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All Journal Jurnal Pendidikan Biologi Undiksha Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Medula Indonesian Journal of Urology Bioeksperimen: Jurnal Penelitian Biologi Jurnal Penelitian Pertanian Terapan Paediatrica Indonesiana Jurnal Biologi Tropis Manuju : Malahayati Nursing Journal Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Kesehatan Jurnal Ilmiah Biologi Eksperimen dan Keanekaragaman Hayati (J-BEKH) Jurnal Ilmu Medis Indonesia AMMA : Jurnal Pengabdian Masyarakat Bioma : Jurnal Biologi dan Pembelajaran Biologi IJIS Edu : Indonesian Journal of Integrated Science Education
Hendri Busman
Jurusan Biologi Fakultas Matematika dan Ilmu Pengetahuan Universitas Lampung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Bacterial patterns and antibiotic sensitivity among neonatal sepsis patients in Dr. H. Abdul Moeloek Hospital, Lampung Ervina, Leni; Busman, Hendri; Berawi, Khairunnisa; Irawan, Bambang; Azizah, Nailul; Yolanda, Jennifer Ester
Paediatrica Indonesiana Vol. 65 No. 4 (2025): July 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.4.2025.297-306

Abstract

Background Neonatal infections cause more than 550,000 deaths each year worldwide. Sepsis is a serious neonatal infection, defined as a severe form of infection that causes organ dysfunction. The incidence of neonatal sepsis in Dr. H. Abdul Moeloek Hospital, Lampung increased by 25% from 2017 to 2018 and by 30% from 2018 to 2019. Inappropriate use of antibiotics as therapy can lead to bacterial resistance to the medication. Understanding the most common bacterial patterns and using the guidance of antibiotic sensitivity tests can help health workers determine the empirical antibiotics needed to achieve optimal management, especially in neonatal sepsis patients. Objective To identify bacteria and their antibiotic sensitivity patterns in neonatal sepsis patients at Dr. H. Abdul Moeloek Hospital, Lampung between January and June 2024. Method  Descriptive study was conducted using medical record data from neonates suspected of having sepsis in Dr. H. Abdul Moeloek Hospital Lampung between January and June 2024. Blood culture data and antibiotic sensitivity testing was obtained from medical records. Results Of 65 blood culture of neonates suspected of having sepsis, 31 results were positive (47.6%). The most common microorganisms found were Klebsiella pneumoniae (23%), Burkholderia cepacia (19%), Acinetobacter baumannii (10%), Pseudomonas aeruginosa (10%), Enterococcus faecium (10%) Staphylococcus aureus (10%), Staphylococcus epidermidis (6%), Enterococcus faecalis (6%), Escherichia coli (3%), and Enterobacter cloacae (3%). Based on the sensitivity data calculated using weighted averages, ciprofloxacin (64.7%) and tigecycline (61.1%) showed highest sensitivity across more than five bacterial species. In contrast, ampicillin/sulbactam (96.0%), gentamicin (94.2%), and ceftriaxone (87.7%) had the highest resistance rates. Conclusion The most common bacteria causing neonatal sepsis were Klebsiella pneumoniae and Burkholderia cepacia. Among more than five bacterial species, the highest overall sensitivity was observed to ciprofloxacin and tigecycline, while the highest resistance rates were observed to ampicillin/sulbactam, gentamicin, and ceftriaxone.
Tempat Perindukan dan Kepadatan Larva Aedes spp. sebagai Indikator Risiko Penularan Demam Berdarah di Tempat Wisata Bandar Lampung Ilyas, Muhammad; Setyaningrum, Endah; Mumtazah, Dzul Fithria; Busman, Hendri
Bioma : Jurnal Biologi dan Pembelajaran Biologi Vol. 10 No. 1 (2025): BIOMA: JURNAL BIOLOGI DAN PEMBELAJARAN BIOLOGI
Publisher : Universitas Muhammadiyah Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32528/bioma.v10i1.2701

