Exsa; Sutyarso; Busman, Hendri; Ramdini, Dwi Aulia
Indonesian Journal of Urology Vol 32 No 3 (2025)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v32i3.949

Abstract

Objective: To compare the effect of red ginger ethanol extract and Sildenafil on increasing the libido of diabetic rat models and determine the dose that significantly affects the increase in libido of diabetic rat models. Materials & Methods: This study is an experimental was conducted on 30 male Sprague dawley white rats divided into 6 groups, namely normal control group, negative control group, sildenafil positive control group, 200 mg ginger group, 400 mg ginger group and 600 mg ginger groupstudy consisting of test animal groups: normal control group; negative control; positive control with sildenafil administration, and treatment groups consisting of: dose I (200mg/kgBB); dose II (400mg/kgBB) and, dose III (600mg/kgBB). All groups except the normal control received alloxan induction at the initial stage of testing. The effect of increasing the libido of rats is seen from sexual activity including: latency of copulation, latency of riding (climbing) and frequency of riding. Results: The results of this study indicate that the administration of red ginger ethanol extract at a dose of 400mg/kgBB or 600mg/kgBB has the same potential as sildenafil in increasing the libido of diabetic rat models. Conclusion: The administration of red ginger ethanol extract at a dose of 400mg/kgBB or 600mg/kgBB has the same potential as sildenafil in increasing the libido of diabetic rat models. Keywords: Red ginger, libido, diabetic rat models.
Bacterial patterns and antibiotic sensitivity among neonatal sepsis patients in Dr. H. Abdul Moeloek Hospital, Lampung Ervina, Leni; Busman, Hendri; Berawi, Khairunnisa; Irawan, Bambang; Azizah, Nailul; Yolanda, Jennifer Ester
Paediatrica Indonesiana Vol. 65 No. 4 (2025): July 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.4.2025.297-306

Abstract

Background Neonatal infections cause more than 550,000 deaths each year worldwide. Sepsis is a serious neonatal infection, defined as a severe form of infection that causes organ dysfunction. The incidence of neonatal sepsis in Dr. H. Abdul Moeloek Hospital, Lampung increased by 25% from 2017 to 2018 and by 30% from 2018 to 2019. Inappropriate use of antibiotics as therapy can lead to bacterial resistance to the medication. Understanding the most common bacterial patterns and using the guidance of antibiotic sensitivity tests can help health workers determine the empirical antibiotics needed to achieve optimal management, especially in neonatal sepsis patients. Objective To identify bacteria and their antibiotic sensitivity patterns in neonatal sepsis patients at Dr. H. Abdul Moeloek Hospital, Lampung between January and June 2024. Method  Descriptive study was conducted using medical record data from neonates suspected of having sepsis in Dr. H. Abdul Moeloek Hospital Lampung between January and June 2024. Blood culture data and antibiotic sensitivity testing was obtained from medical records. Results Of 65 blood culture of neonates suspected of having sepsis, 31 results were positive (47.6%). The most common microorganisms found were Klebsiella pneumoniae (23%), Burkholderia cepacia (19%), Acinetobacter baumannii (10%), Pseudomonas aeruginosa (10%), Enterococcus faecium (10%) Staphylococcus aureus (10%), Staphylococcus epidermidis (6%), Enterococcus faecalis (6%), Escherichia coli (3%), and Enterobacter cloacae (3%). Based on the sensitivity data calculated using weighted averages, ciprofloxacin (64.7%) and tigecycline (61.1%) showed highest sensitivity across more than five bacterial species. In contrast, ampicillin/sulbactam (96.0%), gentamicin (94.2%), and ceftriaxone (87.7%) had the highest resistance rates. Conclusion The most common bacteria causing neonatal sepsis were Klebsiella pneumoniae and Burkholderia cepacia. Among more than five bacterial species, the highest overall sensitivity was observed to ciprofloxacin and tigecycline, while the highest resistance rates were observed to ampicillin/sulbactam, gentamicin, and ceftriaxone.
Tempat Perindukan dan Kepadatan Larva Aedes spp. sebagai Indikator Risiko Penularan Demam Berdarah di Tempat Wisata Bandar Lampung Ilyas, Muhammad; Setyaningrum, Endah; Mumtazah, Dzul Fithria; Busman, Hendri
Bioma : Jurnal Biologi dan Pembelajaran Biologi Vol. 10 No. 1 (2025): BIOMA: JURNAL BIOLOGI DAN PEMBELAJARAN BIOLOGI
Publisher : Universitas Muhammadiyah Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32528/bioma.v10i1.2701

