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All Journal Majalah Ilmiah Sultan Agung SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Majalah Kedokteran Bandung Indonesian Journal of Cancer Chemoprevention Jurnal Kesehatan Andalas Mutiara Medika: Jurnal Kedokteran dan Kesehatan Universa Medicina Indonesian Journal of Community Services INTERACTION: Jurnal Pendidikan Bahasa Jurnal Informatika dan Rekayasa Elektronik Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Infotek : Jurnal Informatika dan Teknologi Akrab Juara : Jurnal Ilmu-ilmu Sosial Jurnal Kesehatan Tambusai Jurnal Litbang Edusaintech Jurnal Pengabdian Masyarakat Kedokteran International Journal of Cell and Biomedical Science INTERACTION: Jurnal Pendidikan Bahasa Journal of Nutrition and Public Health
Chodidjah Chodidjah
Bagian Anatomi Fakultas Kedokteran Universitas Islam Sultan Agung Semarang
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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The Role of Hypoxic Mesenchymal Stem Cells Conditioned Medium in Increasing Vascular Endothelial Growth Factors (VEGF) Levels and Collagen Synthesis to Accelerate Wound Healing Sunarto, Hadi; Trisnadi, Setyo; Putra, Agung; Sa'dyah, Nur Anna Chalimah; Tjipta, Arya; Chodidjah, Chodidjah
Indonesian Journal of Cancer Chemoprevention Vol 11, No 3 (2020)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev11iss3pp134-143

Abstract

Full-thickness wound are areas damage of skin associated with loss of epidermis and dermis. The wound healing mechanism consists proliferation, migration and remodeling. Hypoxic conditional medium of mesenchymal stem cells (HMSCs-CM) contains lots of soluble molecules, such as protein growth factor and cytokine anti-inflammation. The soluble molecule of HMSCs-CM plays a critical role in wound healing by upregulation of VEGF and collagen synthesis. The objective of this study was to evaluate the effect of HMSCs-CM on VEGF and collagen concentrations in rats with incised wounds. The methods of this study were an experimental animal study with post-test only control group design was performed involving 24 Wistar rats. The rats were randomized into four groups consisting of sham, control and two treatment groups (gel of HMSCs-CM at doses of 200 μL and 400 μL). The VEGF levels and collagen density were analyses using ELISA assay and Masson-trichome specific staining, respectively. One-way ANOVA and Post Hoc LSD were used to analyses the data. The results of this study showed that a VEGF levels was significant increased on day 6 with doses-dependent manner. Interestingly, the VEGF levels gradual decrease on day 9. In addition, the decreased of VEGF levels on day 9 in this study in line with our findings in which we found there was a trend in the decreased of collagen density, it indicated the completion of remodeling phase and there has been an acceleration in wound healing. This study demonstrated that HMSCs-CM were able to regulate VEGF levels and collagen synthesis in accelerate wound healing. The role of HMSCs-CM stimulate cutaneous wound healing should be clarified further.Keywords: hypoxic conditional medium of mesenchymal stem cells (HMSCs-CM), vascular endothelial growth factor, collagen synthesis, paracrine factors
Penyuluhan bagi Kader PKK Desa Banjardowo tentang Potensi Tanaman Kemangi (Ocinum Sanctum Linn) terhadap Kesehatan Sumarawati, Titiek; Chodidjah, Chodidjah; Widayati, Eni; Soetoko, Anita Soraya
Jurnal Pengabdian Masyarakat Kedokteran Vol 3, No 1 (2024): Januari
Publisher : Fakultas Kedokteran, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/abdimasku.3.1.33-38

