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All Journal Indonesian Journal of Cancer Chemoprevention Majalah Obat Tradisional MPI (Media Pharmaceutica Indonesiana) Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JURNAL FARMASIMED (JFM) Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Majalah Kesehatan Pharmamedika Jurnal Ners Indonesian Journal of Pharmaceutical and Clinical Research IJOEP : International Journal of Ecophysiology International Journal Of Science, Technology & Management (IJSTM) Unri Conference Series: Community Engagement JOURNAL LA MEDIHEALTICO Cakradonya Dental Journal Journal of Pharmaceutical and Sciences.
Aminah Dalimunthe
Departement Of Pharmacology, Faculty Of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Transportation Veterinary

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Journal : JURNAL FARMASIMED (JFM)

 1 
The Effect of Pharmacist Homecare Services on Medication Adherence, Drug-Related Problems, Clinical Outcomes, and Quality of Life of Hypertensive Patients at Sei Mencirim Public Health Center Fragilie, Dimas; Dalimunthe, Aminah; Khairunnisa, Khairunnisa
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/d4bc3z22

Abstract

Background: Hypertension is one of the most prevalent chronic diseases in Indonesia (25.8%) and remains a leading cause of death globally, accounting for approximately three million deaths annually. Poor patient adherence to antihypertensive therapy continues to be a major challenge in achieving optimal blood pressure control and preventing cardiovascular complications. Objective: This study aimed to analyze the effect of pharmacist-led homecare interventions on medication adherence, drug-related problems (DRPs), clinical outcomes, and quality of life among hypertensive patients at Sei Mencirim Primary Health Center. Methods: A pre- and post-cohort study was conducted involving 38 hypertensive patients aged over 55 years between April and June 2024. Medication adherence was assessed using the MASES-R (Medication Adherence Self-Efficacy Scale-Revised) questionnaire, DRPs were identified according to the PCNE V9.0 classification, clinical outcomes were evaluated through blood pressure measurements, and quality of life was measured using the SF-36 (Short Form-36) questionnaire. Data were analyzed using the Wilcoxon Signed Rank test. Results: The majority of respondents were female (76.3%) and aged 56–66 years (71.0%). The mean adherence score significantly increased from 16.29 ± 2.35 to 40.97 ± 10.03 (p < 0.001), with adherence rates improving from 0% to 76.3%. A significant reduction was observed in drug-related problems, dropping from 14 to 2 cases, while adverse drug reactions decreased from 18 to 4 cases. The patients’ systolic blood pressure declined from 166.13 ± 17.85 mmHg to 129.07 ± 5.39 mmHg, and diastolic pressure decreased from 86.28 mmHg to 79.26 mmHg (p < 0.001). Furthermore, the average quality-of-life scores increased across all dimensions, including physical function (19.74–87.76), general health (2.19–90.46), and social functioning (4.28–94.41). Conclusion: Pharmacist-led homecare interventions involving continuous education, counseling, and patient support were proven effective in significantly improving medication adherence and quality of life among hypertensive patients. These findings suggest that such interventions should be implemented routinely in primary healthcare settings.
Effect of Tocotrienol Rich Fraction (TRF) Administration on Blood Glucose and Cholesterol in Streptozotocin Induced and High Fat Diet Rats Simangunsong, Irene; Pertiwi, Dewi; Dalimunthe, Aminah; Asfianti, Vivi
Jurnal FARMASIMED (JFM) Vol 8 No 2 (2026): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/139epr61

Abstract

Diabetes mellitus (DM) is a chronic metabolic disorder with a continuously increasing global prevalence and remains a major health problem, characterized by hyperglycemia and dyslipidemia, including elevated Low Density Lipoprotein (LDL) and decreased High Density Lipoprotein (HDL) levels. This study aimed to evaluate the effect of tocotrienol rich fraction administration on blood glucose levels and lipid profile in rats induced with streptozotocin and a high fat diet. The study used 24 white rats divided into six groups: a negative control group, a positive control group treated with glibenclamide, and four treatment groups receiving tocotrienol rich fraction at doses of 50, 100, 200, and 400 mg/kg body weight. The measured parameters included blood glucose, HDL, and LDL levels. The results show that tocotrienol rich fraction significantly reduces blood glucose levels and improves the lipid profile compared to the negative control group. The highest dose demonstrates the most optimal effect and approaches that of the positive control. Tocotrienol rich fraction increases HDL levels and decreases LDL levels in a dose dependent manner. These findings indicate that tocotrienol rich fraction significantly lowers blood glucose levels and improves lipid profile in streptozotocin induced and high fat diet rats in a dose dependent manner. Therefore, tocotrienol rich fraction has potential as an alternative therapeutic agent for diabetes mellitus with dyslipidemia.
Co-Authors . S, Aminah Ade Sri Rohani Amalyuri, Annisa Ghassani Anjelisa Z. Hsb, Poppy Arfita Sipahutar Arianto, Anayanti Asfianti, Vivi Darmirani, Yosi Denny Satria, Denny Dewi Pertiwi Effendy De Lux Putra, Effendy De Lux Ellyza Herda Embun Suci Nasution Emil Salim Fragilie, Dimas Hafid Syahputra Hakim Bangun* Hayatun Nufus Herawaty Ginting Iksen, Iksen Julia Reveny Khairunnisa Khairunnisa Khairunnisa Lisda Rimayani Lubis, Arga Lubis, Meiva Amelia Lumbanraja, Linnon Bastian Masfria Muhammad Wahyu, Muhammad Nasri Nasri, Nasri Nasution, Azizah Nazliniwaty Nazliniwaty* Perangin-angin, Arihta Sri Pintauli, Sondang Prayoga, Andre Putri Fiari, Hera Zalia Rexi, Daniel Reza Destri Anggi Ririn Anastasia Butar Butar Rizki Doli Hartama Harahap Sanjaya, Angga Nugraha Simangunsong, Irene Simbolon, Rohana Oktofariday Siswahyudianto Siti Morin Sinaga Sitorus, Panal Sondang Pintauli Sumaiyah Syukur Berkat Waruwu Tarigan, Betharina Br Tarigan, Eunike Victorita Tri Susanti Sirait Urip Harahap Vadhila, Mumtaz Wardono, Sri Wira Septama, Abdi Wiryanto Wiryanto M.S Wiryanto Wiryanto Yuandani Yudhit, Astrid Zumaira