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All Journal Jurnal Teknologi Dan Industri Pangan JURNAL GIZI INDONESIA Jurnal Ilmu keperawatan Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Reproduksi UNEJ e-Proceeding Sari Pediatri Paediatrica Indonesiana Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) Jurnal Gizi Klinik Indonesia Jurnal Keperawatan Respati Yogyakarta Basic and Applied Nursing Research Journal Berita Kedokteran Masyarakat Jurnal Farmasi Indonesia Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)

Madarina Julia

Universitas Gadjah Mada

Author-ID : 257273

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Comparison of daily vs. weekly single-dose ferrous sulphate treatment in female junior high students with iron deficiency anemia Dedy Afandi, Sri Mulatsih, Madarina Julia
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 41, No 01 (2009)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Background: Complianc~ of daily treatment of iron deficiency anemia in children is still low. The compliance will be increased if the iron supplementation is given weekly. Previous study showed that there was no significant difference in the increase in hemoglobin level between daily and weekly treatment in prepubertal children. Objective: To study the difference in the increase in hemoglobin and serum ferritin levels between daily and weekly sirigle-dose treatment of ferrous sulphate in female junior high school students with iron deficiency anemia after menarche. Methods: This was a quasi-experimental study recruiting 179 and 174 anemic female students in the weekly and daily group, respectively. They receive weekly or daily single-dose of ferrous sulphate capsules. Hemoglobin levels were measured before and after the 12 weeks treatment, while serum ferritin levels were measured before and after in a subset of the study subjects. Result: Mean:t SD levels of hemoglobin before and after iron supplementation were 11.18:1: 0.51 and 12.79:t0.63 g/dl (p=0.001) in the weekly group, and 11.17:1:0.61 and 12.68:1:0.57 g/dl (p=0.001) in the daily group. Mean:l: SD levels of ferritin before and after iron supplementation were 6.95:1: 1.85 and 41.5:1:33.93 ng/ml (p=0.001) in the weekly group, and 6.61 :1:2.17 and 40.7:1:22.73 ng/ml (p=0.001) in the daily group. The prevalence of anemia after supplementation is similar in both groups, i.e. 6.7% in the weekly group and 8.0% in the daily group (p = 0.631. There were no significance difference in the occurrence of side effects of diarrhea and nausea in both groups (p>0.05). Conclusion: This study concluded that daily vs. weekly ferrous sulphate supplementation did not result in significantly different level of both hemoglobin and serum ferritin after treatment. The difference in the occurrence of side effects was also not statistically significant. Key words: anemia iron deficiency - hemoglobin level - serum ferritin level - ferrous sulphate

Diabetes mellitus type 1 in congenital rubella syndrome: a case report Carina Lisa Madarina Julia E.S. Herini
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 04 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Corina Lisa, Madarina Julia, E.S. Herini . Diabetes Mellitus Type 7 in Congenital Rubella SyndromeDiabetes mellitus type 1 has been reported as a very rare delayed manifestation of congenital rubella syndrome. We reported a confirmed case of congenital rubella syndrome that developed diabetes mellitus at the age of seven years. The girl had been complaining of diabetes symptoms since six months before admission, but had been misdiagnosed. The patient finally came with symptoms of diabetic ketoacidosis, a life threatening complication of diabetes mellitus. Diabetes mellitus type 1 as a delayed manifestation of congenital rubella syndrome has to be kept in mind to prevent missing the diagnosis.Key words: rubella infection - congenital rubella syndrome - diabetes mellitus type 1ABSTRAKCorina Lisa, Madarina Julia, E.S. Herini - Diabetes Mellitus Tipe 7 pada Sindroma Rubella KongenitalDiabetes melitus adalah salah satu manifestasi lambat sindrom rubella kongenital yang jarang, tetapi perlu diwaspadai. Kami melaporkan satu kasus sindrom rubela kongenital yang mengalami diabetes melitus tipe 1 pad a usia 7 tahun. Meskipun gejala diabetes telah dikeluhkan sejak enam bulan sebelum masuk rumah sakit, penyakit diabetes tetap tidak terdiagnosis. Penderita akhirnya datang dengan gejala dan tanda ketosidosis diabetikum, suatu komplikasi diabetes mellitus yang mengancam jiwa. Manifestasi lambat sindrom rubella yang berupa diabetes mellitus tipe I harus diwaspadai untuk mencegah tidak terdiagnosanya penyakit tersebut.

