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EVALUASI PENGELOLAAN OBAT RUSAK, OBAT EXPIRED DATE DAN OBAT DEAD STOCK DI APOTEK “X” KOTA TANGERANG SELATAN TAHUN 2023 Rahajeng, Suny Koswara; Kristiyowati, Anis Dwi; Listiana, Ida; Sayyidah, Sayyidah; Haryani, Setianti; Ismaya, Nurwulan Adi
PHRASE (Pharmaceutical Science) Journal Vol 5, No 1 (2025): Vol 5 No 1 : Pharmaceutical Science Journal
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v5i1.914

Abstract

Latar belakang: Pengelolaan obat merupakan serangkaian proses perencanaan, pengadaan, penerimaan, penyimpanan, pemusnahan, pengendalian dan pencatatan serta pelaporan. Jika pengelolaan tidak dilakukan dengan benar maka akan timbul beberapa masalah di antaranya obat rusak yaitu obat yang mengalami kerusakan pada fisik, obat expired date adalah obat yang sudah melewati batas expired date yang tertera pada kemasan dan obat dead stock yaitu obat yang selama 3 bulan tidak terdapat transaksi hal – hal yang akan menimbulkan kerugian. Penyebabnya karena pengelolaan obat yaitu penyimpanan dan pengadaan. Sehingga obat menjadi rusak sebelum waktu expired date dan stok obat mengalami penumpukan akibat pengadaan dan sistem yang kurang tepat. Oleh karena itu tempat penyimpanan obat harus sesuai denganstandar agar pelayanan obat dapat berjalan dengan baik. Tujuan: untuk mengetahui melalui persentase obat rusak, obat expired date dan dead stock. Metode penelitian: Penelitian ini menggunakan deskriptif menggunakan pendekatan kuantitatif serta pengambilan data secara retrospektif. Data yang dikumpulkan menggunakan lembar observasi kemudian diolah dengan menggunakan microsoft excel setelah itu data diukur sesuai dengan indikator. Hasil: Penelitian menunjukkan persentase obat rusak 0,5% , obat expired date 2,1% dan obat dead stock sebesar 18%. Dari hasil tersebut tingkat pengelolaan obat yang kurang baik terutama pada perencanaan dan pengadaan serta penyimpanan yang belum baik karena masih melebihi nilai indikatornya yaitu 0%. Maka dapat lebih diperhatikan untuk penyusunan, penyimpanan dan pengadaan obat di Apotek.
PROFIL PERESEPAN OBAT ASMA PADA PASIEN ANAK DI INSTALASI FARMASI RAWAT JALAN RUMAH SAKIT “X” JAKARTA PERIODE JANUARI – MARET 2023 Dewantoro, Agung; Fahriati, Andriyani Rahmah; Galih Pratiwi, Rekiyan Tuhu; Dewi, Bheta Sari; Rahajeng, Suny Koswara; Ismaya, Nurwulan Adi
PHRASE (Pharmaceutical Science) Journal Vol 4, No 1 (2024): Pharmaceutical Science Journal Vol 4 No 1, 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v4i1.730