Abstract

Tanaman Daun Kemangi (Ociumum sanctum Linn) mengandung banyak senyawa aktif seperti golongan alkaloid, terpenoid, fenolik, saponoid, tannin dan flavonoid yang terbukti mempunyai aktivitas sitotoksik, serta memiliki kadar nilai IC50 pada sel MCF-7 sebesar 6,95 µg/ml. Selain itu juga terbukti bahwa ekstrak etanol kemangi mempunyai aktivitas antioksidan yang sangat kuat. Tujuan pengabdian masyarakat ini adalah untuk mensosialisasikan terkait dengan hasil penelitian mengenai kandungan zat aktif dalam tanaman kemangi yang mempunyai potensi terhadap Kesehatan. Kelurahan banjardowo merupakan desa binaan Fakultas kedokteran universitas islam sultan Agung sehingga lokasi ini dipilih untuk mensosialisasikan hasil penelitian tentang tanaman kemangi mengingat banyaknya manfaat bagi Kesehatan dan meningkatkan pengetahuan ibu ibu. Metode penyuluhan yang digunakan adalah Metode ceramah dan diskusi kelompok, para ibu ibu kader PKK kelurahan BanjarDowo yang mengikuti penyuluhan sebanyak 23 orang, usia 41- 60 tahun sebanyak 16 orang dan usia 25 – 40 tahun sebanyak 7 orang. Hasil analisis nilai pretest dan postest peserta menunjukan terdapat kenaikan nilai rerata peserta pada postest, yaitu 6,70±1,8, dimana sebelum kegiatan penyuluhan dimulai nilai rerata peserta hanya mencapai angka 4,78±1,9. Dari analisis statistik menunjukan adanya perbedaan yang bermakna antara nilai pretest dan postest peserta dengan nilai p=0,000. Dengan pemberian penyuluhan pada kader PKK di kelurahan Banjardowo tentang potensi tanaman kemangi terhadap Kesehatan menunjukkan hasil adanya nilai peningkatan pengetahuan peserta sebelum diberi penyuluhan dan sesudah penyuluhan.The basil leaf plant (Ociumum sanctum Linn) contains many active compounds such as alkaloids, terpenoids, phenolics, saponoids, tannins and flavonoids which have been proven to have cytotoxic activity, and have an IC50 value in MCF-7 cells of 6.95 µg/ml. Apart from that, it has also been proven that basil ethanol extract has very strong antioxidant activity. The aim of this community service is to disseminate research results regarding the content of active substances in basil plants which have potential for health. Banjardowo sub-district is a village supported by the Faculty of Medicine, Sultan Agung Islamic University, so this location was chosen to disseminate the results of research on basil plants considering the many benefits for health and increasing mothers' knowledge. The counseling method used was the lecture and group discussion method, 23 people from PKK cadres from BanjarDowo sub-district took part in the counseling, 16 people aged 41-60 years and 7 people aged 25-40 years. The results of the analysis of participants' pretest and posttest scores showed that there was an increase in the participants' average score on the posttest, namely 6.70 ± 1.8, where before the counseling activities began, the participants' average score only reached 4.78 ± 1.9. Statistical analysis shows that there is a significant difference between the participants' pretest and posttest scores with a p value = 0.000. By providing counseling to PKK cadres in the Banjardowo sub-district about the potential of basil plants for health, the results showed that there was a value in increasing participants' knowledge before being given the counseling and after the counseling.
Tingkat Pengetahuan Penyakit Diabetes Mellitus pada Lansia Peserta BPJS di Klinik Mugi Sehat Jatingaleh Semarang Chodidjah, Chodidjah; Sumarawati, Titiek; Soetoko, Anita Soraya
Jurnal Pengabdian Masyarakat Kedokteran Vol 3, No 1 (2024): Januari
Publisher : Fakultas Kedokteran, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/abdimasku.3.1.1-5

