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All Journal Jurnal Ilmu Dasar Journal of Tropical Soils Jurnal Pendidikan Indonesia Jurnal Keterapian Fisik INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Dinamika Pengabdian (JDP) Science and Technology Indonesia AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Chemistry Jurnal Perikanan Universitas Gadjah Mada JSFK (Jurnal Sains Farmasi & Klinis) Seminar Nasional Lahan Suboptimal Molekul: Jurnal Ilmiah Kimia JFIOnline SELL (Scope of English Language Teaching, Linguistics, and Literature) Journal CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Jurnal Ilmiah IT CIDA : Diseminasi Teknologi Informasi Pharmaceutical Sciences and Research (PSR) Gaster Journal of Global Pharma Technology Journal of Pharmacy Science and Technology Journal of Prosthetics Orthotics and Science Technology (JPOST) Jurnal Penelitian Sistem Informasi Jurnal Informatika Polinema (JIP) Jurnal Terapi Wicara dan Bahasa Jurnal Kefarmasian Indonesia

Dwi Setyawan

Department Of Pharmaceutics, Faculty Of Pharmacy, Universitas Airlangga, Jl. Dharmawangsa Dalam, Surabaya 60286, Indonesia

Author-ID : 256573

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Formation of Ketoprofen-Malonic Acid Cocrystal by Solvent Evaporation Method Yudi Wicaksono; Dwi Setyawan; Siswandono Siswandono
Indonesian Journal of Chemistry Vol 17, No 2 (2017)
Publisher : Universitas Gadjah Mada

The purpose of this work was to explore the formation of ketoprofen-malonic acid cocrystal by solvent evaporation method. Early detection of cocrystal formation was conducted by hot stage microscopy and solid-liquid phase diagram. Cocrystal were prepared by solvent evaporation method by using isopropyl alcohol as solvent. Characterization of cocrystal was done by Powder X-Ray Diffractometry (PXRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared (FTIR) Spectroscopy and Scanning Electron Microscopy (SEM). The results of hot stage microscopic and solid-liquid phase diagram indicated formation of ketoprofen-malonic acid cocrystal. PXRD and DSC measurements showed stoichiometric ratio of cocrystal ketoprofen-malonic acid (2:1). The ketoprofen-malonic acid cocrystal had melting point at 86.2 °C and unique peaks of PXRD pattern at 2θ of 6.1°, 17.8°, 23.2° and 28.6°. FTIR spectra indicated the formation of cocrystal due to interaction of C=O ketone group of ketoprofen with MA molecule. SEM images show that ketoprofen-malonic acid cocrystal have multi-shaped particles with rough surfaces.

Improvement in vitro Dissolution Rate of Quercetin Using Cocrystallization of Quercetin-Malonic Acid Dwi Setyawan; Sukma Adhi Permata; Ahmad Zainul; Maria Lucia Ardhani Dwi Lestari
Indonesian Journal of Chemistry Vol 18, No 3 (2018)
Publisher : Universitas Gadjah Mada

The aim of the study was to improve the in-vitro dissolution rate of quercetin (Qu) using cocrystallization of quercetin. Cocrystals of quercetin (Co Qu) were produced with malonic acid (Ma) as coformer at ratio 1:2 using solvent evaporation method. Cocrystals quercetin-malonic acid (Co Qu-Ma) was characterized using Differential Thermal Analysis (DTA), Powder X-Ray Diffraction (PXRD), Scanning Electron Microscope (SEM), and Fourier Transforms Infrared Spectrophotometer (FTIR) and in-vitro dissolution study. A new endothermic peak at 277.9 °C was shown from the thermogram. Diffractogram of Co Qu-Ma showed a new diffraction peak at 2θ 9.81, 12.99, and 19.80°. Microphotograph showed that Qu and Ma exhibited a columnar-shaped and a pebble-shaped crystal, respectively, and FTIR wavenumber of O-H functional group of quercetin was shifted from its original position at 3411 to 3428 cm-1 in the physical mixture (pm) of Qu-Ma and 3418 cm-1 in Co Qu-Ma, respectively. The physicochemical characterizations using DTA, PXRD, SEM and FTIR indicated that Co Qu-Ma were successfully obtained through solvent evaporation method. The in-vitro dissolution rate of Co Qu-Ma was 95.30% at 60 min. Cocrystals effectively increased dissolution rate and dissolution efficiency in comparison to the pure quercetin and physical mixture of quercetin-malonic acid.

