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Journal : Journal of Global Pharma Technology

Asthma Exercise Enhanced IL-10 Secretion but Had No Effect on IFN-ɣ in Patients with Persistent Atopic Asthma Rahmaya Nova Handayani
Journal of Global Pharma Technology Volume 11 Issue 08 (2019) Aug. 2019
Publisher : Journal of Global Pharma Technology

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Abstract

Background: Asthma is a chronic respiratory disease which is considered as a frequent non-communicable disease that could affect the quality of life. It is widely known that Th1 and Th2 imbalance is one of the underlying pathogenesis of asthma and many approaches had been devised to interfere this process. One of the well-known non-pharmacological approaches in asthma is asthma exercise. Therefore, this study aimed to investigate the role of asthma exercises on the balance of Th1 (IFN gamma) and T-regulator (IL-10). Methods: A pre-post-test group quantitative study was conducted using 39 subjects with persistent atopic asthma. All subjects participated on asthma exercise program that was conducted twice a day, 60 min per session. Atopic status was determined by skin prick test while IFN-Ɣ and IL-10 was determined by ELISA. Results: Median level of IL-10 was increased from 1.6 pg/ml before intervention to 2.2 pg/ml after intervention (p=0.000). However, the exercise program failed to produce any effect on IFN-Ɣ level which only showed a slight median increase from 9.374 pg/ml before intervention to 10.238 pg/ml in the post-test analysis (p=0.07). Conclusion: Asthma exercises significantly increased IL-10 level, but not significantly affect serum IFN-Ɣ in patients with persistent atopic asthma.Keywords: Asthma exercise, IL-10, IFN-Ɣ, T-h1/T-h2 balance.
Co-Authors A, Anggiatwan A, M Aryadi Achmad Djuneadi Adi Ryanto Adiratna Sekar Siwi Adriyani, Fauziah Hanum Nur Afandy, Dian Nurnatasha Afrilies, Marlia Hafny Agus, Dwi Aldi Hartono, Mochamad Amana, Titin Selwia Aprilyani, Ita Arni Nur Rahmawati Asmat Burhan Atun Raudotul Ma'rifah Atun Raudotul Ma’rifah Atun Raudotul Ma’rifah AZ ZAHRA, FITRAH ANNISA Bambang P, Yohanes Burhan, Asmat Cahyani, Regita Lintang Cahyaningrum, Etika Dewi Cahyono, Anar Catur Sayekti Denni, Febby Febrian Denny Agustiningsih Diah Rahmawati Djafar , Anisa Dwiyanti Dwi Novitasari Eko Hermawan Krisiyanto Evi Dayanti Eza Kemal Firdaus Fadlillah Fadlillah Fadlillah, Fadlillah Fandi Gunawan Farah Fildzah Fauziah, Dian Nur Febriyani, Ceria febriyanti febriyanti Feti Kumala Dewi Firdaus, Eza Kemal Frengky, Frengky JF Futuh, Muhammad Fathul Gatri Asti Putri HARNITA HARNITA Hasibuan, Verawati Hidu, Asfan La Hikmanti, Arlyana Indri Heri Susanti, Indri Heri Ita Aprilyani Jarod, Muhammad Jerau, Emiliani Elsi Kelvin Angling Kusumo Kharisma Aditama Khoirussalim, Moh Kholiqin, Nur Kisdyanti, Yuniar Melissa Linda Yanti Ma?rifah, Atun Raudotul Ma’rifah, Atun Raudotul Made Suandika Mariah Ulfah Maryadi, Adi Mawuntu, Jordan Herling Turang Meliana, Vanessa Febri Mohammad Thoriq Hasan Muhammad Galih Widyanto Muhammad Hanif I’zaaz Mulyaningsih, Amalia Erna Muntasir, Eva Muris, Theresia Uci Ikayun Murniati - Murniati . Murniati Murniati Murniati Murniati Muti, Refa Teja Nailli, Yuris Tri Ningrum, Ema Wahyu Nisha, Zuhrotun Noor Yunida Triana Novaliyanto, Sakhfa Syesar Nurjanah, Putri Aulia Permata, Pramudya Putra Pramesti Dewi Pratiwi, Syavira Salsabilah Putri Nola Puspitasari, Nevalia Kinanda Rian Arif Kurniawan Ririn Isma Sundari Rohmah, Ayu Nurita Sandi Saputra Sasmitha, Anggraeny Rara Savitri, Annistia Intan Septian Mixrova Sebayang Setianingsih, Sitti Setyawati, Martyarini Budi Setyo, Tri Panji Sofia Nanda Arista Suandika , Made Suci Khasanah Sufyan, Muhammad Ali Suhendro , Anton Surtiningsih SURTININGSIH, SURTININGSIH Suryani, Roro Lintang Susanto, Amin Susilawati, Evawani Syabilla Afifuddin Suat Syahputra, Yoga Tanjung, Ar-Rahman Utami, Firda Aulia Putri Vian Putria Isma Wardani , Ayu Wibowo, Tophan Heri Wijayanti, Indri Yantoro , Awal Tunis Yantoro, Awal Tunis Yazid Muhammad Fardan Yudha, Magenda Bisma Yulianto, Dwi Agus