Wilms tumor associated with Cushing 's syndrome - A case report Madarina Julia Madarina Julia
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 29, No 04 (1997)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Ectopic ACTH syndrome associated with Wilms tumor is ver

The association of single nucleotide polymorphism (SNP) rs2922126 within ghrelin and growth hormone secretagogue receptor 1a (GHSR1a) gene with insulin resistance in obese female adolescents in Yogyakarta Special Region Cut Gina Inggriyani Rina Susilowati Madarina Julia
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 44, No 02 (2012)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

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Previous study reported that among 79 obese female adolescents in Yogyakarta Special Region, 44 (55.7%) of them have insulin resistance. However, no significant differences on dietary habits and physical activity between the obese female who have insulin resistance and thosewho are insulin sensitive were observed. Therefore, it was thought that genetic factors are involved in the occurrence of insulin resistance. Ghrelin and growth hormone secretagogue receptor (GHSR) genes have been associated with the insulin signaling pathway with implicationsin insulin resistance. The study aimed to analyze the association between SNP (single nucleotid polymorphism) rs2922126 in GHSR1a gene with insulin resistance in obese female adolescents in Yogyakarta Special Region. Seventy eight obese female adolescents who were selected in theprevious study were involved in this study. Secondary data including name of subjects, age, body height, body weight, BMI (body mass index), fasting glucose level, fasting insulin level, waist circumference and HOMA-IR index were obtained from previous study. Polymerase Chai Reaction (PCR) and Restriction Fragment Length Polymorphism (RFLP) methods were used to the genotype analysis of SNP rs2922126. Chi-square test was used to calculate odds ratio on genotype and allele of SNP rs2922126 GHSR1a gene in insulin resistance and insulin sensitive groups. The results showed that A/A genotype individuals in SNP rs2922126 had higher risk to develop insulin resistance, compared to A/T and T/T genotypes individuals (OR: 2.03; 95%CI: 0.54-7.57). However, it was not significantly different (p>0.05). Individuals with A/A genotype and A allele carriers at SNP rs2922126 tended to have a higher value of BMI, fasting glucose level, fasting insulin level, HOMA-IR, and waist circumference compared to other carriers, althoughit was not significant (p>0.05). It can be concluded that SNP rs2922126 in GHSR1a gene is not associated with insulin resistance in obese female adolescents in Yogyakarta Special Region.Keywords: GHSR1a gene - SNP rs2922126 - insulin resistance - female - obese

Precocious puberty in McCune-Albright syndrome: a case report Rianti Puji Lestari; Retno Sutomo; Madarina Julia
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

McCune-Albright syndrome (MAS) is a rare disease characterized by a triad of fibrousdysplasia, cafe-au-lait spots and peripheral precocious puberty. We reported a 5-year-8-month old girl with MAS who has been followed-up for 2 years and 8 months. Shewas referred to pediatric endocrinology clinic in our hospital for vaginal bleeding at ageof 2 years 11 months. She had peripheral precocious puberty, i.e. increased estrogenlevel associated with very low gonadotropins, and cafe-au-lait spots on her face and wasdiagnosed as MAS. The patient was treated with estrogen receptor blocker (tamoxifen).She had no menses during the 2 years and 8 months of tamoxifen treatment. Her growthrate and bone maturation were also in normal ranges. However, at the end of tamoxifentreatment she had an episode of vaginal bleeding so that we had to change to othertreatment modalities.