Abstract

Diabetes mellitus (DM) merupakan penyakit degeneratif atau gangguan metabolisme kronis dengan multi etiologi yang ditandai dengan tingginya kadar gula darah disertai dengan gangguan metabolisme karbohidrat, lipid dan protein sebagai akibat insufisiensi insulin. Klinik Mugi Sehat Jatingaleh merupakan klinik yang melayani peserta BPJS dan tiap bulan dilakukan kegiatan penyuluhan kesehatan bagi lansia penderita Diabetes Mellitus, maka masyarakat lansia peserta BPJS di klinik Mugi Sehat Jatingaleh perlu diberi penyuluhan tentang. Mengenal penyakit Diabetes Mellitus. Metode Penelitian 26 peserta BPJS di Klinik Mugi Sehat Jl. Jatingaleh Semarang sebagai responden dilakukan pretest sebelum diberi penyuluhan post tes setelah penyuluhan, untuk mengetahui tingkat pengetahuan tentang pentingnya pengetahuan penyakit Diabetes Mellitus bagi lansia peserta BPJS di Klinik mugi Sehat Jatingaleh Semarang serta di bagi leaflet untuk belajar menghitung kebutuhan kalori. Hasil pemahaman peserta meningkat setelah di berikan penyuluhan. Kesimpulan Peserta BPJS Lansia yang menderita Diabetes Mellitus memahami dan dapat menghitung kebutuhan kalori untuk mengontrol kadar gula darah.Diabetes mellitus (DM) is a degenerative disease or chronic metabolic disorder with multiple etiologies characterized by blood sugar levels accompanied by metabolic, lipid and protein disorders as a result of insulin insufficiency. Mugi Sehat Jatingaleh Clinic is a clinic that serves BPJS participants and every month health counseling activities are carried out for the elderly with Diabetes Mellitus, so the elderly people who are BPJS participants at the Mugi Sehat Jatingaleh clinic need to be given counseling about. Knowing Diabetes Mellitus. Research Methods 26 BPJS participants at the Mugi Sehat Clinic Jl. Jatingaleh Semarang as a respondent did a pretest before being given counseling after counseling, to determine the level of knowledge about the importance of knowledge about Diabetes Mellitus for the elderly BPJS participants at the Mugi Sehat Clinic Jatingaleh Semarang and distributed leaflets to learn to calculate calorie needs. The results of participants' understanding increased after being given counseling. Conclusion BPJS Elderly participants who suffer from Diabetes Mellitus understand and can calculate calorie needs to control blood sugar levels.
INTRODUCTION TO NUTRITION AND EXCERSICE ON PKK CADRES DURING THE COVID-19 PANDEMIC TIME IN GAJI VILLAGE, DEMAK Sumarawati, Titiek; Chodidjah, Chodidjah; Widayanti, Eni; Fatmawati, Dina
Abdi Dosen : Jurnal Pengabdian Pada Masyarakat Vol. 6 No. 3 (2022): SEPTEMBER
Publisher : LPPM Univ. Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (308.962 KB) | DOI: 10.32832/abdidos.v6i3.1262

Abstract

Corona Virus Disease 2019 or commonly abbreviated as COVID-19 is an infectious disease caused by SARS-CoV-2. People with COVID-19 may experience fever, dry cough, and difficulty breathing. With the outbreak, the government gives appealed to the community to leave the house as necessary, work from home and maintain health. Salary village is a village located in Demak Regency, Central Java. Public knowledge about the COVID 19 pandemic is still limited, most people do not know that nutrition and physical exercise can improve the body's immune system and prevent COVID 19 disease. Community service is carried out in Gaji Village due to low public knowledge about nutrition and physical exercise (exercise) during the Covid 19 pandemic. Activities were carried out by providing pre and post-tests, counseling to increase public knowledge, and measuring Body Mass Index with 23 participants. Knowledge about Covid 19 increased but not very significantly while increasing knowledge about nutrition and physical exercise experienced a significant increase among the pre and post-test participants. The results of the BMI measurement of 23 respondents had an ideal body weight of 9 people (39.13 %), overweight 12 people (52.17%), and 2 people obese (8.70%). BMI ideal body weight 39.13%; overweight 52.17% and 8.70% fat.
PREDIKSI STATUS AKADEMIK MAHASISWA BERDASARKAN DATA PEMBAYARAN DENGAN NAIVE BAYES DAN PARTICLE SWARM OPTIMIZATION Rukiastiandari, Sinta; Rohimah, Luthfia; Mutia, Fara; Aprillia; Chodidjah, Chodidjah
Jurnal Informatika dan Rekayasa Elektronik Vol. 8 No. 2 (2025): JIRE November 2025
Publisher : LPPM STMIK Lombok

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36595/jire.v8i2.1756

Abstract

Pendidikan tinggi di Indonesia menghadapi tantangan dalam pengelolaan pembayaran mahasiswa, di mana keterlambatan dapat berdampak pada status akademik, termasuk risiko cuti atau pengunduran diri. Penelitian ini bertujuan mengembangkan model prediksi status akademik berbasis data pembayaran kuliah dengan metode Naive Bayes (NB) yang dioptimasi menggunakan Particle Swarm Optimization (PSO). Dataset berjumlah 15.697 record mahasiswa yang telah melalui pra-pemrosesan, termasuk penanganan nilai hilang dan pengkodean atribut kategorikal. Hasil menunjukkan bahwa model NB menghasilkan akurasi 98,83%, precision 98,21%, recall 65,09%, dan AUC 0,905. Optimasi dengan PSO meningkatkan recall menjadi 65,13% dan AUC menjadi 0,907, sementara akurasi dan precision tetap stabil. Analisis fitur mengindikasikan bahwa Jenis Kelamin, Jurusan SLTA, dan Kuliah Sambil Bekerja merupakan atribut paling berpengaruh, sedangkan Pekerjaan Ayah relatif kurang signifikan. Temuan ini menegaskan potensi NB-PSO sebagai pendekatan prediktif untuk mendukung pengelolaan administrasi akademik yang lebih efektif.
Differences in CEA Levels and Nutritional Status in Stage III Rectal Cancer Patients Undergoing Different Types of Therapy Abdullah Rizky; Vito Mahendra; Chodidjah Chodidjah
Journal of Nutrition and Public Health Vol. 1 No. 2 (2025): Journal of Nutrition and Public Health
Publisher : CV. Dyoqu Publishing Management

