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All Journal Jurnal Pendidikan Biologi Undiksha Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Medula Indonesian Journal of Urology Bioeksperimen: Jurnal Penelitian Biologi Jurnal Penelitian Pertanian Terapan Paediatrica Indonesiana Jurnal Biologi Tropis Manuju : Malahayati Nursing Journal Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Kesehatan Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Jurnal Ilmu Medis Indonesia AMMA : Jurnal Pengabdian Masyarakat Bioma : Jurnal Biologi dan Pembelajaran Biologi IJIS Edu : Indonesian Journal of Integrated Science Education
Hendri Busman
Jurusan Biologi Fakultas Matematika dan Ilmu Pengetahuan Universitas Lampung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Case Report: Comprehensive Management Of Patients With Lung Cancer Suspected Of Brain Metastases Accompanied By Pneumonia Mustofa, Syazili; Nursidiq, Iqbal Muhammad Rafi; Yuningrum, Hesti; Busman, Hendri; NA, Ahmad Mufid
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 11 (2024): Volume 11 Nomor 11
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i11.16235

Abstract

Worldwide, the most frequently diagnosed cancer is lung cancer. The chief complaints of the disease are dyspnea and chest discomfort. Lung cancer causes an immunodeficiency state in the body, which can lead to infection. Lung cancer is also known to complicate cerebrovascular disease, causing an infarction or stroke. This case report aims to elucidate the etiology of lung cancer-associated infection and cerebrovascular disease and effectively detect and heal the disease. A 58-year-old man came with his family to the emergency department of Abdoel Moeloek Hospital, Lampung Province with complaints of shortness of breath that worsened, accompanied by complaints of cough and pain in the right chest. The doctor conducted a detailed examination and then the doctor diagnosed the patient with community-acquired pneumonia because of immunodeficiency from lung squamous cell carcinoma, hemiparesis dextra, dysarthria due to cerebrovascular disease, and malnutrition. The doctor administered oxygen and a nebulizer to the patient. Subsequently, he was hospitalized for symptomatic therapy and antibiotic treatment.
Pengenalan Dan Penggunaan Edible Coating Dalam Meningkatkan Mutu Buah Dan Sayuran Bagi KWT Anggrek Kecamatan Merbau Mataram Kabupaten Lampung Selatan Nurcahyani, Endang; Yulianty; Rosa, Emantis; Busman, Hendri
AMMA : Jurnal Pengabdian Masyarakat Vol. 3 No. 9 : Oktober (2024): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Fruits and vegetables are horticultural products. This product is easily damaged, so it needs good handling and sufficient attention. So that damage arising from poor handling can be reduced and avoided. Fast handling, sometimes by using materials that are not safe for humans, such as wax. Problems in handling fruits and vegetables occur not only in villages but also in urban areas. So it is necessary to understand and practice for women members of KWT Anggrek  in Merbau Mataram District, South Lampung Regency about the use of natural Edible Coatings that are safe for health. The use of Edible Coating is not just giving a thin layer on fruits and vegetables, but it is necessary to find the use of Edible Coating that does not make problems when eaten and of course is environmentally friendly, such as aloe vera, cassava, taro and sweet potato. The pre-test results of the Community Service Participants were 83.2. The post-test results showed an increase with a score of 96.8. This result proves that there is an increase in the understanding and skills of Community Service participants. The existence of this service is expected that KWT Anggrek  members can handle fruits and vegetables that are easily damaged and rotten so that they can last longer, namely by using Edible Coating Natural  that are easily obtained in the surrounding environment and are environmentally friendly.  
The Effect of Black Pepper (Piper nigrum L.) Extract on Morphology and number of Mice (Mus musculus L.) Spermatozoa Induced by Progestin Hormone Indriyani; Sutyarso; Busman, Hendri; Nurcahyani, Nuning; Setyaningrum, Endah
Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Vol. 11 No. 2 (2024)
Publisher : Department of Biology Faculty of Mathematics and Natural Sciences Universitas Lampung in collaboration with The Indonesian Association of Biology (PBI) Lampung Branch.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jbekh.v11i2.384