Preparation and Characterization of a Novel Cocrystal of Atorvastatin Calcium with Succinic Acid Coformer Yudi Wicaksono; Dwi Setyawan; Siswandono Siswandono; Tri Agus Siswoyo
Indonesian Journal of Chemistry Vol 19, No 3 (2019)
Publisher : Universitas Gadjah Mada

Preparation and characterization of a novel cocrystal of atorvastatin calcium with succinic acid coformer were successfully performed. This research aims to modify the crystalline form of atorvastatin calcium through cocrystallization with succinic acid coformer. The cocrystal was prepared by a solvent evaporation method and characterized by Powder X-Ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC), Fourier Transform Infrared Spectroscopy (FTIR) and Scanning Electron Microscopy (SEM). The atorvastatin calcium-succinic acid cocrystal has new crystalline peaks at 2θ of 12.9, 18.2 and 26.7° indicating the formation of a new crystalline phase. The cocrystal showed the melting point at 205.7 °C with an enthalpy of fusion 30.2 J/g which is different from the initial components. The FTIR spectra of cocrystal showed the shifting of absorption peaks of groups of initial components indicating of formation of atorvastatin calcium-succinic acid cocrystal through acid–amide intermolecular hydrogen bond interactions. The solubility and dissolution test showed that the cocrystal has solubility and dissolution rate significantly higher than the solubility and dissolution rate of pure atorvastatin calcium.

Pengaruh Avicel PH 102 Terhadap Karakteristik Fisik dan Laju Disolusi Orally Disintegrating Tablet Piroksikam Dengan Metode Cetak Langsung Setyawan, Dwi; Widjaja, Bambang; Ningtyas, Zimy Fianti
Majalah Ilmu Kefarmasian Vol. 7, No. 1
Publisher : UI Scholars Hub

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The influence of Avicel PH 102 as disintegrant on physical characteristic and dissolution rate of piroxicam Orally Disintegrating Tablet prepared by direct compression method was observed in this research. Concentration of Avicel PH 102 used were 5%, 10%, 15% and 0% as a control. Physical characteristics of the powder blend including flow rate and angle of repose showed good attributes. The powder blend was pressed into tablet by hydraulic press with a pressure of 1 ton and diameter of 8 mm. The physical characteristic of piroxicam orally disintegrating tablet including hardness, friability, disintegration time, and dissolution rate were examined. The hardness of all formulas were between 0,99 – 2,78 kP, friability were between 3,45% – 1,25%, disintegration time were between 223,67– 18,33 sec and drug released at 45 minutes were between 32,71%– 88,63%. The results showed that increasing the concentration of Avicel PH 102 would increase the hardness, and dissolution rate and decrease the friability and disintegration time of piroxicam orally disintegrating tablet . From statistical analysis (µ = 0,05), it could be seen that there was significant difference in physical characteristics and dissolution rate of all formulas. Among all formulas, it could be concluded that formula with 10% concentration of Avicel PH 102 was the optimum formula

Pengaruh Ac-Di –Sol Terhadap Karakteristik Fisik dan Laju Disolusi Orally Disintegrating Tablet Piroksikam dengan Metode Cetak Langsung Setyawan, Dwi; Widjaja, Bambang; Sayekti, Indah
Majalah Ilmu Kefarmasian Vol. 7, No. 2
Publisher : UI Scholars Hub

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Orally Disintegrating Tablet (ODT) or Fast Release Tablet is solid dosage form which disintegrated rapidly in mouth and its residue easy to swallowed. This research observed the influence of Ac-Di-Sol concentration as disintegrant on physical characteristics and dissolution rate of piroxicam orally disintegrating tablet which were prepared by direct compression. Ac-Di-Sol was used in concentration of 1%, 3% and 5%, and 0% as control. The powder blend was pressed into tablet by hydraulic press with a pressure of 1 ton and diameter of 8 mm and its hardness, friability, disintegration time and dissolution rate were examined. The results showed that the increasing of Ac-Di-Sol concentration would increase hardness, disintegration time, dissolution rate and decrease friability of the tablet. From statistical analysis (µ =0,05), it was showed that there was significant difference among formulas on the hardness, friability, disintegration time and dissolution rate. The hardness of piroxicam Orally Disintegrating Tablet of all formulas were between 0.99 - 2.77 kP, friability were between 3.45 – 1.35%, disintegration time were between 223.67 – 20,0 sec and drug released at 45 minutes were between 32.71 – 96.25%. From this research, it could be concluded that formula with 3% concentration of Ac- Di-Sol give the most desirable output, even though there was a problem with the friability.