Abstract

Kondisi lingkungan yang beragam di tempat wisata wilayah Kota Bandar Lampung, dan variabel lingkungan yang ada di dalamnya memiliki kontribusi besar terhadap peningkatan dan penurunan risiko kejadian demam berdarah dengue (DBD), karena tempat tersebut berpotensi sebagai tempat perindukan nyamuk Aedes spp. Penelitian ini bertujuan untuk mengidentifikasi jenis tempat perindukan nyamuk Aedes spp. dan menganalisis indeks kepadatan larva di tempat wisata di Bandar Lampung sebagai indikator risiko penularan DBD. Penelitian ini dilaksanakan pada Maret hingga Mei 2023, di tempat wisata Wira Garden, Pantai Tiska, Pantai Duta Wisata, dan Taman Hutan Raya Wan Abdul Rachman (Tahura). Penelitian ini menggunakan teknik pengambilan sampel non probability dengan analisis indeks kepadatan larva yaitu House Index (HI), Container Index (CI), Breteau Index (BI), yang digunakan untuk menghitung Density Figure (DF). Hasil dari penelitian ini yaitu ditemukan tempat perindukan nyamuk alami (phytotelmata dan genangan air) dan non-alami (kotak sampah, drum, ember, bak mandi, ban bekas). Wira Garden memiliki kepadatan larva tertinggi (HI = 70%, CI = 50%, BI = 80%), Taman Hutan Raya memiliki kepadatan terendah (HI = 22,2%, CI = 9%, BI = 22,2%). Wira Garden memiliki nilai DF tertinggi = 8 (kategori tinggi, risiko tinggi penularan virus Dengue), sedangkan Taman Hutan Raya memiliki nilai DF terendah = 4 (kategori sedang, risiko sedang).
Histopathological Observation of The Qurban Goat’s (Capra Aegagrus Hircus) Lung Organs in Tulus Rejo Village, Pekalongan District, East Lampung 2019 Suspected Of Being Infected With Pneumonia Alqoriani A, Ostarica; Busman, Hendri; Susanto, Gregorius Nugroho; Nurcahyani, Nuning; Arofah, Nur Lailatul
IJIS Edu : Indonesian Journal of Integrated Science Education Vol 2, No 2 (2020): July 2020
Publisher : UIN Fatmawati Sukarno Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29300/ijisedu.v2i2.6480

Abstract

Placement of goats of various ages and the number of animals that exceed the maximum limit in one cage can cause the spread of diseases caused by viruses, bacteria, etc. One of them can cause pneumonia. Dirt and extreme temperatures in East Lampung are feared to increase the growth of bacteria that cause pneumonia. The purpose of this research was to determine the type of pneumonia that infects and the differences between the histopathological organs of the healthy qurban goats and those infected with pneumonia. This research was conducted in October-November 2019 at the Pathology Laboratory of the Veterinary Institute of Lampung. About 13 samples of lung organ of goat qurban (Capra aegagrus hircus) were taken from the Baburahman mosque of Tulus Rejo Village, Pekalongan District, East Lampung. The results of the study found 6 samples of positive qurban goat lungs infected with pneumonia, with the characteristics of inflammatory cells accompanied by thickening of the septa alveoli, edema, and the presence of hemorrhage. Based on observations, the most infecting types of pneumonia are pulmonary edema and peri-bronchial edema
Analisis Korelasi Absolute Lymphocyte Count (ALC) Dan Nilai Cycle Threshold (CT) Dari Reverse Transcription Polymerase Chain Reaction (RT-PCR) Pasien Covid-19 Di RSUD Dr. H. Abdul Moeloek Periode Juli 2020-Juli 2021 Angelia, Tisa; Kurniati, Intanri; Busman, Hendri; Darwis, Iswandi
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 7 (2024): Volume 11 Nomor 7
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i7.15326

Abstract

COVID-19 merupakan pandemi global yang menyebabkan banyak kematian. Baku emas diagnosis COVID-19 adalah RT-PCR. Pemeriksaan hematologi merupakan screening untuk COVID-19. Keparahan pasien COVID berhubungan dengan penurunan CT value dan limfopenia. Penelitian bertujuan untuk mengetahui korelasi ALC dan nilai CT pasien COVID-19 di RSUD Abdul Moeloek, Bandar Lampung. Penelitian ini adalah penelitian analitik dengan metode cross sectional yang menggunakan data sekunder berupa rekam medis periode Juli 2020-Juli 2021. Sampel diambil dengan teknik purposive sampling. Primer yang di gunakan yaitu MBioCoV-19 yang menargetkan gen RdRp dan ORF1b dari virus SARS-CoV-2. Nilai CT dinyatakan positif jika <40. Data di analisis menggunakan uji korelasi pearson. Sampel terdiri dari 40 laki-laki (34,8%) dan 75 perempuan (65,2%) dengan rata rata usia 43,61 tahun. Distribusi penyakit penyerta yaitu 34 orang (29,6%) dengan diabetes melitus (13%), hipertensi (9,6%) dan penyakit ginjal (7%). Rerata ALC yaitu 1516,4 Sel/μL. Rerata CT value untuk gen ORF1b dan RdRp masing-masing yaitu 25,479 dan 27,996. Terdapat korelasi positif antara ALC dan CT value gen ORF1b (p=0.032 r=0.2). Terdapat korelasi positif antara ALC dan CT value gen RdRp (p=0.048 r=0.185). Terdapat korelasi positif secara signifikan dengan kekuatan korelasi lemah (ORF1b) dan sangat lemah (RdRp) antara ALC dengan CT value kedua gen spesifik SARS-CoV-2 penyebab COVID-19.
A Case Report: Side Effect Of Linezolid In Pulmonary Rifampicin Resistance Tuberculosis Mustofa, Syazili; Karina, Salwa Al; Putri, Giska Tri; Busman, Hendri; Syakir, Muhammad Addin
Jurnal Ilmu Kedokteran dan Kesehatan Vol 12, No 1 (2025): Volume 12 Nomor 1
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v12i1.18144

