Article Per Year (5 Year)
p-Index From 2021 - 2026
2.629
P-Index
This Author published in this journals
All Journal HAYATI Journal of Biosciences VALENSI Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Alchemy : Journal of Chemistry INDONESIAN JOURNAL OF PHARMACY Jurnal Kimia Riset Chimica et Natura Acta Indonesian Journal of Chemistry Pharmaceutical And Biomedical Sciences Journal (PBSJ) Journal of Social Research Molekul: Jurnal Ilmiah Kimia Jurnal Sains Materi Indonesia Jurnal Kefarmasian Indonesia Annales Bogorienses
Sofa Fajriah
Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK Serpong, Banten
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

Published : 24 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 24 Documents
Search

 1   2   3 
Identification and Antibacterial Activity of Propionibacterium Acnes of Ethyl P-Methoxy Cinnamate Isolated from Kaempferia Galanga Linn Utami, Usi Hikmah; Djami, Ratna; Rahmat, Deni; Fajriah, Sofa; Swandiny, Greesty Finotory
Journal of Social Research Vol. 3 No. 1 (2023): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v3i1.1718

Abstract

Kaempferia galanga Linn is a typical Indonesian plant that contains the compound Ethyl P-Methoxy Sinnamate which has antibacterial activity. Acne is a common skin condition characterized by inflammation of the hair follicles and oil glands in the skin. The most effective acne treatment is the use of antibiotics. This research is an experimental study and aims to identify galangal rhizome isolates (Kaemperia galangan L) obtained from N-Hexane extract. using Thin Layer Chromatography (TLC) and Densitometry TLC as well as testing the antibacterial activity of the acne-causing Propionibacterium acnes ATCC 6919 using Complete Tool Design (RAL) with SPSS analysis, confidence level (p<0.05) and continued with the ANOVA test using the disc diffusion and liquid dilution methods for MIC. On In Vitro test Kaempferia galanga Linn contains antibacterial compounds that cause acne, namely Ethyl P-Methoxy Sinnamate with medium-strong strength at a concentration of 0.6%; 1.2%, and 2.4% with an inhibition zone of 8.70 mm; 10,10 mm and 11.70 mm. The clear zone for Clindamycin is 27.30 mm. Ethyl P-Methoxy Cinnamate (EPMS) isolated from Kaempferia galanga Linn N-Hexane extract Kaempferia galanga Linn has a concentration of 1.572 g/mL and has activity against Propionibacterium acnes bacteria at a concentration of 0.6%; 1.2% and 2.4%
Formulation and Characterization of Dewandaru Fruit Extract in Nanocarrier System Septiyanti, Melati; Nurfauziyah; Angelina, Marissa; Triana Dewi, Rizna; Fajriah, Sofa; Meliana, Yenny
Jurnal Sains Materi Indonesia Vol. 25 No. 2 (2024): Jurnal Sains dan Materi Indonesia
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jsmi.2024.3121

Abstract

Dewandaru (Eugenia uniflora L.) is a herbaceous plant that grows in tropical and subtropical regions. The fruit extract can prevent oxidative damage and cholinergic changes. It contributes to antihyperglycemic, antihyperlipidemic, and neuroprotective due to its antioxidants and antidepressant effect. It also possesses antibacterial and anti-inflammatory activity and potentially prevents cardiovascular disease and cancer. In this study, dewandaru fruit extract was formulated in the nanocarrier system (nanoemulsion and nanoencapsulation) to preserve product stability and improve product dispersibility and bioavailability. The nanoemulsion optimum formulation condition was obtained on dewandaru fruit extract concentration 10 wt%, oil/surfactant ratio 0.25, and homogenization speed 20.000 rpm, resulting in particle size of 46.4 ± 0.4 nm and polydispersity index 0.480 ± 0.015. The optimum nanoemulsion formulation was further processed to nanoencapsulation along with milling to produce finer particles. The nanoencapsulation milled for 120 minutes produced encapsulation powder with a size of 5.8 ± 3.340 μm. Accordingly, the nanocarrier technology for dewandaru fruit extract promoted a versatile medicinal preparation both in liquid and solid form. However, the size reduction by milling might disrupt the efficiency of the encapsulation release system. Without the proper coating, as orally administrated, the compound rapidly dissolved before it reached the targeted site.
Cytotoxic Activity of Flavonoid Compounds Isolated from Tetrameles Nudliflora Leaves Megawati, Megawati; Darmawan, Akhmad; Fajriah, Sofa
Annales Bogorienses Vol. 23 No. 2 (2019): Annales Bogorienses
Publisher : BRIN

