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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Majalah Kesehatan FKUB Medical Laboratory Technology Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Bioscientia Medicina : Journal of Biomedicine and Translational Research MMJ (Mahakam Midwifery Journal) Journal of Issues in Midwifery Jurnal Aisyah : Jurnal Ilmu Kesehatan Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Klinik dan Riset Kesehatan Zona Kebidanan : Program Studi Kebidanan Universitas Batam
Eviana Norahmawati
Department Of Anatomic Pathology, Faculty Of Medicine, Brawijaya University, Malang, East Java
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Leaflet Lebih Efektif Meningkatkan Pemahaman Penggunaan Pil Kontrasepsi Hormonal Kombinasi Dibandingkan Dengan Video Edukasi Pada Akseptor KB di Puskesmas Bareng Kota Malang Rahmana, Rahima Azzahra; Norahmawati, Eviana; Wati, Linda Ratna
Journal of Issues in Midwifery Volume 8 No 3 Tahun 2024
Publisher : Journal of Issues in Midwifery

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.JOIM.2024.008.03.1

Abstract

ABSTRACT Background: Based on Badan Pusat Statistik Data (2022) total acceptors of hormonal contraceptive pills in Malang is up to 14.580 women. Hormonal contraceptive pills are a contraceptive method that has to be consumed per-oral daily to give an effective result. Hormonal contraceptive usage could increase estrogen exposure to acceptors’ body, this exposure on the long term (usage > 3 years) could increase the risk of breast cancer. Knowing this risk, it is exceedingly needed for the acceptors to be given an education about how to use the hormonal contraceptive pills correctly. Leaflets and educational videos are proven to be effective to increase someone’s knowledge quiet well. Aim: to determine the difference in effectiveness between educational leaflets and videos on the understanding level of the use of combined hormonal contraceptive pills among family planning acceptors at Puskesmas Bareng Malang City. Method: an experimental research using comparison group design using Wilcoxon Matched Pairs Test. Result: After being provided with educational leaflets, there was an increase in understanding. The significance value obtained was p < 0.001 < α = 0.05. Similarly, using educational videos yielded the same value of p < 0.001 < α = 0.05. The Wilcoxon Signed Rank Test value indicates that there are 12 respondent values from the educational video group that are lower than the values of the leaflet group, with a mean rank of 10.54 and a sum of ranks of 126.50. The Asymp. Sig. (2-tailed) is 0.017 < 0.05, suggesting a significant difference in the effectiveness of education delivery between leaflets and educational videos. The use of leaflet educational media is more effective than educational videos. Conclusion: giving health education while using leaflet and educational video as the media is proven to significantly increase someone’s knowledge, with leaflet is slightly more significant to increase someone’s knowledge. Keywords: Hormonal Contraceptive Pill, Health Education, Leaflet, Educational Video, Women ABSTRAK Latar Belakang: Data Badan Pusat Statistik pada tahun (2022) menunjukkan bahwa jumlah akseptor kontrasepsi hormonal pil pada Kota Malang adalah sebanyak 14.580 jiwa. Kontrasepsi hormonal pil merupakan kontrasepsi yang harus dikonsumsi rutin setiap hari untuk mendapatkan hasil yang efektif mencegah kehamilan. Pemakaian kontrasepsi hormonal meningkatkan paparan hormon estrogen pada tubuh, hal ini menyebabkan pil kontrasepsi hormonal dapat meningkatkan risiko kanker payudara. Melihat risiko yang berbahaya ini, maka penting untuk diadakan edukasi cara tepat penggunaan pil kontrasepsi hormonal. Leaflet dan video edukasi dapat meningkatkan