Abstract

The progestin hormone is used as male hormonal contraception. Giving progestin to normal men can  suppress libido and testicular function effectively, and reduce testosterone levels so that it can interferer with the spermatogenesis process. This study is about the effectiveness of black pepper (Piper nigrum L.) extract on morphology and number of spermatozoa in mice (Mus musculus L.)  induced by progestin. This study used a completely randomized design (CRD) which has divided into four treatment groups, each group contained 5 mice and treated according to the experimental design. Group P0 as a control (given H2O), P1 (induced by 1,25 mg progestin), P2 (induced by 1,25 mg progestin and 3.33mg/Kg BW ethanol extract of black pepper), and P3 (induced by 1,25 mg progestin and 3.33mg/Kg BW distilled water extract of black pepper). The Progestin hormone is given twice (week 1 and week 2). Black pepper extract was given daily for 35 days. Data were analyzed by one-way ANOVA and continued with the LSD test with a level of 5%. The result showed that giving of ethanol extract and distilled water extract from black pepper could improve the normal morphology and number of spermatozoa in mice after induced by progestin hormone so that fertility in men increases.
A Case Report: Multidrug-Resistant Tuberculosis in A 53-Year-Old Patient Mustofa, Syazili; Ananta, Yoga; Ginting, Bisart; Septiani, Linda; Busman, Hendri
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 2 (2025): Volume 12 Nomor 2
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i2.18173

Abstract

A 53-year-old man with multidrug-resistant tuberculosis (MDR-TB) presented with clinical symptoms such as cough with yellow-white sputum for a month, shortness of breath, fever, night sweats, and weight loss. After completing six months of TB treatment in 2010, he developed MDR-TB, proven by resistance to rifampicin. Initial diagnosis by chest X-ray showed signs of pulmonary TB and right pleural effusion, while the sputum test confirmed Mycobacterium tuberculosis with moderate bacterial load. Laboratory results showed anemia, leukocytosis, and hypoalbuminemia. The patient's therapy included a combination of bedaquiline, levofloxacin, linezolid, clofazimine, cycloserine, and vitamin B6, along with additional treatments such as antibiotics, symptomatic therapy, and nutritional support. The medical team conducted regular monitoring and consultation with pulmonary, psychiatry, and nutrition specialists to ensure treatment compliance. This case highlights the challenges in managing MDR-TB, especially in patients with a history of TB. Early detection of drug resistance and prompt implementation of appropriate therapy are essential to improve treatment outcomes and prevent further spread. This report emphasizes the need for a multidisciplinary approach and close monitoring in the management of MDR-TB.
Uji Daya Hambat Ekstrak Daun Bakau Lindur (Bruguiera gymnorrhiza) Terhadap Pertumbuhan Bakteri Pseudomonas aeruginosa Syarif, Muhammad Reza; Kurniawaty, Evi Kurniawaty; Busman, Hendri; Rahmanisa, Soraya Rahmanisa
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 3 (2025): Volume 12 Nomor 3
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i3.18963

Abstract

Pseudomonas aeruginosa adalah bakteri Gram-negatif oportunistik yang menyebabkan infeksi nosokomial berat. Virulensinya didukung oleh pembentukan biofilm dan resistansi antibiotik, sehingga diperlukan terapi alternatif. Bruguiera gymnorrhiza (bakau lindur) diketahui memiliki senyawa bioaktif dengan sifat antibakteri. Penelitian ini menggunakan ekstrak etanol daun bakau untuk menguji aktivitas antibakteri terhadap Pseudomonas aeruginosa. Ekstraksi dilakukan dengan metode maserasi, dan uji fitokimia dilakukan untuk mengidentifikasi senyawa aktif. Aktivitas antibakteri dianalisis melalui uji zona hambat dan evaluasi statistik. Ekstrak menunjukkan efek antibakteri bergantung konsentrasi dengan zona hambat 12,82 mm; 14,18 mm; dan 15,34 mm masing-masing untuk konsentrasi 50%, 75%, dan 100%. Senyawa aktif seperti flavonoid dan saponin merusak membran sel bakteri dan metabolisme, berkontribusi pada hasil yang diamati. Meski efektif, ekstrak menunjukkan daya hambat lebih rendah dibandingkan antibiotik standar karena perbedaan dalam kemurnian dan konsentrasi. Temuan ini menegaskan potensi ekstrak bakau sebagai agen antibakteri alami yang membutuhkan optimalisasi lebih lanjut. Ekstrak etanol daun Bruguiera gymnorrhiza menunjukkan aktivitas antibakteri signifikan terhadap Pseudomonas aeruginosa, memberikan dasar untuk pengembangan terapi berbasis tanaman.
Laboratory and Clinical Manifestation Correlation of Neonatal Sepsis in Abdul Moeloek Hospital Ervina, Leni; Berawi, Khairunnisa; Busman, Hendri; Irawan, Bambang; Azizah, Nailul; Yolanda, Jennifer Ester
Jurnal Ilmu Medis Indonesia Vol. 4 No. 2 (2025): Maret
Publisher : Penerbit Goodwood

