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Molecular docking of alkaloid compounds from the pule pandak plant (Rauvolfia serpentina L.) as inhibitors of angiotensin-converting enzyme Rahma, Annisa Nur; Aghalfi, Revin Rindra Aghalfi; Panggabean, Diva Selviana; Muflihah, Hanny; Gusman, Adisti Faradilla; Aulia, Yasinta Sahma; Regita, Putu Ayu; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 2 No. 3 (2022): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.69

Abstract

Hypertension is a major global health issue requiring effective treatments with minimal side effects. The angiotensin-converting enzyme (ACE) is a key target in hypertension therapy, and plant-derived compounds are being explored as potential ACE inhibitors. The pule pandak plant (Rauvolfia serpentina L.) contains alkaloid compounds that may have antihypertensive properties. This study aimed to evaluate the potential of alkaloid compounds (ajmaline, rescinnamine, reserpine, and serpentine) from the pule pandak plant as antihypertensive agents using an in silico molecular docking approach. Molecular docking was conducted to analyze the binding affinity of the alkaloid compounds to the ACE protein (PDB ID: 1UZF). Binding free energy values were calculated using AutoDockTools software. The ajmaline-1UZF complex exhibited the lowest binding free energy (-5.89 kcal/mol), indicating the strongest binding affinity among the tested compounds. This suggests that ajmaline has the highest inhibitory potential for ACE.
Molecular docking analysis of acetogenin and procyanidin, components of soursop (Annona muricata Linn.) seed, as potential anti-cervical cancer agents Pravita, Nabila Cahya; Fazilla, Rizki Fakhri; Febrian, Tobi; Mellina, Echa Dian; Kumara, Gusti Made Bagus; Nugraha, Muhammad Aditya; Vernanda, Pramyudha; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 3 No. 2 (2023): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.71

Abstract

Cervical cancer is one of the most prevalent cancers among women. This study aimed to investigate the molecular interactions of acetogenin and procyanidin, compounds found in soursop (Annona muricata Linn.) seed extract, as potential anti-cervical cancer agents using a molecular docking approach. The software tools used included Biovia Discovery Studio® 2024, Autodock Tools 1.5.6, Avogadro, pkCSM, PubChem, Notepad++, and Molview. Molecular docking analysis focused on the interaction of these compounds with the human vaccinia-related kinase 2 (VRK-2) protein (PDB ID: 5UU1). The native ligand-5UU1 protein complex exhibited two hydrogen bonds, a binding free energy of -8.84 kcal/mol, and an inhibition constant of 331.88 nM. In comparison, acetogenin formed three hydrogen bonds with 5UU1, achieving a binding free energy of -7.33 kcal/mol and an inhibition constant of 4.21 nM. Similarly, procyanidin also formed three hydrogen bonds, with a binding free energy of -2.99 kcal/mol and an inhibition constant of 6.38 nM. The results indicate that both acetogenin and procyanidin have potential as anti-cervical cancer agents, with acetogenin demonstrating stronger binding affinity and inhibition potential compared to procyanidin.
Exploring the anti-diabetic potential of stevia-derived compounds through PPAR-γ targeted molecular docking Putri, Amalia Sonita; Prawicha, Ertika Agtha; Putri, Esterike Alfatien; Wulandari, Indah; Saputri, Mutiara Anggun; Syakilla, Nadia Nur; Hidayati, Putri Aulia Nurul; Auli, Winni Nur; Saputro, Anjar Hermadi
Pharmacy Reports Vol. 3 No. 2 (2023): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.78

