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Journal : Acta Biochimica Indonesiana

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Jamblang (Syzygium cumini) leaf extract decreased hydrogen peroxide in lead acetate-induced rats Rauza Sukma Rita; Elmatris Sy; Endrinaldi
Acta Biochimica Indonesiana Vol. 5 No. 2 (2022): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.118

Abstract

Background: Free radicals are atoms or molecules with one or more unpaired electrons. Lead acetate has been reported to increase the presence of free radicals in the body. Objective: This study aims to investigate the effect of oral administration of jamblang (Syzygium cumini) leaf extract on hydrogen peroxide (H2O2) serum levels in rats induced with lead acetate. Methods: A total of 24 male rats were divided into three groups: the negative control, the positive control, and the treatment group. The negative control group received a standard diet, the positive control group received lead acetate at a dose of 40 mg/kg body weight, and the treatment group received lead acetate at the same dose along with jamblang leaf extract at a dose of 150 mg/kg body weight. Lead acetate and jamblang leaf extract administration was carried out for 30 days. Afterward, serum H2O2 levels were examined using the colorimetry method. Results: Results revealed that H2O2 levels in the negative control, positive control, and treatment groups were 3.08±0.24, 4.94±0.75, and 3.44±0.65 nmol/L, respectively. Significant differences were observed between the groups, as well as between the negative control and positive control, and between the positive control and treatment group. Conclusion: The study showed that jamblang leaf extract can reduce hydrogen peroxide levels in Wistar rats treated with lead acetate, indicating its ability to address oxidative stress.
Co-Authors Adrial Adrial Afriani, Nita Afriwardi Afriwardi Almurdi Almurdi Alvin Muhammad Arni Amir Asrawati Nurdin Asterina Asterina Aswiyanti Asri Aswiyanti Asri Bobby Indra Utama Delmi Sulastri Desmiwati Desmiwati2 Dessy Arisanti Dessy Arisanty Dia Rofinda, Zelly Dia Dian Pertiwi Dira Hefni Dira, Atshyfa Zsazsa Djosan, Al Hafiz Dwi Yulia Effy Huriyati Efrida Efrida Eldi Sauma Elmatris Elmatris Elmatris Sy Elmatris, Elmatris Ennesta Asri Erlina Rustam Erly Erly Ervan Arditya Kusuma Fadil Oenzil Fathoni Afif Feby Febriatama Fitria Ramanda Fortuna, Fory Gardenia Akhyar Gian Primahana Gita Rahmadani Gusti Revilla Hasmiwati Husna Yetti Husnil Kadri Ibrahim Ibrahim Ilham, Nur Muhammad Intan, Shinta Ayu Irrahmah, Miftah Jepri Agung Priyanto Julizar Nazar Linosefa Linosefa Lisma Evareny Magza, Dekasih Tria Mahata, Liganda Endo Masrul Mayetti Mayetti Miftah Irramah Mohamad Reza Muchtar, Masrul Muhammad Eka Prastya Nadhira Isza Qushoyyi Nadia Oktarina Nailatul Fadhila Novita Sari Nur Afrainin Syah Nur Indrawaty Lipoeto Nurhayati Nurhayati Nurul Fadila Oea Khairsyaf Putri, Biomechy Oktomalio Rafifa Ridha Rahmani Welan Raisa Hussein Ramadhani, Dhea Amaliya Rani Afrisetiawati Rauza Sukma Rita Rikarni Rikarni Rizki Amelia Roslaili Rasyid Saptino Miro Saptino Miro, Saptino Sari Handayani Utami Setiawan, Mentari Adinda Sisca Dwi Yarni Siti Utari Agustina Sri Wahyuni Suci Aulia Yude Tofrizal Triyunita, Rian Ulya Uti Fasrini Vitresia, Havriza Yarni, Sisca Dwi Yaumil Fauziah Yerizel , Eti Yuniar Lestari Yusticia Katar Yustini Alioes Zelly Dia Rofinda Zetryana Puteri Tachrim Zulkarnain Edward