Preparation and Evaluation of Antihypercholesterolemic Activity of Atorvastatin Calcium-Maleic Acid Co-Amorphous Solids Yudi Wicaksono; Shofiatul Izzah Al Amaliyah; Finas Rahmayanti; Viddy Agustian Rosidi; Lina Winarti; Dwi Setyawan
Science and Technology Indonesia Vol. 7 No. 2 (2022): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Atorvastatin calcium is a statin drug used for antihypercholesterolemic. The oral bioavailability of atorvastatin calcium is relatively low because it is poorly soluble in water. The low oral bioavailability of the drug causes a decrease in its therapeutic effectiveness. This study aimed to increase the solubility of atorvastatin calcium through the formation of co-amorphous solids and evaluate its activity as antihypercholesterolemic. Atorvastatin calcium was prepared into co-amorphous solids with a maleic acid coformer using the spray drying method. Solids characterization was carried out using Powder X-Ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC), Fourier Transforms Infra Red (FTIR), and Scanning Electronic Microscopy (SEM). The solubility test was carried out using the shaking method, while the evaluation of antihypercholesterolemic was carried out in vivo in experimental animals. The results of the analysis of diffractograms, thermograms, FTIR spectra, and micrograph images showed that the atorvastatin calcium-maleic acid solids prepared by spray drying were a co-amorphous solid. The atorvastatin calcium-maleic acid co-amorphous solids had a greater solubility in water (p<0.05) when compared to pure atorvastatin calcium. However, the in vivo antihypercholesterolemic activity results in experimental animals showed that the cholesterol-lowering activity of the atorvastatin calcium-maleic acid co-amorphous solidswas not significantly different (p>0.05) with pure atorvastatin calcium. This phenomenon is thought to be because atorvastatin calcium from co-amorphous solids in solution is more present as a charged fraction, affecting the permeability and absorption process.

Effect of Pregelatinization on Suweg Tuber Starch (Amorphophallus Paeonifolius) as Tablet Crusher Dwi Setyawan
Journal of Global Pharma Technology Volume 12 Issue 09 (2020) Sept. 2020
Publisher : Journal of Global Pharma Technology

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Background: Disintegrant tablet from starch is more often used to crush the tablet that has been swallowed. However, the material of this starch is tablet crusher which very weak. In contrast to the suweg starch (Amorphophallus paeonifolius) which has undergone pregelatinization where the content of amylose and amylopectin and the water absorption capacity that is high enough so that it can crush the tablet quickly. The aim of this study was to determine the influence of pregelatinization towards elephant foot yam (Amorpophallus paeonifolius) starch as disintegrant against tablet physical quality profile of the Paracetamol tablet. Method: The research was carried out by making suweg natural starch which then it made a suspension in the water with a concentration of 20% and heated to the temperature of 60 ± 5 0C and 70 ± 5 0C within 15 minutes. After the suweg pregelatin starch has been made, then a paracetamol tablet and a qualitative examination also made which includes the determination of the paracetamol infrared spectrum, the examination of moisture content, the testing with iodine, the testing with optical microscopy, X-ray diffraction analysis, the starch thermal analysis with DTA, and the examination of swelling power which then compared to each tablet formula made by the wet granulation method. after that, it was continued with the examination of the granule quality, including the examination of moisture content, the examination of granule particle size and number of fines, the examination of flow velocity and rest angle of the granule. Moreover, it was carried out an evaluation of the paracetamol tablet physical quality in the form of hardness test, friability test, and disintegration time test. The data obtained was further analyzed by One Way ANOVA. Result: Tablet formula with pregelatinization of suweg natural starch can reduce the hardness, increased the tablet disintegration time, and made no difference in friability compared to the formulas containing natural suweg tuber starch and SSG. The result of increased disintegration time was then compared with the result of the swelling power test, but did not indicate a correlation both of them. The different of disintegration was not showed a correlation with values of swelling power. Keywords: Suweg Tuber Starch, Starch Pregelatinization, Pregelatinized Starch Tablet.