Abstract

This study explores the potential of Stevia rebaudiana Bertoni-derived compounds as anti-diabetic agents by targeting the peroxisome proliferator-activated receptor gamma (PPAR-γ), a key regulator of glucose metabolism. Utilizing in silico molecular docking, we evaluated the binding affinities of four stevia-derived compounds (dulcoside A, steviol, isosteviol, steviolmonoside) and compared them to the native ligand (J35) and the well-known PPAR-γ agonist, rosiglitazone. Isosteviol exhibited the strongest binding affinity to PPAR-γ, with a binding energy of -8.89 kcal/mol, surpassing that of rosiglitazone (-8.26 kcal/mol) and closely following the native ligand (-9.01 kcal/mol). The interactions between isosteviol and PPAR-γ included multiple hydrogen bonds and hydrophobic interactions. These findings indicate that isosteviol, along with other stevia-derived compounds, has a potential as a natural anti-diabetic agent.
In silico analysis of quercetin and its derivatives as potential TRPC6-targeted treatments for diabetic neuropathy Pangestu, Maryo Adjie; Auli, Winni Nur; Saputro, Anjar Hermadi; Pasaribu, Romualdo; Maharani, Gita Putri; Yunita, Nadia Rahma; Choiriah, Ika Putri; Ainun, Hadhistia Nur; Erniningsih, Ni Ketut; Andini, Citra
Acta Pharmaciae Indonesia Vol 12 No 1 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.1.12119

Abstract

Background: Diabetic neuropathy is a condition that arises as a complication of diabetes mellitus and often causes pain in patient. Quercetin and its derivatives have antinociceptive activity, making them potential agents for relieving the pain associated with diabetic neuropathy. Objective: This study aims to analyze the interactions between quercetin and its eight derivatives with canonical transient receptor potential channels 6 (TRPC6) as protein target. Method: The TRPC6 structure (PDB ID: 6UZ8) was prepared and validated with redocked to native ligand R0D using Autodock 4.2.6, with the established grid box and grid center settings. The test compounds were then optimized and docked using the same grid box and grid center settings as in the validation process, followed by visualization and analysis of the docking results. Results: The compound with the best affinity for TRPC6 was tamarixetin, with a binding energy value of -3.27 kcal/mol, close to the binding energy value of the native ligand, which was -4.22 kcal/mol. The amino acid residues interacting with tamarixetin at the active site were 702-Asn, 705-Tyr, 706-Val, and 709-Gly. This indicates that tamarixetin and the native ligand bind to the same active site amino acids, resulting in a similar affinity to the native ligand in inhibiting TRPC6. Conclusion: A total of eight quercetin derivatives were predicted to have TRPC6 antagonistic activity against diabetic neuropathy, with tamarixetin exhibiting the highest affinity compared to the other quercetin derivatives.
PENAMBATAN MOLEKUL SENYAWA AKTIF CURCUMA XANTHORRHIZA ROXB KANDIDAT ANTI KANKER KOLOREKTAL TERHADAP RESEPTOR LYMPHOCYTE-SPECIFIC PROTEIN TYROSINE KINASE Sativa, Nasywa Oryza; Putri, Adelia Ofira; Natasya, Zaskiya; Rislia, Rana Atikah; Ulfa, Lutfiyana; Karima, Miska Aulia; Balqis, Selvi; Saputro, Anjar Hermadi; Auli, Winni Nur
Kartika : Jurnal Ilmiah Farmasi Vol 9 No 2 (2024)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v9i2.702

Abstract

Background: Temulawak (Curcuma xanthorrhiza Roxb) contains essential oils and curcuminoid compounds which have anti-cancer activity. Temulawak (Curcuma xanthorrhiza Roxb) can increase colorectal cancer chemotherapy agents against Lck receptors on colon epithelial cells. Purpose(s): The aim of this research is to identify active compounds that have the potential to act as colorectal anticancer contained in Temulawak (Curcuma xanthorrhiza Roxb) against Lck receptors through in silico studies using molecular docking methods. Methods: This study was carried out of molecular docking using software AutoDock Tools-1.5.6., Lipinski predictions with LigandScout, and visualitation using Biovia Discovery Studio 2021 Client. Results: Xanthorrizol has hydrogen bonds with the same amino acid residues as native ligand and reference compound, namely GLU317 and MET319. The results of the molecular binding energy of the native ligand are -10.12 kcal/mol. Conclusion: Based on research results, the xanthorrizol compound has the best potential to be a colorectal anticancer candidate and qualified of Lipinski's rules so it is safe to be administered orally.
PEMBERDAYAAN USAHA EKONOMI KREATIF MELALUI PENDEKATAN PELATIHAN DAN PENDAMPINGAN USAHA PEMBUATAN PRODUK JAMU KEKINIAN SEBAGAI UPAYA PENCAPAIAN SDGS DI KELURAHAN YOSOREJO, KOTA METRO Yulianti Suprahman, Nisa; Hidayaturahmah, Rizky; Hermadi Saputro, Anjar; Irna Windari, Nurul; Sarmoko, Sarmoko
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 7, No 11 (2024): MARTABE : JURNAL PENGABDIAN MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v7i11.4924-4929