LOCAL WISDOM OF JEMBER COMMUNITY IN REDUCING CYANOGENIC LEVELS TO LOWER URINE THIOCYANATE LEVELS Farida Wahyu Ningtyias; Ahmad Husain Asdie; Madarina Julia; Yayi Suryo Prabandari
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Disorders caused by iodine deficiency remains aglobal health problem in the world with a prevalenceof 30.6% in 2007 (De Benoist et al., 2003; De Benoistet al., 2008). The causing factors are not only limitedto iodine deficiency. Instead, other factors of IDD aregoitrogenic substances; one of them is thiocyanateresulted from cyanide detoxification. The workmechanism of thiocyanate disrupts thyroid functionby inhibiting the uptake of the iodine and interfereswith the thyroid peroxidase (TPO) activities (Gaitan,1990; Taurog, 1970; Van Etten, 1969; Stoewsand,1995; Virion et al., 1980 cit Chandra & Ray, 2001;Chandra et al., 2004; Delange, 2000; Erdogan, 2003;Gibbs, 2006; Sinebeeh, 2007; Semba & Delange,2008). In addition, small amount of cyanide is alwaysavailable in many kinds of plants commonlyconsumed by community. Goitrogenik source foodsare easily accessible by the community because theprices are cheap or they can be self-planted (Nio,1989; Chandra et al., 2004).Some studies mention that most of the goitrogenicsubstances do not cause clinical effects except theyare going along with iodine deficiency. Therefore,the consumption of goitrogenic substances becomesetiologic agent in an endemic area (Zimmermann etal., 2008). Jember is one of regencies in East Javawhich experiences an increase in TGR from 21.94%in 2003 to 23.57% in 2007. Most of its districts areincluded in the category of endemic goiter area(Jember regency Health Department, 2007). Theresults of previous studies made by the researchersshow that goitrogenic substance as a causativefactor of IDD in Jember, through one of theindicators of urinary iodine levels, is included in thecategory of normal and tend to be high. In addition,urinary thiocyanate levels goiter group are higherthan those in non-goiter group (Ningtyias, 2006;Ningtyias et al., 2007; Ningtyias et al., 2008).Consumption pattern of goitrogenic source food inJember of at least 3-5 times per week with anaverage consumption of 505 μg per day is a riskfactor of IDD in Jember (Megawati, 2007; Ningtyiaset al., 2008). The existence of these substances willdisrupt the process of the formation of thyroidhormones; therefore, it needs to be eliminated, orthe levels are reduced, so that the food ingredientscontaining goitrogenic substances are safe forconsumption. This study used local wisdom to solveproblems of nutrition, that is, one of the habits ofpeople in Jember to boil vegetables for freshvegetables for overcoming nutritional problem ofIDD because the boiling process can reducecyanogenic levels up to 93% (Murdiana, 2001). Bythe decrease in cyanogenic levels, it is expected thatgoitrogenic substance intake into the body willdecrease indicated by the decreasing biomarkers ofgoitrogenic substance of urinary thiocyanate levels.

Dismenore dan Kecemasan pada Remaja Handayani Handayani; Indria Laksmi Gamayanti; Madarina Julia
Sari Pediatri Vol 15, No 1 (2013)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Latar belakang. Prevalensi dismenore cukup tinggi pada remaja. Dampak yang ditimbulkan dari dismenore adalah penurunan aktifitas sehari-hari sampai memerlukan terapi. Faktor risiko dismenore tidak hanya berkaitan dengan faktor fisiologis tapi juga faktor psikologis termasuk kecemasanTujuan. Mengetahui prevalensi dismenore, prevalensi kecemasan tinggi, dan hubungan antara kecemasan dan dismenore pada remaja di kota Surakarta.Metode. Rancangan penelitian adalah cross sectional. Sembilan puluh subyek remaja putri yang memenuhi kriteria inklusi dan eksklusi mengikuti penelitian.Hasil. Prevalensi dismenore pada remaja di kota Surakarta 87,7%. Delapan puluh tujuh koma tujuh persen remaja tetap beraktivitas saat mengalami dismenore dan 12,2% menggunakan analgetik untuk mengurangi keluhan dismenore. Prevalensi skor kecemasan tinggi pada remaja di kota Surakarta 47,8%. Rerata skor VAS 4,1Â±2,2, dan rerata skor TMAS 22,6Â±5,7. Pada uji chi square, tidak didapatkan hubungan antara skor kecemasan yang tinggi dengan skor dismenore (RP 1,1 (IK 95% 0,4-2,8, Pearson chi square= 0,05, p=0,82). Hasil uji korelasi Spearman antara skor VAS dan skor TMAS diperoleh nilai 0,04, p=0,74. Berat ringannya dismenore tidak mempengaruhi jumlah subyek yang mencari pertolongan kesehatan (RP 4,1 (IK 95% 0,5-34), p=0,28).Kesimpulan. Prevalensi dismenore pada remaja di kota Surakarta cukup tinggi, namun berat ringannya dismenore tidak mempengaruhi subyek untuk mencari pertolongan kesehatan. Faktor informasi menstruasi, persepsi dismenore, dan karakteristik kepribadian diduga terkait dengan perilaku pencarian pertolongan kesehatan terkait dismenore remaja.