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35912/jimi.v4i2.4250

Abstract

Purpose: The prognosis of neonatal sepsis critically depends on early detection; however, its nonspecific clinical signs and variable laboratory findings often complicate the timely diagnosis. This study aimed to assess the correlation between clinical manifestations and laboratory results in neonatal sepsis cases, focusing on patients at Abdul Moeloek Hospital. Methodology/approach: A cross-sectional approach was used to analyze the medical records of neonates diagnosed with sepsis between January and June 2024. All neonates admitted to the neonatal unit with suspected sepsis during this period were included in the study. Results/findings: The majority of patients were male (65.1%) and 1 week old (58.7%). Hyperthermia (44.4%) was the most common symptom, followed by a normal heart rate (68.3%) and respiratory rate (81%). Most patients had normal hemoglobin (55.6%) and leukocyte levels (71.4%), low platelet counts (50.8%), and negative culture results (74.6%). Statistically significant correlations were found between heart rate (OR=0.4) and respiratory rate (OR=0.3) and laboratory findings (p<0.05), although the strength was weak to moderate. No significant correlation was observed with body temperature (p=0.412). Conclusions: Heart and respiratory rates were significantly associated with sepsis-related laboratory results, whereas body temperature was not. Most affected neonates were male, one week old, and presented with hyperthermia but otherwise normal vital signs and blood cell counts. Limitations: The limited sample size and study duration suggest the need for further research. Contribution: These findings provide insights into improving the early detection and management of neonatal sepsis, particularly in pediatric care settings in Indonesia.
INFEKSI SALURAN KEMIH AKIBAT PENGGUNAAN KATETER PADA PASIEN RAWAT INAP DI RUMAH SAKIT Ananta, Yoga; Mustofa, Syazili; Septiani, Linda; Busman, Hendri
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1436

Abstract

Urinary tract infection (UTI) is a disorder caused by microorganisms that multiply in the urinary tract, which is normally sterile from bacteria. Risk factors for UTI include age, gender, medical procedures such as catheterization, hygiene, and duration of catheter use. Catheter-related UTI is the most common type of nosocomial infection, with a prevalence of up to 80% in patients who use catheters. The main cause of UTI is gram-negative bacteria, such as Escherichia coli (48.44%) and Klebsiella pneumoniae. In women, the risk is higher because the urethra is shorter and closer to the anus. UTI is divided into lower and upper urinary tract infections, where symptoms vary from pain during urination to serious complications such as pyelonephritis and urosepsis. The pathophysiology of UTI often involves the colonization of microorganisms on the catheter or urinary tract. The risk of infection increases with the duration of catheter placement, reaching 5–10% per day. Diagnosis of UTI involves history taking, physical examination, and urine culture, although modern methods such as flow cytometry are increasingly used for efficiency. Prevention involves personal hygiene, aseptic technique during catheter insertion, and prophylactic antibiotic use in selected cases. Treatment of UTI includes empiric antibiotics such as trimethoprim-sulfamethoxazole, fluoroquinolones, or nitrofurantoin, depending on the severity and causal pathogen. Appropriate preventive and treatment approaches can reduce the incidence of UTI, improve patient quality of life, and decrease the rate of complications. Keywords: Trigger Factors, Urinary Tract Infection (UTI), Catheter
The Effectiveness of Breadfruit Leaf Ethanol Extract to Reduce Level of Blood Glucose Levels in Mice that Induced by Alloxan Indriyani, Indriyani; Sarasati, Filia; Nurcahyani, Nuning; Sutyarso, Sutyarso; Busman, Hendri
Jurnal Biologi Tropis Vol. 25 No. 3 (2025): Juli-September
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i3.9734