Abstract

Sebagian besar masyarakat di Kelurahan Yosorejo, Kecamatan Metro Timur memiliki pekarangan rumah atau kebun yang sebagian ditanami tanaman obat keluarga (TOGA) seperti kunyit, temulawak, temugiring, jahe kencur, sirih, kecombrang, sambiloto, binahong dan lain-lain. Kendala utama yang dihadapi adalah belum optimalnya pemanfaatan tanaman obat keluarga (TOGA), rendahnya pengetahuan dan teknologi untuk membuat jamu kekinian yang berkualitas, jumlah diproduksi masih terbatas, jenis dan variasi produk juga masih sedikit dan market share masih rendah. Selain produk jamu, tanaman TOGA belum dilakukan pengembangan teknologi menjadi produk herbal yang bernilai ekonomi tinggi seperti sabun.  Faktor tersebut yang membuat industri jamu tradisional tidak bisa berkembang. Maksud Pengabdian Kepada Masyarakat (PKM) adalah mengembangkan usaha jamu kekinian pada Ibu-ibu PKK kelurahan Yosorejo agar dapat membantu meningkatkan pendapatan masyarakat. Tujuannya Mengembangkan dan memperbaiki usaha jamu tradisional menjadi jamu kekinian yang modern yang bisa mengangkat salah satu produk warisan leluhur turun temurun. Dengan cara memproses tahap-tahapan pembuatan produk secara benar, mengedukasi Ibu-Ibu PKK untuk giat mengembangkan usaha yang menguntungkan dan memiliki peluang yang sangat terbuka. Kegiatan dilakukan dengan metode pelatihan secara langsung serta pembagian produk jamu kekinian dan sabun organik ke masyarakat. Hasil dari kegiatan ini adalah masyarakat dapat memahami dan mampu membuat jamu dan sabun organik berbahan dasar tanaman TOGA.
STUDI KOMPARATIF PREDIKSI PROFIL ADMET OBAT SINTETIS DENGAN SENYAWA AKTIF TANAMAN HERBAL ANTIMALARIA MELALUI PENDEKATAN IN SILICO Rima Rasida; Pinanga, Yangie Dwi Marga; Anjar Hermadi Saputro; Damayanti, Sophi
Acta Pharmaceutica Indonesia Vol. 49 No. 2 (2024)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Resistance to antimalarial drugs has become a global challenge in achieving the target of malaria eradication. To address this issue, effective and safe alternative treatments are urgently needed. This study compares the ADMET profiles (absorption, distribution, metabolism, excretion, and toxicity) of synthetic antimalarial drugs with active compounds derived from herbal sources using an in-silico approach. The analyzed herbal compounds, including piperine, kaempferol, berberine, quassin, and limonin, demonstrated high intestinal absorption (>30%), good water solubility, and sufficient skin permeability. In the distribution analysis, kaempferol exhibited high volume distribution due to its lipophilic interactions with body tissues, although most compounds were unable to penetrate the blood-brain barrier. The herbal compounds piperine and kaempferol inhibited metabolic enzymes CYP2C19 and CYP1A2, whereas synthetic drugs tended to act as substrates. Regarding excretion, piperine served as a renal OCT2 substrate, while pyrimethamine exhibited low clearance. Toxicity assessments revealed that herbal compounds generally exhibited better toxicity profiles compared to synthetic drugs, with limonin showing the lowest acute and chronic toxicity. These findings suggest that herbal active compounds hold significant potential for development as alternative antimalarial agents, particularly in addressing drug resistance. This study highlights the importance of further developing herbal-based drugs through in silico approaches to enhance the efficacy and safety of malaria therapy. Keyword : malaria drug resistance, active herbal compounds, ADMET, In silico
Molecular docking of ferulic acid, bakuchiol and niazirin on peroxisome proliferator-activated receptor gamma (PPAR-γ) as anti-diabetic agents Saputro, Anjar Hermadi; Fauziyya, Riri; Sarmoko; Saputra, Iwan Syahjoko
Acta Biochimica Indonesiana Vol. 7 No. 2 (2024): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.181

