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All Journal HAYATI Journal of Biosciences VALENSI Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Alchemy : Journal of Chemistry Journal of Mathematical and Fundamental Sciences INDONESIAN JOURNAL OF PHARMACY Jurnal Kimia Riset Chimica et Natura Acta Indonesian Journal of Chemistry Pharmaceutical And Biomedical Sciences Journal (PBSJ) Journal of Social Research Molekul: Jurnal Ilmiah Kimia Jurnal Sains Materi Indonesia Jurnal Kefarmasian Indonesia Annales Bogorienses
Sofa Fajriah
Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK Serpong, Banten
Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences

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Formulation and Characterization of Dewandaru Fruit Extract in Nanocarrier System Septiyanti, Melati; Nurfauziyah; Angelina, Marissa; Triana Dewi, Rizna; Fajriah, Sofa; Meliana, Yenny
Jurnal Sains Materi Indonesia Vol. 25 No. 2 (2024): Jurnal Sains dan Materi Indonesia
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jsmi.2024.3121

Abstract

Dewandaru (Eugenia uniflora L.) is a herbaceous plant that grows in tropical and subtropical regions. The fruit extract can prevent oxidative damage and cholinergic changes. It contributes to antihyperglycemic, antihyperlipidemic, and neuroprotective due to its antioxidants and antidepressant effect. It also possesses antibacterial and anti-inflammatory activity and potentially prevents cardiovascular disease and cancer. In this study, dewandaru fruit extract was formulated in the nanocarrier system (nanoemulsion and nanoencapsulation) to preserve product stability and improve product dispersibility and bioavailability. The nanoemulsion optimum formulation condition was obtained on dewandaru fruit extract concentration 10 wt%, oil/surfactant ratio 0.25, and homogenization speed 20.000 rpm, resulting in particle size of 46.4 ± 0.4 nm and polydispersity index 0.480 ± 0.015. The optimum nanoemulsion formulation was further processed to nanoencapsulation along with milling to produce finer particles. The nanoencapsulation milled for 120 minutes produced encapsulation powder with a size of 5.8 ± 3.340 μm. Accordingly, the nanocarrier technology for dewandaru fruit extract promoted a versatile medicinal preparation both in liquid and solid form. However, the size reduction by milling might disrupt the efficiency of the encapsulation release system. Without the proper coating, as orally administrated, the compound rapidly dissolved before it reached the targeted site.
Cytotoxic Activity of Flavonoid Compounds Isolated from Tetrameles Nudliflora Leaves Megawati, Megawati; Darmawan, Akhmad; Fajriah, Sofa
Annales Bogorienses Vol. 23 No. 2 (2019): Annales Bogorienses
Publisher : BRIN

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Abstract

Tetrameles nudliflora is one of the endemic plants in Wallace region, especially in Mekongga Forest, Southeast Sulawesi, Indonesia. As part of our project in the field of natural drug discovery based on local bioresources, this study aimed to isolate secondary metabolite compounds from the ethyl acetate fractions of the leaves of T. nudiflora and evaluate their cytotoxic activities against breast carcinoma cancer lines, MCF-7. The methods used were various chromatography techniques such as vacuum column chromatography, gravitation column chromatography, thin layer chromatography, preparative thin layer chromatography, and re-crystallization using two different organic solvents. In the present study, two flavonoid compounds, kaempferol (1) and quercetin (2) were identified. The structures of 1-2 were determined using serial spectroscopic techniques, including mass spectrometry, one- and two-dimensional nuclear magnetic resonance. Moreover, using 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide (MTT) assay method, both compounds showed in vitro cytotoxic activity IC50 of 34.162 and 133.148 μg mL-1, respectively against MCF-7 cell lines.
Eudesman-Type Sesquiterpenoids from Stem Bark Dysoxylum gaudichaudianum and Cytotoxic Evaluation Against Human HeLa Cervical Cancer Maira, Faizah; Naini, Al Arofatus; Mayanti, Tri; Farabi, Kindi; Fajriah, Sofa; Retnowati, Rurini; Supratman, Unang
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 2, November 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i2.46788