Faktor Risiko Hiperbilirubinemia pada Bayi Lahir dari Ibu Diabetes Melitus Dio Biade; Tunjung Wibowo; Setya Wandita; Ekawaty L. Haksari; Madarina Julia
Sari Pediatri Vol 18, No 1 (2016)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Latar belakang. Bayi yang lahir dari ibu diabetes melitus (IDM) memiliki risiko lebih tinggi mengalami berbagai morbiditas padaÂ masa neonatus. Metabolisme bilirubin merupakan salah satu sistem yang mungkin terganggu.Tujuan. Mengetahui faktor risiko hiperbilirubinemia pada bayi IDM dan hubungannya dengan faktor risiko hiperbilirubinemiaÂ yang lain.Metode. Studi kohort retrospektif pada 71 IDM dan 71 bayi ibu tidak diabetes melitus (ITDM) yang lahir di RSUP Dr.SardjitoÂ antara Januari 2007 - Desember 2014. Data diperoleh dari register neonatal-perinatal WHO-SEARO.Hasil. Risiko hiperbilirubinemia lebih tinggi pada bayi IDM dibandingkan ITDM (42% vs 17%) (RR 2,5 IK95%: 1,4-4,5). Analisis stratifikasi menunjukkan bahwa risiko dipengaruhi oleh usia kehamilan, berat lahir, polisitemia, dan inisiasi menyusu dini. SepsisÂ meningkatkan risiko pada IDM (RR 11,5 IK95%: 3,7-36,0), sedangkan inisiasi menyusu dini merupakan faktor pencegah (RR 0,6, IK95%: 0,3-0,9).Kesimpulan. Ibu diabetes melitus meningkatkan risiko hiperbilirubinemia pada masa neonatus. Risiko ini dipengaruhi oleh beratÂ lahir, usia kehamilan, kondisi sepsis, dan inisiasi menyusu dini.

Corticosteroids and obesity in steroid-sensitive and steroid-resistant nephrotic syndrome Nina Lestari; Neti Nurani; Madarina Julia
Paediatrica Indonesiana Vol 55 No 4 (2015): July 2015
Publisher : Indonesian Pediatric Society

Background Children with nephrotic syndrome need high-dose corticosteroids to achieve remission. Studies have estimated a 35-43% risk of obesity in these patients after corticosteroid treatment.Objective To determine the prevalence of obesity in children who received corticosteroids for nephrotic syndrome, and to compare the risk of obesity in children with steroid-sensitive nephrotic syndrome (SSNS) and steroid-resistant nephrotic syndrome (SRNS).Methods We performed a retrospective cohort study in 50 children with SSNS or SRNS who received corticosteroid treatment. Obesity was defined to be a BMI-for-age Z-score above +2.0 SD, according to the WHO Growth Reference 2007. Central obesity was defined to be a waist-to-height ratio > 0.50.Results The overall prevalence of obesity was 22%, with 29% and 14% in the SSNS and SRNS groups, respectively. The overall prevalence of central obesity was 50%, with 54% and 46% in the SSNS and SRNS groups, respectively. The cumulative steroid doses in this study were not significantly different between the SSNS and SRNS groups. There were also no significant differences between groups for risk of obesity (RR 2.53; 95%CI 0.58 to 10.99) or central obesity (RR 1.39; 95%CI 0.45 to 4.25).Conclusion In children with nephrotic syndrome who received corticosteroids, the prevalence of obesity is 22% and of central obesity is 50%. In a comparison of SSNS and SRNS groups, cumulative steroid dose as well as risks of obesity and central obesity do not significantly differ between groups.

The influence of socioeconomic status and birth weight on blood pressure of Indonesian pre-pubertal children Madarina Julia; M M van Weissenburch; HA Delemarrevan de Waal; Achmad Surjono
Paediatrica Indonesiana Vol 47 No 6 (2007): November 2007
Publisher : Indonesian Pediatric Society