Abstract

Background: Diabetes mellitus remains one of the most dangerous illnesses worldwide. The PPAR-gamma protein plays a crucial role in lipid and carbohydrate metabolism, making it a key target for diabetes therapy. Research into plant-derived active compounds for diabetes treatment is increasingly important. Objective: This study aims to evaluate and analyze the interaction of ferulic acid, niazirin, and bakuchiol with the peroxisome proliferator-activated receptor gamma (PPAR-γ) protein using molecular docking. Methods: Molecular docking was employed to assess the interactions between ferulic acid, niazirin, bakuchiol, and the PPAR-γ protein (PDB ID: 2PRG). The analysis focused on binding free energy values, amino acid residue interactions, the number of hydrogen bonds, and bond distances, comparing these results to those of the native ligand and pioglitazone, a known anti-diabetic drug targeting PPAR-γ. Results: The binding free energies for the ferulic acid-PPAR-γ, bakuchiol-PPAR-γ, niazirin-PPAR-γ, native ligand-PPAR-γ, and pioglitazone-PPAR-γ complexes were -5.54 kcal/mol, -8.47 kcal/mol, -6.56 kcal/mol, -10.08 kcal/mol, and -9.94 kcal/mol, respectively. The amino acid residue similarity percentages with the native ligand were 18.18% for ferulic acid, 27.27% for bakuchiol, 18.18% for niazirin, and 81.82% for pioglitazone. The native ligand-2PRG and pioglitazone-2PRG complexes exhibited superior hydrogen bond numbers and shorter bond distances compared to the other compounds. Conclusion: Although bakuchiol showed the most promising interaction among the tested compounds, none surpassed the binding affinity and stability of the native ligand or pioglitazone. Further research is needed to optimize these compounds for potential anti-diabetic therapy.
Bioactive Compounds of Insulin Leaves (Smallanthus sonchifolius) as DPP4 Enzyme Inhibitors in Insulin Signaling Mechanism for the Treatment of Type 2 Diabetes Mellitus: In Silico Study Wardani, Intan Kusuma; Aulia, Winni Nur; Saputro, Anjar Hermadi; Ainiya, Aliva; Mariska, Soraya; Kamilaini, Diva Arisanti; Vega, Amelia; Maharani, Ayu Puspita; Fransisca, Ni Putu Vina
Chimica et Natura Acta Vol 13, No 1 (2025)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v13.n1.55137

