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All Journal The Journal of Pure and Applied Chemistry Research Journal of Islamic Pharmacy Public Health of Indonesia Industria: Jurnal Teknologi dan Manajemen Agroindustri AcTion: Aceh Nutrition Journal SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan JPSCR : Journal of Pharmaceutical Science and Clinical Research Poltekita : Jurnal Ilmu Kesehatan Majalah Farmasetika JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Ilmiah Jophus: Journal of Pharmacy UMUS Miracle Journal Of Public Health (MJPH) Humanism : Jurnal Pengabdian Masyarakat Jurnal Ilmiah Kesehatan (JIKA) Proceedings Series on Health & Medical Sciences Jurnal Gizi Masyarakat Indonesia (The Journal of Indonesian Community Nutrition) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pengabdian Mandiri Pharmaceutical Reports Pharmacology And Pharmacy Scientific Journals (PAPS Journals) Indonesian Health Journal MULTIPLE: Journal of Global and Multidisciplinary CERATA Jurnal Sains dan Kesehatan
Saparuddin Latu
Department Of Pharmacy, Pharmacy Faculty, Megarezky University, Jl. Antang Raya No. 43 Makassar, South Sulawesi, Indonesia 90234
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Industria: Jurnal Teknologi dan Manajemen Agroindustri

 1 
The Potential of Bitter Leaf (Vernonia amygdalina) in Herbal Medicine as Anti-Inflammatory Agent Fawwaz, Muammar; Pratama, Mamat; Latu, Saparuddin; Rahayu, Rita; Nurkamilah, Andi
Industria: Jurnal Teknologi dan Manajemen Agroindustri Vol 12, No 1 (2023)
Publisher : Department of Agro-industrial Technology, University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.industria.2023.012.01.4