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Tetrameles nudliflora is one of the endemic plants in Wallace region, especially in Mekongga Forest, Southeast Sulawesi, Indonesia. As part of our project in the field of natural drug discovery based on local bioresources, this study aimed to isolate secondary metabolite compounds from the ethyl acetate fractions of the leaves of T. nudiflora and evaluate their cytotoxic activities against breast carcinoma cancer lines, MCF-7. The methods used were various chromatography techniques such as vacuum column chromatography, gravitation column chromatography, thin layer chromatography, preparative thin layer chromatography, and re-crystallization using two different organic solvents. In the present study, two flavonoid compounds, kaempferol (1) and quercetin (2) were identified. The structures of 1-2 were determined using serial spectroscopic techniques, including mass spectrometry, one- and two-dimensional nuclear magnetic resonance. Moreover, using 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyl tetrazolium bromide (MTT) assay method, both compounds showed in vitro cytotoxic activity IC50 of 34.162 and 133.148 μg mL-1, respectively against MCF-7 cell lines.
Eudesman-Type Sesquiterpenoids from Stem Bark Dysoxylum gaudichaudianum and Cytotoxic Evaluation Against Human HeLa Cervical Cancer Maira, Faizah; Naini, Al Arofatus; Mayanti, Tri; Farabi, Kindi; Fajriah, Sofa; Retnowati, Rurini; Supratman, Unang
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 2, November 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i2.46788

Abstract

Two eudesmane-type sesquiterpenoids were isolated from the stem bark of Dysoxylum gaudichaudianum: 6α-hydroxy-eudesm-4(15)-en-1-one (1) and eudesm-4(15),7-dien-1β-ol (2). This study represents the first report of these compounds not only from D. gaudichaudianum but also from the genus Dysoxylum. The cytotoxic potential of two sesquiterpenoids was assessed against human cervical carcinoma (HeLa) cells employing the Resazurin-based PrestoBlue assay. Using cisplatin as a positive control, compound 1 exhibited moderate cytotoxicity with an IC₅₀ of 28.04 µM, whereas compound 2 showed comparatively weaker activity, with an IC₅₀ of 58.37 µM. Their structures were elucidated through comprehensive spectroscopic analyses, including HR-ESI-MS, ¹H NMR, and ¹³C NMR. Structure–activity relationship analysis indicates that hydroxylation at C-6 enhances cytotoxic activity, whereas the C-6/C-7 olefinic moiety reduces potency, likely due to increased molecular rigidity, highlighting key structural features for activity modulation in the eudesmane scaffold.
Co-Authors . Megawati A Darmawan Abdi Wira Septama Ace Tatang Hidayat Akhmad Darmawan Alifia Agustina, Putri Antonius Herry Cahyana Azmi, Mohamad Nurul Darwati Darwati Desi Harneti Putri Huspa Dewa Gede Katja Dewijanti, Indah Dwiatmi Djami, Ratna Eka Prasasti Nur Rachmani Farabi, Kindi Febi Nurilmala Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Galuh Widiyarti Gunawan, Latifah Harizon Harizon Herdini Herdini , Herdini Hidayatullah, Sigit Hilmayanti, Erina Hutagaol, Ricson Pemimpin Indah D Dewijanti, Indah D Isramiharti Isramiharti Kautsari, Arsi Khalijah Awang Kusumiyati Leonardus B.S. Kardono Lia Meilawati Maira, Faizah Marissa Angelina Maulina Handayani Megawati - Meliana, Yenny Munfarikhatin, Atina Mustaqim, Iqbal Wahyu Mustofa, Hidayat Nurul Naini, Al Arofatus Narti Fitriana, Narti Nurfauziyah Nurlelasari Nurlelasari Ofa Suzanti Betha Prastya, Muhammad Eka Primahana, Gian PUJI LESTARI Putria, Devi Kasih RAHMAT, DENI Rani Maharani Rehana Romundza, Febbry Rurini Retnowati Sabrina Dahlizar Sandra Amalia Riyadi Saputra, Ziyan Saputri, Ariyanti Sari, Aprilia Permata Satyaningsih, Desy Septiyanti, Melati Shiono, Yoshihito Sinaga, Siska Elisahbet Sofna Dewita Sari Banjarnahor, Sofna Dewita Sari Soleh Kosela Supriadi, Edi suryani, nelly Swandiny, Greesty Finotory Tjandrawati Mozef Tri Mayanti Triana Dewi, Rizna Unang Supratman Utami, Usi Hikmah Wahyudi P. Suwarso, Wahyudi P. Wira Septama, Abdi Yuni Anggraeni Zilhadia Zilhadia Zilhadia