pengatahuan seseorang dengan baik. Tujuan Penelitian: untuk mengetahui perbedaan efektivitas leaflet dan video edukasi terhadap tingkat pemahaman penggunaan pil kontrasepsi hormonal kombinasi pada akseptor KB di Puskesmas Bareng Kota Malang. Metode Penelitian: penelitian eksperimental menggunakan desain comparison group design diuji menggunakan Wilcoxon Matched Pairs Test. Hasil Penilitian: terjadi peningkatan pemahaman setelah diberikan edukasi leaflet nilai signifikansi yang didapatkan adalah sebesar p value = <0.001 < α=0.05 dan menggunakan video edukasi mendapatkan nilai yang sama yaitu sebesar p value= < 0.001 < α=0.05. Nilai Wilcoxon Sign Ranked Test menunjukkan ada 12 nilai responden dari kelompok video edukasi yang lebih rendah dari nilai kelompok leaflet dengan nilai mean rank 10.54 dan sum of rank 126.50. Asymp. Sig. (2-tailed) adalah sebesar 0,017 < 0,05 dan dapat diartikan sebagai adanya perbedaan signifikansi pemberian edukasi menggunakan leaflet dan video edukasi, dengan penggunaan media edukasi leaflet lebih efektif dibandingkan dengan video edukasi. Kesimpulan: pemberian edukasi menggunakan leaflet dan video edukasi dapat meningkatkan pemahaman seseorang, leaflet sedikit lebih efektif dibandingkan video edukasi. Kata Kunci: Pil Kontrasepsi Hormonal, Sosialisasi Kesehatan, Leaflet, Video Edukasi, Wanita
PROFIL KLINIKOPATOLOGI DAN METODE DIAGNOSTIK TUMOR METASTASIS PADA TULANG DI RSUD Dr. SAIFUL ANWAR MALANG PERIODE 2016-2020 Norahmawati, Eviana; Nabila, Astrid Hanan; Irsan, Istan Irmansyah
Majalah Kesehatan Vol. 12 No. 1 (2025): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Tulang merupakan predileksi ketiga tersering dari kejadian metastasis. Pasien dengan tumor metastasis pada umumnya mengalami nyeri hebat yang berpengaruh pada menurunnya mobilitas pasien, fraktur patologis, dan komplikasi metabolik seperti hiperkalsemia. Manajemen penatalaksanaan pasien metastasis pada tulang memerlukan metode diagnostik yang tepat dengan menerapkan prinsip triple diagnostic. Penelitian ini bertujuan untuk mengetahui profil klinikopatologi dan metode diagnostik tumor metastasis pada tulang di RSUD dr. Saiful Anwar Malang periode 2016-2020. Metode penelitian yang digunakan adalah deskriptif cross sectional, dengan mengumpulkan data dari arsip CPC di Laboratorium Patologi Anatomi dan data Tumor  Registry Departemen Ortopedi dari pasien dengan tumor metastasis pada tulang di RSUD dr. Saiful Anwar Malang. Didapatkan 104 sampel dalam penelitian ini, dengan hasil rentang usia terbanyak adalah 50-59 tahun (dekade ke-6) (43,2%), dengan mean 53,7 tahun dan median 53,5 tahun. Jenis kelamin terbanyak adalah perempuan (62,5%) dengan rasio perempuan dibanding laki-laki 5:3. Lokasi tumor terbanyak pada tulang apendikular (55,8%), dengan asal tumor primer terbanyak adalah unknown origin (26,9%), disusul dengan karsinoma payudara (20,1%), karsinoma tiroid (19,2%), dan karsinoma paru (13,4%). Metode diagnostik radiologi yang paling banyak digunakan adalah X-ray (95,1%) dan bone survey (67,3%), sedangkan untuk metode diagnostik patologi anatomi terbanyak menggunakan FNAB (83,6%). Diagnosis patologi anatomi untuk jenis tumor metastasis pada tulang yang terbanyak adalah adenocarcinoma (74%). Hasil penelitian ini diharapkan dapat memberikan peran dalam penentuan diagnosis dan tatalaksana yang efektif dan tepat untuk meningkatkan kualitas hidup pasien dengan tumor metastasis pada tulang.
Beyond Tumor Grade: Investigating the Heterogeneity of PD-L1 Expression in Soft Tissue Sarcomas and the Need for Subtype-Specific Analysis Hamka Muhammad Nasir Laitupa; Eviana Norahmawati; RA Rose Khasana Dewi; Rachmad Sarwo Bekti; Diah Prabawati Retnani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 8 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i8.1350