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64780/jnph.v1i2.78

Abstract

Background: Rectal cancer is a type of malignancy with a higher rate of local recurrence compared to colon cancer. Various therapies such as surgery, chemotherapy, and radiotherapy are commonly used for treatment. Monitoring the effectiveness of these therapies can be supported by clinical parameters such as Carcinoembryonic Antigen (CEA) levels and nutritional status measured by Body Mass Index (BMI). Aims: This study aimed to examine the differences in CEA levels and nutritional status among rectal cancer patients receiving different types of therapies. Methods: This was an observational analytic study with a cross-sectional design. The sample consisted of 56 patients with stage III rectal cancer at Sultan Agung Islamic Hospital Semarang during the period of 2018-2024. Data were collected from medical records and included patients who received either surgery + chemotherapy (n = 33) or surgery + chemotherapy + radiotherapy (n = 23). CEA levels were analyzed using the Mann-Whitney U test, and nutritional status was analyzed using the Independent Sample T-Test. Result: The results showed no statistically significant difference in CEA levels between the two therapy groups (p = 0.405). However, a significant difference was found in nutritional status, with patients undergoing radiotherapy showing lower BMI values compared to those without radiotherapy (p = 0.000). Conclusion: CEA levels did not significantly differ between types of therapy in stage III rectal cancer patients. However, radiotherapy was associated with a significant decline in nutritional status. These findings highlight the importance of integrating nutritional monitoring in the management of rectal cancer patients receiving combined therapy
Co-Authors Abdullah Rizky Ady Try Himawan Zen, Ady Try Himawan Agung Putra Agung Tri Cahyono Agung Tri Cahyono Agus Suprijono Agus Suprijono Alamsyah Alamsyah Amalina, Nur Dina Anita Soraya Soetoko Annisa Nurul Hikmah Apriliyani , Apriliyani Aprillia Aprillia, Aprillia Atina Hussaana Auliya, Qurrotu A'yuni Bagas Widiyanto, Bagas Danis Pertiwi Dina Fatmawati Dinanti, Fathia Kesuma Djoko Tri Hadi, Djoko Tri Edi Dharmana Edijanti Goenarwo Elvira, Lela Endang Sri Andayani Eni Widayati Firdaus, Chalid Hadi Sarosa Hamzah Hamzah Heny Pramita Heri Susanto Ibrahim, Sugeng Iwan Asmadi Joko Wahyu Widodo Joko Wahyu Widodo Kuntardjo, Novalia Maryam Mulyaningsih, Ruri Eka Masfiyah Masfiyah, Masfiyah Merin Awu Sari, Merin Awu Minidian Fasitasari Moch Agus Suprijono Mutia, Fara Nenik Faozah Nur Anna Chalimah Sadyah Purwaningsih, Hesti Rohimah, Luthfia Saugi Abduh Saugi Abduh, Saugi Abduh Setyo Trisnadi Shaher Banun Shofa Chaasani Sinta Rukiastiandari Soraya, Anita Sri Mastuti Sri Priyantini Sri Priyantini Mulyani Sulistyo, Sona Sunarto, Hadi tadihoedojo, ersje retnowati Taufiq R Nasihun, Taufiq R Taufiqurrachman Nasihu Taufiqurrachman Nasihun Taufiqurrachman Nasihun Thomas Erwin Christian Junus Huwae Titiek Sumarawati Tjipta, Arya Trisnadi, Reza Adityas Tyagita, Nurina Ulayatilmiladiyyah, Nur Ulfah Dian Indrayani Vito Mahendra Widayanti, Eni Zahra Zahra