Abstract

AbstractThe inflammatory process involves increased vascular permeability, protein denaturation, and membrane alteration. Flavonoids are a class of secondary metabolites with biological and pharmacological activities, including anti-inflammatory. The bitter leaf, Vernonia amygdalina (VA), are used in various alternative medicine in several countries, including Indonesia. Chemical components in VA leaf are polyphenolic compounds, flavonoids, terpenes, and coumarins. The previous study exhibited that the anti-inflammatory activities of plants are closely related to the levels of polyphenols and flavonoids. Therefore, this study aimed to evaluate the anti-inflammatory activity of VA leaf and determine the total flavonoid-phenolic content of VA leaf ethanolic extract. The extraction method used maceration by ethanol as a solvent. The anti-inflammatory activity was measured by protein denaturation inhibition properties. The total flavonoid and phenolic content were determined by colorimetric and Folin-Ciocalteu methods, in which both procedures were measured by UV-Visible spectrophotometry at maximum wavelength. The results showed that VA leaf ethanolic extract has an anti-inflammatory effect with a half inhibition concentration (IC50) of 346.23 μg/mL. The total flavonoid and phenolic content of the ethanolic extract of VA leaves were 25.62 mgQE/g extracts and 21.47 mgGAE/g extract, respectively. Thus, the ethanolic extract of VA leaves can potentially be developed as an anti-inflammatory agent in herbal medicine.Keywords: anti-inflammatory, flavonoid, gallic acid, phenolic, quercetin AbstrakProses inflamasi melibatkan peningkatan permeabilitas vaskular, denaturasi protein, dan perubahan membran. Flavonoid merupakan senyawa metabolit sekunder dengan aktivitas biologis dan farmakologis potensial, termasuk sebagai antiinflamasi. Daun pahit, Vernonia amygdalina (VA), digunakan dalam berbagai pengobatan alternatif di beberapa negara, termasuk Indonesia. Komponen kimia dalam daun VA adalah senyawa polifenol, flavonoid, terpen, dan kumarin. Studi sebelumnya menunjukkan bahwa aktivitas anti-inflamasi tanaman terkait erat dengan kadar polifenol dan flavonoidnya. Oleh karena itu, penelitian ini bertujuan untuk mengevaluasi aktivitas antiinflamasi daun VA dan mengetahui kandungan flavonoid-fenolik total pada ekstrak daun VA. Metode ekstraksi menggunakan maserasi dengan etanol sebagai pelarut. Aktivitas antiinflamasi diukur dengan menggunakan metode penghambatan denaturasi protein. Kandungan total flavonoid dan fenolik ditentukan dengan metode kolorimetri dan Folin-Ciocalteu. Kedua prosedur tersebut diukur pada spektrofotometri UV-Visible pada panjang gelombang maksimum. Hasil penelitian menunjukkan bahwa ekstrak etanol daun VA memiliki efek anti-inflamasi dengan konsentrasi daya hambat 50% (IC50) sebesar 346,23 µg/mL. Kandungan total flavonoid dan fenolik ekstrak etanolik daun VA berturut-turut adalah 25,62 mgQE/g ekstrak dan 21,47 mgGAE/g ekstrak. Dengan demikian, ekstrak etanol daun VA berpotensi untuk dikembangkan sebagai agen anti-inflamasi dalam pengobatan herbal.Kata kunci: anti-inflamasi, asam galat, fenolik, flavonoid, quercetin
Co-Authors Abdul Wahid Suleman Agus Susanto Aisyah Nur Sapriati Aisyah Nur Saptriati Amir, Arfenti Andi Irdawati Andi Muh Yagkin P Andi Muh Yagkin Padjalangi A Andi Muh. Yaqkin P Andi Muhammad Yaqkin Andi Muhammad Yaqkin Padjalangi Asjur, Asti Vebriyanti Asnah Marzuki Aziz, Yuliana Bahar, Muhammad Yusuf Bambang, Ayu Wulansari Baso, Bachtiar Dewi Marhaeni Diah Herawati Firdaus Firdaus Firman, Imran Fitrianingsih, Julia Gaffar, Herry Darsim Gajali, Nurdila Haerawati Idris Haerawati Idris, Haerawati Hasmar, Wahyu Nuraini Hasnany, Hasnany Herman, Sriyana Hilmiati Wahid Ikhsan, Mifta Khaerti Jalal, Jalal Jangga Jangga Jangga, Jangga Junita, Nurfitria K, Aswanto M Fais Satrianegara Mahmudah, Rifa’atul Mamat Pratama, Mamat Mansur Mansur Mansur - Mansur Mansur Mansur Marthen Arie Marwan, Ummi Kalsum Muammar Fawwaz Muhammad Basir Muhammad Basir Muhammad Idris Patarai Muhammad Rifai Musdar, Tamzil Azizi Musliani, Musliani Musnur, Aldha Irjayanti Mustamin Nia Putri Citra Ningsih, Nining Ade Nur Afni Ponseng Nurhikmah Nurkamilah, Andi Nurul Inayah Obed Rame Padjalangi, Andi Muh Yagkin Padjalangi, Andi Muhammad Yaqkin Pakinde, Ayisti Pasinggi, Adinda Sari Patarai, Muhammad Idris Pradila Putri, Hardyanti Eka R. Rusli Rahayu, Rita Rahmaniah, Rahmaniah Rifa’atul Mahmudah Rika Handayani Risnah Rosdiana Rosdiana Rosdiana Rosdiana Rusli Safaruddin Santi, Elvira Saputro, Syaifullah Satrianegara, Faiz Siti Helmyati Sri Wulan Rini Sriyanty Sadsyam Supardi, Nurjannah Surya Syarifuddin Syahruddin, Akmal Novrian Syamsidar Syamsuriyati, Syamsuriyati Tamira Tansy Timbuleng Wattimena, Jans Goldman Yagkin Padjalangi, Andi Muh Yaqkin-P, Andi Muh. Yulianti Yulis, Dian Meiliani Yunaldi Yunaldi Zainuddin