Abstract

Kondisi lingkungan yang beragam di tempat wisata wilayah Kota Bandar Lampung, dan variabel lingkungan yang ada di dalamnya memiliki kontribusi besar terhadap peningkatan dan penurunan risiko kejadian demam berdarah dengue (DBD), karena tempat tersebut berpotensi sebagai tempat perindukan nyamuk Aedes spp. Penelitian ini bertujuan untuk mengidentifikasi jenis tempat perindukan nyamuk Aedes spp. dan menganalisis indeks kepadatan larva di tempat wisata di Bandar Lampung sebagai indikator risiko penularan DBD. Penelitian ini dilaksanakan pada Maret hingga Mei 2023, di tempat wisata Wira Garden, Pantai Tiska, Pantai Duta Wisata, dan Taman Hutan Raya Wan Abdul Rachman (Tahura). Penelitian ini menggunakan teknik pengambilan sampel non probability dengan analisis indeks kepadatan larva yaitu House Index (HI), Container Index (CI), Breteau Index (BI), yang digunakan untuk menghitung Density Figure (DF). Hasil dari penelitian ini yaitu ditemukan tempat perindukan nyamuk alami (phytotelmata dan genangan air) dan non-alami (kotak sampah, drum, ember, bak mandi, ban bekas). Wira Garden memiliki kepadatan larva tertinggi (HI = 70%, CI = 50%, BI = 80%), Taman Hutan Raya memiliki kepadatan terendah (HI = 22,2%, CI = 9%, BI = 22,2%). Wira Garden memiliki nilai DF tertinggi = 8 (kategori tinggi, risiko tinggi penularan virus Dengue), sedangkan Taman Hutan Raya memiliki nilai DF terendah = 4 (kategori sedang, risiko sedang).
Histopathological Observation of The Qurban Goat’s (Capra Aegagrus Hircus) Lung Organs in Tulus Rejo Village, Pekalongan District, East Lampung 2019 Suspected Of Being Infected With Pneumonia Alqoriani A, Ostarica; Busman, Hendri; Susanto, Gregorius Nugroho; Nurcahyani, Nuning; Arofah, Nur Lailatul
IJIS Edu : Indonesian Journal of Integrated Science Education Vol 2, No 2 (2020): July 2020
Publisher : UIN Fatmawati Sukarno Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29300/ijisedu.v2i2.6480

Abstract

Placement of goats of various ages and the number of animals that exceed the maximum limit in one cage can cause the spread of diseases caused by viruses, bacteria, etc. One of them can cause pneumonia. Dirt and extreme temperatures in East Lampung are feared to increase the growth of bacteria that cause pneumonia. The purpose of this research was to determine the type of pneumonia that infects and the differences between the histopathological organs of the healthy qurban goats and those infected with pneumonia. This research was conducted in October-November 2019 at the Pathology Laboratory of the Veterinary Institute of Lampung. About 13 samples of lung organ of goat qurban (Capra aegagrus hircus) were taken from the Baburahman mosque of Tulus Rejo Village, Pekalongan District, East Lampung. The results of the study found 6 samples of positive qurban goat lungs infected with pneumonia, with the characteristics of inflammatory cells accompanied by thickening of the septa alveoli, edema, and the presence of hemorrhage. Based on observations, the most infecting types of pneumonia are pulmonary edema and peri-bronchial edema
Co-Authors Adli, Farhan Kamali Ajeng Pawesti, Ammanda Sadiva Al Hafidz, Muhammad Alqoriani A, Ostarica Amani Raya, Latansa Ananta, Yoga Andriani, Silvia Angelia, Tisa Arofah, Nur Lailatul Ayu Ayssca Besty Prastiwy, Ayu Ayssca Azizah, Nailul Bayu Putra DJ Bilqis, Khorina Fatin Cahyani, Endang Nur Choerunnisa, Nida Dyah Wulan Sumekar Rengganis Wardani Endah Setyaningrum, Endah Ernawiati, Eti Fitri, Reggina Annisa Gina Dania Pratami, Gina Dania Ginting, Bisart Giska Tri Putri Hadibrata, Exsa Hafidz, Muhammad Al Hafidz Hak, Mohammad Hafid Hanifah, Farah Hendri Tarigan S Indri Windarti Indriyani Indriyani Indriyani Intanri Kurniati Iswandi Darwis Jausal, Anisa Nuraisa Justisia, Adilla Kanedi, M. Kanedi Karina, Salwa Al Khairun Nisa Kurniawaty, Evi Kurniawaty, Evi Kurniawaty Kusuma Handayani, Kusuma Leni Ervina, Leni Maulana, Rifadly Yusril Muhammad Ilyas Muhartono Muhartono Muhartono Sudarmo Kasban Mumtazah, Dzul Fithria Mz, Fannia Khairani NA, Ahmad Mufid Nuning Nurcahyani Nursidiq, Iqbal Muhammad Rafi Prasetio, Iradah Lia Purwati Purwati Puspa, Egita Windrianatama Putri, Lolyta Mutiara Rahmadi, Antun Rahmanisa, Soraya Rahmanisa Ramdini, Dwi Aulia Rosa, Emantis RR. Ella Evrita Hestiandari Safitri, Dewi Restika Ayu Sahroni, Mizan Sangging, Putu Ristyaning Ayu Sarasati, Filia Sembiring, Rinawati Septiani, Linda Soemarwoto, Retno Ariza Sulastri Sulastri Susanto, Gregorius Nugroho Susianti Susianti Sutyarso Sutyarso Sutyarso Syakir, Muhammad Addin Syarif, Muhammad Reza Syazili Mustofa Tri Putri, Giska Utami, Hanifa Fauzia Widiastuti, Endang Linirin Wiratmoko, Wien Yolanda, Jennifer Ester Yulia Sari, Umi Yuniastini, Yuniastini Yuningrum, Hesti