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All Journal Jurnal Veteriner Jurnal Kedokteran Syiah Kuala Althea Medical Journal Indonesian Journal of Urology Berkala Ilmu Kesehatan Kulit dan Kelamin Jurnal Biosains Pascasarjana Jurnal Farmasi Klinik Indonesia Indonesian Journal of Tropical and Infectious Disease Journal of Agromedicine and Medical Sciences Health Notions Molecular and Cellular Biomedical Sciences (MCBS) Journal Of Vocational Health Studies Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Medik Veteriner J-Dinamika: Jurnal Pengabdian Kepada Masyarakat JURNAL ILKES (Jurnal Ilmu Kesehatan) Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Layanan Masyarakat (Journal of Public Service) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology Indonesian Archives of Biomedical Research (InABR) Indonesian Andrology and Biomedical Journal Journal of Innovation Research and Knowledge Jurnal Pengabdian Masyarakat Bhinneka Jurnal Pengabdian Masyarakat Bangsa Folia Medica Indonesiana
Arifa Mustika
Faculty Of Medicine, Universitas Airlangga
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Jurnal Veteriner

 1 
Penurunan Kerusakan Jaringan Paru Terinfeksi Tuberkulosis oleh Ekstrak Pegagan Melalui Peningkatan Ekspresi Tissue Inhibitor of Matrix Metalloproteinase-1 (SUPLEMENTATION OF EFFECT ANILYSIS OF CENTELLA ASIATICA EXTRACT IN REDUCE LUNG TUBERCULOSIS TISSUE D Arifa Mustika; Anny Setijo Rahaju; Roostantia Indrawati
Jurnal Veteriner Vol 15 No 4 (2014)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

Centella asiatica is a medicinal plant used for wound healing through increasing of collagen synthesis.This evidence generates a new expectation that it could be used for therapy of tuberculosis infection,especially for healing lung tissue damage. Until now, the effects and mechanisms onC. asiatica to cure thelung tissue damage due to M. tuberculosis infection remains unclear. The aim of this study was to prove theeffect and mechanism of ethanol extract of C. asiatica to repair the rats lung tissue damaged throughexpression of the enzimmatrix metalloproteinase-1(MMP-1)danenzimtissue inhibitor of matrixmetalloproteinase-1 (TIMP-1). The study was conducted in male rats. Twenty four rats were infected withM. tuberculosis through intratrachea and randomly divided into four groups. Group 1, 2 and 3 were thetreatment groups that they were given the ethanol extract of C. asiatica at dose 375mg/kgbw, 750 mg /kgbw, and 1500 mg / kgbw, orally and once a day for fourteen days. The fourth group was a control groupthat given distilled water. On day 15 rats were euthanized and lungs tissue have been taken. Evaluationof lungs tissue damage were assessed by the Dorman’s score in Hematoxylin Eosin and evaluation of the expression of MMP - 1 and TIMP 1 were performed by immunohistochemistry. Data of TIMP-1 wereanalyzed with ANOVA and data of lung tissue damage and MMP–1 were analyzed with Mann WhitneyU (á = 0.05). The results showed that there was a significant differences in the lungs tissue damagebetween the dose groups of 375 mg / kgbw and controls (p = 0.006), the dose groups at dose 750 mg / kgbwand controls (p = 0.004 ), the dose groups of 1500 mg / kgbw and controls (p = 0.043). There wasn’t asignificant difference between the treatment groups and control in the expression of MMP-1. In the expressionof TIMP – 1, there was a significant difference between the treatment group at dose of 750 mg / kg andcontrol. The conclusion of the study is the ethanol extract of C. asiatica has the ability to reduce lung tissuedamage of rats infected with M. tuberculosis, through increasesthe expression of TIMP-1
Co-Authors Achmad Firdaus Pamudya Wardhana Achmad Ilham Rizwani Adelia Handoko Agesti, Dyah Ahadini, Putri Aliya Akbar Kurniawan, Mohammad Alimsardjono, Lindawati Amustikarani, Dewa Ayu Praba Aniek Meidi, Aniek Annette d’Arqom, Annette Anny Setijo Rahaju, Anny Setijo Ario Imandiri, Ario Aszar, Farah Dynah Daeq Athoillah, Nabil Bambang Purwanto Cholis Abrori, Cholis Claudi Artha Dau, Daniel Deby Kusumaningrum Desie Dwi Wisudanti Dewinta, Nena Ristra Diah Mira Indramaya Dinda Dwi Purwati Edith Frederika Puruhito, Edith Frederika Elly Nurus Sakinah, Elly Nurus Faizah Sugiarto Farros Yuftariq Izzad Afla Fatimah, Nurmawati Fedelita Aistania Putri Firsta Wahono Febrianto Firsta Wahono Febrianto Fithriyah, Nathania Elma Gadis M. Sari Gondo Mastutik Halimatus Zahrah Harlina Soetjipto Herisulistyo, Aldilatama Herley Windo Setiawan I'tishom, Reny Indiastuti, Danti Nur Indri Safitri Mukono, Indri Safitri Irda Bella Isnaini Nur Jannah, Isnaini Nur Jieputra, Alden Kartuti Debora, Kartuti Kenconowungu, Citrawati Dyah Khaerunnisa, Siti Kurniawan, Mohammad Akbar Linda Astari, Linda Lukman Hakim Maftuchah Maftuchah Mah Zhook Yueng Miranda Jemyma Mas'ulun MOCHAMMAD THAHA Muhammad Arsy Reza Suyudi Muhammad Faizi, Muhammad Muhammad Hanun Mahyuddin Myrna Adianti Nabila Anisa Harum Naibaho, Ardy Hamonangan Nanang Haryono Nurina Hasanatuludhhiyah Nurlaili Susanti Nurrosyidah, Iif Hanifa Pamudya Wardhana, Achmad Firdaus Prabowo, Gwenny Ichsan Priyo Budi Purwono Purwanta, Marijam Puspa Wardhani Putri Aliya Ahadini Qurnianingsih, Ema Raden Mohamad Herdian Bhakti Rahmadhani, Khafiyah Hikmah Rahmawati, Lita Diah Rania Ratri Fauziyah Rejeki, Purwo Sri Renny I’tishom Rini Hamsidi Rizal, M Masrur Roostantia Indrawati Roostantia Indrawati Roostantia Indrawati, Roostantia Safira Raissa Dwi Putri Sandra Dewi Sitaresmi Sari, Gadis M. Sitaresmi, Sandra Dewi Siti Khaerunnisa Sjahjenny Mustokoweni, Sjahjenny Sriwijayanti Sulistyawati Stefanus, Lusiana Sukarno, Devitya Angielevi Sumardiko, Dwi Setiani Supangat Supangat Suryani Dyah Astuti Susanti, Luthfiana Rofhani Susanto, Ester Chateline Syahruna, Pradipta Reza Teguh Wahjudi Trisniartami Setyaningrum Vania Azalia Gunawan Wibsono, Sony WITA SARASWATI, WITA Wiwin Retnowati Wungu, Citrawati Dyah Kencono Wungu, Citrawati Dyah Kencono Yetti Hernaningsih Yuani Setiawati Zharfan, Rahmat Sayyid Zumara Ma'rifah Azzahra Zumara Ma'rifah Azzahra