Abstract

Asma merupakan penyakit inflamasi (peradangan) kronis saluran napas yang ditandai dengan adanya mengi episodik, batuk, dan rasa sesak di dada akibat penyumbatan saluran napas. Asma pada bayi dan anak-anak memiliki angka kejadian yang lebih tinggi dibandingkan pada orang dewasa. Asma pada anak juga memiliki angka morbiditas dan mortalitas yang lebih tinggi dibandingkan orang dewasa. Penyakit asma tidak dapat disembuhkan namun dapat di kontrol sehingga pasien anak yang menderita asma akan mengkonsumsi atau menggunakan obat obatan asma dalam kurun waktu yang cukup panjang. Disamping itu serangan asma yang tidak dapat terprediksi serta munculnya sesak napas pada pasien asma dapat menyebabkan kematian apabila tidak ditangani dengan cepat. Oleh karenannya obat asma harus selalu tersedia dan tidak boleh terjadi kekosongan disarana pelayanan kesehatan sehingga pola peresepan obat asma pada pasien anak perlu diketahui agar data yang diperoleh dapat digunakan sebagai evaluasi pengadan obat asma pada pasien anak agar tidak terjadi kekosongan  Tujuan : Penelitian ini bertujuan untuk mengetahui profil peresepan obat asma pada pasien anak di instalasi farmasi rawat jalan Rumah Sakit “X” di wilayah Jakarta Selatan. Metode : Penelitian ini merupakan penelitian non eksperimental dengan rancangan penelitian bersifat deskriptif. Metode penelitian ini dilakukan dengan pendekatan kuantitatif dengan pengambilan data secara retrospektif dengan menggunakan data rekam medis pasien asma anak secara retrospektif pada periode Januari – Maret 2023 di instalasi farmasi rawat jalan Rumah Sakit “X” di wilayah Jakarta Selatan. Hasil :  penelitian ini menunjukkan bahwa mayoritas pasien asma adalah anak laki-laki sebanyak 56 orang (57,73%) dengan usia 0 – 4 tahun sebanyak 53 (54,64%). Jenis obat bronkodilator yang paling banyak digunakan adalah salbutamol (54,69%), golongan kortikostreroid menggunakan obat jenis budesonide (46,47%), antihistamin yaitu cetirizine (68,18%), mukolitik yaitu acetylcysteine (36%), dan analgetik antipiretik yaitu paracetamol (100%). Golongan obat asma yang paling banyak digunakan yaitu golongan bronkodilator (46,21%). Bentuk sediaan obat yang paling banyak diresepkan adalah nebulizer (35%). Jumlah obat asma dalam 1 resep yang paling banyak diresepkan yaitu 2 macam obat (34,02%).
PROFIL PERESEPAN OBAT ANTI TUBERKULOSIS PADA PASIEN ANAK DI INSTALASI FARMASI RAWAT JALAN RUMAH SAKIT X BOGOR PERIODE JANUARI – MARET 2023 Dewantoro, Agung; Andriati, Riris; Haryani, Setianti; Sakinah, Nur; Dewi, Bheta Sari; Rahajeng, Suny Koswara; Ismaya, Nurwulan Adi
PHRASE (Pharmaceutical Science) Journal Vol 3, No 2 (2023): Pharmaceutical Science Journal Vol 3 No 2, 2023
Publisher : Sekolah Tinggi Ilmu Kesehatan Widya Dharma Husada Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52031/phrase.v3i2.609