PEMBENTUKAN KOKRISTAL KETOKONAZOL-ASAM SUKSINAT YANG DIBUAT DENGAN METODE PENGGILINGAN (GRINDING) Yuli Ainun Najih; Dwi Setyawan; Achmad Radjaram
JOURNAL OF PHARMACY SCIENCE AND TECHNOLOGY Voume 1 Nomor 1
Publisher : Prodi Farmasi Fakultas Kedokteran Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/pst.v1i1.30

The Co-crsytal formation ketoconazole (KTZ) - succinic acid (SA) has been performed by molar ratio (1:1) using milling method (grinding).. Milling is done using Planetary Ball mill PM 200 MA-type tool, Retsch with 75 rpm milling speed. The physical mixture of KTZ and AS molar ratio (1:1) was prepared in the absence of a dry grinding solution with milling time of 5, 15, 30, 45 and 60 min at a constant velocity. The milling results are seen by using powder X-ray diffraction (PXRD) at an angle (2Î¸ = 7.8o). From the results of X-ray powder diffraction there is an increase in the percentage of crystalline (% w/w). The result of the grinding time curve with the percentage of crystal (%w/w), the result that the percentage of crystalline (% w/w) increases linearly with increasing milling time (min) based on the maximum intensity data of each milling time by the line equation (y = 0.690x + 51.09) and correlation coefficient r = 0.9905. As conclusion, based on kinetic formation of cocristal with milling method obtained for slope value = 0,690 % cocrystall (%b/b)/min.

Increasing the Solubility and Anti-Inflammatory Activity of Curcumin by Cocrystallization Yudi Wicaksono; Kuni Zu’aimah Barikah; Amanda Della Yudatama; Havidhatul Maulia; Nuri; Dwi Setyawan
Science and Technology Indonesia Vol. 8 No. 3 (2023): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2023.8.3.501-508

Curcumin (CUR) is a polyphenolic compound that exhibits potent anti-inflammatory activity. However, only a tiny amount of CUR is absorbed during oral administration, which is because CUR is difficult to dissolve in water. The aim of the research was to increase the solubility of CUR through the cocrystallization technique using isonicotinamide coformer (INIC) by solvent evaporation. Cocrystal characterization was carried out using a powder X-ray diffractometer (PXRD), a differential scanning calorimeter (DSC), a Fourier transform infrared spectrometer (FTIR), and a scanning electron microscope (SEM). Solubility was evaluated using the shaking method, while the anti-inflammatory activity test was carried out using the carrageenan induced mouse leg edema method. The resulting CUR-INIC (1:1) cocrystal has a diffractogram with new diffraction peaks of 2theta at 15.00, 16.22, and 22.89◦ compared to the individual diffractograms of CUR and INIC. In the cocrystal, CUR and INIC form intermolecular interactions of hydrogen bonds, resulting in a new solid phase with a melting point of 160.1◦C. The solubility of the CUR-INIC cocrystal in water was 73.1±0.23 ug/mL, which increased 14 times compared to the solubility of initial CUR, which was only 5.05±0.07 ug/mL. The CUR-INIC cocrystal showed a percentage of edema inhibition in mice (5 hours) 130% more potent than that of initial CUR. Therefore, CUR-INIC cocrystals can be used to improve CUR solubility to obtain more excellent anti-inflammatory effects.

SISTEM PENCATATAN POIN PELANGGARAN SISWA PADA SMA NEGERI 1 PURWOSARI Dwi Setyawan; Ely Setyo Astuti; Ekojono Ekojono
Jurnal Informatika Polinema Vol. 1 No. 1 (2014): Vol 1 No 1 (2014)
Publisher : UPT P2M State Polytechnic of Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33795/jip.v1i1.84