Abstract

Linezolid is a very potent treatment for pulmonary tuberculosis, but it has some side effects. Patients with drug-resistant pulmonary tuberculosis may experience anemia as a side effect of taking the multidrug-resistant tuberculosis medication Linezolid. A 58-year-old man's primary complaint in one case reported to RSUD dr. H. Abdul Moeloek Lampung was a weakness. The diagnosis was made based on anamnesis, a physical examination, and supporting examinations. Treatment was given both pharmacologically and non-pharmacologically, including the intervention to discontinue Linezolid. Although linezolid-based combination therapy in program conditions is associated with favorable outcomes, side effects should be monitored closely, which may require discontinuation of the drug and taking appropriate steps to treat side effects. 
Literature Review: Antioxidant Activity of Water Apple Leaves (Syzygium aqueum) Justisia, Adilla; Susianti; Jausal, Anisa Nuraisa; Busman, Hendri
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1321

Abstract

Antioxidant is a complex inhibit, prevent or dampen the reactions of free radicals and oxidants, as well as to prevent tissue damage. Antioxidant works by donating one of its electron to oxidant compounds thereby inhibiting the activity of these oxidant compounds. An imbalance between antioxidants and free radicals, where free radicals are more prevalent, can damage molecular organisms and cause oxidative stress that triggers damage to body cells. Oxidative damage to DNA triggers mutations that initiates cancer, cardiovascular disease, neurodegenerative disorder, autoimmune diseases, aging processes and several hereditary diseases. Currently, the use of natural antioxidants as traditional treatments is widely consumed by the community. Natural antioxidants are found in several plant sources, it is known to be more affordable and have lower side effects, making it as popular treatment choice in the community. One of the plants with a high antioxidant content is the water apple leaf (Syzygium aqueum) which rich in flavonoids, phenolics, and tannins. DPPH (2,2-diphenyl-1-picrylhydrazyl) is a common method to measure antioxidant activity, it works with the principle of hydrogen capture from antioxidants by free radicals. The parameter IC50 is used to represents the sample concentration required to capture 50% of DPPH radicals. Several studies using the DPPH method have shown that water apple leaves have strong antioxidant activity, indicated by its low IC50 value. The lower the IC50 value, the stronger the antioxidant activity.
Uji Potensi Tepung Daun Kelor (Moringa oleifera) Sebagai Anthelmintik Terhadap Ascaridia galli pada Ayam Petelur (Gallus domesticus) Utami, Hanifa Fauzia; Rosa, Emantis; Pratami, Gina Dania; Busman, Hendri
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 8, No 3 (2023): October 2023
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v8i3.6475