Abstract

Two eudesmane-type sesquiterpenoids were isolated from the stem bark of Dysoxylum gaudichaudianum: 6α-hydroxy-eudesm-4(15)-en-1-one (1) and eudesm-4(15),7-dien-1β-ol (2). This study represents the first report of these compounds not only from D. gaudichaudianum but also from the genus Dysoxylum. The cytotoxic potential of two sesquiterpenoids was assessed against human cervical carcinoma (HeLa) cells employing the Resazurin-based PrestoBlue assay. Using cisplatin as a positive control, compound 1 exhibited moderate cytotoxicity with an IC₅₀ of 28.04 µM, whereas compound 2 showed comparatively weaker activity, with an IC₅₀ of 58.37 µM. Their structures were elucidated through comprehensive spectroscopic analyses, including HR-ESI-MS, ¹H NMR, and ¹³C NMR. Structure–activity relationship analysis indicates that hydroxylation at C-6 enhances cytotoxic activity, whereas the C-6/C-7 olefinic moiety reduces potency, likely due to increased molecular rigidity, highlighting key structural features for activity modulation in the eudesmane scaffold.
Penta- and Tetra-cyclic Triterpenoids from Aglaia cucullata Stembark and Cytotoxicity against Cancer and Normal Cells Farabi, Kindi; Safriansyah, Wahyu; Harneti, Desi; Kuncoro, Hadi; Fajriah, Sofa; Supratman, Unang
Journal of Mathematical and Fundamental Sciences Vol. 57 No. 2 (2025)
Publisher : Directorate for Research and Community Services (LPPM) ITB

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/j.math.fund.sci.2025.57.2.1

Abstract

Three triterpenoid compounds, belonging to the penta- and tetracyclic groups, were successively isolated from the stembark of Aglaia cucullata and identified as b-amyron (1), dammaradienon (2), and cabralealactone (3). After extensive extraction, chromatographic separation and purification, compounds 1 to 3 were gained. Spectroscopic analysis in addition to HRMS, FTIR, 1D and 2D NMR analysis were utilized to determine the chemical structure. After that, compounds 1 to 3 were tested against breast cancer, melanoma as well as normal kidney cells (MCF-7, B16-F10, and CV-1, respectively). The resulted cytotoxicity test revealed that compound 1 had the best cytotoxicity against all cells compared with the other isolated compounds. This result suggests that the pentacyclic triterpenoid core in compound 1 increases cytotoxicity compared with a tetracyclic skeleton.
Co-Authors . Megawati A Darmawan Abdi Wira Septama Ace Tatang Hidayat Akhmad Darmawan Alifia Agustina, Putri Antonius Herry Cahyana Azmi, Mohamad Nurul Darwati Darwati Desi Harneti Putri Huspa Dewa Gede Katja Dewijanti, Indah Dwiatmi Djami, Ratna Eka Prasasti Nur Rachmani Farabi, Kindi Febi Nurilmala Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Galuh Widiyarti Gunawan, Latifah Hadi Kuncoro Harizon Harizon Herdini , Herdini Hidayatullah, Sigit Hilmayanti, Erina Hutagaol, Ricson Pemimpin Indah D Dewijanti, Indah D Isramiharti Isramiharti Kautsari, Arsi Khalijah Awang Kusumiyati Leonardus B.S. Kardono Lia Meilawati Maira, Faizah Marissa Angelina Maulina Handayani Megawati - Meliana, Yenny Munfarikhatin, Atina Mustaqim, Iqbal Wahyu Mustofa, Hidayat Nurul Naini, Al Arofatus Narti Fitriana, Narti Nelly Suryani Nurfauziyah Nurlelasari Nurlelasari Ofa Suzanti Betha Prastya, Muhammad Eka Primahana, Gian PUJI LESTARI Putria, Devi Kasih RAHMAT, DENI Rani Maharani Rehana Romundza, Febbry Rurini Retnowati Sabrina Dahlizar Safriansyah, Wahyu Sandra Amalia Riyadi Saputra, Ziyan Saputri, Ariyanti Sari, Aprilia Permata Satyaningsih, Desy Septiyanti, Melati Shiono, Yoshihito Sinaga, Siska Elisahbet Sofna Dewita Sari Banjarnahor, Sofna Dewita Sari Soleh Kosela Supriadi, Edi Swandiny, Greesty Finotory Tjandrawati Mozef Tri Mayanti Triana Dewi, Rizna Unang Supratman Utami, Usi Hikmah Wahyudi P. Suwarso, Wahyudi P. Wira Septama, Abdi Yuni Anggraeni Zilhadia Zilhadia