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Nurwahyuni, Atik
Departemen Administrasi Dan Kebijakan Kesehatan, Fakultas Kesehatan Masyarakat, Universitas Indonesia
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Journal : Neurona

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INTERAKSI HORMON DAN EPILEPSI Ahmad Sulaiman Alwahdy; Astri Budikayanti; Fitri Octaviana; Donny Hamid
NEURONA Vol 37 No 2 (2020)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52386/neurona.v37i2.115

Abstract

HORMONE AND EPILEPSY INTERACTIONABSTRACTHormones are signaling chemical molecules between cells that circulated in blood within the human body and play important roles for human being. Unfortunately, not all their functions are known, especially in epilepsy. Studies reported interactions between hormones and epilepsy, also with antiepileptic drugs (AEDs). For example, seizures may be induced by estrogen, whileAEDs can decrease hormone level by inducing enzyme in P450 cytochrome and accelerating hormone clearance.These conditions are known as tridirectional interactions. Understanding the interactions between hormones, epilepsy and AEDs would raise an awareness and insight for clinicians especially neurologist for basic knowledges as considerations in treating patients with epilepsy.Keyword: Antiepileptic drugs, epilepsy, hormone, seizureABSTRAKHormon merupakan molekul pembawa pesan kimiawi antar sel yang berada dalam tubuh manusia, beredar di dalam darah dan sangat penting bagi kehidupan manusia. Perannya pada epilepsi belum seluruhnya diketahui, akan tetapi berbagai penelitian yang ada menunjukan adanya interaksi antara hormon dan epilepsi begitu juga terhadap obat antiepilepsi (OAE). Sebagai contoh, bangkitan epilepsi dapat dicetuskan oleh estrogen, namun beberapa OAE yang merupakan penginduksi enzim sitokrom P450 di hati, dapat menurunkan kadar hormon di dalam tubuh dan juga mempercepat pembersihan hormon terutama hormon steroid seks. Hubungan ketiga faktor ini menciptakan hubungan yang disebut hubungan tridireksional. Dengan memahami mengenai interaksi yang terjadi antara hormon, epilepsi dan OAE, diharapkan dapat membuka wawasan bagi neurologis untuk memiliki pengetahuan dasar sebagai pertimbangan dalam tata laksana pasien epilepsi.Kata kunci: Bangkitan,epilepsi, hormon, obat antiepilepsi
GAMBARAN ARSITEKTUR TIDUR PADA PASIEN TUMOR OTAK YANG MENGALAMI GANGGUAN TIDUR Yesi Astri; Manfaluthy Hakim; Tiara Aninditha; Renindra Ananda Aman; Astri Budikayanti
NEURONA Vol 38 No 2 (2021)
Publisher : PERDOSNI