Abstract

Background: Soft tissue sarcomas (STS) represent a diverse group of malignant mesenchymal neoplasms with considerable histological variety and differing degrees of malignancy. Programmed Death-Ligand 1 (PD-L1) expression is a crucial immunotherapy target in various cancers, but its role and expression patterns in STS, particularly within the Indonesian population, remain inadequately defined. This study aimed to investigate the differences in PD-L1 expression between low-grade and high-grade STS and to determine the correlation between PD-L1 expression and histological grading in an Indonesian cohort. Methods: This analytical observational study utilized a cross-sectional design, incorporating 29 archival paraffin-embedded tissue blocks from STS patients diagnosed at Dr. Saiful Anwar Regional General Hospital, Malang, Indonesia. PD-L1 expression was assessed immunohistochemically using the monoclonal antibody clone 22c3, and scoring was performed using the Combined Positive Score (CPS). Statistical analyses, including the Mann-Whitney U test and Spearman correlation, were employed to evaluate differences and correlations. Results: The majority of STS cases (89.7%) exhibited negative PD-L1 expression. The mean PD-L1 CPS was 0.1429 in low-grade STS and 0.233 in high-grade STS. No statistically significant difference in PD-L1 expression was observed between the low-grade and high-grade groups (p=0.620). Furthermore, Spearman correlation analysis revealed no significant association between PD-L1 expression (numeric CPS and categorical positivity) and histological grade (r=0.094, p=0.629 for CPS; r=0.102, p=0.600 for interpretation). Conclusion: This study found no significant difference in PD-L1 expression between low-grade and high-grade soft tissue sarcomas, nor a significant correlation with histological grade in the investigated Indonesian patient cohort. These findings suggest that PD-L1 expression, when assessed independently, may not be a reliable prognostic biomarker based solely on tumor grading in STS. Further research with larger sample sizes, encompassing diverse histological subtypes and incorporating additional immune biomarkers, is warranted.
Beyond Tumor Grade: Investigating the Heterogeneity of PD-L1 Expression in Soft Tissue Sarcomas and the Need for Subtype-Specific Analysis Hamka Muhammad Nasir Laitupa; Eviana Norahmawati; RA Rose Khasana Dewi; Rachmad Sarwo Bekti; Diah Prabawati Retnani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 8 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i8.1350

Abstract

Background: Soft tissue sarcomas (STS) represent a diverse group of malignant mesenchymal neoplasms with considerable histological variety and differing degrees of malignancy. Programmed Death-Ligand 1 (PD-L1) expression is a crucial immunotherapy target in various cancers, but its role and expression patterns in STS, particularly within the Indonesian population, remain inadequately defined. This study aimed to investigate the differences in PD-L1 expression between low-grade and high-grade STS and to determine the correlation between PD-L1 expression and histological grading in an Indonesian cohort. Methods: This analytical observational study utilized a cross-sectional design, incorporating 29 archival paraffin-embedded tissue blocks from STS patients diagnosed at Dr. Saiful Anwar Regional General Hospital, Malang, Indonesia. PD-L1 expression was assessed immunohistochemically using the monoclonal antibody clone 22c3, and scoring was performed using the Combined Positive Score (CPS). Statistical analyses, including the Mann-Whitney U test and Spearman correlation, were employed to evaluate differences and correlations. Results: The majority of STS cases (89.7%) exhibited negative PD-L1 expression. The mean PD-L1 CPS was 0.1429 in low-grade STS and 0.233 in high-grade STS. No statistically significant difference in PD-L1 expression was observed between the low-grade and high-grade groups (p=0.620). Furthermore, Spearman correlation analysis revealed no significant association between PD-L1 expression (numeric CPS and categorical positivity) and histological grade (r=0.094, p=0.629 for CPS; r=0.102, p=0.600 for interpretation). Conclusion: This study found no significant difference in PD-L1 expression between low-grade and high-grade soft tissue sarcomas, nor a significant correlation with histological grade in the investigated Indonesian patient cohort. These findings suggest that PD-L1 expression, when assessed independently, may not be a reliable prognostic biomarker based solely on tumor grading in STS. Further research with larger sample sizes, encompassing diverse histological subtypes and incorporating additional immune biomarkers, is warranted.
Effect of Bengkoang (Pachyrhizus erosus) Extract on Estrogen Receptor-?, Progesterone Receptor Expression, and Follicle-Stimulating Hormone Levels Suryanti; Putri Ardela, Mayasari; Frenty Hadiningsih, Eka; Winarsih, Sri; Noorhamdani; Nurseta, Tatit; Norahmawati, Eviana
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 3 July 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i3.2180