Abstract

Dalam menjalankan usaha peternakan unggas, para peternak tak lepas dari hambatan dan masalah yang harus dihadapi, salah satunya adalah penyakit yang menyerang unggas. Ascaridia galli merupakan nematoda parasitik yang sering ditemukan pada unggas. Penanggulangan cacing oleh peternak dapat dilakukan dengan pemberian anthelmintik dari bahan-bahan kimiawi atau anthelmintik sintetik. Namun, penggunaan anthelmintik sintetik dalam jangka panjang dapat mengakibatkan resistensi terhadap cacing dan meninggalkan residu pada daging serta telur. Oleh karena itu, disarankan menggunakan bahan alami. Tujuan penelitian ini yaitu mengetahui potensi tepung daun kelor dan efektivitasnya sebagai anthelmintik terhadap A. galli. Perlakuan pemberian tepung daun kelor dilakukan dengan cara dicampurkan pada pakan dengan 4 dosis berbeda selama 14 hari. Data jumlah telur cacing dalam Egg Per Gram (EPG) kemudian dianalisis secara statistik menggunakan uji ANOVA dan didapatkan perbedaan yang signifikan, maka selanjutnya dilakukan uji Duncan. Hasil penelitian menunjukkan bahwa tepung daun kelor berpotensi sebagai anthelmintik terhadap cacing A. galli karena mampu mereduksi nilai EPG sebelum perlakuan. Dosis efektif pemberian tepung daun kelor yakni terdapat pada dosis 20% dari 120 kg pakan namun belum mampu mencapai standar efektivitas (≥ 95 %).  
Pengamatan Kerusakan Histopatologi Jantung Pada Mencit Hiperglikemia Yang Diberi Ekstrak Daun Kersen (Muntingia calabura) Putri, Lolyta Mutiara; Busman, Hendri; Ernawiati, Eti
Bioeksperimen: Jurnal Penelitian Biologi Vol 9, No 1: March 2023
Publisher : Universitas Muhammadiyah Surakarta

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Abstract

Pemberdayaan Kreativitas Petani Aren Melalui Pelatihan Pembuatan Nata de Legen Di Desa Sidokaton, Kecamatan Gisting, Kabupaten Tanggamus, Lampung Nurcahyani, Endang; Busman, Hendri; Yulianty
AMMA : Jurnal Pengabdian Masyarakat Vol. 4 No. 11 : Desember (2025): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

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Abstract

Communities have long recognized the sugar palm (Arenga pinnata Merr.) as a plant that produces various economically valuable products, particularly for the craft and food industries; however, its development and cultivation have received relatively little attention. In Sidokaton Village, Gisting District, Tanggamus Regency, the sugar palm is one of the leading local commodities widely cultivated by farmers. Most farmers process sugar palm into palm sugar and kolang-kaling, while the sap is commonly used only as a fresh beverage with a low selling price that fluctuates significantly during the harvest season. This condition highlights the need for innovations in utilizing sugar palm sap to increase its added value for farmers. This community service activity introduces an innovation in processing sugar palm sap into Nata de Legen as an alternative to nata de coco. This innovation aims to enhance the community’s knowledge and skills regarding product diversification of sugar palm and to encourage increased income through higher-value processed products. There was an increase in public knowledge about processing and utilizing palm sap to produce the economically valuable nata de legen. The average increase in knowledge among training participants was 17.33 points. The training activities are expected to serve as an initial step in the development of sustainable local resource–based enterprises in Sidokaton Village.
Co-Authors Adli, Farhan Kamali Alqoriani A, Ostarica Ananta, Yoga Andriani, Silvia Angelia, Tisa Arofah, Nur Lailatul Ayu Ayssca Besty Prastiwy, Ayu Ayssca Azizah, Nailul Bayu Putra DJ Dyah Wulan Sumekar Rengganis Wardani Endah Setyaningrum, Endah Endang Nurcahyani Ernawiati, Eti Farisi, Salman Gina Dania Pratami, Gina Dania Ginting, Bisart Giska Tri Putri Hadibrata, Exsa Hanifah, Farah Hendri Tarigan S Indri Windarti Indriyani Indriyani Indriyani Intanri Kurniati Iswandi Darwis Jausal, Anisa Nuraisa Justisia, Adilla Karina, Salwa Al Khairun Nisa Kurniawaty, Evi Kurniawaty, Evi Kurniawaty Leni Ervina, Leni Muhammad Ilyas Muhartono Muhartono Muhartono Sudarmo Kasban Mumtazah, Dzul Fithria NA, Ahmad Mufid Nuning Nurcahyani Nursidiq, Iqbal Muhammad Rafi Puspa, Egita Windrianatama Putri, Lolyta Mutiara Rahmanisa, Soraya Rahmanisa Ramdini, Dwi Aulia Rosa, Emantis RR. Ella Evrita Hestiandari Safitri, Dewi Restika Ayu Sahroni, Mizan Sangging, Putu Ristyaning Ayu Sarasati, Filia Sembiring, Rinawati Septiani, Linda suratman Susanto, Gregorius Nugroho Susianti Susianti, Susianti Sutyarso Sutyarso Sutyarso Syakir, Muhammad Addin Syarif, Muhammad Reza Syazili Mustofa Tengku Riza Zarzani N Utami, Hanifa Fauzia Yolanda, Jennifer Ester Yulianty Yuningrum, Hesti