Abstract

Childhood tuberculosis is a disease caused by Mycobacterium tuberculosis at the age of 0-11 years. In Indonesia, tuberculosis is the third leading cause of death after cardiovascular disease and respiratory disease in all age groups. Tuberculosis in children is the most important factor in developing countries because the number of children aged 15 years is 40-50% of the total population. Objective: To find out the Prescribing Profile of Anti-Tuberculosis Drugs in Pediatric Patients at the Bogor X  Hospital Outpatient Pharmacy Installation for the January – March 2023 period. Methods: The type of research conducted was a non-experimental study with a descriptive research design. This research method was carried out using a quantitative approach and retrospective data collection. The retrospective approach is a study that looks backwards, which means collecting data from medical records with a diagnosis of tuberculosis. Results: This study showed that of the 94 tuberculosis patients at Bogor X  Hospital, the dominant sex was male (55.4%), with an age range of 0-5 years (65.9%), with an anatomical location of the disease in pulmonary tuberculosis (91.4%), with treatment for 6 months (95.7%) with comorbid dyspepsia (29.6%), with an intensive treatment phase, namely anti-tuberculosis drugs (66%), with an advanced treatment phase, namely anti-tuberculosis drugs (72.8%) and the use of other drugs, namely vitamins (72.8%).
Potentially Inappropriate Medication (PIM) Prescribing According to Beers Criteria among Elderly Outpatients at Pasar Minggu Hospital, Jakarta Pebriani, Mala; Sumarny, Ros; Arozal, Wawaimuli; Eviarini, Prawitasari; Ismaya, Nurwulan Adi
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 1, FEBRUARY 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Elderly patients generally have physiological changes that cause multipathological conditions, so they require several drugs to treat these conditions, it is necessary to evaluate the use of drugs to optimize the treatment of geriatric patients. Beers Criteria 2019 is a criteria that is commonly used to present Potentially Inappropriate Medication (PIM). This study aimed to examine the inaccuracy of prescription drugs in the elderly using Beer's criteria 2019. This research is an observational analytic study with a cross-sectional descriptive design. The Beer's 2019 criteria classify PIM into five categories. Data were taken retrospectively as many as 847 prescriptions met the inclusion criteria at the Pasar Minggu Hospital Outpatient Polyclinic. Data were analysed by Univariate and Bivariate. The results showed that from 847 prescriptions for geriatric patients, there are 160 prescriptions for geriatric patients who experienced PIM (18.89%). Percentage of PIM incidents by category; namely, category 1 was 29.17%, category 2 was 6.77%, category 3 was 44.79%, category 4 was 16.67%, and category 5 was 2.60%. The results of the analysis showed that there was a significant relationship between the number of drugs and Heart Failure and CAD with the incidence of PIM with a p value of 0.000 and 0.035. DM and Heart Failure are 2 diseases that significantly influence the incidence of PIM. This study concludes that the elderly are at risk for receiving potentially inappropriate medications.
In vivo Study of Uric Acid Inhibitory of Catechin from Gambir [Uncaria gambir (Hunter) Roxb] in Male Rats Yunarto, Nanang; Ismaya, Nurwulan Adi; Reswandaru, Uud Nourma; Hermiyanti, Evika; Gumilang, Nabila Cahya; Salina, Fitri
Jurnal Kefarmasian Indonesia VOLUME 14, NUMBER 1, FEBRUARY 2024
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Hyperuricemia is a metabolic disease characterized by high levels of uric acid in the blood. In silico studies of catechin compounds using molecular docking were able to inhibit the activity of the xanthin oxidase enzyme so that it could reduce uric acid levels. One of the native Indonesian plants that contains catechin is gambier (Uncaria gambir (Hunter) Roxb). This research aims to obtain the efficacy and safety of gambier leaf catechins in reducing uric acid levels. In vivo efficacy testing at doses of 20, 40, and 40 mg/Kg BW with allopurinol as a comparison and the safety of gambier leaf catechin in hyperuricemic male mice through macroscopic and microscopic examination of the liver and kidney organs. The results of research on determining catechin levels using HPTLC obtained levels of 96.06%. Gambier leaf catechin at doses of 20, 40, and 40 mg/Kg BW was able to reduce uric acid levels in the blood serum of mice. The higher the dose of catechin, the better the anti-hyperuricemia effect. In the results of the safety parameters, gambier leaf catechins, there were no specific abnormalities in the liver and kidneys of mice both macroscopically and microscopically. Based on research, it can be concluded that gambier leaf catechin has great potential as an anti-hyperuricemia drug and has good safety if consumed for a long time.
Nutraceutical Drink as Immune Booster Made from Red Ginger Combined with Lime and Honey to Prevent Viral Infection Hasanah, Nur; Utami, Sheila Meitania; Ismaya, Nurwulan Adi; Imansari, Aulia Nadya Rizki
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 1, FEBRUARY 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

Nutraceutical drinks are increasingly being chosen by the public as alternative medicine or as supportive therapy for disease prevention, offering minimal side effects with long-term use. This trend has gained momentum, mainly due to the rising incidence of COVID-19 and the emergence of highly transmissible variants. The combination of red ginger, lime juice, and honey will produce a healthy drink preparation containing antioxidants with vitamin C levels as an immune booster. This study aims to formulate a nutraceutical drink made from red ginger ((Zingiber officinale var. rubrum) combined with lime (Citrus aurantifolia) and honey also determine the antioxidant activity and the highest vitamin C levels. Physical stability tests include organoleptic, homogeneity, pH, specific gravity, viscosity, and accelerated stability tests using freeze-thaw cycling method. The antioxidant activity test using DPPH (1,1-diphenyl-2-picrylhydrazyl) method and analysis of vitamin C levels using the UV-Vis spectrophotometry method. The formulation was made with variations of lime juice FI (1%), FII (2%), and FIII (4%). The results of physical stability of the three formulations are not much different but based on organoleptic, FI has the best taste which is not too spicy and we are sure that most people will like it. Meanwhile, the highest antioxidant activity was possessed by FIII with an IC50 value of 11.21 ppm, which is classified as very strong and has the highest vitamin C content of 9103.88 µg/mL.
Level Of Knowledge Self-Medication Of Dysmenorrhea, Iron Supplement Consumption During Menstruation Student SMK Kesehatan Banten Dewantoro, Agung; Ismaya, Nurwulan Adi; Rahajeng, Sunny Koswara; Anggraeni, Niken Diah; Nurlela, Nurlela
Journal of Pharmacy and Nutrition Research Vol. 1 No. 02 (2025): December, 2025
Publisher : LPPM STIKes KHAS Kempek