Abstract

Severe hyperglycemia symptoms can be brought on by elevated blood glucose levels. Diabetes mellitus will result if this occurs consistently over a period of years. The aim of this study was to determine the effects of breadfruit leaf extract on blood glucose reduction and the effects of alloxan on mice's weight. Data analysis using ANOVA at 5% confidence interval and LSD (Least Significant Difference) test. The research results showed that the K+ group (which was only induced by alloxan) experienced a significant decrease in blood glucose levels when breadfruit leaf extract was administered. Blood glucose level of mice was found to decrease by 61% (87.60 ± 1.07) at an effective dose of 22.4 mg/grbw/day (P3), which was almost the same as the blood glucose level of K (-) on day 0; in addition, the body weight of mice increased after a hyperglycemic episode when the ethanol extract of breadfruit leaves was administered.
Efek Protektif Ekstrak Daun Jambu Air (Syzygium Aqueum) terhadap Kerusakan Lambung Tikus Putih Jantan (Rattus Norvegicus) Galur Wistar yang Diinduksi Indometasin Justisia, Adilla; Susianti, Susianti; Jausal, Anisa Nuraisa; Busman, Hendri
Malahayati Nursing Journal Vol 7, No 8 (2025): Volume 7 Nomor 8 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v7i8.21126

Abstract

ABSTRACT The prevalence of peptic ulcers caused by the use of Nonsteroidal Anti-Inflammatory Drugs (NSAID) has increased over the past 10 years. Oxidative stress induced by NSAID can trigger the formation of peptic ulcers. The objective of this research was to determine the protective effect of water apple leaf extract (Syzygium aqueum) on gastric damage of male white rats (Rattus norvegicus) wistar strain induced by indomethacin. This laboratory experimental study with a randomized post-test only control group design involved 24 male Wistar strain white rats divided into 6 groups. Group K(0) was given food and water, K(-) was administered indomethacin at a dose of 30 mg/kgBW, K(+) received vitamin C at a dose of 9 mg/kgBW and indomethacin at 30 mg/kgBW, while P1, P2, and P3 were given water apple leaf extract at doses of 100 mg/kgBW, 300 mg/kgBW, and 900 mg/kgBW, along with indomethacin at 30 mg/kgBW. The results of the Mann-Whitney statistical test analysis showed a significant difference (p<0.05) between group K(-), which was administered only indomethacin, and group P2 and P3, which were administered extracts of water apple leaf at doses of 300 mg/kgBW and 900 mg/kgBW along with indomethacin at 30 mg/kgBW. There is an protective effect of water apple leaf extract (Syzygium aqueum) on gastric damage of male white rats (Rattus norvegicus) Wistar strain induced by indomethacin. Keywords: Water Apple Leaf, Syzygium Aqueum, Antioxidants, Indomethacin, Peptic Ulcer  ABSTRAK Prevalensi ulkus peptikum yang disebabkan oleh penggunaan Nonsteroidal Anti-Inflammatory Drugs (NSAID) mengalami peningkatan dalam kurun waktu 10 tahun. Stres oksidatif yang disebabkan oleh NSAID dapat memicu terbentuknya ulkus peptikum. Tujuan penelitian ini untuk mengetahui efek protektif ekstrak daun jambu air (Syzygium aqueum) terhadap kerusakan lambung tikus putih jantan (Rattus norvegicus) galur wistar yang diinduksi indometasin. Penelitian eksperimental laboratorik dengan rancangan randomized post-test only control group ini menggunakan 24 tikus putih jantan galur Wistar yang dibagi ke dalam 6 kelompok. K(0) diberikan makan dan minum, K(-) diberikan indometasin 30 mg/kgBB, K(+) diberikan vitamin C 9 mg/kgBB dan indometasin 30 mg/kgBB, serta P1, P2, P3 diberikan ekstrak daun jambu air dengan dosis berturut-turut 100 mg/kgBB, 300 mg/kgBB, 900 mg/kgBB dan indometasin 30 mg/kgBB. Hasil analisis uji statistik Mann-Whitney didapatkan perbedaan bermakna (p<0.05) antara kelompok K(-) yang hanya diberikan indometasin dengan kelompok P2 dan P3 yang diberikan ekstrak 300 mg/kgBB dan 900 mg/kgBB serta indometasin 30 mg/kgBB. Ekstrak daun jambu air (Syzygium aqueum) memberikan efek protektif terhadap kerusakan lambung tikus putih (Rattus norvegicus) jantan galur Wistar yang diinduksi indometasin. Kata Kunci: Daun Jambu Air, Syzygium aqueum, Antioksidan, Indometasin, Ulkus Peptikum
EFFECT OF RED GINGER (Zingiber officinale Rosc. Var Rubrum) ETHANOL EXTRACT OR SILDENAFIL IN LIBIDO: A COMPARATIVE STUDY USING MALE WHITE RATS (Rattus norvegicus) MODEL WITH DIABETES MELLITUS Hadibrata, Exsa; Sutyarso; Busman, Hendri; Ramdini, Dwi Aulia
Indonesian Journal of Urology Vol 32 No 3 (2025)
Publisher : Indonesian Urological Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32421/juri.v32i3.949