Abstract

Type 2 Diabetes Mellitus (DM) is characterized by a relative insulin deficiency caused by pancreatic cell dysfunction and insulin resistance. Herbal-based traditional medicine can be an alternative, one of which is insulin leaf (Smallanthus sonchifolius), which has antidiabetic effects and can lower blood sugar levels by inhibiting glycogenolysis and gluconeogenesis. DPP4 inhibitors are a class of antidiabetic drugs used in the treatment of type 2 DM. This study aims to analyze and predict the binding patterns of flavonoid derivatives from insulin leaf (Smallanthus sonchifolius) compounds to the DPP4 enzyme inhibitor, to determine the binding affinity of these compounds to the target protein as an antidiabetic agent. The study was conducted using an in silico method, utilizing the Research Collaboratory for Structural Bioinformatics (RCSB), Avogadro Software, AutoDockTools (version 1.5.6), and Biovia Discovery Studio 2021 for molecular docking and prediction of binding patterns and affinity for the DPP4 N7F protein. The results of this study showed that the binding energy value obtained from the natural ligand N7F was -11.0 kcal/mol. The binding energy value for 1,19-dihydroxy-2,6,10,14-phytateraen-18-oic-acid with the N7F protein was -9.8 kcal/mol. Therefore, 1,19-dihydroxy-2,6,10,14-phytateraen-18-oic-acid has a more stable binding with the DPP4 enzyme N7F target protein. Based on the results obtained from molecular docking of the flavonoid derivative compounds from insulin leaf (S. sonchifolius), the compound 1,19-dihydroxy-2,6,10,14-phytateraen-18-oic-acid  showed the most potential as a DPP4 enzyme inhibitor among the other compounds.
STUDI IN SILICO METABOLIT AKTIF GOLONGAN ALKALOID DARI Ficus fitulosa TERHADAP RESEPTOR HIV-1 RT Auli, Winni Nur; Billa, Firly Shalsha; Zusela, Titah; Aulia, Nanda; Anjani, Arfina Puteri; Sarini, Sarini; Utami, Firanti Putri; Ummi, Ummi; Utami, Widia; Saputro, Anjar Hermadi
Jurnal Sains dan Teknologi Farmasi Indonesia Vol 13, No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58327/jstfi.v13i2.245

