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All Journal HAYATI Journal of Biosciences Damianus Journal of Medicine Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Jurnal Ilmu Kedokteran dan Kesehatan Acta Biochimica Indonesiana SRIWIJAYA JOURNAL OF MEDICINE Jurnal Muara Sains, Teknologi, Kedokteran dan Ilmu Kesehatan Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Ilmiah Biologi UMA (JIBIOMA) Jurnal Kesehatan Tambusai Bioscientist : Jurnal Ilmiah Biologi Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) EduNaturalia: Jurnal Biologi dan Kependidikan Biologi Jurnal Sehat Indonesia (JUSINDO) Tarumanagara Medical Journal Jurnal Sosial dan Sains Ebers Papyrus Jurnal Muara Medika dan Psikologi Klinis Jurnal Kedokteran Meditek International Journal of Psychology and Health Science Cermin Dunia Kedokteran
Frans Ferdinal
Department Of Biochemistry And Molecular Biology, Faculty Of Medicine, Tarumanagara University, Jakarta, Indonesia
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary

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Phytochemical Screening, Antioxidant Activity, and Toxicity of Imperata Cylindrica Root Extract Using the Brine Shrimp Lethality Test Prasasti Marsya Ayu Palupi; David Limanan; Frans Ferdinal; Eny Yulianti
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 12 No. 3 (2026)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/6s03ac45

Abstract

Background: Oxidative stress contributes to the pathogenesis of chronic diseases, increasing interest in plant derived antioxidants. Imperata cylindrica root is traditionally used, but its antioxidant potential and preliminary toxicity require evaluation. Objective: To characterize the phytochemical profile, antioxidant activity, and preliminary toxicity of methanolic I. cylindrica root extract. Methods: Dried roots were extracted by maceration and percolation. Qualitative phytochemical screening was performed. Antioxidant activity was evaluated using the DPPH assay at 100–900 mcg/mL, while toxicity was assessed using the Brine Shrimp Lethality Test (BSLT) with Artemia salina at 100–1000 mcg/mL for 24 hours. IC50 and LC50 values were estimated by linear regression. Results: Twelve groups of secondary metabolites were detected. DPPH inhibition increased from 30.957% to 72.912%, with an IC50 of 437.632 mcg/mL, indicating weak antioxidant activity. BSLT mortality increased from 13.462% to 98.684%, with an LC50 of 290.084 mcg/mL, indicating preliminary toxicity. Conclusion: I. cylindrica root extract demonstrated weak DPPH radical-scavenging activity and BSLT lethality. These findings do not establish mammalian or human toxicity and require confirmation through cell-based and in vivo toxicological studies.
Co-Authors Alvionica, Selina Ani R. Prijanti Ani Retno Prijanti Annisaa Nurrahma Ardyati Aspasia, Ariadne Calista Asyraf, Muhammad Zain Alwi Audina Leonita Azra Morley Iksanti Bethy S. Hernowo Cinthia Catherine Clareta Vero Patricia Widya Daiva Pattra Yoe Darlene Zaneta David Limanan Dewi, Mietha Apriyanti E Efrany E Yulianti Elhapidi, Nafisa Zulpa Eloydia Vintari, Clarista Enny Yulianti, Enny Eny Yulianti Eny Yulianti Eny Yulianti Eny Yulianti Eny Yulianti Eny Yulianti Eny Yulianti, Eny Erics Efrany Ezra, Pasuarja Jeranding F Wandy Fanny Septiani Farhan Febriana C. Iswanti Felix Felix Ferdian Ferdian Fernando Yosafat Franciscus D. Suyatna Frankson, Desvin Frans D Suyatna Gaofman, Brian Albert Gita Manerlin Kasihita Simatupang Habibah, Rizka Azahra HANS-JOACHIM FREISLEBEN Hartono, Daniswara Aliya Helmi Rizal Hilmi, Fakih Husna Iftinan Jessica Geselda Salim Jessie Farica Gunardi Julianty, Eny Karinnia Karinnia Kusuma, Andrea Bianca Castafiore Lis Diana Husni Putri M Lirendra Maharani, Karennina Larissa Malano, Zahra Khoirunissa Malihah, Ely Marcella, Agnes Maria Christina Dwiyanti Mellenia, Kelnia Michael Chen Mohamad Sadikin Mohamad Sadikin Muhammad Fitrianur Ramadansyah Najukha, Yusrifa Natasha Olivia Christian Ngestinuari Salim Ni Made Swantari NO Christian Noer Saelan Tadjudin Noer Saelan Tadjudin Novelee Irawan Putri Prasasti Marsya Ayu Palupi Putri, Nawaika Shafira R Benettan Resta Emelia Rejoltri Tumon Rizky Audryan Rizky Putri Agustina Rostika Flora Rumengan, Peterjohn Andrew Benhard Saerang, Stefanus Handy Salim, Melanie Santoso, Stanley Septelia I. Wanandi Shirly Gunawan Sindy Merliyani Siufui Hendrawan Siufui Hendrawan Siufui Hendrawan Soebrata, Linginda Sri W.A. Jusman Sri Widia A Jusman Sri Widia A. Jusman Swantari, Ni Made Tamba, Monica Diva Maharani Tanowijono, Gabriella Frederica Tanuhariono, Ardhita Felicia Thalia Gabriella Siriwa Verita, Chaeza Nara Wardaya Wardaya Wawan Mulyawan Wijayadi, Linda Julianti William Lukman