Abstract

Abstract Objective: Progesterone functions by inhibiting the release of Gonadotropin-Releasing Hormone (GnRH), which decreases Follicle-Stimulating Hormone (FSH) levels and converts them into hypoestrogens. This condition affects the expression of steroid, estrogen, and progesterone receptors, contributing to endometrial proliferation and secretion during the menstrual cycle. Methods: This study aims to demonstrate that Bengkoang extract administration increases the expression of Estrogen Receptor (ER), Progesterone Receptor (PR), and Follicle-Stimulating Hormone (FSH) in Wistar model rats. This study divided 25 female Wistar rats into five groups: one control group without progesterone and Bengkoang extract and four treatment groups injected with progesterone. After exposure, Bengkoang extract was administered to three treatment groups at doses of 70 mg/200 g BW/day (treatment 1), 140 mg/200 g BW/day (treatment 2), and 280 mg/200 g BW/day (treatment 3). Results: The results showed an increase in the expression of Estrogen Receptor- ? (Er?), Progesterone Receptor (PR), and Follicle-Stimulating Hormone (FSH) levels in treatment 1, treatment 2, and treatment 3 groups compared to the KP with p <0.05 Conclusion: The study investigating the effect of Bengkoang (Pachyrhizus erosus) extract on estrogen receptor-? (ER?), progesterone receptor (PR) expression, and follicle-stimulating hormone (FSH) levels has demonstrated significant findings. Keywords: Estrogen, Estrogen receptor-?, Follicle-stimulating hormone, Pachyrhizus erosus, Progesterone, Progesterone receptor
Co-Authors A.A. Ketut Agung Cahyawan W Adilah Ulfiati Adilah Ulfiati, Adilah Aina Angelina Ainun Ganisia Aliesya Patricia Amalia Pradanti Widarso, Amalia Pradanti Ardhian Wardana Ardhian Wardana, Ardhian Aris Rosidah Dian Sutarini, Ni Luh Gede Didiek Darmadi Ts Dwi Yuni Nur Hidayati Ega Prosfera, Rahma Haryunita Elisa Danik Kurniawati Endah Wijayanti Ervina, Rita Fadli, Muhammad Luqman Fitriana Nugraheni Fitriana Nugraheni, Fitriana Frenty Hadiningsih, Eka Ganisia, Ainun Hamka Muhammad Nasir Laitupa Harun Al Rasyid Harun Al Rasyid Herpan Syafii Harahap Ihda Dian Kusuma Ineke Permatasari Irsan, Istan Irmansyah Kenty Wantri Anita, Kenty Wantri Kurnia Penta Seputra Loeki Enggar Fitri lumban gaol, andy Miftahul Jannah MIFTAHUL JANNAH Mochammad Dalhar Nabila, Astrid Hanan Nanik Setijowati Ni Putu Sri Haryati Noorhamdani Nur Fahma Pradiptasari Nur Fahma Pradiptasari, Nur Fahma Nurdiana Nurdiana Patricia, Aliesya Pratista Adi Krisna, Pratista Adi Pratiwi, Suryanti Dwi Putra, Ngakan Putu Putri Ardela, Mayasari RA Rose Khasana Dewi Rachmad Sarwo Bekti Rahmana, Rahima Azzahra Retnani, Diah Prabawati Retty Ratnawati Ririn Handayani Rose Dewi Sawitri, Lia Sri Winarsih Sujarot Dwi Sasmito sujarot dwi sasmito, sujarot dwi SURYANTI Tanti Tri Lestary Tatit Nurseta Teguh Prihanto Teguh Wahju Sardjono Teguh Wahju Sardjono Tinny Endang Endang H Ulfaningtyas, Kiki Wati, Linda Ratna Wiyasa, I Wayan Arsana Yahya Irwanto Yahya Irwanto Yudhanto, Hendy Setyo Zakiyah Zulaifa Zakiyah Zulaifa, Zakiyah