Abstract

Human Immunodeficiency Virus (HIV) atau Acquired Immune Defisiency Syndrome (AIDS) merupakan salah satu penyakit yang sulit ditangani. Hingga kini, belum ada pengobatan dalam menangani serta mencegahnya. Ficus fistulosa diketahui memiliki metabolit aktif berupa alkaloida yang memiliki aktivitas sebagai antiviral yaitu; thyloporine, phenanthroindolizidine, antofine, secoantofine, thylocrebrine, dan septicine. Penelitian ini bertujuan untuk mengetahui potensi F. fistulosa sebagai pengobatan terbaru pada terapi HIV secara in silico. Metode yang digunakan di dalam penelitian ini yaitu molekuler docking menggunakan software Autodock, Avogadro, serta BIOVIA Discovery Studio Visualizer 2021. Berdasarkan hasil penelitian, diketahui bahwa binding energy yang diperoleh pada senyawa dari golongan alkaloida pada F. fistulosa yaitu senyawa antofine memiliki nilai ikatan sebesar -9,21 kcal/mol dan nilai ikatan ligan alami sebesar -9,91.kcal/mol antofine memiliki potensi sebagai agen anti HIV. 
Co-Authors Adilla, Annisa Rahma Afada, M. Mufti Afrian, Mahisa Shzara Aghalfi, Revin Rindra Aghalfi Agustin, Desti Ahmad Bayu Satriawan Ahmad, Winda Tiara Ainiya, Aliva Ainun, Hadhistia Nur Al-Husni, Ihza Adzkiya Mubarak Alhestha, Salsabila Zahra Amalia, Miranti Andriani, Wellen Putri Anggini, Joya Talitha Anggraeni, Fibria Anggraeni, Inggrid Anjani, Arfina Puteri Annisa Nofriani Annisa Rahma Aryanti Arrafi, Muhammad Zhafran Aulia, Nanda Aulia, Yasinta Sahma Ayuwulanda, Aditya Azizah, Nadya Nur Azti, Zahara Azzahra, Zeta Agustri Azzahrah, Qurrota A’yun Balqis, Selvi Billa, Firly Shalsha Bokshow, Rency Violita Vanden Cahyani, Ayu Sukma Cahyani, Nabila Chandra, Nabella Oktaviana Choiriah, Ika Putri Chrisnanda, Anang Agung Christine Natalia Citra Andini Clarensia, Elisa Grace Cristiannanda, Daniel Dhiya, Syifa Nasywa Dwinna Rahmi Erniningsih, Ni Ketut Esa Amelia Ratri Yuniasri Fadillah, Muhammad Zakki Farah Zahira Shofa Fauziyya, Riri Fazilla, Rizki Fakhri Febrian, Tobi Febriyanti, Kharisma Fida, Marsa Jannatul Fransisca, Ni Putu Vina Geralda, Rifka Gusman, Adisti Faradilla Hafid, Gina Mutia Hasanah, Siti Fadhilatul Hati, Dinda Mutiara Herayati, Herayati Hidayati, Putri Aulia Nurul Hidayaturahmah, Rizky Hutabarat, Stefanny Herlin Natalya I Dewa Gde Mayun Permana Indah Puspita Sari Indah Puspita Sari, Indah Puspita Indah Wulandari intan kusuma wardani Irna Windari, Nurul Iwan Syahjoko Saputra Iwan Syahjoko Saputra Kamilaini, Diva Arisanti Karima, Miska Aulia Kumara, Gusti Made Bagus Kusumawati, Maiya Liswatini, Putri Made Helen Susanti Maharani, Ayu Puspita Maharani, Gita Putri Mariska, Putri Mariska, Soraya Melki, Yana Putri Amelia Mellina, Echa Dian Mentari, Corona Mubarika Sekarsari Yusuf Muflihah, Hanny Muhammad Aditya Nugraha Mumtaz, Fakhira Chairunnisa Mutiara Putri, Mutiara Nadapdap, Ezra Gabriella Oktaviany Napitu, Ade Shinta Maria Br Natalia, Dela Natasya, Zaskiya Naurah Rosyidah Hasna Nisa Yulianti Suprahman Nisa Yulianti Suprahman Nopiandi, Yogi Novelina, Laras Nur Adliani Nur Adliani Pangestu, Maryo Adjie Panggabean, Diva Selviana Pasaribu, Romualdo Pebriyanti, Ine Pinanga, Yangie Dwi Marga Pravita, Nabila Cahya Prawicha, Ertika Agtha Primasty, Ratna Dewi Putri, Adelia Ofira Putri, Amalia Sonita Putri, Esterike Alfatien Putri, Gladys Ellnora Raden Mohamad Herdian Bhakti Rahma, Annisa Nur Rahma, Sophia Rahmadini, Celina Fadila Rajwa, Raihan M Dhiya Regita, Putu Ayu Reny Haryani Riani, Nadia Nanda Rima Rasida Rislia, Rana Atikah Rosviena, Nyi Ayu Fayza Saabirah, Ghania Parsa Sabrina Rakhel Zahirah Saeli, Pinka Mustika Sakti, Nickyta Salsabila Ira Salsabila, Fathul Aini Saputri, Mutiara Anggun Sari, Desi Puspita Sari, Victoria Rekina Sarini, Sarini Sarmoko Sarmoko Sarmoko Sarmoko Sativa, Nasywa Oryza Setiawati, Luh Gede Elen Simorangkir, Nanda Lenny Yuniaty br Sitohang, Nada Nikita Sophi Damayanti Sudarsono Sudarsono Sudewi Mukaromah Khoirunnisa Sudirman Sudirman Sudirman Sudirman Sutjiningsih, Ni Nyoman Ota Syaadatun Nadiah Syah, Vicky Ardian Syahjoko Saputra, Iwan Syakilla, Nadia Nur Tantri Liris Nareswari Tikarahayu Putri Ulfa, Lutfiyana Ulisya, Azzaima Ayu Ulya, Salsa Nabila Ahlika Ummi, Ummi Uswatunhasanah, Putri Utami, Amalda Utami, Firanti Putri Utami, Widia Vega, Amelia Vernanda, Pramyudha Winni Nur Auli Wulandari, Valentri Yogi Nopiandi Permana Yogi Nopiandi Permana Yoki Yulizar Yulanda, Nola Rohmi Eka Yunita, Nadia Rahma Zaqia, Lulu Zusela, Titah