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.64689/jopanur.v1i02.16

Abstract

Dysmenorrhea has an impact on young women, it can causing disturbances in daily activities. Losing blood during menstruation can affect iron lever in the body. women who menstruate monthly having risk of anemia. The prevalence of primary dysmenorrhea is 54.89% and the prevalence of anemia in Indonesia is 19.7% in women. Dysmenorrhea is often considered normal even though it affects daily activities so that adolescents do not visit health facilities but do self-medication. The purpose of riset is to find out the level of self-medication knowledge of dysmenorrhea drugs and the consumption of iron supplements during menstruation in students of the Banten Health Vocational School. The research method uses a descriptive design with a quantitative approach. Data was collected using a questionnaire that was distributed to 138 respondents who were selected using accidental. Results The level of self-medication knowledge of dysmenorrhea drugs was 65 repsondens or 40.10% in the good category, the level of knowledge of iron tablet consumption during menstruation was 66 respondents or 47.83% in the fair category. The conclusion of this study is that most of the students have an understanding and knowledge of self-medication dysmenorrhea and the consumption of iron tablets during menstruation.
Co-Authors Afriyani, Mirta Sepi Agung Dewantoro Al-Hafiz, Mohammad Alfianur Alfianur Alita, Dini Arum Alwiyati, Nurkhikmah Amelia Nurul Hakim Ananda Eka Safitri Andriyani Rahmah Fahriati Anggraeni, Niken Diah Annisa, Fitra ARDIYANTI, WIDYA Arief, Ilham Aripin Aripin Aripin Asep Hidayat Aulia, Gina Ayu Werawati Azzahra, Aristi Azzahra, Elsa Bagaskara Danumaya Bayu Prihantoro Beny Maulana Satria Betty Bheta Sari Dewi Dede Anggraeni Delianah, Anisha Desy Darmayanti DEWI FITRIANI Dewi Yulianti Diah Permata Sari Diah Permata Sari Eri Sigit Wibowo Erwin Herdiawan Eviarini, Prawitasari Fadly Putajaya Faizah Tafdhiila Fajar Tri Kuncoroyekti Farma, Ritta Fenita Purnama Sari Indah Fitriah, Nada Galih Pratiwi, Rekiyan Tuhu Gama Bagus Kuntoadi Gina Aulia Gita Ayuningtyas Gumilang, Nabila Cahya Handayani, Putri Handayani Hermiyanti, Evika Humaira Fadhilah Imansari, Aulia Nadya Rizki Ita La Tho Kasumawati, Frida Kristiyowati, Anis Dwi Kurniawati, Dewi Indah Lilis Suryani Butar Butar Listiana, Ida Luciana Luciana Lukman Handoyo Magdalena Niken Oktovina Muhammad Iqbal Fathoni Nanang Yunarto Nanang Yunarto Nanda Nurul Aini Neneng Sri Purwaningsih Ni Bodro Ardi Nining Prihatin Nur Hasanah Nur Hasanah Nur Hasanah Nur Hasanah Nur Sakinah Nurhaetami, Cut Intan Nurhafeni Nurhafeni Nurlela Nurlela Nursobah, Ihsan Okpri Melia Pebriani, Mala Permatasari, Putri Indah PUJI LESTARI Puji Rahayu Puji, Lela Kania Rahsa Putrajaya, Fadly Putri Handayani Putri, Annisa Septyana R Tri Rahyuning Lestari Rahajeng, Sunny Koswara Ramdan, Raka Fahri Rani Riskha Wahyuni Ratna Sitorus Resti Dwi Wahyuni Reswandaru, Uud Nourma RIRIS ANDRIATI Rita Dwi Pratiwi Rofiqo Syafa’a Fatulloh Ros Sumarny Salina, Fitri Sayyidah, Sayyidah Setianti Haryani Sheila Meitania Utami Sheli, Sheli Silvester Maximus Tulandi Siti Novy Romlah Sitorus, Christina Apnirosi Sucipto Sucipto Sumarwati Sumarwati Sumarwati Suny Koswara Rahajeng Tifani Monika TITA HARDIANTI Toni Zayendra Tri Okta Ratnaningtyas Tria Monja Mandira Uswatun Hasanah Utami Ulfa Veri, Veri Vini Irnia Wafa, Wafa Wawaimuli Arozal Yuliandanur, Eka Yulianti Yulianti