Background It has been shown that elevated blood pressure (BP)in childhood contributes to the development of coronary arterydisease, cerebrovascular accidents, heart failure, and renal failurein adults. There is also evidence of some correlations betweenchildhood BP and BP in adulthood. Obesity as well as low birthweight are a risk factors for elevated BP, both in children and inadults. Most epidemiological studies have also shown arelationship between high BP and socioeconomic status (SES).Objective To assess the influence of socioeconomic status andbirth weight on blood pressure of school-aged prepubertal childrenliving in Indonesia.Methods A cross-sectional survey on 2922 school-agedprepubertal children from the rural, poorurban and nonpoor urbancommunities was performed. Data on age, sex, stature, BMI, birthweight, systolic and diastolic BP were collected from all children.Results Overall and within every socioeconomic status group,blood pressures were positively associated with stature and bodymass index (BMI). Children from poor-socioeconomic families,i.e. rural and poor urban, had significantly lower height and BMI,and hence, in the unadjusted analyses, poor socioeconomic statuswas associated with lower systolic and diastolic BP. However, afteradjustment for age, sex, stature and BMI, rural children were foundto have significantly higher systolic BP compared to nonpoor urbanchildren, with regression coefficient (95% CI) of 1.19(0.42 to1.96). Birth weight was not associated with blood pressure inchildhood.Conclusion This study indicated that for a given stature and BMI,poor children had a higher systolic BP

Co-Authors A.A. Ketut Agung Cahyawan W Achmad Surjono Adhila Fayasari Agustini Utari Ahmad Husain Asdie Ahmad Husain Asdie Ahmad Husain Asdie Ahmad Husain Asdie Almira Sitasari Aman B Pulungan Andi Imam Arundhana Ari Tri Astuti, Ari Tri Arief Priambodo Astuti, Lucia Mawarti Dwi Attika A. Andarie Basuki, Siswanto Betaditya, Dika Burhan, Fatimah Zahra Cerdasari, Carissa Dewi Astiti Diadra Annisa Dio Biade Djaswadi Dasuki Djauhar Ismail Ekawaty L. Haksari Emy Huriyati Endang Baliarti Endy P. Prawirohartono Endy Paryanto Prawirohartono, Endy Paryanto Eni Harmayani Esti Nurwanti Farida Wahyu Ningtyas Farida Wahyu Ningtyas Farida Wahyu Ningtyias, Farida Wahyu Fitri Haryanti Frida Soesanti Gunawan, I Made Alit H. A. Delemarre-van de Waal HA Delemarrevan de Waal Hamam Hadi Hamam Hadi Handayani Handayani Harry Freitag Luglio Muhammad Helmyati, Siti Hendratini, Julita Hizni, Alina I Made Alit Gunawan I Wayan Bikin ika agustina Indria Laksmi Gamayanti Indria Laksmi Gamayanti Irma Yunawati Joko Susilo Jufrrie, Muhammad Junaidi Junaidi Jurianto Gambir Kandarina, Bernadette Josephine Istiti Khaerul Anwar Kunayarti, Wahyuni Kurnia Febriana Laksono Trisnantoro Lamana, Aspia Legawati Legawati, Legawati Lely Lusmilasari, Lely Lisma Evareny, Mohammad Hakimi, Retna Siwi Padmawati M M van Weissenburch M. M. van Weissenbruch Mohammad Hakimi Muchtar, Mohammad Mursyid, Abidillah Neti Nurani Niken Pritayati Nina Lestari Nisa, Fatma Zuhrotun Noormanto Noormanto, Noormanto Nugroho, Akmad Kharis Nur Afia Amin Nurliyani Nurul Hadi, Nurul Nuryanti Nuryanti Pangesti, Neni Paulinus Deny Krisnanto Purnama, Ni Luh Agustini Putra, Irwansyah R. Dwi Budiningsari Rahayu, Endah Sri Rahmawati, Rahmawati Ramadhaniah, Ramadhaniah Ramli, Nurlaili Retno Sutomo Rianti Puji Lestari Rina Susilowati Riris Andono Ahmad Roni Naning Ronny Martien Ruqoyatul Himah S. Yudha Patria Santi Gunarwati Setya Wandita Shelly Puspa Anggraini Shinta Prawitasari Shoim, Mohammad Siti Nurfadilah H Slamet Rohaedi, Slamet Soeroyo Machfudz, Soeroyo Soi, Beatrix Solly Aryza Sri Mulyati Sri Sugiharti Sri Wahyuni Subardjo, Yovita Puri Sulistyaningrum, Elisa Sunartini Sunartini, Sunartini Susetyowati Tarigan, Noviani Titih Huriah Titih Huriah Toto Sudargo Tunjung Wibowo Tuti Nuraini Tuti Nuraini Winda Irwanti, Winda Winda Nurmayani M Yayah Lakoro Yayi Suryo Prabandari Zulfayeni, Zulfayeni

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