Abstract

Objective: To compare the effect of red ginger ethanol extract and Sildenafil on increasing the libido of diabetic rat models and determine the dose that significantly affects the increase in libido of diabetic rat models. Materials & Methods: This study is an experimental was conducted on 30 male Sprague dawley white rats divided into 6 groups, namely normal control group, negative control group, sildenafil positive control group, 200 mg ginger group, 400 mg ginger group and 600 mg ginger groupstudy consisting of test animal groups: normal control group; negative control; positive control with sildenafil administration, and treatment groups consisting of: dose I (200mg/kgBB); dose II (400mg/kgBB) and, dose III (600mg/kgBB). All groups except the normal control received alloxan induction at the initial stage of testing. The effect of increasing the libido of rats is seen from sexual activity including: latency of copulation, latency of riding (climbing) and frequency of riding. Results: The results of this study indicate that the administration of red ginger ethanol extract at a dose of 400mg/kgBB or 600mg/kgBB has the same potential as sildenafil in increasing the libido of diabetic rat models. Conclusion: The administration of red ginger ethanol extract at a dose of 400mg/kgBB or 600mg/kgBB has the same potential as sildenafil in increasing the libido of diabetic rat models. Keywords: Red ginger, libido, diabetic rat models.
Co-Authors Adli, Farhan Kamali Alqoriani A, Ostarica Ananta, Yoga Andriani, Silvia Angelia, Tisa Arofah, Nur Lailatul Ayu Ayssca Besty Prastiwy, Ayu Ayssca Azizah, Nailul Bayu Putra DJ Dyah Wulan Sumekar Rengganis Wardani Endah Setyaningrum, Endah Endang Nurcahyani Ernawiati, Eti Farisi, Salman Gina Dania Pratami, Gina Dania Ginting, Bisart Giska Tri Putri Hadibrata, Exsa Hanifah, Farah Hendri Tarigan S Indri Windarti Indriyani Indriyani Indriyani Intanri Kurniati Iswandi Darwis Jausal, Anisa Nuraisa Justisia, Adilla Karina, Salwa Al Khairun Nisa Kurniawaty, Evi Kurniawaty, Evi Kurniawaty Leni Ervina, Leni Muhammad Ilyas Muhartono Muhartono Muhartono Sudarmo Kasban Mumtazah, Dzul Fithria NA, Ahmad Mufid Nuning Nurcahyani Nursidiq, Iqbal Muhammad Rafi Puspa, Egita Windrianatama Putri, Lolyta Mutiara Rahmanisa, Soraya Rahmanisa Ramdini, Dwi Aulia Rosa, Emantis RR. Ella Evrita Hestiandari Safitri, Dewi Restika Ayu Sahroni, Mizan Sangging, Putu Ristyaning Ayu Sarasati, Filia Sembiring, Rinawati Septiani, Linda suratman Susanto, Gregorius Nugroho Susianti Susianti, Susianti Sutyarso Sutyarso Sutyarso Syakir, Muhammad Addin Syarif, Muhammad Reza Syazili Mustofa Tengku Riza Zarzani N Utami, Hanifa Fauzia Yolanda, Jennifer Ester Yulianty Yuningrum, Hesti