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction: Sleep disorder is commonly found in brain tumor patients (42-46%). It can be detected using thePittsburg Sleep ????uality Inde???? (PS????I) as a screening tool and confirmed by analyzing the sleep architecture obtainedthrough a Polysomnographic (PSG) examination.Aim: To evaluate the sleep architecture in brain tumor patients who experience sleep disorder.Methods: In this descriptive cross-sectional study, patients with primary brain tumor were screened for sleep disorderusing the PSQI. The ‘poor sleepers’ would proceed to PSG examination.Results: Of 40 participants, 14 were males and 26 were females with a mean age of 45.5±11.7 years old. The mostprevalent tumor was meningioma (42.5%), while the most affected regions were the frontal lobe (40%) and the sellarsuprasellarregion (2????.5%). Poor sleep ????uality and difficulty in initiating sleep (????3 times per week) was reported in77.5% and 60% of participants, respectively. All participants experienced reduced sleep duration, the majority of whichdemonstrated low sleep efficiency (8????.5%). An estimate of 60% participants e????perienced headache at night and 50% tooksleeping pills for these complaints. Most of them reported disruption in daytime activities. On PSG analysis, we observedshortening of sleep latency, reduced sleep efficiency, total sleep time, N2, N3, REM, arousal inde????, and increase of N1.There was a statistically significant difference between ????5 hours of sleep duration and decrease of N3 phase (p????0.05).Discussion: Abnormal sleep architecture presents in brain tumor patients with sleep disorder.Keywords: brain tumor, Pittsburgh Sleep Quality Index, polysomnography, sleep architecture
Co-Authors ', Gusnardi ', Sumarno Adang Bachtiar Adik Wibowo Ahmad Sulaiman Alwahdy Alexsander Putra Ambarita, Anna Tirawani Amelia Intan Andre Yunianto Anis Sakinah Utami Anna Tirawani Ambarita Annathasia Annathasia Arif Awaludin Ashar Asri Hikmatuz Zahroh Athiyah, Athiyah Atmiroseva, Atmiroseva Ayu Novia Kurnia Ayunda Oktavia Bagas Yushila Tamami Rizqo Baros, Wan Aisyiah Benjamin Saut Budi Safari Cicih Opitasari Citra Jaya Cyntiya Rahmawati Cyntiya Rahmawati Daeli, Widi Astutty Casimira Damaryanti, Laksmi Damayan, Anak Agung Istri Agung Sri Stuti Daruki, Maria Wahyu Dedy Revelino Diah Fitri Novita Sari Diah Melly Marlyana Dian Agnesa Sembiring Dian Elawati Dibyo Iskandar Dilla Syamola Dini Karwati Djoko M Hartono Donny Hamid Dwi Budi Prastiani Endah Sih Prihatini Erdayani Erdayani Ery setiawan Ery Setiawan Setiawan Erzan Dhanalvin Estherlina Sitorus Euis Nurjannah Evie Ni'matunnisa Fachmi Idris Fadliyah, Hilyatul Fadllil Kaafi Fahminur ' Faisol Mas’ud Faisol Masud Farianti, Yuli Febriadi, Yudi Felicitas Nia Aryani Firda Jusela Fitri Octaviana Fredinan Yulianda Fuquh Rahmat Shaleh Gani Haryana Garaika Genoveva Maditias Dwi Pertiwi Gimin Gimin Giusman, Reli Gusnardi ' Heny Hendrayati Hilyatul Fadliyah Ida Bagus N Maharjana Idris, Salman Mauluddin Ika Purnamasari Jawanri Citra PS Kurnia Sari Kurnia, Ayu Novia Latanza Shima Lestari, Erna Madya, Sri Denti On Mangunsong, Emmy Ridhawaty Marshia Rehatalanit Megraini, Amila Mirza Aulia Moch Saad, S.Pi.,M.Si Mochamad Achyarsyah Muhammad Lian Kautsar Mukhlisa, Mazda Novi Mukti Ali Mundiharno Mundiharno Nadjib, Mardiati Natalia Melani Nia Priyatiningsih Nurhabibah Nurhabibah Pantri Widyastuti Pantri Widyastuti Pradya Rafthudyanti Prastuti Soewondo Pujiyanto Pujiyanto Pujiyanto Pulungan, Nopiana Pusposari Purwoko Rabiulyati, May Rasinta Ria Ginting Rejeki, Vera Marietha Meinar Reli Giusman Renindra Ananda Aman Rina Selva Johan Rira Martaliza Rizki Asriani Putri Rudi Suryo Kristanto Rybob Khomes Sakdanur Nas Salman Mauluddin Idris Sayekti, Sekar Arum Handarbeni Sembiring, Dian Agnesa setyo Pantawis Simbolon, Joni Pranata Soetedja, Silvia Vinawaty Sri Denti On Madya Sri Denti On Madya Suarman ' Suci Atiningsih Suherman, Suherman Suryana Suwedia, I Nyoman Gede Bayu Wiratama Tetriadi Tetri Tetriadi Tetriadi, Tetriadi Tetriyadi, Tetriyadi Tiara Aninditha Tri Priyo Anggoro Tri Priyo Anggoro Ulil Amri, Anugrah Aulia Vera Marietha Meinar Rejeki Wahyudi, Chandra Tri Wahyuni, Asri Nur Wahyuningsih, Helmi Wan Aisyiah Baros Widi Astutty Casimira Daeli Widi Astutty Casimira Daeli Widyastuti, Pantri Widyatutti Widyatuti Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono Yenni Khristiana Yesi Astri Yoam, Crefinda Hanna Ananda Yohanes Fery Cahaya Yuliani Yuliani Yunavita Uzzie Elsanti Yunita Yunita Zahrul Arief Intasar