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All Journal HAYATI Journal of Biosciences VALENSI Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Alchemy : Journal of Chemistry INDONESIAN JOURNAL OF PHARMACY Jurnal Kimia Riset Chimica et Natura Acta Indonesian Journal of Chemistry Pharmaceutical And Biomedical Sciences Journal (PBSJ) Molekul: Jurnal Ilmiah Kimia Jurnal Sains Materi Indonesia Jurnal Kefarmasian Indonesia Annales Bogorienses
Sofa Fajriah
Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK Serpong, Banten
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Energy Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Cytotoxic Activity of Flavonoid Compounds Isolated from Tetrameles Nudliflora Leaves Megawati, Megawati; Darmawan, Akhmad; Fajriah, Sofa
Annales Bogorienses Vol. 23 No. 2 (2019): Annales Bogorienses
Publisher : BRIN

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Abstract

Tetrameles nudliflora is one of the endemic plants in Wallace region, especially in Mekongga Forest, Southeast Sulawesi, Indonesia. As part of our project in the field of natural drug discovery based on local bioresources, this study aimed to isolate secondary metabolite compounds from the ethyl acetate fractions of the leaves of T. nudiflora and evaluate their cytotoxic activities against breast carcinoma cancer lines, MCF-7. The methods used were various chromatography techniques such as vacuum column chromatography, gravitation column chromatography, thin layer chromatography, preparative thin layer chromatography, and re-crystallization using two different organic solvents. In the present study, two flavonoid compounds, kaempferol (1) and quercetin (2) were identified. The structures of 1-2 were determined using serial spectroscopic techniques, including mass spectrometry, one- and two-dimensional nuclear magnetic resonance. Moreover, using 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide (MTT) assay method, both compounds showed in vitro cytotoxic activity IC50 of 34.162 and 133.148 μg mL-1, respectively against MCF-7 cell lines.
Eudesman-Type Sesquiterpenoids from Stem Bark Dysoxylum gaudichaudianum and Cytotoxic Evaluation Against Human HeLa Cervical Cancer Maira, Faizah; Naini, Al Arofatus; Mayanti, Tri; Farabi, Kindi; Fajriah, Sofa; Retnowati, Rurini; Supratman, Unang
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 2, November 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i2.46788

Abstract

Two eudesmane-type sesquiterpenoids were isolated from the stem bark of Dysoxylum gaudichaudianum: 6α-hydroxy-eudesm-4(15)-en-1-one (1) and eudesm-4(15),7-dien-1β-ol (2). This study represents the first report of these compounds not only from D. gaudichaudianum but also from the genus Dysoxylum. The cytotoxic potential of two sesquiterpenoids was assessed against human cervical carcinoma (HeLa) cells employing the Resazurin-based PrestoBlue assay. Using cisplatin as a positive control, compound 1 exhibited moderate cytotoxicity with an IC₅₀ of 28.04 µM, whereas compound 2 showed comparatively weaker activity, with an IC₅₀ of 58.37 µM. Their structures were elucidated through comprehensive spectroscopic analyses, including HR-ESI-MS, ¹H NMR, and ¹³C NMR. Structure–activity relationship analysis indicates that hydroxylation at C-6 enhances cytotoxic activity, whereas the C-6/C-7 olefinic moiety reduces potency, likely due to increased molecular rigidity, highlighting key structural features for activity modulation in the eudesmane scaffold.
Co-Authors . Megawati A Darmawan Abdi Wira Septama Ace Tatang Hidayat Akhmad Darmawan Alifia Agustina, Putri Antonius Herry Cahyana Azmi, Mohamad Nurul Darwati Darwati Desi Harneti Putri Huspa Dewa Gede Katja Dewijanti, Indah Dwiatmi Eka Prasasti Nur Rachmani Farabi, Kindi Febi Nurilmala Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Galuh Widiyarti Gunawan, Latifah Harizon Harizon Herdini , Herdini Hidayatullah, Sigit Hilmayanti, Erina Indah D Dewijanti, Indah D Isramiharti Isramiharti Kautsari, Arsi Khalijah Awang Kusumiyati Leonardus B.S. Kardono Lia Meilawati Maira, Faizah Marissa Angelina Maulina Handayani Megawati - Meliana, Yenny Munfarikhatin, Atina Mustaqim, Iqbal Wahyu Mustofa, Hidayat Nurul Naini, Al Arofatus Narti Fitriana, Narti Nelly Suryani Nurfauziyah Nurlelasari Nurlelasari Ofa Suzanti Betha Prastya, Muhammad Eka Primahana, Gian PUJI LESTARI Putria, Devi Kasih Rani Maharani Rehana Ricson Pemimpin Hutagaol Romundza, Febbry Rurini Retnowati Sabrina Dahlizar Sandra Amalia Riyadi Saputra, Ziyan Saputri, Ariyanti Sari, Aprilia Permata Satyaningsih, Desy Septiyanti, Melati Shiono, Yoshihito Sinaga, Siska Elisahbet Sofna Dewita Sari Banjarnahor, Sofna Dewita Sari Soleh Kosela Supriadi, Edi Tjandrawati Mozef Tri Mayanti Triana Dewi, Rizna Unang Supratman Wahyudi Priyono Suwarso Wira Septama, Abdi Yuni Anggraeni Zilhadia Zilhadia