Tingkat pelanggaran siswa pada SMA Negeri 1 Purwosari dari tahun ke tahun terus bertambah dengan berbagai macam pelanggaran yang dilakukan. Selama ini pencatatan poin pelanggaran yang dilakukan oleh guru BK (Bimbingan Konseling) menggunakan buku tatib yang dimiliki oleh sekolah. Pengendalian pada pelanggaran yang dilakukan masih belum dapat dilakukan secara optimal karena guru BK (Bimbingan Konseling) tidak dapat dengan mudah menentukan tingkat tertinggi pelanggaran yang dilakukan oleh siswa. Karena itulah sebuah sistem pencatatan poin pelanggaran siswa pada sekolah sangat diperlukan untuk mengetahui tingkat ketidak disiplinan para siswa dalam lingkungan sekolah. Sistem informasi tersebut juga dapat menghasilkan informasi tersebut secara efektif dan efisien. Sistem pencatatan pelangaran ini menggunakan metode penjumlahan dari tiap komponen pelanggaran yaitu komponen sikap dan perilaku, komponen kerajinan dan komponen kerapian, sehingga nanti didapatkan jumlah point dari tiap siswa beserta sanksi yang didapat dan jumlah statistik pelanggaran yang dilakukan oleh siswa. Dengan demikian sistem pencatatan poin pelanggaran ini dapat menjadi pendukung keputusan bagi guru BK yang memberi penilaian terhadap pelanggaran siswa di lingkungan sekolah.

Co-Authors AA Sudharmawan, AA Achmad Radjaram Agnes Nuniek Winanta Ahmad Zainul Amanda Della Yudatama Astuti, Ely Setyo Atok Miftachul Hudha Auzal Halim Bambang Widjaja Bambang Widjaja Bambang Widjaja Bambang Widjaja Betari, Sita Desti Bhisma Murti D Budianta, D Dafa C, Muhammad Dewanthy, Kyrana Sekar Dewi Isadiartuti Dewi Melani Hariyadi Dicky Pratama Dina Ayu Fatmawati Diyah, Nuzul Wahyuning Ekojono Ekojono Erizal Zaini Fadjar Mulya Fajar R, Allak Farid, Saif Aiman Fatati, Muhibbah Fauzi Ahmad Muda Fauzia, Alfi Nur Fendy Hardian Permana Fery Eko Pujiono, Fery Eko Finas Rahmayanti Gatot Sugiarto Gilkes, Robert Hafidz, Moh Handayani, Ning Rahayu Havidhatul Maulia Herlina Hanum, Herlina HERMANU JOEBAGIO Ichsan Luqmana Indra Putra, Ichsan Luqmana Indra Idha Kusumawati Iin Hindun Ina Sholihah Widiati, Ina Sholihah Indah Sayekti Indah Sayekti, Indah Juni Ekowati Kanzaffa, Firly Afnauriza Tedja Kuamit, Thanawit Kuni Zu’aimah Barikah Kurdi Wijaya, Moh Kurniawan, Muhammad Fariez Lina Winarti Maghzarini, Nessa Regitha Marcellino Rudyanto Maren, A Maria Lucia Ardhani Dwi Lestari Martinus, Ali Melanny Ika Sulistyowaty Misbahul Munir Moh. Mirza Nuryady Muhammad Adi Nugroho Muhammad Setiyawan Ningsih, Cica Trimandasari Noorma Rosita Novira Widajanti, Novira Nugroho, Surya Adi Nuri Nuruddin, Mahrus Naufal Nurwidodo, Nurwidodo Oktavia Eka Puspita, Oktavia Eka Paramita, Diajeng Putri Prameswari, Putu Pradnya Mimba Pratiwi, Ambar Priatna, S J Pujiono, Ferry Eko Raden Joko Kuncoroningrat Susilo Rani, Karina Citra Refraugati, Irwandi Retno Sari Rohana, Melissa Rudy Salam, Rudy Samsun hadi Sari, Ketut Intan Yunika Septiani, Annisa Eka Shofiatul Izzah Al Amaliyah Siammita, Dhea Anansya Siswandono, S. Siswandono, Siswandono Soraya, Yasmin Sukma Adhi Permata Sundani N. Soewandhi, Sundani N. Syafi'ie, Hisyam Tahta Amrillah Tongway, David Tri Agus Siswoyo Utami, Inggita Viddy Agustian Rosidi Wahyu Prihanta Warsito Warsito Widji Soeratri Winantari, Agnes Nuniek Yuanita Windusari Yudi Wicaksono Yudi Wicaksono Yudi Wicaksono Yuli Ainun Najih Zidan, Sabry A. H. Zimy Fianti Ningtyas Zimy Fianti Ningtyas, Zimy Fianti

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